SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TAD'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 9 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
None
TAD  A 901 (-2.3A)
None
None
None
0.95A 1hxwA-1lrtA:
undetectable
1hxwA-1lrtA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
6 / 11 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 314
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
0.82A 1jr1A-1lrtA:
46.0
1jr1A-1lrtA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 8 ASP A 261
SER A 263
ASN A 291
GLY A 314
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
0.37A 1jr1B-1lrtA:
45.9
1jr1B-1lrtA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
0.33A 1me7A-1lrtA:
57.8
1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
6 / 8 SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
GLY A 409
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
0.60A 1me7A-1lrtA:
57.8
1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 ASP A 261
ASN A 291
GLY A 315
GLU A 408
GLY A 407
TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
1.17A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
6 / 10 ASP A 261
ASN A 291
GLY A 316
GLU A 408
GLY A 409
ARG A 414
TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.6A)
None
IMP  A 801 ( 3.2A)
None
1.42A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 ASP A 261
ASN A 291
GLY A 359
GLU A 408
GLY A 407
TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
1.28A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
6 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 407
TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 (-3.2A)
1.32A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
7 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
ARG A 414
TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
None
0.85A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
8 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
0.30A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 SER A 263
ASN A 291
GLY A 315
GLU A 408
GLY A 407
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
1.26A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 SER A 263
ASN A 291
GLY A 359
GLU A 408
GLY A 407
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
0.95A 1mehA-1lrtA:
58.0
1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLU A 408
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
None
IMP  A 801 ( 3.2A)
0.33A 1meiA-1lrtA:
58.5
1meiA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
4 / 8 SER A 263
ASN A 291
GLU A 408
GLY A 407
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
IMP  A 801 (-3.2A)
0.91A 1meiA-1lrtA:
58.5
1meiA-1lrtA:
74.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 12 ARG A 299
ASP A 294
ILE A 313
GLY A 265
ILE A 292
None
None
TAD  A 901 (-4.1A)
None
None
1.32A 1q8jA-1lrtA:
6.5
1q8jA-1lrtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
None
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
None
0.82A 1sdvA-1lrtA:
undetectable
1sdvA-1lrtA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 12 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
None
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
None
0.81A 2avvA-1lrtA:
undetectable
2avvA-1lrtA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 7 ARG A 295
SER A 338
ARG A 352
GLU A 380
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
0.67A 2c8aA-3buzA:
23.1
2c8aA-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 7 ARG A 295
SER A 338
ARG A 352
GLU A 380
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
0.75A 2c8aB-3buzA:
22.9
2c8aB-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 6 ARG A 295
SER A 338
ARG A 352
GLU A 380
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
0.61A 2c8aC-3buzA:
22.6
2c8aC-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 7 ARG A 295
SER A 338
ARG A 352
GLU A 380
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
0.67A 2c8aD-3buzA:
18.4
2c8aD-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 7 LEU A 258
ILE A 337
SER A 387
TYR A 251
None
None
None
TAD  A 500 (-4.1A)
1.14A 2hc4A-3buzA:
undetectable
2hc4A-3buzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
3 / 3 GLY A 265
ASP A 264
SER A 262
None
TRS  A 600 ( 3.1A)
TAD  A 901 ( 2.6A)
0.65A 2qhfA-1lrtA:
undetectable
2qhfA-1lrtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 12 GLY A 290
VAL A  55
SER A  63
ASP A 358
ASP A 261
None
None
None
IMP  A 801 (-2.5A)
TAD  A 901 (-2.3A)
1.42A 2vqyA-1lrtA:
0.1
2vqyA-1lrtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
None
TAD  A 901 (-2.3A)
None
None
None
0.89A 2z54A-1lrtA:
undetectable
2z54A-1lrtA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
None
TAD  A 901 (-2.3A)
None
None
None
0.87A 3em3A-1lrtA:
undetectable
3em3A-1lrtA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
None
TAD  A 901 (-2.3A)
None
None
None
0.96A 3ndxA-1lrtA:
undetectable
3ndxA-1lrtA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
0.42A 4af0A-1lrtA:
45.3
4af0A-1lrtA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
0.41A 4af0B-1lrtA:
45.3
4af0B-1lrtA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
CYH A 319
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
0.88A 4fo4A-1lrtA:
47.0
4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
5 / 8 SER A 262
SER A 263
ASN A 291
CYH A 319
GLY A 409
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
0.69A 4fo4A-1lrtA:
47.0
4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
6 / 8 SER A 262
SER A 263
ASN A 291
GLY A 314
CYH A 319
GLY A 409
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
0.66A 4fo4B-1lrtA:
46.3
4fo4B-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
6 / 9 ASP A 261
SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
0.97A 4fxsA-1lrtA:
46.8
4fxsA-1lrtA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
7 / 9 SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
CYH A 319
ASP A 358
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 (-2.5A)
0.64A 4fxsA-1lrtA:
46.8
4fxsA-1lrtA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 5 LEU A 304
TRP A 326
ILE A 331
ASN A 335
None
None
None
TAD  A 500 (-2.8A)
1.35A 4i00A-3buzA:
undetectable
4i00A-3buzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
4 / 8 ASP A 264
ASP A 358
SER A 263
ALA A 334
TRS  A 600 ( 3.1A)
IMP  A 801 (-2.5A)
TAD  A 901 (-2.7A)
None
0.88A 4m48A-1lrtA:
undetectable
4m48A-1lrtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 7 ARG A 295
SER A 338
GLU A 378
GLU A 380
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
None
TAD  A 500 (-2.6A)
0.87A 4xzkA-3buzA:
10.4
4xzkA-3buzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 7 TYR A 251
ARG A 295
SER A 338
GLU A 380
TAD  A 500 (-4.1A)
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.6A)
0.62A 4xzkA-3buzA:
10.4
4xzkA-3buzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
4 / 8 GLY A 314
GLY A 315
VAL A 293
ASP A 358
TAD  A 901 (-3.9A)
None
None
IMP  A 801 (-2.5A)
0.76A 5f8yA-1lrtA:
undetectable
5f8yA-1lrtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis)
4 / 8 GLY A 314
GLY A 315
VAL A 293
ASP A 358
TAD  A 901 (-3.9A)
None
None
IMP  A 801 (-2.5A)
0.76A 5f8yB-1lrtA:
undetectable
5f8yB-1lrtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens)
4 / 8 PRO A 334
TYR A 333
THR A 332
ILE A 331
TAD  A 500 (-4.6A)
TAD  A 500 (-4.4A)
None
None
0.71A 5mzrE-3buzA:
undetectable
5mzrE-3buzA:
11.30