SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TAC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2hdn ELONGATION FACTOR
EF-TU
(Escherichia
coli) 		5 / 12 ASP B  80
GLY B 100
VAL B 127
TYR B  87
ASN B  90
 TAC  B1888 (-3.5A)
None
None
None
None
 1.48A 3hiiB-2hdnB:
0.0		 3hiiB-2hdnB:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		11 / 11 PRO A 144
VAL A 147
ASN A 149
TYR A 152
TYR A 170
ILE A 182
TYR A 187
PHE A 224
TYR A 229
GLU A 253
ILE A 255
 TAC  A7101 (-3.9A)
TAC  A7101 (-4.1A)
TAC  A7101 (-3.1A)
TAC  A7101 (-4.8A)
TAC  A7101 ( 3.9A)
None
None
TAC  A7101 (-4.0A)
TAC  A7101 (-3.8A)
TAC  A7101 (-4.2A)
TAC  A7101 (-4.2A)
 0.30A 3q5rA-3q5pA:
31.7		 3q5rA-3q5pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		6 / 6 VAL A 147
ASN A 149
TYR A 152
TYR A 187
GLU A 253
ILE A 255
 TAC  A7101 (-4.1A)
TAC  A7101 (-3.1A)
TAC  A7101 (-4.8A)
None
TAC  A7101 (-4.2A)
TAC  A7101 (-4.2A)
 0.38A 3q5sA-3q5pA:
31.6		 3q5sA-3q5pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		4 / 5 GLU A 145
GLY A 143
TYR A 229
GLU A 253
 None
None
TAC  A7101 (-3.8A)
TAC  A7101 (-4.2A)
 1.49A 3w9tA-3q5pA:
undetectable		 3w9tA-3q5pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		4 / 5 GLU A 145
GLY A 143
TYR A 229
GLU A 253
 None
None
TAC  A7101 (-3.8A)
TAC  A7101 (-4.2A)
 1.49A 3w9tC-3q5pA:
undetectable		 3w9tC-3q5pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		4 / 5 GLU A 145
GLY A 143
TYR A 229
GLU A 253
 None
None
TAC  A7101 (-3.8A)
TAC  A7101 (-4.2A)
 1.49A 3w9tD-3q5pA:
undetectable		 3w9tD-3q5pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		4 / 5 GLU A 145
GLY A 143
TYR A 229
GLU A 253
 None
None
TAC  A7101 (-3.8A)
TAC  A7101 (-4.2A)
 1.48A 3w9tG-3q5pA:
undetectable		 3w9tG-3q5pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		4 / 8 ASN A 168
PRO A 193
GLN A 115
ILE A 255
 None
None
None
TAC  A7101 (-4.2A)
 1.10A 4iilA-3q5pA:
undetectable		 4iilA-3q5pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		5 / 12 LEU A 155
ALA A 139
ILE A 134
GLY A 171
ALA A 172
 None
None
None
None
TAC  A7101 ( 4.3A)
 0.99A 4nkvD-3q5pA:
undetectable		 4nkvD-3q5pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR
(Bacillus
subtilis) 		6 / 10 ALA A 150
THR A 192
ILE A 190
LEU A 148
VAL A 147
LEU A 142
 None
None
None
None
TAC  A7101 (-4.1A)
None
 1.49A 4rz7A-3q5pA:
undetectable		 4rz7A-3q5pA:
15.28