SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T8N'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_A_SAMA300_0 (PUTATIVE METHYLTRANSFERASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	5 / 12	GLY A 44 GLY A 46 ASP A 68 SER A 97 GLU A 121	SAH A 308 (-3.6A) SAH A 308 (-3.6A) SAH A 308 (-2.6A) SAH A 308 (-3.7A) T8N A 309 ( 4.4A)	1.27A	3t7sA-3g5tA: 15.1	3t7sA-3g5tA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_B_SAMB300_0 (PUTATIVE METHYLTRANSFERASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	5 / 12	GLY A 44 GLY A 46 ASP A 68 SER A 97 GLU A 121	SAH A 308 (-3.6A) SAH A 308 (-3.6A) SAH A 308 (-2.6A) SAH A 308 (-3.7A) T8N A 309 ( 4.4A)	1.34A	3t7sB-3g5tA: 15.5	3t7sB-3g5tA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_D_SAMD300_0 (PUTATIVE METHYLTRANSFERASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	5 / 12	GLY A 44 GLY A 46 ASP A 68 SER A 97 GLU A 121	SAH A 308 (-3.6A) SAH A 308 (-3.6A) SAH A 308 (-2.6A) SAH A 308 (-3.7A) T8N A 309 ( 4.4A)	1.35A	3t7sD-3g5tA: 15.4	3t7sD-3g5tA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A3U_A_NCAA1359_0 (NADH:FLAVIN OXIDOREDUCTASE/NADH OXIDASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	4 / 7	TRP A 246 TRP A 179 TYR A 170 TYR A 242	EDO A 301 ( 4.1A) None None T8N A 309 ( 4.2A)	1.50A	4a3uA-3g5tA: undetectable	4a3uA-3g5tA: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7H_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	3 / 3	ARG A 184 THR A 245 TRP A 246	T8N A 309 ( 2.9A) None EDO A 301 ( 4.1A)	0.99A	4d7hA-3g5tA: undetectable	4d7hA-3g5tA: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HTF_A_SAMA301_0 (S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	5 / 12	GLY A 44 GLY A 46 LEU A 69 SER A 70 TRP A 125	SAH A 308 (-3.6A) SAH A 308 (-3.6A) SAH A 308 (-4.1A) SAH A 308 (-4.8A) T8N A 309 (-3.9A)	0.56A	4htfA-3g5tA: 14.0	4htfA-3g5tA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HTF_B_SAMB301_0 (S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	5 / 12	GLY A 44 GLY A 46 LEU A 69 SER A 70 TRP A 125	SAH A 308 (-3.6A) SAH A 308 (-3.6A) SAH A 308 (-4.1A) SAH A 308 (-4.8A) T8N A 309 (-3.9A)	0.51A	4htfB-3g5tA: 14.1	4htfB-3g5tA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QTU_D_SAMD301_0 (PUTATIVE METHYLTRANSFERASE BUD23)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	5 / 12	TYR A 14 GLY A 44 GLY A 46 MET A 73 TRP A 125	SAH A 308 ( 4.6A) SAH A 308 (-3.6A) SAH A 308 (-3.6A) SAH A 308 (-4.4A) T8N A 309 (-3.9A)	0.89A	4qtuD-3g5tA: 13.9	4qtuD-3g5tA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UGL_A_H4BA902_1 (NITRIC OXIDE SYNTHASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	3 / 3	ARG A 184 THR A 245 TRP A 246	T8N A 309 ( 2.9A) None EDO A 301 ( 4.1A)	0.99A	4uglA-3g5tA: undetectable	4uglA-3g5tA: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CFS_A_TOYA203_1 (AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANS FERASE,GENTAMICIN RESISTANCE PROTEIN)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	4 / 8	ASP A 266 TYR A 249 ASP A 263 TYR A 242	None None EDO A 300 (-4.8A) T8N A 309 ( 4.2A)	0.92A	5cfsA-3g5tA: undetectable	5cfsA-3g5tA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G6C_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	3g5t	TRANS-ACONITATE 3-METHYLTRANSFERASE (Saccharomyces cerevisiae)	3 / 3	ARG A 184 THR A 245 TRP A 246	T8N A 309 ( 2.9A) None EDO A 301 ( 4.1A)	1.01A	5g6cA-3g5tA: undetectable	5g6cA-3g5tA: 19.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3T7S_A_SAMA300_0","PUTATIVE METHYLTRANSFERASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",5,"GLY A  44;GLY A  46;ASP A  68;SER A  97;GLU A 121","SAH A 308 (-3.6A);SAH A 308 (-3.6A);SAH A 308 (-2.6A);SAH A 308 (-3.7A);T8N A 309 ( 4.4A)","1.27A","3t7sA-3g5tA:15.1",null],["3T7S_B_SAMB300_0","PUTATIVE METHYLTRANSFERASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",5,"GLY A  44;GLY A  46;ASP A  68;SER A  97;GLU A 121","SAH A 308 (-3.6A);SAH A 308 (-3.6A);SAH A 308 (-2.6A);SAH A 308 (-3.7A);T8N A 309 ( 4.4A)","1.34A","3t7sB-3g5tA:15.5","3t7sA-3g5tA:23.10"],["3T7S_D_SAMD300_0","PUTATIVE METHYLTRANSFERASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",5,"GLY A  44;GLY A  46;ASP A  68;SER A  97;GLU A 121","SAH A 308 (-3.6A);SAH A 308 (-3.6A);SAH A 308 (-2.6A);SAH A 308 (-3.7A);T8N A 309 ( 4.4A)","1.35A","3t7sD-3g5tA:15.4","3t7sB-3g5tA:23.10"],["4A3U_A_NCAA1359_0","NADH:FLAVIN OXIDOREDUCTASE\/NADH OXIDASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",4,"TRP A 246;TRP A 179;TYR A 170;TYR A 242","EDO A 301 ( 4.1A);None;None;T8N A 309 ( 4.2A)","1.50A","4a3uA-3g5tA:undetectable","3t7sD-3g5tA:23.10"],["4D7H_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",3,"ARG A 184;THR A 245;TRP A 246","T8N A 309 ( 2.9A);None;EDO A 301 ( 4.1A)","0.99A","4d7hA-3g5tA:undetectable","4a3uA-3g5tA:23.47"],["4HTF_A_SAMA301_0","S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",5,"GLY A  44;GLY A  46;LEU A  69;SER A  70;TRP A 125","SAH A 308 (-3.6A);SAH A 308 (-3.6A);SAH A 308 (-4.1A);SAH A 308 (-4.8A);T8N A 309 (-3.9A)","0.56A","4htfA-3g5tA:14.0","4d7hA-3g5tA:19.41"],["4HTF_B_SAMB301_0","S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",5,"GLY A  44;GLY A  46;LEU A  69;SER A  70;TRP A 125","SAH A 308 (-3.6A);SAH A 308 (-3.6A);SAH A 308 (-4.1A);SAH A 308 (-4.8A);T8N A 309 (-3.9A)","0.51A","4htfB-3g5tA:14.1","4htfA-3g5tA:22.63"],["4QTU_D_SAMD301_0","PUTATIVE METHYLTRANSFERASE BUD23","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",5,"TYR A  14;GLY A  44;GLY A  46;MET A  73;TRP A 125","SAH A 308 ( 4.6A);SAH A 308 (-3.6A);SAH A 308 (-3.6A);SAH A 308 (-4.4A);T8N A 309 (-3.9A)","0.89A","4qtuD-3g5tA:13.9","4htfB-3g5tA:22.63"],["4UGL_A_H4BA902_1","NITRIC OXIDE SYNTHASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",3,"ARG A 184;THR A 245;TRP A 246","T8N A 309 ( 2.9A);None;EDO A 301 ( 4.1A)","0.99A","4uglA-3g5tA:undetectable","4qtuD-3g5tA:22.12"],["5CFS_A_TOYA203_1","AAD(2''),GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE,GENTAMICIN RESISTANCE PROTEIN","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",4,"ASP A 266;TYR A 249;ASP A 263;TYR A 242","None;None;EDO A 300 (-4.8A);T8N A 309 ( 4.2A)","0.92A","5cfsA-3g5tA:undetectable","4uglA-3g5tA:19.41"],["5G6C_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","3g5t","TRANS-ACONITATE 3-METHYLTRANSFERASE","Saccharomyces cerevisiae",3,"ARG A 184;THR A 245;TRP A 246","T8N A 309 ( 2.9A);None;EDO A 301 ( 4.1A)","1.01A","5g6cA-3g5tA:undetectable","5cfsA-3g5tA:16.45"]]