SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T6T'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		4 / 4 TRP A 264
LEU A  33
ARG A 339
THR A 338
 T6T  A 501 (-2.9A)
None
None
None
 1.33A 1ao8A-5ci5A:
0.0		 1ao8A-5ci5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 ASP A 121
TYR A 129
TYR A 142
THR A 179
 T6T  A 401 (-2.0A)
None
None
T6T  A 401 (-3.0A)
 1.26A 1ceaA-5dkvA:
undetectable
1ceaB-5dkvA:
undetectable		 1ceaA-5dkvA:
13.45
1ceaB-5dkvA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		3 / 3 GLU A 244
HIS A 188
ASP A 134
 None
None
T6T  A 501 (-1.9A)
 0.88A 1i9gA-5ci5A:
undetectable		 1i9gA-5ci5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		4 / 5 ASP A  82
GLU A 187
THR A 119
LEU A 295
 T6T  A 501 (-2.3A)
None
None
None
 1.03A 1u18B-5ci5A:
undetectable		 1u18B-5ci5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		5 / 12 LEU A  33
GLY A  28
ASP A 134
GLY A 297
TYR A 132
 None
None
T6T  A 501 (-1.9A)
T6T  A 501 (-3.4A)
T6T  A 501 (-4.4A)
 1.09A 1zz1C-5ci5A:
undetectable		 1zz1C-5ci5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 ALA A 144
PRO A  97
GLY A  40
LEU A  41
ASP A 121
 None
None
None
None
T6T  A 401 (-2.0A)
 1.36A 2nv4B-5dkvA:
undetectable		 2nv4B-5dkvA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		5 / 12 ARG A 136
ALA A 366
ASP A  82
TRP A 298
GLY A  84
 T6T  A 501 (-3.0A)
None
T6T  A 501 (-2.3A)
T6T  A 501 (-3.5A)
T6T  A 501 ( 4.6A)
 1.44A 3jzjA-5ci5A:
45.6		 3jzjA-5ci5A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		5 / 12 GLY A  58
ASP A 134
ASP A 245
GLY A 296
ARG A 367
 None
T6T  A 501 (-1.9A)
None
T6T  A 501 (-3.2A)
T6T  A 501 (-3.0A)
 1.09A 3jzjA-5ci5A:
45.6		 3jzjA-5ci5A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 PHE A  73
GLY A  40
ALA A  96
THR A 119
ILE A 124
 T6T  A 401 ( 4.5A)
None
None
None
None
 1.26A 3ld6A-5dkvA:
undetectable		 3ld6A-5dkvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 PHE A  73
GLY A  40
ALA A  96
THR A 119
ILE A 124
 T6T  A 401 ( 4.5A)
None
None
None
None
 1.25A 3ld6B-5dkvA:
undetectable		 3ld6B-5dkvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 5 THR A 179
THR A 122
ASP A 121
TYR A  47
 T6T  A 401 (-3.0A)
T6T  A 401 ( 4.7A)
T6T  A 401 (-2.0A)
T6T  A 401 (-4.0A)
 1.18A 4oltB-5dkvA:
undetectable		 4oltB-5dkvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 PHE A 235
GLY A 239
ALA A 213
SER A 214
ASP A 208
 T6T  A 401 ( 4.5A)
None
None
None
None
 1.21A 4rtpA-5dkvA:
undetectable		 4rtpA-5dkvA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 THR A 179
ASP A 121
TYR A  47
GLY A  40
 T6T  A 401 (-3.0A)
T6T  A 401 (-2.0A)
T6T  A 401 (-4.0A)
None
 1.01A 5hwaA-5dkvA:
undetectable		 5hwaA-5dkvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		3 / 3 ARG A 367
HIS A 188
ARG A 136
 T6T  A 501 (-3.0A)
None
T6T  A 501 (-3.0A)
 0.87A 5iaoC-5ci5A:
undetectable		 5iaoC-5ci5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		3 / 3 ARG A 367
HIS A 188
ARG A 136
 T6T  A 501 (-3.0A)
None
T6T  A 501 (-3.0A)
 0.90A 5iaoF-5ci5A:
undetectable		 5iaoF-5ci5A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 THR A 179
PHE A  46
MET A  50
THR A 307
 T6T  A 401 (-3.0A)
T6T  A 401 (-3.2A)
None
None
 1.42A 5u6mA-5dkvA:
5.3		 5u6mA-5dkvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 THR A 179
PHE A  46
MET A  50
THR A 307
 T6T  A 401 (-3.0A)
T6T  A 401 (-3.2A)
None
None
 1.48A 5u6mB-5dkvA:
5.6		 5u6mB-5dkvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Pseudothermotoga
lettingae) 		5 / 12 ARG A 367
PHE A 196
GLY A 219
ILE A 260
GLY A 202
 T6T  A 501 (-3.0A)
None
None
None
None
 1.06A 5veuH-5ci5A:
undetectable		 5veuH-5ci5A:
24.13