SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T6P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 ASP A 210
THR A 213
GLU A 180
 MG  A 401 (-2.8A)
None
T6P  A 402 (-2.7A)
 0.75A 1pj7A-5dx9A:
undetectable		 1pj7A-5dx9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 6 ASP A  26
THR A 138
GLU A 180
GLU A 131
 T6P  A 402 ( 2.9A)
T6P  A 402 (-3.1A)
T6P  A 402 (-2.7A)
T6P  A 402 (-2.4A)
 1.46A 2dttB-5dx9A:
undetectable
2dttC-5dx9A:
undetectable		 2dttB-5dx9A:
19.30
2dttC-5dx9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		5 / 11 GLY A 246
GLY A 221
SER A  74
LEU A  75
SER A  76
 None
None
T6P  A 401 (-2.6A)
T6P  A 401 (-4.8A)
T6P  A 401 (-2.7A)
 1.01A 2qmmA-4xxhA:
2.6
2qmmB-4xxhA:
4.5		 2qmmA-4xxhA:
21.37
2qmmB-4xxhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.25A 5vooA-5dx9A:
undetectable		 5vooA-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.25A 5vooB-5dx9A:
undetectable		 5vooB-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.23A 5vooC-5dx9A:
undetectable		 5vooC-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.22A 5vooD-5dx9A:
undetectable		 5vooD-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.22A 5vooE-5dx9A:
undetectable		 5vooE-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 4 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.24A 5vooF-5dx9A:
1.4		 5vooF-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 HIS A 140
ASN A 178
LEU A 179
 T6P  A 402 (-3.7A)
T6P  A 402 (-3.5A)
BME  A 403 ( 4.3A)
 0.90A 6f7lB-5dx9A:
2.6		 6f7lB-5dx9A:
19.87