SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T5A'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		6 / 11 GLU A  60
ILE A  77
TYR A  78
GLN A 102
ARG A 139
ARG A 152
 T5A  A 501 (-2.5A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.7A)
T5A  A 501 (-4.2A)
 1.14A 1ki2A-1p75A:
37.0		 1ki2A-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
ILE A  77
ARG A 139
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.7A)
T5A  A 501 (-3.7A)
T5A  A 501 (-4.2A)
 0.88A 1ki2B-1p75A:
37.5		 1ki2B-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
ILE A  77
GLN A 102
ARG A 139
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.7A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.7A)
 0.95A 1ki2B-1p75A:
37.5		 1ki2B-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
ILE A  77
TYR A  78
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-4.2A)
 1.03A 1ki2B-1p75A:
37.5		 1ki2B-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
ILE A  77
TYR A  78
GLN A 102
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
 0.97A 1ki2B-1p75A:
37.5		 1ki2B-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		6 / 12 GLU A  60
TRP A  65
ILE A  74
ILE A  77
TYR A  78
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-4.2A)
 0.99A 1ki3A-1p75A:
36.9		 1ki3A-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		6 / 12 TRP A  65
ILE A  74
ILE A  77
TYR A  78
GLN A 102
ARG A 152
 None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-4.2A)
 1.01A 1ki3A-1p75A:
36.9		 1ki3A-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		7 / 12 GLU A  60
TRP A  65
ILE A  74
ILE A  77
TYR A  78
GLN A 102
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-4.2A)
 1.01A 1ki3B-1p75A:
37.5		 1ki3B-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		6 / 12 GLU A  60
TRP A  65
ILE A  74
ILE A  77
TYR A  78
GLN A 102
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
 0.68A 1ki7A-1p75A:
36.3		 1ki7A-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
ILE A  74
GLN A 102
ARG A 139
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.4A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.7A)
 0.72A 1ki7B-1p75A:
37.8		 1ki7B-1p75A:
38.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
ILE A  77
GLN A 102
ARG A 139
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.7A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.7A)
 0.76A 1ki7B-1p75A:
37.8		 1ki7B-1p75A:
38.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		4 / 7 LEU A 308
ILE A  36
ALA A 306
ILE A 179
 None
T5A  A 501 (-4.5A)
None
None
 0.76A 1oniB-1p75A:
0.0
1oniC-1p75A:
0.0		 1oniB-1p75A:
20.56
1oniC-1p75A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		4 / 8 VAL A  33
TYR A  34
ASP A 204
HIS A 189
 None
T5A  A 501 (-3.9A)
None
None
 1.19A 1pk2A-1p75A:
undetectable		 1pk2A-1p75A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		3 / 3 ASP A  56
GLU A  12
ARG A 113
 None
T5A  A 214 (-3.7A)
None
 0.79A 1wopA-4tmkA:
undetectable		 1wopA-4tmkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
GLN A 102
ARG A 139
PHE A 148
 T5A  A 501 (-2.5A)
None
T5A  A 501 (-3.1A)
T5A  A 501 (-3.7A)
T5A  A 501 (-3.5A)
 1.22A 2a7qA-1p75A:
15.5		 2a7qA-1p75A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		4 / 4 LEU A 211
THR A 210
ILE A  36
HIS A 189
 None
None
T5A  A 501 (-4.5A)
None
 1.29A 2jfaB-1p75A:
undetectable		 2jfaB-1p75A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		6 / 12 GLU A  60
TRP A  65
ILE A  74
ILE A  77
TYR A  78
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-4.2A)
 1.09A 2ki5A-1p75A:
36.5		 2ki5A-1p75A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		6 / 12 TRP A  65
ILE A  74
ILE A  77
TYR A  78
GLN A 102
ARG A 152
 None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-4.2A)
 0.98A 2ki5A-1p75A:
36.5		 2ki5A-1p75A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
GLN A 102
ARG A 139
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 (-3.1A)
T5A  A 501 (-3.7A)
T5A  A 501 (-4.2A)
 1.00A 2ki5B-1p75A:
37.5		 2ki5B-1p75A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		7 / 12 GLU A  60
TRP A  65
ILE A  74
ILE A  77
TYR A  78
GLN A 102
ARG A 152
 T5A  A 501 (-2.5A)
None
T5A  A 501 ( 4.4A)
T5A  A 501 ( 4.7A)
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-4.2A)
 1.18A 2ki5B-1p75A:
37.5		 2ki5B-1p75A:
35.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 TYR A 215
ILE A  36
ALA A 143
VAL A 142
ASP A 138
 None
T5A  A 501 (-4.5A)
None
None
None
 1.25A 2qo4A-1p75A:
undetectable		 2qo4A-1p75A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 TYR A 215
ILE A  36
ALA A 143
VAL A 142
ASP A 138
 None
T5A  A 501 (-4.5A)
None
None
None
 1.25A 2qo6A-1p75A:
undetectable		 2qo6A-1p75A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
TYR A  78
GLN A 102
PHE A 148
 T5A  A 501 (-2.5A)
None
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.5A)
 1.10A 2zi9B-1p75A:
15.8		 2zi9B-1p75A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
TYR A  78
GLN A 102
PHE A 148
 T5A  A 501 (-2.5A)
None
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.5A)
 1.01A 2ziaA-1p75A:
16.2		 2ziaA-1p75A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		5 / 12 GLU A  60
TRP A  65
TYR A  78
GLN A 102
PHE A 148
 T5A  A 501 (-2.5A)
None
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.5A)
 1.05A 2ziaB-1p75A:
15.8		 2ziaB-1p75A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1p75 THYMIDINE KINASE
(Equid
alphaherpesvirus
4) 		3 / 3 SER A 103
GLN A 102
PHE A 105
 None
T5A  A 501 (-3.1A)
T5A  A 501 (-3.4A)
 0.80A 3g4lC-1p75A:
0.0		 3g4lC-1p75A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		4 / 4 LEU A 147
GLY A 146
LEU A  11
GLU A  12
 None
None
None
T5A  A 214 (-3.7A)
 1.04A 3tgvB-4tmkA:
undetectable		 3tgvB-4tmkA:
21.05