SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T4K'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	5 / 11	LEU A1147 VAL A1358 TYR A1298 TYR A1329 PRO A1332	None None None T4K A1500 ( 4.2A) None	1.01A	1klmA-2po3A: 1.8	1klmA-2po3A: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SGU_B_MK1B2632_1 (POL POLYPROTEIN)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	5 / 8	ASP A1171 ALA A1173 GLY A1207 GLY A1208 ALA A1106	T4K A1500 ( 2.7A) T4K A1500 ( 3.4A) None None None	0.98A	1sguA-2po3A: undetectable	1sguA-2po3A: 12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_A_GBNA2414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	4 / 8	GLY A1024 GLY A1364 THR A1365 ALA A1366	T4K A1500 ( 3.3A) None None None	0.57A	2ej3A-2po3A: undetectable	2ej3A-2po3A: 25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G1U_B_ADNB438_1 (ADENOSYLHOMOCYSTEINA SE)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	5 / 12	THR A1103 THR A1351 LEU A1147 GLY A1144 PHE A1116	T4K A1500 ( 4.6A) None None None None	1.37A	3g1uB-2po3A: undetectable	3g1uB-2po3A: 23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_P_TFPP201_1 (PROTEIN S100-A4)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	4 / 7	GLY A1149 GLY A1186 PHE A1100 PHE A1330	None None T4K A1500 ( 4.0A) None	0.92A	3ko0M-2po3A: undetectable 3ko0P-2po3A: undetectable	3ko0M-2po3A: 12.29 3ko0P-2po3A: 12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJZ_A_BEZA1001_0 (BENZOATE-COENZYME A LIGASE)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	5 / 8	ALA A1209 VAL A1061 PHE A1196 GLY A1208 ALA A1076	None None None None T4K A1500 ( 3.1A)	1.46A	4zjzA-2po3A: 3.8	4zjzA-2po3A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJZ_B_BEZB601_0 (BENZOATE-COENZYME A LIGASE)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	5 / 8	ALA A1209 VAL A1061 PHE A1196 GLY A1208 ALA A1076	None None None None T4K A1500 ( 3.1A)	1.48A	4zjzB-2po3A: 4.8	4zjzB-2po3A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F8C_A_STRA502_1 (CYTOCHROME P450 CYP260A1)	2po3	4-DEHYDRASE (Streptomyces venezuelae)	5 / 6	ALA A1172 SER A1195 GLY A1208 THR A1073 ILE A1221	None T4K A1500 ( 2.8A) None None None	1.20A	6f8cA-2po3A: 0.0	6f8cA-2po3A: 11.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KLM_A_SPPA999_1","HIV-1 REVERSE TRANSCRIPTASE","2po3","4-DEHYDRASE","Streptomyces venezuelae",5,"LEU A1147;VAL A1358;TYR A1298;TYR A1329;PRO A1332","None;None;None;T4K A1500 ( 4.2A);None","1.01A","1klmA-2po3A:1.8",null],["1SGU_B_MK1B2632_1","POL POLYPROTEIN;POL POLYPROTEIN","2po3","4-DEHYDRASE","Streptomyces venezuelae",5,"ASP A1171;ALA A1173;GLY A1207;GLY A1208;ALA A1106","T4K A1500 ( 2.7A);T4K A1500 ( 3.4A);None;None;None","0.98A","1sguA-2po3A:undetectable","1klmA-2po3A:18.92"],["2EJ3_A_GBNA2414_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","2po3","4-DEHYDRASE","Streptomyces venezuelae",4,"GLY A1024;GLY A1364;THR A1365;ALA A1366","T4K A1500 ( 3.3A);None;None;None","0.57A","2ej3A-2po3A:undetectable","1sguA-2po3A:12.41"],["3G1U_B_ADNB438_1","ADENOSYLHOMOCYSTEINASE","2po3","4-DEHYDRASE","Streptomyces venezuelae",5,"THR A1103;THR A1351;LEU A1147;GLY A1144;PHE A1116","T4K A1500 ( 4.6A);None;None;None;None","1.37A","3g1uB-2po3A:undetectable","2ej3A-2po3A:25.23"],["3KO0_P_TFPP201_1","PROTEIN S100-A4;PROTEIN S100-A4","2po3","4-DEHYDRASE","Streptomyces venezuelae",4,"GLY A1149;GLY A1186;PHE A1100;PHE A1330","None;None;T4K A1500 ( 4.0A);None","0.92A","3ko0M-2po3A:undetectable;3ko0P-2po3A:undetectable","3g1uB-2po3A:23.59"],["4ZJZ_A_BEZA1001_0","BENZOATE-COENZYME A LIGASE","2po3","4-DEHYDRASE","Streptomyces venezuelae",5,"ALA A1209;VAL A1061;PHE A1196;GLY A1208;ALA A1076","None;None;None;None;T4K A1500 ( 3.1A)","1.46A","4zjzA-2po3A:3.8","3ko0M-2po3A:12.29;3ko0P-2po3A:12.29"],["4ZJZ_B_BEZB601_0","BENZOATE-COENZYME A LIGASE","2po3","4-DEHYDRASE","Streptomyces venezuelae",5,"ALA A1209;VAL A1061;PHE A1196;GLY A1208;ALA A1076","None;None;None;None;T4K A1500 ( 3.1A)","1.48A","4zjzB-2po3A:4.8","4zjzA-2po3A:24.42"],["6F8C_A_STRA502_1","CYTOCHROME P450 CYP260A1","2po3","4-DEHYDRASE","Streptomyces venezuelae",5,"ALA A1172;SER A1195;GLY A1208;THR A1073;ILE A1221","None;T4K A1500 ( 2.8A);None;None;None","1.20A","6f8cA-2po3A:0.0","4zjzB-2po3A:24.42"]]