SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T3Q'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 LEU A 130
GLY A 126
GLN A 127
THR A 188
ILE A 212
 None
None
None
T3Q  A 301 ( 4.2A)
None
 1.45A 1p93A-3px2A:
undetectable		 1p93A-3px2A:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		11 / 12 ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
MET A 102
ARG A 103
PHE A 118
SER A 120
LEU A 124
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-4.5A)
SAH  A 263 ( 4.7A)
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
None
 0.41A 3bxoA-3px2A:
37.0		 3bxoA-3px2A:
59.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		11 / 12 ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
MET A 102
ARG A 103
MET A 117
PHE A 118
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-4.5A)
SAH  A 263 ( 4.7A)
None
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
 0.55A 3bxoB-3px2A:
36.9		 3bxoB-3px2A:
59.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		11 / 12 TYR A  14
ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
ASP A 101
MET A 102
PHE A 118
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.5A)
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
 0.15A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
PHE A 118
HIS A 210
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
T3Q  A 301 ( 3.2A)
T3Q  A 301 ( 4.5A)
 1.46A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 7 TYR A  22
HIS A  26
TYR A  14
VAL A 192
 SAH  A 263 (-4.6A)
T3Q  A 301 (-4.1A)
SAH  A 263 ( 3.9A)
None
 1.00A 6g2pA-3px2A:
undetectable		 6g2pA-3px2A:
20.53