SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'T28'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
VAL A 453
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.60A 1fmoE-4idtA:
26.1		 1fmoE-4idtA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 VAL A 414
LYS A 429
VAL A 453
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.64A 2eufB-4idtA:
25.1		 2eufB-4idtA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 11 GLY A 407
GLY A 409
VAL A 414
ALA A 427
MET A 469
LEU A 522
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.90A 2evaA-4idtA:
25.9		 2evaA-4idtA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 11 GLY A 407
GLY A 409
VAL A 414
ALA A 427
MET A 469
SER A 476
LEU A 522
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 (-3.8A)
T28  A 701 (-3.9A)
 0.74A 2evaA-4idtA:
25.9		 2evaA-4idtA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
ASP A 515
LYS A 517
ASN A 520
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.66A 2fumA-4idtA:
26.6		 2fumA-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
MET A 469
LYS A 517
ASN A 520
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.81A 2fumB-4idtA:
26.7		 2fumB-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
MET A 469
ASN A 520
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 ( 4.9A)
 0.71A 2fumC-4idtA:
24.8		 2fumC-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 GLY A 407
VAL A 414
ALA A 427
MET A 469
LYS A 517
ASN A 520
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.94A 2fumD-4idtA:
24.7		 2fumD-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 517
ASN A 520
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.74A 2fumD-4idtA:
24.7		 2fumD-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 6 LEU A 406
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 ( 3.8A)
None
None
 0.90A 2hyyA-4idtA:
21.6		 2hyyA-4idtA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 10 LEU A 406
ALA A 427
LYS A 429
VAL A 453
LEU A 471
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 (-3.9A)
 0.84A 3aoxA-4idtA:
22.7		 3aoxA-4idtA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 10 LEU A 406
ALA A 427
VAL A 453
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.87A 3aoxA-4idtA:
22.7		 3aoxA-4idtA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 VAL A 414
ALA A 427
LEU A 455
LEU A 471
GLY A 475
LEU A 522
PHE A 535
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
None
 0.97A 3bbtB-4idtA:
22.8		 3bbtB-4idtA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 VAL A 414
ALA A 427
LEU A 455
LEU A 471
LEU A 522
ASP A 534
PHE A 535
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
None
 1.02A 3bbtB-4idtA:
22.8		 3bbtB-4idtA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
ALA A 427
LYS A 429
VAL A 453
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.80A 3c7qA-4idtA:
21.1		 3c7qA-4idtA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 10 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.79A 3cs9A-4idtA:
21.7		 3cs9A-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 9 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
LEU A 472
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-4.5A)
 1.42A 3cs9B-4idtA:
22.1		 3cs9B-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 9 LEU A 406
VAL A 414
VAL A 453
ILE A 467
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
None
None
T28  A 701 (-3.9A)
 0.80A 3cs9B-4idtA:
22.1		 3cs9B-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 9 LEU A 406
VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.77A 3cs9C-4idtA:
21.4		 3cs9C-4idtA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		9 / 12 LEU A 406
GLY A 407
GLY A 409
GLY A 412
VAL A 414
ALA A 427
LYS A 429
SER A 476
ASN A 520
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
None
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 (-3.8A)
T28  A 701 ( 4.9A)
 0.75A 3eygA-4idtA:
2.5		 3eygA-4idtA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		11 / 12 LEU A 406
GLY A 407
GLY A 412
VAL A 414
ALA A 427
LYS A 429
MET A 469
SER A 476
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
None
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 (-2.6A)
T28  A 701 (-3.8A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.70A 3eygA-4idtA:
2.5		 3eygA-4idtA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		10 / 12 LEU A 406
GLY A 407
GLY A 412
VAL A 414
ALA A 427
LYS A 429
MET A 469
SER A 476
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
None
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 (-2.6A)
T28  A 701 (-3.8A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.81A 3fupA-4idtA:
25.4		 3fupA-4idtA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 429
VAL A 453
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.76A 3fupB-4idtA:
25.0		 3fupB-4idtA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 6 LEU A 406
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-3.8A)
T28  A 701 ( 3.8A)
None
None
 0.85A 3k5vB-4idtA:
21.4		 3k5vB-4idtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 429
VAL A 453
MET A 469
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-2.6A)
T28  A 701 ( 3.4A)
 0.83A 3lxkA-4idtA:
24.5		 3lxkA-4idtA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
VAL A 453
MET A 469
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 (-2.6A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.98A 3lxkA-4idtA:
24.5		 3lxkA-4idtA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 429
SER A 476
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 (-3.8A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.72A 3lxnA-4idtA:
25.3		 3lxnA-4idtA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 6 VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.78A 3mssD-4idtA:
21.6		 3mssD-4idtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 ALA A 427
LYS A 429
GLU A 440
VAL A 453
ILE A 467
GLY A 475
LEU A 522
 T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.90A 3ue4A-4idtA:
23.9		 3ue4A-4idtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
ALA A 427
LYS A 429
GLU A 440
ILE A 467
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 1.07A 3ue4A-4idtA:
23.9		 3ue4A-4idtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 VAL A 414
ALA A 427
GLU A 440
VAL A 453
ILE A 467
GLY A 475
LEU A 522
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
None
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.76A 3ue4B-4idtA:
23.6		 3ue4B-4idtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.96A 3ug2A-4idtA:
23.8		 3ug2A-4idtA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
ALA A 427
LYS A 429
GLU A 440
LEU A 506
HIS A 513
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
None
T28  A 701 (-3.9A)
 0.72A 3zosA-4idtA:
21.1		 3zosA-4idtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.75A 4ag8A-4idtA:
22.0		 4ag8A-4idtA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
VAL A 453
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.71A 4ag8A-4idtA:
22.0		 4ag8A-4idtA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
VAL A 414
LYS A 429
GLU A 440
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.74A 4agcA-4idtA:
21.5		 4agcA-4idtA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 11 LEU A 406
ALA A 427
VAL A 453
GLY A 475
LEU A 522
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
 0.80A 4agdA-4idtA:
21.2		 4agdA-4idtA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 12 ILE A 467
MET A 469
ASP A 515
LYS A 517
ASN A 520
 None
T28  A 701 (-2.6A)
None
None
T28  A 701 ( 4.9A)
 0.63A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LYS A 429
LEU A 441
ILE A 467
ASN A 520
ASP A 534
GLY A 558
 T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
None
 1.46A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LYS A 429
LEU A 441
ILE A 467
ASP A 515
ASN A 520
ASP A 534
 T28  A 701 ( 3.8A)
None
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 1.15A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LYS A 429
LEU A 441
ILE A 467
MET A 469
ASN A 520
GLY A 558
 T28  A 701 ( 3.8A)
None
None
T28  A 701 (-2.6A)
T28  A 701 ( 4.9A)
None
 1.31A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LYS A 429
LEU A 441
ILE A 467
MET A 469
ASP A 515
ASN A 520
 T28  A 701 ( 3.8A)
None
None
T28  A 701 (-2.6A)
None
T28  A 701 ( 4.9A)
 0.94A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LYS A 429
LEU A 441
LEU A 455
ILE A 467
ASP A 515
ASP A 534
 T28  A 701 ( 3.8A)
None
None
None
None
T28  A 701 ( 3.4A)
 1.40A 4an2A-4idtA:
25.4		 4an2A-4idtA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
GLY A 475
LEU A 506
HIS A 513
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
None
None
 0.84A 4asdA-4idtA:
21.6		 4asdA-4idtA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 VAL A 414
ALA A 427
ASP A 515
LYS A 517
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
None
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.66A 4i41A-4idtA:
25.2		 4i41A-4idtA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 10 ALA A 427
VAL A 453
MET A 469
LEU A 472
GLY A 475
LEU A 522
 T28  A 701 (-3.0A)
None
T28  A 701 (-2.6A)
T28  A 701 (-4.5A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.68A 4ks8A-4idtA:
29.6		 4ks8A-4idtA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
GLY A 409
VAL A 414
ALA A 427
LYS A 429
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.78A 4mkcA-4idtA:
23.6		 4mkcA-4idtA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 6 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-3.9A)
 0.48A 4o0wA-4idtA:
25.3		 4o0wA-4idtA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 8 GLY A 409
VAL A 414
ALA A 427
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.73A 4ogrA-4idtA:
26.4		 4ogrA-4idtA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 7 GLY A 407
ALA A 427
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.75A 4ogrE-4idtA:
25.4		 4ogrE-4idtA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 9 GLY A 409
VAL A 414
ALA A 427
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.60A 4ogrI-4idtA:
26.6		 4ogrI-4idtA:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 11 ALA A 427
LYS A 429
GLU A 440
ILE A 467
LEU A 472
LEU A 522
ASP A 534
 T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-4.5A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 1.00A 4qmsA-4idtA:
28.1		 4qmsA-4idtA:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 12 ALA A 427
LYS A 429
ILE A 467
SER A 476
PHE A 535
 T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.8A)
None
 0.90A 4rzvA-4idtA:
7.3		 4rzvA-4idtA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 12 LEU A 406
ALA A 427
LEU A 506
HIS A 513
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
None
None
T28  A 701 (-3.9A)
 0.62A 4uxqA-4idtA:
22.2		 4uxqA-4idtA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LEU A 406
VAL A 414
ALA A 427
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.82A 5h2uA-4idtA:
22.8		 5h2uA-4idtA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 VAL A 414
ALA A 427
LYS A 429
ILE A 467
CYH A 533
GLY A 536
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.7A)
None
 1.27A 5hesB-4idtA:
22.0		 5hesB-4idtA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 VAL A 414
ALA A 427
LYS A 429
ILE A 467
CYH A 533
PHE A 535
 T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.7A)
None
 0.99A 5hesB-4idtA:
22.0		 5hesB-4idtA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 GLY A 407
GLY A 409
VAL A 414
ALA A 427
LYS A 429
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 ( 3.4A)
 0.94A 5hieC-4idtA:
24.4		 5hieC-4idtA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 7 GLY A 407
GLY A 409
SER A 410
GLY A 412
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
None
None
 0.31A 5izjB-4idtA:
23.6		 5izjB-4idtA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 11 LEU A 406
GLY A 407
VAL A 414
ALA A 427
VAL A 453
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 (-3.9A)
 0.59A 5lvnA-4idtA:
25.3		 5lvnA-4idtA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 10 GLY A 407
VAL A 414
ALA A 427
MET A 469
LEU A 471
 T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 ( 4.8A)
 0.43A 5lw1E-4idtA:
20.0		 5lw1E-4idtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		5 / 9 GLY A 407
VAL A 414
ALA A 427
MET A 469
LEU A 471
 T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 ( 4.8A)
 0.51A 5lw1H-4idtA:
16.9		 5lw1H-4idtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 10 LEU A 406
VAL A 414
LYS A 429
GLU A 440
ILE A 467
GLY A 475
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 3.0A)
 0.92A 5mo4A-4idtA:
18.9		 5mo4A-4idtA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 5 LEU A 406
VAL A 414
MET A 469
CYH A 533
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-2.6A)
T28  A 701 (-3.7A)
 0.85A 5te0A-4idtA:
23.5		 5te0A-4idtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		6 / 12 LEU A 406
ALA A 427
LYS A 429
GLU A 440
VAL A 453
GLN A 479
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-3.0A)
 0.79A 5vcvA-4idtA:
25.0		 5vcvA-4idtA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 4 VAL A 453
LEU A 471
ASN A 520
ASP A 534
 None
T28  A 701 ( 4.8A)
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.90A 5vcyA-4idtA:
24.9		 5vcyA-4idtA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
LEU A 471
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 (-3.9A)
 0.84A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
LEU A 471
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 (-3.9A)
 0.84A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
VAL A 414
LYS A 429
GLU A 440
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.94A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		7 / 12 LEU A 406
VAL A 414
LYS A 429
GLU A 440
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.94A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
ALA A 427
GLU A 440
LEU A 471
GLY A 475
LEU A 522
CYH A 533
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
T28  A 701 ( 3.4A)
 0.83A 5y7zB-4idtA:
22.6		 5y7zB-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
ALA A 427
LYS A 429
GLU A 440
LEU A 471
GLY A 475
CYH A 533
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.7A)
T28  A 701 ( 3.4A)
 1.02A 5y7zB-4idtA:
22.6		 5y7zB-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
VAL A 414
ALA A 427
GLU A 440
LEU A 471
GLY A 475
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.80A 5y80A-4idtA:
21.5		 5y80A-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		8 / 12 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
LEU A 471
GLY A 475
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 ( 3.4A)
 0.99A 5y80A-4idtA:
21.5		 5y80A-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens) 		4 / 8 LEU A 406
VAL A 414
LYS A 429
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
T28  A 701 ( 3.4A)
 0.56A 5y9mX-4idtA:
22.3		 5y9mX-4idtA:
13.26