SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SWA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 7 HIS A  88
ASN A  91
ASP A  92
GLY A 339
 None
None
SWA  A1103 ( 2.4A)
None
 0.82A 2f6dA-1hwwA:
0.3		 2f6dA-1hwwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 204
ASP A 169
ASP A 409
 SWA  A1103 ( 3.0A)
None
None
 0.70A 2igtA-1hwwA:
undetectable		 2igtA-1hwwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 204
ASP A 169
ASP A 409
 SWA  A1103 ( 3.0A)
None
None
 0.74A 2igtB-1hwwA:
undetectable		 2igtB-1hwwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 LEU A 111
ASP A 341
GLY A 339
ILE A 127
ILE A 110
 None
SWA  A1103 (-3.4A)
None
None
None
 0.94A 2o4kA-1hwwA:
undetectable		 2o4kA-1hwwA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 472
LEU A 467
VAL A 178
 SWA  A1103 (-2.9A)
None
None
 0.63A 4jecB-1hwwA:
undetectable		 4jecB-1hwwA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 SER A 173
PHE A 405
PHE A 206
LEU A 467
ASP A  92
 None
None
SWA  A1103 (-4.4A)
None
SWA  A1103 ( 2.4A)
 1.31A 4zjlD-1hwwA:
0.0		 4zjlD-1hwwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		3 / 3 ASP A 472
VAL A 166
LEU A 467
 SWA  A1103 (-2.9A)
None
None
 0.64A 5e5jB-1hwwA:
0.0		 5e5jB-1hwwA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45A-1hwwA:
0.7		 5m45A-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45D-1hwwA:
0.7		 5m45D-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45G-1hwwA:
undetectable		 5m45G-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 6 HIS A 471
ASP A 204
HIS A  90
TRP A  95
 ZN  A1102 ( 3.3A)
SWA  A1103 ( 3.0A)
ZN  A1102 ( 3.3A)
SWA  A1103 (-3.6A)
 1.40A 5m45J-1hwwA:
undetectable		 5m45J-1hwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ASP A 204
HIS A 470
THR A 480
GLY A 877
LEU A 878
 SWA  A1103 ( 3.0A)
None
None
None
None
 1.21A 5m50B-1hwwA:
undetectable		 5m50B-1hwwA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		5 / 12 ASP A 204
HIS A 470
THR A 480
GLY A 877
LEU A 878
 SWA  A1103 ( 3.0A)
None
None
None
None
 1.22A 5m50E-1hwwA:
undetectable		 5m50E-1hwwA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1hww ALPHA-MANNOSIDASE II
(Drosophila
melanogaster) 		4 / 5 THR A 477
HIS A 470
ASP A  92
HIS A 471
 SWA  A1103 ( 4.5A)
None
SWA  A1103 ( 2.4A)
ZN  A1102 ( 3.3A)
 1.37A 6dchA-1hwwA:
undetectable		 6dchA-1hwwA:
16.38