SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SVS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)
(Escherichia
coli) 		3 / 5 GLY A 333
GLY A 337
GLU A 336
 SVS  A 698 (-3.8A)
None
SVS  A 698 ( 4.7A)
 0.50A 4z2eA-3rg2A:
undetectable
4z2eD-3rg2A:
undetectable		 4z2eA-3rg2A:
22.15
4z2eD-3rg2A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)
(Escherichia
coli) 		5 / 12 LEU A 104
ALA A 335
GLN A 188
ILE A 200
PHE A 187
 None
SVS  A 698 (-3.7A)
None
None
None
 1.12A 5ewjC-3rg2A:
3.6
5ewjD-3rg2A:
undetectable		 5ewjC-3rg2A:
22.22
5ewjD-3rg2A:
18.56