SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SUV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 VAL A 140
ALA A  99
GLN A 134
VAL A 103
ASP A 100
 None
None
SUV  A2001 (-3.5A)
None
None
 1.34A 1td2A-4s0vA:
2.5		 1td2A-4s0vA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 VAL A 132
ALA A  91
GLN A 126
VAL A  95
ASP A  92
 None
None
SUV  A2001 (-3.8A)
None
None
 1.26A 1td2A-4zj8A:
3.4		 1td2A-4zj8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 TYR A 311
ILE A 314
VAL A 130
LEU A 135
SER A 138
 None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
None
None
 1.18A 3w67C-4zj8A:
undetectable		 3w67C-4zj8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 GLU A 212
ARG A 328
HIS A 224
 SUV  A2001 (-4.1A)
None
SUV  A2001 ( 4.8A)
 0.76A 4kf9A-4s0vA:
undetectable		 4kf9A-4s0vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 GLU A 204
ARG A 322
HIS A 216
 SUV  A2001 (-4.4A)
None
SUV  A2001 ( 4.8A)
 0.82A 4kf9A-4zj8A:
undetectable		 4kf9A-4zj8A:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		10 / 12 VAL A 106
TRP A 112
GLN A 126
VAL A 130
GLN A 179
GLU A 204
ILE A 314
ASN A 318
HIS A 344
TYR A 348
 SUV  A2001 (-4.5A)
None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
SUV  A2001 (-3.3A)
SUV  A2001 (-4.4A)
SUV  A2001 (-3.8A)
SUV  A2001 (-2.9A)
SUV  A2001 (-3.5A)
SUV  A2001 (-4.8A)
 0.52A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 5 ILE A 122
PRO A 123
HIS A 216
TYR A 311
VAL A 347
 SUV  A2001 ( 4.8A)
SUV  A2001 (-3.9A)
SUV  A2001 ( 4.8A)
None
SUV  A2001 ( 4.6A)
 0.34A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		11 / 12 ALA A 110
VAL A 114
GLN A 134
VAL A 138
GLN A 187
MET A 191
GLU A 212
PHE A 227
ASN A 324
HIS A 350
TYR A 354
 SUV  A2001 ( 4.2A)
SUV  A2001 (-4.6A)
SUV  A2001 (-3.5A)
None
SUV  A2001 (-3.6A)
SUV  A2001 ( 4.6A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.5A)
SUV  A2001 (-3.0A)
SUV  A2001 ( 3.7A)
None
 0.52A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		6 / 6 TRP A 120
ILE A 130
PRO A 131
HIS A 224
ILE A 320
VAL A 353
 None
SUV  A2001 (-4.8A)
SUV  A2001 (-4.0A)
SUV  A2001 ( 4.8A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.9A)
 0.38A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 PHE A 139
ILE A 168
TRP A 169
LEU A  94
ALA A 127
 None
None
None
None
SUV  A2001 ( 4.5A)
 1.46A 5fctB-4zj8A:
undetectable		 5fctB-4zj8A:
20.48