SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SUG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
ASN A 134
GLN A 167
ASN A 110
 SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
 1.33A 1p6kA-1yniA:
undetectable		 1p6kA-1yniA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
ASN A 134
GLN A 167
ASN A 110
 SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
 1.32A 1p6kB-1yniA:
undetectable		 1p6kB-1yniA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
ASN A 134
GLN A 167
ASN A 110
 SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
 1.28A 1rs7B-1yniA:
undetectable		 1rs7B-1yniA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
ASN A 134
GLN A 167
ASN A 110
 SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
 1.30A 1zzqA-1yniA:
undetectable		 1zzqA-1yniA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
ASN A 134
GLN A 167
ASN A 110
 SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
 1.28A 1zzqB-1yniA:
undetectable		 1zzqB-1yniA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
ASN A 134
GLN A 167
ASN A 110
 SUG  A1001 (-3.0A)
None
None
SUG  A1001 (-3.2A)
 1.32A 1zzuB-1yniA:
undetectable		 1zzuB-1yniA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ARG A 212
PRO A 322
GLY A 361
MET A 357
 SUG  A1001 (-3.0A)
None
SUG  A1001 ( 4.2A)
None
 1.04A 2qd5B-1yniA:
undetectable		 2qd5B-1yniA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		5 / 12 TYR A 402
ASN A 306
GLY A  10
GLY A 362
LEU A 353
 None
SUG  A1001 ( 4.1A)
None
None
None
 1.02A 3hs6B-1yniA:
undetectable		 3hs6B-1yniA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		5 / 12 ILE A  62
GLY A  10
ALA A 103
VAL A 108
ASN A 110
 None
None
None
None
SUG  A1001 (-3.2A)
 1.07A 3jb3A-1yniA:
undetectable		 3jb3A-1yniA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		5 / 12 ILE A  62
GLY A  10
ALA A 109
VAL A 108
PRO A 105
 None
None
SUG  A1001 (-3.6A)
None
None
 0.87A 3jb3A-1yniA:
undetectable		 3jb3A-1yniA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		5 / 12 TYR A 402
ASN A 306
GLY A  10
GLY A 362
LEU A 353
 None
SUG  A1001 ( 4.1A)
None
None
None
 0.91A 4e1gA-1yniA:
undetectable		 4e1gA-1yniA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 ASN A  25
ALA A  27
SER A  28
TYR A  18
 SUG  A1001 (-3.9A)
None
SUG  A1001 (-2.7A)
None
 0.99A 4ijiF-1yniA:
undetectable		 4ijiF-1yniA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 7 ASN A  25
ALA A  27
SER A  28
TYR A  18
 SUG  A1001 (-3.9A)
None
SUG  A1001 (-2.7A)
None
 0.98A 4ijiH-1yniA:
undetectable		 4ijiH-1yniA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 8 GLY A 360
GLY A 361
VAL A 251
HIS A 248
 SUG  A1001 (-4.5A)
SUG  A1001 ( 4.2A)
None
SUG  A1001 (-4.0A)
 0.78A 5f8yB-1yniA:
undetectable		 5f8yB-1yniA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		4 / 7 SER A  28
ALA A  27
GLY A 361
ARG A 212
 SUG  A1001 (-2.7A)
None
SUG  A1001 ( 4.2A)
SUG  A1001 (-3.0A)
 0.90A 5fpdB-1yniA:
undetectable		 5fpdB-1yniA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		3 / 3 MET A 106
HIS A  16
GLY A 361
 None
None
SUG  A1001 ( 4.2A)
 0.77A 5gwzB-1yniA:
undetectable		 5gwzB-1yniA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1yni SUCCINYLARGININE
DIHYDROLASE
(Escherichia
coli) 		5 / 12 GLY A 175
ASN A 178
ALA A 364
VAL A 108
ASN A 306
 None
None
None
None
SUG  A1001 ( 4.1A)
 1.33A 5kbwB-1yniA:
undetectable		 5kbwB-1yniA:
17.58