SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SUC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		5 / 12 ASP A 192
ALA A 193
HIS A 289
ASP A 290
ARG A 403
 SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 ( 4.9A)
 0.51A 1dedA-2gduA:
26.5		 1dedA-2gduA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ARG A 403
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 ( 4.9A)
 0.54A 1dedB-2gduA:
24.3		 1dedB-2gduA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)
(Rhinovirus
A) 		5 / 12 SER 1 211
THR 2 147
HIS 2 217
TYR 1 194
GLU 2 129
 SUC  1 288 ( 4.5A)
None
None
None
None
 1.20A 1kw0A-1r1a1:
undetectable		 1kw0A-1r1a1:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)
(Rhinovirus
A) 		5 / 11 SER 1 211
THR 2 147
HIS 2 217
TYR 1 194
GLU 2 129
 SUC  1 288 ( 4.5A)
None
None
None
None
 1.23A 1mmtA-1r1a1:
undetectable		 1mmtA-1r1a1:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA8_0
(GRAMICIDIN C)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 192
VAL A 219
TRP A 194
TRP A 220
 SUC  A1003 (-3.8A)
None
None
None
 1.17A 1nt6A-1x3wA:
undetectable		 1nt6A-1x3wA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB8_0
(GRAMICIDIN C)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 192
VAL A 219
TRP A 194
TRP A 220
 SUC  A1003 (-3.8A)
None
None
None
 1.17A 1nt6B-1x3wA:
undetectable		 1nt6B-1x3wA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 238
TRP A 251
LYS A  94
 SUC  A1001 ( 3.0A)
SUC  A1001 ( 4.3A)
None
 1.27A 1qu2A-1x3wA:
undetectable		 1qu2A-1x3wA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.23A 1rs6B-4m00A:
undetectable		 1rs6B-4m00A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 242
ARG A 230
VAL A 212
TYR A 247
ILE A 246
 None
None
None
None
SUC  A1002 (-4.5A)
 1.37A 1tcoC-1x3wA:
undetectable		 1tcoC-1x3wA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 SER A 107
VAL A 104
ALA A 273
HIS A 270
GLN A 236
 None
SUC  A 290 (-4.7A)
SUC  A 290 ( 4.2A)
SUC  A 290 ( 3.9A)
None
 1.49A 1td2A-2gupA:
undetectable		 1td2A-2gupA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		6 / 11 GLU A 108
GLY A 231
ILE A 132
SER A 107
ALA A 101
ALA A 130
 None
SUC  A 290 ( 4.5A)
None
None
None
None
 1.36A 1x7pA-2gupA:
undetectable
1x7pB-2gupA:
undetectable		 1x7pA-2gupA:
21.91
1x7pB-2gupA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		3 / 3 ASN A  22
TRP A  20
GLN A 316
 SUC  A 800 (-3.6A)
None
None
 0.97A 1xoqA-2qquA:
undetectable		 1xoqA-2qquA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yfs LEVANSUCRASE
(Lactobacillus
johnsonii) 		3 / 3 ASN A 305
TRP A 339
GLN A 261
 SUC  A1710 (-3.5A)
SUC  A1709 (-4.2A)
None
 0.82A 1xoqA-2yfsA:
undetectable		 1xoqA-2yfsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.25A 1zzqB-4m00A:
undetectable		 1zzqB-4m00A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 9 LEU A  64
ALA A 152
LEU A 126
GLU A 122
LEU A 118
 None
None
None
SUC  A 502 ( 4.8A)
None
 1.33A 2azqA-4zxwA:
undetectable		 2azqA-4zxwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A 101
ASP A 100
GLY A 232
ILE A 123
ALA A 119
 None
TRS  A 293 (-2.8A)
SUC  A 290 (-3.2A)
None
None
 0.95A 2b60B-2gupA:
undetectable		 2b60B-2gupA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 101
ASP A 100
GLY A 232
ILE A 123
ALA A 119
 None
TRS  A 293 (-2.8A)
SUC  A 290 (-3.2A)
None
None
 0.99A 2b7zA-2gupA:
undetectable		 2b7zA-2gupA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 CYH A 103
ALA A  56
ASN A 274
ILE A  30
LEU A 275
 None
None
SUC  A 290 (-2.8A)
None
None
 1.21A 2bjfA-2gupA:
undetectable		 2bjfA-2gupA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 485
ALA A 609
LEU A 610
SER A 617
LEU A 616
 None
SUC  A 877 ( 4.0A)
None
None
None
 1.23A 2c12C-4uqgA:
3.4		 2c12C-4uqgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4uqg DNA POLYMERASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 485
ALA A 609
LEU A 610
SER A 617
LEU A 616
 None
SUC  A 877 ( 4.0A)
None
None
None
 1.24A 2c12F-4uqgA:
3.5		 2c12F-4uqgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A 150
ASP A 153
SER A 149
SER A 187
 SUC  A 245 ( 4.6A)
SUC  A 245 ( 4.0A)
SUC  A 245 (-3.6A)
MG  A 247 (-2.6A)
 1.14A 2cmlA-1tj5A:
undetectable		 2cmlA-1tj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 SER A 150
ASP A 153
SER A 149
SER A 187
 SUC  A 245 ( 4.6A)
SUC  A 245 ( 4.0A)
SUC  A 245 (-3.6A)
MG  A 247 (-2.6A)
 1.06A 2cmlC-1tj5A:
undetectable		 2cmlC-1tj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		4 / 6 LEU A 341
ALA A  49
HIS A  88
ASP A 162
 SUC  A2064 (-4.7A)
None
SUC  A2064 (-3.9A)
None
 1.13A 2dpzA-2gduA:
undetectable		 2dpzA-2gduA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 PHE A 728
ALA A 707
ASP A 726
TYR A 721
 SUC  A   1 (-3.4A)
None
None
None
 1.08A 2e5dA-3h6zA:
undetectable
2e5dB-3h6zA:
undetectable		 2e5dA-3h6zA:
21.91
2e5dB-3h6zA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 ASP A 726
TYR A 721
PHE A 728
ALA A 707
 None
None
SUC  A   1 (-3.4A)
None
 1.07A 2e5dA-3h6zA:
undetectable
2e5dB-3h6zA:
undetectable		 2e5dA-3h6zA:
21.91
2e5dB-3h6zA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2zoo PROBABLE NITRITE
REDUCTASE
(Pseudoalteromona
s
haloplanktis) 		4 / 5 PRO A 367
PRO A 362
GLY A 363
TYR A 400
 HEM  A 600 (-4.5A)
SUC  A 700 (-4.4A)
SUC  A 700 ( 3.8A)
None
 1.11A 2jkjD-2zooA:
undetectable		 2jkjD-2zooA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2zoo PROBABLE NITRITE
REDUCTASE
(Pseudoalteromona
s
haloplanktis) 		4 / 5 PRO A 367
PRO A 362
GLY A 363
TYR A 400
 HEM  A 600 (-4.5A)
SUC  A 700 (-4.4A)
SUC  A 700 ( 3.8A)
None
 1.10A 2jkjF-2zooA:
undetectable		 2jkjF-2zooA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 242
ARG A 230
VAL A 212
TYR A 247
ILE A 246
 None
None
None
None
SUC  A1002 (-4.5A)
 1.38A 2vn1A-1x3wA:
undetectable		 2vn1A-1x3wA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 8 GLN A  58
TYR A 679
HIS A 645
GLN A 647
 None
SUC  A 703 (-3.9A)
None
None
 1.19A 2vxaA-3muoA:
undetectable
2vxaB-3muoA:
undetectable
2vxaK-3muoA:
undetectable		 2vxaA-3muoA:
7.15
2vxaB-3muoA:
7.15
2vxaK-3muoA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 8 GLN A  58
TYR A 679
HIS A 645
GLN A 647
 None
SUC  A 703 (-3.9A)
None
None
 1.19A 2vxaD-3muoA:
undetectable
2vxaE-3muoA:
undetectable
2vxaL-3muoA:
undetectable		 2vxaD-3muoA:
7.15
2vxaE-3muoA:
7.15
2vxaL-3muoA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 8 HIS A 645
GLN A 647
TYR A 679
GLN A  58
 None
None
SUC  A 703 (-3.9A)
None
 1.21A 2vxaF-3muoA:
undetectable
2vxaG-3muoA:
undetectable
2vxaI-3muoA:
undetectable		 2vxaF-3muoA:
7.15
2vxaG-3muoA:
7.15
2vxaI-3muoA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		4 / 8 ARG A 190
GLN A 376
ARG A 249
GLN A 240
 SUC  A2064 (-3.4A)
None
None
None
 1.50A 2vxaH-2gduA:
undetectable
2vxaI-2gduA:
undetectable
2vxaJ-2gduA:
undetectable		 2vxaH-2gduA:
9.69
2vxaI-2gduA:
9.69
2vxaJ-2gduA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 8 GLN A  58
TYR A 679
HIS A 645
GLN A 647
 None
SUC  A 703 (-3.9A)
None
None
 1.18A 2vxaH-3muoA:
undetectable
2vxaI-3muoA:
undetectable
2vxaJ-3muoA:
undetectable		 2vxaH-3muoA:
7.15
2vxaI-3muoA:
7.15
2vxaJ-3muoA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 8 HIS A 645
GLN A 647
TYR A 679
GLN A  58
 None
None
SUC  A 703 (-3.9A)
None
 1.19A 2vxaD-3muoA:
undetectable
2vxaJ-3muoA:
undetectable
2vxaL-3muoA:
undetectable		 2vxaD-3muoA:
7.15
2vxaJ-3muoA:
7.15
2vxaL-3muoA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 8 HIS A 645
GLN A 647
GLN A  58
TYR A 679
 None
None
None
SUC  A 703 (-3.9A)
 1.19A 2vxaA-3muoA:
undetectable
2vxaK-3muoA:
undetectable
2vxaL-3muoA:
undetectable		 2vxaA-3muoA:
7.15
2vxaK-3muoA:
7.15
2vxaL-3muoA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 12 PHE A  37
GLY A  84
ALA A 112
ASP A  23
PRO A  27
 None
None
None
SUC  A 800 (-2.6A)
None
 1.12A 2zulA-2qquA:
undetectable		 2zulA-2qquA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 7 ALA A 160
ALA A 159
ALA A 163
GLN A 218
 None
None
None
SUC  A 600 (-3.6A)
 0.87A 3a2qA-1gnxA:
0.0		 3a2qA-1gnxA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 231
ILE A 219
LEU A 216
VAL A 244
ILE A 241
 SUC  A 290 ( 4.5A)
None
None
None
None
 0.97A 3adxB-2gupA:
undetectable		 3adxB-2gupA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.65A 3aicA-2gduA:
7.0		 3aicA-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.67A 3aicB-2gduA:
5.3		 3aicB-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.66A 3aicC-2gduA:
4.9		 3aicC-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.70A 3aicD-2gduA:
4.9		 3aicD-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.70A 3aicE-2gduA:
7.0		 3aicE-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.65A 3aicF-2gduA:
7.1		 3aicF-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.65A 3aicG-2gduA:
7.0		 3aicG-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		6 / 12 ARG A 190
ASP A 192
ALA A 193
HIS A 289
ASP A 290
ASP A  50
 SUC  A2064 (-3.4A)
SUC  A2064 (-3.1A)
SUC  A2064 (-3.6A)
SUC  A2064 (-3.7A)
SUC  A2064 (-2.9A)
SUC  A2064 (-2.6A)
 0.70A 3aicH-2gduA:
5.8		 3aicH-2gduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 266
SER A 233
GLY A 232
GLY A 231
ILE A 190
 None
SUC  A 291 (-2.7A)
SUC  A 290 (-3.2A)
SUC  A 290 ( 4.5A)
None
 0.91A 3douA-2gupA:
undetectable		 3douA-2gupA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.97A 3eluA-4m00A:
undetectable		 3eluA-4m00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.98A 3embA-4m00A:
undetectable		 3embA-4m00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 ALA A 159
VAL A  46
GLY A  47
HIS A 412
VAL A 371
 None
SUC  A 502 (-3.9A)
SUC  A 502 ( 4.8A)
None
None
 0.76A 3f8wA-4zxwA:
undetectable		 3f8wA-4zxwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.98A 3gczA-4m00A:
undetectable		 3gczA-4m00A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL A 111
ARG A  38
VAL A  18
PHE A  90
 None
SUC  A9002 (-4.2A)
None
None
 1.27A 3jx3A-1rzgA:
undetectable
3jx3B-1rzgA:
undetectable		 3jx3A-1rzgA:
18.46
3jx3B-1rzgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 6 VAL A 111
ARG A  38
VAL A  18
PHE A  90
 None
SUC  A9002 (-4.2A)
None
None
 1.34A 3jx4A-1rzgA:
0.0
3jx4B-1rzgA:
0.0		 3jx4A-1rzgA:
18.46
3jx4B-1rzgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 10 VAL A 200
VAL A 208
LEU A 212
TRP A 211
GLY A 221
 None
None
SUC  A 702 (-3.7A)
None
None
 1.28A 3ls4H-3qgvA:
undetectable		 3ls4H-3qgvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.29A 3n66B-4m00A:
undetectable		 3n66B-4m00A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ALA A 119
VAL A 227
GLY A 105
VAL A 104
ILE A 228
 None
None
None
SUC  A 290 (-4.7A)
None
 1.08A 3oxvB-2gupA:
undetectable		 3oxvB-2gupA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 VAL A 371
VAL A 367
ILE A 308
ARG A 243
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-4.7A)
 1.09A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 VAL A 371
VAL A 367
ILE A 308
ARG A 393
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-3.7A)
 1.05A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		5 / 8 ASN A  19
GLY A  44
ALA A  45
ASP A 307
ILE A  50
 None
None
None
None
SUC  A 800 ( 4.6A)
 1.38A 3so9A-2qquA:
undetectable		 3so9A-2qquA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2qqu BETA-FRUCTOFURANOSID
ASE
(Arabidopsis
thaliana) 		4 / 4 PHE A 258
TYR A 246
ARG A 148
LEU A 174
 None
None
SUC  A 800 (-3.9A)
None
 1.22A 3sueA-2qquA:
0.0		 3sueA-2qquA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
 None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
 1.46A 3ticA-1rzgA:
undetectable		 3ticA-1rzgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
 None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
 1.46A 3ticB-1rzgA:
undetectable		 3ticB-1rzgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
 None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
 1.46A 3ticC-1rzgA:
undetectable		 3ticC-1rzgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
 None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
 1.47A 3ticD-1rzgA:
undetectable		 3ticD-1rzgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1x3w PEPTIDE:N-GLYCANASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 242
ARG A 230
VAL A 212
TYR A 247
ILE A 246
 None
None
None
None
SUC  A1002 (-4.5A)
 1.38A 3vawA-1x3wA:
undetectable		 3vawA-1x3wA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 6 THR A 479
ASN A 480
GLY A 331
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.17A 3w9tE-4m00A:
undetectable		 3w9tE-4m00A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 12 ASP A 953
TYR A 848
ILE A 833
TYR A 836
LEU A 918
 None
None
None
None
SUC  A   1 (-4.1A)
 1.35A 4a84A-3h6zA:
undetectable		 4a84A-3h6zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 5 ILE A  45
ALA A 157
MET A 162
ARG A 295
 SUC  A 502 (-4.3A)
None
None
None
 1.29A 4ac9B-4zxwA:
undetectable
4ac9C-4zxwA:
undetectable		 4ac9B-4zxwA:
21.91
4ac9C-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 5 ILE A  45
ALA A 157
MET A 162
ARG A 295
 SUC  A 502 (-4.3A)
None
None
None
 1.30A 4acaB-4zxwA:
undetectable
4acaC-4zxwA:
undetectable		 4acaB-4zxwA:
21.91
4acaC-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		3 / 3 GLU A  72
TYR A  73
SER A 136
 SUC  A 701 (-3.1A)
None
None
 0.99A 4at0A-3qgvA:
undetectable		 4at0A-3qgvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
 None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
 1.47A 4b7qB-1rzgA:
undetectable		 4b7qB-1rzgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PHE A  90
VAL A 111
ARG A  38
VAL A  18
 None
None
SUC  A9002 (-4.2A)
None
 1.31A 4cx4A-1rzgA:
undetectable
4cx4B-1rzgA:
undetectable		 4cx4A-1rzgA:
18.46
4cx4B-1rzgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER A  68
ILE A  69
TRP A  36
GLU A  81
 SUC  A9001 ( 2.7A)
None
None
None
 1.28A 4cx7A-1rzgA:
undetectable
4cx7B-1rzgA:
undetectable		 4cx7A-1rzgA:
20.89
4cx7B-1rzgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER A  68
ILE A  69
TRP A  36
GLU A  81
 SUC  A9001 ( 2.7A)
None
None
None
 1.22A 4cx7C-1rzgA:
undetectable
4cx7D-1rzgA:
undetectable		 4cx7C-1rzgA:
20.89
4cx7D-1rzgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A  43
ASP A 190
ASP A 155
ILE A 147
 SUC  A 245 (-4.9A)
MG  A 247 (-2.9A)
SUC  A 245 (-2.8A)
None
 1.05A 4k0bA-1tj5A:
undetectable		 4k0bA-1tj5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.26A 4kcnB-4m00A:
undetectable		 4kcnB-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1tj5 SUCROSE-PHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A  43
ASP A 190
ASP A 155
ILE A 147
 SUC  A 245 (-4.9A)
MG  A 247 (-2.9A)
SUC  A 245 (-2.8A)
None
 1.06A 4l7iA-1tj5A:
undetectable		 4l7iA-1tj5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		3 / 3 HIS A 154
TRP A 241
SER A 306
 4T7  A 501 (-4.1A)
SUC  A 502 (-4.5A)
None
 0.99A 4lrhD-4zxwA:
undetectable		 4lrhD-4zxwA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 ALA A 373
ALA A 166
ALA A  48
GLY A  47
LEU A 150
 None
None
None
SUC  A 502 ( 4.8A)
None
 1.01A 4oaeA-4zxwA:
undetectable		 4oaeA-4zxwA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 VAL A 104
ILE A  70
VAL A  63
ALA A  62
ALA A 101
 SUC  A 290 (-4.7A)
None
None
None
None
 1.14A 4oqrA-2gupA:
undetectable		 4oqrA-2gupA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		4 / 5 TYR A 251
ASP A 290
ASP A 400
TYR A  10
 None
SUC  A2064 (-2.9A)
None
None
 1.40A 4qdjA-2gduA:
undetectable		 4qdjA-2gduA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 GLY A 231
ALA A 119
ILE A 219
LEU A 216
ILE A 241
 SUC  A 290 ( 4.5A)
None
None
None
None
 1.15A 4xumB-2gupA:
undetectable		 4xumB-2gupA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 6 VAL A 111
ARG A  38
VAL A  18
PHE A  90
 None
SUC  A9002 (-4.2A)
None
None
 1.28A 5addA-1rzgA:
0.0
5addB-1rzgA:
0.0		 5addA-1rzgA:
18.46
5addB-1rzgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens) 		4 / 6 VAL A 111
ARG A  38
VAL A  18
PHE A  90
 None
SUC  A9002 (-4.2A)
None
None
 1.32A 5adeA-1rzgA:
0.0
5adeB-1rzgA:
0.0		 5adeA-1rzgA:
18.46
5adeB-1rzgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.99A 5ehiA-4m00A:
undetectable		 5ehiA-4m00A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.97A 5ehiC-4m00A:
undetectable		 5ehiC-4m00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.99A 5eiwA-4m00A:
undetectable		 5eiwA-4m00A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.97A 5ekxA-4m00A:
undetectable		 5ekxA-4m00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ASN A 274
VAL A 104
GLY A 128
VAL A 122
 SUC  A 290 (-2.8A)
SUC  A 290 (-4.7A)
None
None
 0.80A 5fpdB-2gupA:
10.6		 5fpdB-2gupA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 VAL A 206
ILE A 239
LEU A 241
GLY A 243
PRO A 244
 None
None
None
SUC  A 701 (-4.0A)
SUC  A 701 (-4.0A)
 1.01A 5ienA-3lxyA:
undetectable		 5ienA-3lxyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3qgv ALPHA AMYLASE
(Pyrococcus
woesei) 		5 / 11 ILE A 107
PHE A 197
ILE A 192
VAL A 207
LEU A 212
 None
None
None
None
SUC  A 702 (-3.7A)
 1.21A 5jkwA-3qgvA:
undetectable		 5jkwA-3qgvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN
(Arthrospira
maxima) 		3 / 3 ASP A 211
ASN A 249
GLN A 248
 None
SUC  A 401 (-3.6A)
None
 0.80A 5k7uA-5ui2A:
undetectable		 5k7uA-5ui2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN
(Arthrospira
maxima) 		4 / 8 ARG A 115
GLU A 112
GLY A  57
PRO A  56
 None
None
SUC  A 401 (-4.2A)
SUC  A 401 (-3.8A)
 0.88A 5kf8A-5ui2A:
undetectable		 5kf8A-5ui2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN
(Arthrospira
maxima) 		4 / 8 ARG A 115
GLU A 112
GLY A  57
PRO A  56
 None
None
SUC  A 401 (-4.2A)
SUC  A 401 (-3.8A)
 0.94A 5kgpA-5ui2A:
undetectable		 5kgpA-5ui2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN
(Arthrospira
maxima) 		4 / 8 ARG A 115
GLU A 112
GLY A  57
PRO A  56
 None
None
SUC  A 401 (-4.2A)
SUC  A 401 (-3.8A)
 0.94A 5kgpB-5ui2A:
undetectable		 5kgpB-5ui2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.97A 5kqrA-4m00A:
undetectable		 5kqrA-4m00A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
SUC  A 804 (-3.4A)
None
None
 0.93A 5njvC-4m00A:
undetectable		 5njvC-4m00A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.27A 5vunA-4m00A:
undetectable		 5vunA-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.20A 5vunB-4m00A:
undetectable		 5vunB-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.21A 5vuoB-4m00A:
undetectable		 5vuoB-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 SER A 327
HIS A 331
TYR A 333
 None
SUC  A 601 ( 3.9A)
SUC  A 601 (-4.1A)
 0.83A 5y2tA-1mjtA:
0.4		 5y2tA-1mjtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 234
GLY A 231
LEU A 216
VAL A 244
ILE A 241
 None
SUC  A 290 ( 4.5A)
None
None
None
 1.03A 5ycnA-2gupA:
undetectable		 5ycnA-2gupA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m00 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
SUC  A 804 (-3.3A)
 1.18A 6auuB-4m00A:
undetectable		 6auuB-4m00A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		5 / 12 HIS A 234
PHE A 253
ARG A 365
GLY A 381
GLY A 293
 SUC  A2064 (-3.9A)
None
None
None
None
 1.09A 6brdB-2gduA:
undetectable		 6brdB-2gduA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)
(Rhinovirus
A;
Rhinovirus
A) 		5 / 12 ILE 1 239
TRP 1 173
SER 3  21
PHE 1 179
HIS 1 241
 None
None
None
None
SUC  1 288 (-3.9A)
 1.40A 6chgC-1r1a1:
undetectable		 6chgC-1r1a1:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 SER A  74
ASN A 102
VAL A  95
LEU A  97
 None
None
SUC  A 292 (-4.1A)
None
 0.80A 6dwnB-2gupA:
undetectable		 6dwnB-2gupA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ASP A   7
SER A  58
GLY A 126
SER A 164
ASN A  99
 SUC  A 290 (-3.5A)
None
None
None
TRS  A 293 (-3.9A)
 1.47A 6giqA-2gupA:
0.0
6giqE-2gupA:
0.0
6giqI-2gupA:
0.0		 6giqA-2gupA:
23.64
6giqE-2gupA:
21.68
6giqI-2gupA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		5 / 12 LEU A 341
GLY A 197
ASP A  50
ASN A 347
GLN A 232
 SUC  A2064 (-4.7A)
None
SUC  A2064 (-2.6A)
None
SUC  A2064 (-2.7A)
 0.97A 6gngA-2gduA:
undetectable		 6gngA-2gduA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2gdu SUCROSE
PHOSPHORYLASE
(Bifidobacterium
adolescentis) 		4 / 8 TYR A 251
VAL A  82
ARG A 190
ASP A 290
 None
None
SUC  A2064 (-3.4A)
SUC  A2064 (-2.9A)
 1.02A 6hu9a-2gduA:
undetectable
6hu9e-2gduA:
undetectable		 6hu9a-2gduA:
21.59
6hu9e-2gduA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2gup ROK FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 8 GLY A 231
HIS A 270
GLY A 277
SER A 107
ALA A 111
 SUC  A 290 ( 4.5A)
SUC  A 290 ( 3.9A)
None
None
None
 1.21A 6hu9H-2gupA:
undetectable
6hu9e-2gupA:
undetectable		 6hu9H-2gupA:
16.44
6hu9e-2gupA:
17.93