SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'STX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 11 GLY A  45
GLY A  46
SER A 113
PHE A 228
HIS A 296
 STX  A 401 (-3.6A)
STX  A 401 (-3.6A)
STX  A 401 (-2.8A)
None
STX  A 401 (-4.5A)
 1.12A 1w76A-1x2bA:
12.3		 1w76A-1x2bA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 LEU A 288
ILE A 290
HIS A 296
GLY A 265
GLY A 112
 None
None
STX  A 401 (-4.5A)
None
STX  A 401 (-4.8A)
 1.14A 1zz1C-1x2bA:
undetectable		 1zz1C-1x2bA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 GLY A 295
GLY A 265
ASP A 268
ALA A 270
THR A 207
 None
None
None
STX  A 401 ( 4.7A)
None
 1.07A 2gluA-1x2bA:
2.4		 2gluA-1x2bA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 6 GLY A 115
HIS A 296
HIS A 264
CYH A 271
 None
STX  A 401 (-4.5A)
None
STX  A 401 ( 4.9A)
 1.43A 3ai8B-1x2bA:
undetectable		 3ai8B-1x2bA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 CYH A 271
ASN A 275
LEU A 249
GLY A 137
GLY A 111
 STX  A 401 ( 4.9A)
None
None
None
None
 1.20A 4n09A-1x2bA:
undetectable		 4n09A-1x2bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 7 HIS A 296
CYH A 271
GLY A 295
HIS A 264
 STX  A 401 (-4.5A)
STX  A 401 ( 4.9A)
None
None
 1.38A 5a5zC-1x2bA:
undetectable		 5a5zC-1x2bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 GLY A 240
THR A  88
ASN A 275
LEU A 141
CYH A 271
 None
None
None
None
STX  A 401 ( 4.9A)
 1.44A 5fhzA-1x2bA:
undetectable		 5fhzA-1x2bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 5 GLY A  46
SER A 113
ARG A 136
GLY A 112
 STX  A 401 (-3.6A)
STX  A 401 (-2.8A)
STX  A 401 (-2.8A)
STX  A 401 (-4.8A)
 1.05A 5kprA-1x2bA:
undetectable		 5kprA-1x2bA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 5 LEU A 242
PHE A 241
LEU A 141
PHE A 139
 None
None
None
STX  A 401 ( 4.7A)
 1.24A 5xdxP-1x2bA:
undetectable
5xdxW-1x2bA:
undetectable		 5xdxP-1x2bA:
20.40
5xdxW-1x2bA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 7 GLY A 112
GLY A  46
PRO A  47
GLY A  48
GLY A  49
 STX  A 401 (-4.8A)
STX  A 401 (-3.6A)
None
None
None
 0.86A 6ag0A-1x2bA:
undetectable		 6ag0A-1x2bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 8 THR A 207
VAL A 208
GLU A 204
SER A 201
 None
None
STX  A 401 (-3.1A)
None
 1.09A 6fbvC-1x2bA:
undetectable		 6fbvC-1x2bA:
15.27