SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'STI'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FMO_E_ADNE351_1 (CAMP-DEPENDENTPROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621VAL A 654ASN A 797LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)NoneSTI A 3 (-4.4A) | 0.66A | 1fmoE-1t46A:21.4 | 1fmoE-1t46A:24.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_A_STIA201_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.72A | 1iepA-1t46A:34.7 | 1iepA-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_B_STIB202_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670GLY A 676ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-3.9A) | 0.72A | 1iepB-1t46A:34.7 | 1iepB-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_B_STIB202_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | VAL A 643VAL A 654ARG A 791LEU A 799 | NoneSTI A 3 (-4.3A)NoneSTI A 3 (-4.4A) | 0.65A | 1iepB-1t46A:34.4 | 1iepB-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1M17_A_AQ4A999_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.68A | 1m17A-1t46A:26.4 | 1m17A-1t46A:31.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MUO_A_ADNA1_1 (AURORA-RELATEDKINASE 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 9 | LEU A 595GLY A 596VAL A 603ALA A 621TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.76A | 1muoA-1t46A:7.7 | 1muoA-1t46A:27.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OPJ_A_STIA3_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.55A | 1opjA-1t46A:34.0 | 1opjA-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OPJ_B_STIB4_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654THR A 670GLY A 676ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-3.9A) | 0.55A | 1opjB-1t46A:34.0 | 1opjB-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1OPJ_B_STIB4_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | LEU A 595LYS A 623VAL A 643ARG A 791 | STI A 3 ( 3.8A)STI A 3 (-3.7A)NoneNone | 0.79A | 1opjB-1t46A:34.0 | 1opjB-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640LEU A 644THR A 670CYH A 673LEU A 783HIS A 790 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)NoneSTI A 3 (-4.5A) | 0.57A | 1uwhA-1t46A:19.3 | 1uwhA-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | VAL A 603VAL A 643ILE A 653ASP A 810 | STI A 3 ( 4.6A)NoneNoneSTI A 3 (-3.9A) | 0.69A | 1uwhA-1t46A:19.3 | 1uwhA-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | ALA A 621LYS A 623GLU A 640LEU A 644THR A 670CYH A 673LEU A 783HIS A 790 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)NoneSTI A 3 (-4.5A) | 0.59A | 1uwhB-1t46A:18.9 | 1uwhB-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_B_BAXB1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | VAL A 603VAL A 643ILE A 653ASP A 810 | STI A 3 ( 4.6A)NoneNoneSTI A 3 (-3.9A) | 0.69A | 1uwhB-1t46A:18.9 | 1uwhB-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670CYH A 673LEU A 783HIS A 790 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A)NoneSTI A 3 (-4.5A) | 0.66A | 1uwjA-1t46A:28.2 | 1uwjA-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | LYS A 623LEU A 644ILE A 653ASP A 810 | STI A 3 (-3.7A)STI A 3 (-4.4A)NoneSTI A 3 (-3.9A) | 0.55A | 1uwjA-1t46A:28.2 | 1uwjA-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670CYH A 673LEU A 783HIS A 790 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A)NoneSTI A 3 (-4.5A) | 0.65A | 1uwjB-1t46A:28.4 | 1uwjB-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 3 / 3 | ILE A 798ASP A 810PHE A 811 | NoneSTI A 3 (-3.9A)STI A 3 (-3.6A) | 0.57A | 1uwjB-1t46A:28.4 | 1uwjB-1t46A:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XKK_A_FMMA91_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621THR A 670GLY A 676LEU A 679ARG A 683LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.2A)STI A 3 ( 3.8A)NoneNoneSTI A 3 (-4.4A) | 0.63A | 1xkkA-1t46A:24.4 | 1xkkA-1t46A:31.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EUF_B_LQQB401_1 (CELL DIVISIONPROTEIN KINASE 6) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | VAL A 603LYS A 623VAL A 654ASP A 677ASN A 797LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 (-4.3A)NoneNoneSTI A 3 (-4.4A) | 0.61A | 2eufB-1t46A:18.8 | 2eufB-1t46A:26.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_C_MIXC2539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621TYR A 672ASN A 797 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)None | 0.50A | 2fumC-1t46A:17.7 | 2fumC-1t46A:27.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2GQG_B_1N1B502_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.70A | 2gqgB-1t46A:31.6 | 2gqgB-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_A_STIA600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.63A | 2hyyA-1t46A:34.4 | 2hyyA-1t46A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_A_STIA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | LEU A 595LYS A 623VAL A 643ARG A 791 | STI A 3 ( 3.8A)STI A 3 (-3.7A)NoneNone | 1.01A | 2hyyA-1t46A:34.4 | 2hyyA-1t46A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_A_STIA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | LEU A 595VAL A 643VAL A 654ARG A 791 | STI A 3 ( 3.8A)NoneSTI A 3 (-4.3A)None | 0.61A | 2hyyA-1t46A:34.4 | 2hyyA-1t46A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_B_STIB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.61A | 2hyyB-1t46A:34.9 | 2hyyB-1t46A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_C_STIC600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.55A | 2hyyC-1t46A:29.4 | 2hyyC-1t46A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_D_STID600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | VAL A 603ALA A 621GLU A 640THR A 670LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.64A | 2hyyD-1t46A:34.8 | 2hyyD-1t46A:37.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITO_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.74A | 2itoA-1t46A:24.9 | 2itoA-1t46A:31.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITY_A_IREA2020_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621LYS A 623THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.83A | 2ityA-1t46A:26.6 | 2ityA-1t46A:31.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ITZ_A_IREA2021_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621LYS A 623GLU A 640THR A 670GLY A 676LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.71A | 2itzA-1t46A:30.8 | 2itzA-1t46A:31.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2IVU_A_ZD6A3015_0 (PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RETPRECURSOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595GLY A 596VAL A 603LYS A 623GLU A 640LEU A 644TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.60A | 2ivuA-1t46A:33.2 | 2ivuA-1t46A:45.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2OIQ_A_STIA1001_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621GLU A 640THR A 670TYR A 672GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.64A | 2oiqA-1t46A:26.2 | 2oiqA-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2OIQ_A_STIA1001_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-3.9A) | 0.82A | 2oiqA-1t46A:26.2 | 2oiqA-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2OIQ_A_STIA1001_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 5 | LEU A 595VAL A 643LEU A 647ARG A 791 | STI A 3 ( 3.8A)NoneNoneNone | 0.96A | 2oiqA-1t46A:26.2 | 2oiqA-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2PL0_A_STIA200_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640VAL A 654THR A 670TYR A 672LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.72A | 2pl0A-1t46A:25.2 | 2pl0A-1t46A:36.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2PL0_A_STIA200_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-3.9A) | 0.81A | 2pl0A-1t46A:25.2 | 2pl0A-1t46A:36.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2Y6O_A_1N1A1892_1 (EPHRIN TYPE-ARECEPTOR 4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.52A | 2y6oA-1t46A:33.0 | 2y6oA-1t46A:33.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2YFX_A_VGHA9000_1 (TYROSINE-PROTEINKINASE RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 8 | LEU A 595ALA A 621GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.59A | 2yfxA-1t46A:25.3 | 2yfxA-1t46A:36.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ZVA_A_1N1A513_1 (TYROSINE-PROTEINKINASE LYN) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640VAL A 654THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.85A | 2zvaA-1t46A:24.8 | 2zvaA-1t46A:37.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BBT_B_FMMB91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | VAL A 603ALA A 621LEU A 656THR A 670GLY A 676LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)NoneSTI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.66A | 3bbtB-1t46A:25.7 | 3bbtB-1t46A:29.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3C7Q_A_XINA1172_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595GLY A 596GLU A 605ALA A 621LYS A 623VAL A 654CYH A 673GLY A 676LEU A 799CYH A 809 | STI A 3 ( 3.8A)NoneNoneSTI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A) | 0.79A | 3c7qA-1t46A:30.7 | 3c7qA-1t46A:53.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_A_NILA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640VAL A 643THR A 670GLY A 676HIS A 790LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-4.4A) | 0.50A | 3cs9A-1t46A:34.7 | 3cs9A-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640GLY A 676HIS A 790ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 1.01A | 3cs9B-1t46A:32.3 | 3cs9B-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640VAL A 643THR A 670GLY A 676HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.50A | 3cs9B-1t46A:32.3 | 3cs9B-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_C_NILC600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640VAL A 643THR A 670HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.47A | 3cs9C-1t46A:26.9 | 3cs9C-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640VAL A 643THR A 670GLY A 676HIS A 790 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.5A) | 0.49A | 3cs9D-1t46A:33.1 | 3cs9D-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | LEU A 595VAL A 603LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.78A | 3cs9D-1t46A:33.1 | 3cs9D-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_D_NILD600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | LEU A 595VAL A 603LYS A 623ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 (-3.9A) | 0.88A | 3cs9D-1t46A:33.1 | 3cs9D-1t46A:37.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3FUP_B_MI1B1_1 (TYROSINE-PROTEINKINASE JAK2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621LYS A 623TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.47A | 3fupB-1t46A:23.8 | 3fupB-1t46A:34.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3FUP_B_MI1B1_1 (TYROSINE-PROTEINKINASE JAK2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621VAL A 654TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.41A | 3fupB-1t46A:23.8 | 3fupB-1t46A:34.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G0E_A_B49A9000_1 (MAST/STEM CELLGROWTH FACTORRECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 11 | LEU A 595VAL A 603ALA A 621VAL A 654THR A 670TYR A 672CYH A 673GLY A 676LEU A 799CYH A 809 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A) | 0.69A | 3g0eA-1t46A:41.4 | 3g0eA-1t46A:93.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G0F_A_B49A9001_1 (MAST/STEM CELLGROWTH FACTORRECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 11 / 11 | LEU A 595VAL A 603ALA A 621THR A 670TYR A 672CYH A 673GLY A 676ASP A 677LEU A 799CYH A 809PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.5A)STI A 3 ( 3.8A)NoneSTI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.6A) | 0.76A | 3g0fA-1t46A:41.9 | 3g0fA-1t46A:92.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G0F_B_B49B9001_1 (MAST/STEM CELLGROWTH FACTORRECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 10 | LEU A 595VAL A 603ALA A 621THR A 670TYR A 672CYH A 673GLY A 676LEU A 799CYH A 809PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.6A) | 0.63A | 3g0fB-1t46A:41.6 | 3g0fB-1t46A:92.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G5D_A_1N1A1_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.64A | 3g5dA-1t46A:30.9 | 3g5dA-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G5D_A_1N1A1_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.71A | 3g5dA-1t46A:30.9 | 3g5dA-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G5D_B_1N1B1_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.82A | 3g5dB-1t46A:31.0 | 3g5dB-1t46A:35.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GCS_A_BAXA401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | ALA A 621LEU A 644THR A 670HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.78A | 3gcsA-1t46A:19.5 | 3gcsA-1t46A:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GCS_A_BAXA401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LEU A 647LEU A 644THR A 670 | STI A 3 ( 4.6A)STI A 3 (-3.5A)NoneSTI A 3 (-4.4A)STI A 3 (-3.2A) | 0.98A | 3gcsA-1t46A:19.5 | 3gcsA-1t46A:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GP0_A_NILA1_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 11) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621GLU A 640LEU A 644THR A 670HIS A 790ASP A 810PHE A 811 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.73A | 3gp0A-1t46A:16.2 | 3gp0A-1t46A:25.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3GVU_A_STIA1001_1 (TYROSINE-PROTEINKINASE ABL2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.58A | 3gvuA-1t46A:28.7 | 3gvuA-1t46A:35.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HEC_A_STIA1_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | ALA A 621LEU A 644THR A 670ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.60A | 3hecA-1t46A:20.3 | 3hecA-1t46A:26.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HEC_A_STIA1_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621LYS A 623GLU A 640LEU A 644THR A 670PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-3.6A) | 0.67A | 3hecA-1t46A:20.3 | 3hecA-1t46A:26.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HEG_A_BAXA1_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623LEU A 644THR A 670 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A) | 0.60A | 3hegA-1t46A:20.3 | 3hegA-1t46A:26.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IK3_A_0LIA1_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.82A | 3ik3A-1t46A:28.5 | 3ik3A-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IK3_A_0LIA1_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640VAL A 654HIS A 790LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.46A | 3ik3A-1t46A:28.5 | 3ik3A-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IK3_A_0LIA1_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | LEU A 595LYS A 623VAL A 643ARG A 791 | STI A 3 ( 3.8A)STI A 3 (-3.7A)NoneNone | 1.08A | 3ik3A-1t46A:28.5 | 3ik3A-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IK3_B_0LIB2_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.84A | 3ik3B-1t46A:29.2 | 3ik3B-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IK3_B_0LIB2_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640VAL A 654HIS A 790LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.48A | 3ik3B-1t46A:29.2 | 3ik3B-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IK3_B_0LIB2_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | LEU A 595LYS A 623VAL A 643ARG A 791 | STI A 3 ( 3.8A)STI A 3 (-3.7A)NoneNone | 1.09A | 3ik3B-1t46A:29.2 | 3ik3B-1t46A:35.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3K54_A_1N1A1_1 (TYROSINE-PROTEINKINASE BTK) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.82A | 3k54A-1t46A:30.5 | 3k54A-1t46A:34.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3K5V_A_STIA2_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.54A | 3k5vA-1t46A:34.0 | 3k5vA-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3K5V_B_STIB2_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.54A | 3k5vB-1t46A:28.4 | 3k5vB-1t46A:36.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LFA_A_1N1A361_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 8 | ALA A 621LYS A 623GLU A 640THR A 670 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A) | 0.40A | 3lfaA-1t46A:9.0 | 3lfaA-1t46A:26.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3LXK_A_MI1A1125_1 (TYROSINE-PROTEINKINASE JAK3) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621LYS A 623VAL A 654TYR A 672 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.3A)STI A 3 ( 4.0A) | 0.61A | 3lxkA-1t46A:16.5 | 3lxkA-1t46A:33.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3LXK_A_MI1A1125_1 (TYROSINE-PROTEINKINASE JAK3) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621VAL A 654TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.62A | 3lxkA-1t46A:16.5 | 3lxkA-1t46A:33.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3LXN_A_MI1A1_1 (NON-RECEPTORTYROSINE-PROTEINKINASE TYK2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596VAL A 603ALA A 621LYS A 623TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.49A | 3lxnA-1t46A:22.8 | 3lxnA-1t46A:33.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MS9_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.64A | 3ms9A-1t46A:33.8 | 3ms9A-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MS9_B_STIB1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.66A | 3ms9B-1t46A:34.4 | 3ms9B-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.66A | 3mssA-1t46A:34.0 | 3mssA-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_B_STIB1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670GLY A 676ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-3.9A) | 0.68A | 3mssB-1t46A:34.0 | 3mssB-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_B_STIB1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.58A | 3mssB-1t46A:34.0 | 3mssB-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_C_STIC1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.69A | 3mssC-1t46A:33.9 | 3mssC-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_D_STID1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.65A | 3mssD-1t46A:34.1 | 3mssD-1t46A:36.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OCT_A_1N1A663_1 (TYROSINE-PROTEINKINASE BTK) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.70A | 3octA-1t46A:30.2 | 3octA-1t46A:34.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OEZ_A_STIA601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | ALA A 621GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.46A | 3oezA-1t46A:31.9 | 3oezA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OEZ_A_STIA601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654TYR A 672GLY A 676LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.67A | 3oezA-1t46A:31.9 | 3oezA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OEZ_B_STIB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640VAL A 643THR A 670TYR A 672LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.56A | 3oezB-1t46A:31.9 | 3oezB-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OEZ_B_STIB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621LYS A 623VAL A 643THR A 670TYR A 672LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)NoneSTI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.81A | 3oezB-1t46A:31.9 | 3oezB-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623LEU A 644THR A 670 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A) | 0.74A | 3og7A-1t46A:26.9 | 3og7A-1t46A:30.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623THR A 670CYH A 673 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.35A | 3og7A-1t46A:26.9 | 3og7A-1t46A:30.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OHT_A_1N1A1000_1 (P38A) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | GLY A 596VAL A 603ALA A 621LYS A 623LEU A 644THR A 670 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A) | 0.59A | 3ohtA-1t46A:16.2 | 3ohtA-1t46A:25.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OHT_A_1N1A1000_1 (P38A) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | GLY A 596VAL A 603ALA A 621LYS A 623THR A 670LEU A 799 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.4A) | 1.07A | 3ohtA-1t46A:16.2 | 3ohtA-1t46A:25.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OHT_B_1N1B1000_1 (P38A) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | GLY A 596VAL A 603ALA A 621LYS A 623LEU A 644THR A 670GLY A 676 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 ( 3.8A) | 0.70A | 3ohtB-1t46A:16.2 | 3ohtB-1t46A:25.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OXZ_A_0LIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640GLY A 676HIS A 790ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.87A | 3oxzA-1t46A:33.1 | 3oxzA-1t46A:36.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OXZ_A_0LIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640VAL A 654THR A 670GLY A 676HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.35A | 3oxzA-1t46A:33.1 | 3oxzA-1t46A:36.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OXZ_A_0LIA1_2 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 9 | LEU A 595LYS A 623VAL A 643ARG A 791LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.7A)NoneNoneSTI A 3 (-4.4A) | 0.89A | 3oxzA-1t46A:33.1 | 3oxzA-1t46A:36.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3PYY_A_STIA3_1 (V-ABL ABELSON MURINELEUKEMIA VIRALONCOGENE HOMOLOG 1ISOFORM B VARIANT) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640THR A 670GLY A 676LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.47A | 3pyyA-1t46A:34.5 | 3pyyA-1t46A:35.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3PYY_B_STIB4_1 (V-ABL ABELSON MURINELEUKEMIA VIRALONCOGENE HOMOLOG 1ISOFORM B VARIANT) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.57A | 3pyyB-1t46A:32.5 | 3pyyB-1t46A:35.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3QLG_A_1N1A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.87A | 3qlgA-1t46A:31.5 | 3qlgA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3QLG_A_1N1A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.85A | 3qlgA-1t46A:31.5 | 3qlgA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3QLG_B_1N1B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.83A | 3qlgB-1t46A:30.9 | 3qlgB-1t46A:35.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RGF_A_BAXA465_1 (CYCLIN-DEPENDENTKINASE 8) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640LEU A 644TYR A 672LEU A 783HIS A 790 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 ( 4.0A)NoneSTI A 3 (-4.5A) | 0.85A | 3rgfA-1t46A:8.3 | 3rgfA-1t46A:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RGF_A_BAXA465_2 (CYCLIN-DEPENDENTKINASE 8) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | LEU A 799VAL A 654LEU A 647ASP A 810 | STI A 3 (-4.4A)STI A 3 (-4.3A)NoneSTI A 3 (-3.9A) | 0.64A | 3rgfA-1t46A:8.3 | 3rgfA-1t46A:25.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3SXR_A_1N1A1_1 (CYTOPLASMICTYROSINE-PROTEINKINASE BMX) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.56A | 3sxrA-1t46A:30.0 | 3sxrA-1t46A:35.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3SXR_B_1N1B2_1 (CYTOPLASMICTYROSINE-PROTEINKINASE BMX) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.55A | 3sxrB-1t46A:29.7 | 3sxrB-1t46A:35.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3UE4_B_DB8B601_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621VAL A 654THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.75A | 3ue4B-1t46A:32.8 | 3ue4B-1t46A:36.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3WZD_A_LEVA1201_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640LEU A 644CYH A 673GLY A 676CYH A 809 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.5A) | 0.51A | 3wzdA-1t46A:35.2 | 3wzdA-1t46A:53.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3WZE_A_BAXA1201_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640LEU A 644GLY A 676LEU A 783HIS A 790 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 ( 3.8A)NoneSTI A 3 (-4.5A) | 0.53A | 3wzeA-1t46A:43.5 | 3wzeA-1t46A:53.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3WZE_A_BAXA1201_2 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 8 | VAL A 654CYH A 673LEU A 799ILE A 808CYH A 809ASP A 810PHE A 811 | STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)NoneSTI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.41A | 3wzeA-1t46A:43.5 | 3wzeA-1t46A:53.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZOS_A_0LIA1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670LEU A 783HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)NoneSTI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.61A | 3zosA-1t46A:34.3 | 3zosA-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZOS_A_0LIA1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595ALA A 621LYS A 623THR A 670LEU A 783HIS A 790ARG A 791LEU A 799ASP A 810PHE A 811 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)NoneSTI A 3 (-4.5A)NoneSTI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.72A | 3zosA-1t46A:34.3 | 3zosA-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZOS_B_0LIB1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | ALA A 621LYS A 623GLU A 640THR A 670LEU A 783HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)NoneSTI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.61A | 3zosB-1t46A:34.9 | 3zosB-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZOS_B_0LIB1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | ALA A 621LYS A 623THR A 670LEU A 783HIS A 790ARG A 791LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)NoneSTI A 3 (-4.5A)NoneSTI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.75A | 3zosB-1t46A:34.9 | 3zosB-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4AG8_A_AXIA2000_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640VAL A 654GLY A 676LEU A 799CYH A 809PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.6A) | 0.50A | 4ag8A-1t46A:35.1 | 4ag8A-1t46A:53.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4AGC_A_AXIA2000_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640LEU A 644GLY A 676LEU A 799CYH A 809PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.6A) | 0.48A | 4agcA-1t46A:42.9 | 4agcA-1t46A:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4AGD_A_B49A2000_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 11 | LEU A 595ALA A 621LYS A 623VAL A 654CYH A 673GLY A 676LEU A 799CYH A 809PHE A 811 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.6A) | 0.65A | 4agdA-1t46A:33.3 | 4agdA-1t46A:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ASD_A_BAXA1500_1 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640LEU A 644GLY A 676LEU A 783HIS A 790PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 ( 3.8A)NoneSTI A 3 (-4.5A)STI A 3 (-3.6A) | 0.70A | 4asdA-1t46A:32.9 | 4asdA-1t46A:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ASD_A_BAXA1500_2 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 6 | VAL A 654CYH A 673LEU A 799ILE A 808CYH A 809 | STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)NoneSTI A 3 (-4.5A) | 0.32A | 4asdA-1t46A:32.9 | 4asdA-1t46A:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4BKJ_A_STIA1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640THR A 670TYR A 672LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.87A | 4bkjA-1t46A:33.6 | 4bkjA-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4BKJ_B_STIB1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | VAL A 603ALA A 621GLU A 640THR A 670LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.78A | 4bkjB-1t46A:33.7 | 4bkjB-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4BKJ_B_STIB1000_2 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 5 | LYS A 623LEU A 647TYR A 672ARG A 791 | STI A 3 (-3.7A)NoneSTI A 3 ( 4.0A)None | 1.04A | 4bkjB-1t46A:33.7 | 4bkjB-1t46A:32.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C8B_A_0LIA1000_1 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621LYS A 623GLU A 640HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.77A | 4c8bA-1t46A:27.3 | 4c8bA-1t46A:26.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C8B_A_0LIA1000_1 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | ALA A 621LYS A 623GLU A 640LEU A 644THR A 670HIS A 790LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.46A | 4c8bA-1t46A:27.3 | 4c8bA-1t46A:26.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C8B_A_0LIA1000_2 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 5 | VAL A 603ILE A 653TYR A 672ILE A 808 | STI A 3 ( 4.6A)NoneSTI A 3 ( 4.0A)None | 0.44A | 4c8bA-1t46A:27.3 | 4c8bA-1t46A:26.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C8B_B_0LIB1000_1 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621LYS A 623GLU A 640HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.83A | 4c8bB-1t46A:26.8 | 4c8bB-1t46A:26.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C8B_B_0LIB1000_1 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | ALA A 621LYS A 623GLU A 640LEU A 644ILE A 653THR A 670HIS A 790LEU A 799ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)NoneSTI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.59A | 4c8bB-1t46A:26.8 | 4c8bB-1t46A:26.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CKI_A_ADNA2022_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 11 | LEU A 595GLY A 596VAL A 603ALA A 621TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.51A | 4ckiA-1t46A:33.1 | 4ckiA-1t46A:45.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CKJ_A_ADNA2014_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 10 | LEU A 595GLY A 596GLY A 598VAL A 603ALA A 621TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneNoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.53A | 4ckjA-1t46A:33.8 | 4ckjA-1t46A:45.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CSV_A_STIA1265_1 (SRC-ABL TYROSINEKINASE ANCESTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621GLU A 640THR A 670TYR A 672LEU A 799ASP A 810PHE A 811 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.84A | 4csvA-1t46A:32.4 | 4csvA-1t46A:38.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CSV_A_STIA1265_1 (SRC-ABL TYROSINEKINASE ANCESTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654THR A 670TYR A 672LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.53A | 4csvA-1t46A:32.4 | 4csvA-1t46A:38.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4HJO_A_AQ4A1001_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.68A | 4hjoA-1t46A:25.4 | 4hjoA-1t46A:31.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IAA_A_RTZA401_1 (SERINE/THREONINE-PROTEIN KINASE PIM-1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 11 | VAL A 603ALA A 621LYS A 623ASP A 677LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)NoneSTI A 3 (-4.4A)STI A 3 (-3.9A) | 1.16A | 4iaaA-1t46A:3.5 | 4iaaA-1t46A:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_A_8PRA601_1 (RHODOPSIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | VAL A 603ALA A 621ASP A 677LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)NoneSTI A 3 (-4.4A) | 0.79A | 4l9iA-1t46A:7.9 | 4l9iA-1t46A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_B_8PRB601_1 (RHODOPSIN KINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 8 | VAL A 603ALA A 621LYS A 623ASP A 677LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)NoneSTI A 3 (-4.4A) | 0.90A | 4l9iB-1t46A:21.1 | 4l9iB-1t46A:23.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MKC_A_4MKA1503_1 (ALK TYROSINE KINASERECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLY A 676ASP A 677LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 ( 3.8A)NoneSTI A 3 (-4.4A) | 0.54A | 4mkcA-1t46A:25.6 | 4mkcA-1t46A:34.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXO_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A) | 0.88A | 4mxoA-1t46A:31.1 | 4mxoA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXO_B_DB8B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.85A | 4mxoB-1t46A:24.9 | 4mxoB-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXO_B_DB8B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.77A | 4mxoB-1t46A:24.9 | 4mxoB-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXX_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.80A | 4mxxA-1t46A:24.7 | 4mxxA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXX_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.94A | 4mxxA-1t46A:24.7 | 4mxxA-1t46A:35.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4MXX_B_DB8B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.73A | 4mxxB-1t46A:25.9 | 4mxxB-1t46A:35.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0S_A_ADNA500_1 (AURORA KINASE A) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 11 | LEU A 595GLY A 596VAL A 603ALA A 621LYS A 623ASN A 797LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)NoneSTI A 3 (-4.4A) | 0.67A | 4o0sA-1t46A:24.0 | 4o0sA-1t46A:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0U_A_ADNA501_1 (AURORA KINASE A) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 6 | VAL A 603ALA A 621LYS A 623LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A) | 0.63A | 4o0uA-1t46A:22.5 | 4o0uA-1t46A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0W_A_ADNA501_1 (AURORA KINASE A) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 6 | LEU A 595GLY A 596VAL A 603ALA A 621LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.4A) | 0.45A | 4o0wA-1t46A:24.0 | 4o0wA-1t46A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OGR_A_ADNA401_1 (CYCLIN-DEPENDENTKINASE 9) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 8 | VAL A 603ALA A 621ASP A 677ASN A 797LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)NoneNoneSTI A 3 (-4.4A) | 0.54A | 4ogrA-1t46A:22.9 | 4ogrA-1t46A:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OGR_E_ADNE401_1 (CYCLIN-DEPENDENTKINASE 9) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 7 | GLY A 596ALA A 621CYH A 673ASP A 677ASN A 797LEU A 799 | NoneSTI A 3 (-3.5A)STI A 3 (-4.5A)NoneNoneSTI A 3 (-4.4A) | 0.67A | 4ogrE-1t46A:17.4 | 4ogrE-1t46A:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OGR_I_ADNI401_1 (CYCLIN-DEPENDENTKINASE 9) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 9 | VAL A 603ALA A 621CYH A 673ASP A 677ASN A 797LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.5A)NoneNoneSTI A 3 (-4.4A) | 0.52A | 4ogrI-1t46A:17.5 | 4ogrI-1t46A:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OTI_A_MI1A1001_1 (SERINE/THREONINE-PROTEIN KINASE N1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595GLY A 596GLY A 601VAL A 603ALA A 621VAL A 654LEU A 799 | STI A 3 ( 3.8A)NoneNoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-4.4A) | 0.57A | 4otiA-1t46A:14.0 | 4otiA-1t46A:24.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OTW_A_DB8A1101_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-3) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603LYS A 623THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.77A | 4otwA-1t46A:26.4 | 4otwA-1t46A:29.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4QRC_A_0LIA802_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 8 | LEU A 595VAL A 603HIS A 790LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-4.5A)STI A 3 (-4.4A) | 0.25A | 4qrcA-1t46A:35.2 | 4qrcA-1t46A:48.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4R7I_A_STIA1001_1 (MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 12 | VAL A 603ALA A 621LYS A 623GLU A 640THR A 670CYH A 673CYH A 788LEU A 799ASP A 810PHE A 811 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 (-2.8A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.34A | 4r7iA-1t46A:42.4 | 4r7iA-1t46A:67.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4R7I_A_STIA1001_2 (MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 5 | LEU A 595VAL A 654VAL A 668TYR A 672ARG A 791 | STI A 3 ( 3.8A)STI A 3 (-4.3A)STI A 3 (-4.6A)STI A 3 ( 4.0A)None | 0.61A | 4r7iA-1t46A:42.4 | 4r7iA-1t46A:67.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623THR A 670CYH A 673 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.31A | 4rzvB-1t46A:22.9 | 4rzvB-1t46A:30.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TYJ_A_0LIA801_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621GLU A 640CYH A 788HIS A 790LEU A 799ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-2.8A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.79A | 4tyjA-1t46A:35.7 | 4tyjA-1t46A:48.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TYJ_A_0LIA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 6 | LEU A 595VAL A 603ILE A 653ARG A 791ILE A 808 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)NoneNoneNone | 0.60A | 4tyjA-1t46A:35.7 | 4tyjA-1t46A:48.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U0I_A_0LIA1001_1 (MAST/STEM CELLGROWTH FACTORRECEPTORKIT,MAST/STEM CELLGROWTH FACTORRECEPTOR KIT) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 10 / 10 | LEU A 595VAL A 603GLU A 640LEU A 647ILE A 653VAL A 654VAL A 668TYR A 672ARG A 791ILE A 808 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.6A)NoneNoneSTI A 3 (-4.3A)STI A 3 (-4.6A)STI A 3 ( 4.0A)NoneNone | 0.37A | 4u0iA-1t46A:35.8 | 4u0iA-1t46A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U0I_A_0LIA1001_2 (MAST/STEM CELLGROWTH FACTORRECEPTORKIT,MAST/STEM CELLGROWTH FACTORRECEPTOR KIT) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 12 / 12 | ALA A 621LYS A 623LEU A 644THR A 670CYH A 673GLY A 676CYH A 788HIS A 790LEU A 799CYH A 809ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-2.8A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.35A | 4u0iA-1t46A:35.8 | 4u0iA-1t46A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_B_RXTB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 9 | LEU A 595VAL A 603ALA A 621TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.56A | 4u5jB-1t46A:31.3 | 4u5jB-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4U5J_B_RXTB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 9 | LEU A 595VAL A 603ALA A 621TYR A 672LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.74A | 4u5jB-1t46A:31.3 | 4u5jB-1t46A:35.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4UXQ_A_0LIA1752_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595ALA A 621GLU A 640CYH A 788LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-2.8A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.73A | 4uxqA-1t46A:29.7 | 4uxqA-1t46A:49.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4UXQ_A_0LIA1752_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595ALA A 621LEU A 783CYH A 788HIS A 790LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 (-3.5A)NoneSTI A 3 (-2.8A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.52A | 4uxqA-1t46A:29.7 | 4uxqA-1t46A:49.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | ALA A 621GLU A 640HIS A 790ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.82A | 4v01A-1t46A:26.9 | 4v01A-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | ALA A 621GLU A 640LEU A 783HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-4.5A)STI A 3 (-3.9A) | 0.69A | 4v01A-1t46A:26.9 | 4v01A-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 9 | LEU A 595VAL A 603LYS A 623TYR A 672ARG A 791LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 ( 4.0A)NoneSTI A 3 (-4.4A) | 1.07A | 4v01A-1t46A:26.9 | 4v01A-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 9 | LEU A 595VAL A 603TYR A 672CYH A 788ARG A 791LEU A 799ILE A 808 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 ( 4.0A)STI A 3 (-2.8A)NoneSTI A 3 (-4.4A)None | 0.86A | 4v01A-1t46A:26.9 | 4v01A-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_B_0LIB1770_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640LEU A 783CYH A 788HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-2.8A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.60A | 4v01B-1t46A:26.9 | 4v01B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_B_0LIB1770_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 9 | LEU A 595VAL A 603LYS A 623TYR A 672ARG A 791LEU A 799ILE A 808 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 ( 4.0A)NoneSTI A 3 (-4.4A)None | 0.53A | 4v01B-1t46A:26.9 | 4v01B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_B_0LIB1770_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 9 | LEU A 595VAL A 603LYS A 623TYR A 672LEU A 799ILE A 653 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 ( 4.0A)STI A 3 (-4.4A)None | 1.05A | 4v01B-1t46A:26.9 | 4v01B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_A_0LIA1772_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640LEU A 783CYH A 788HIS A 790ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-2.8A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.68A | 4v04A-1t46A:34.3 | 4v04A-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 10 | LEU A 595VAL A 603LYS A 623TYR A 672ARG A 791LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 ( 4.0A)NoneSTI A 3 (-4.4A) | 1.09A | 4v04B-1t46A:28.7 | 4v04B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 10 | LEU A 595VAL A 603LYS A 623TYR A 672LEU A 799ILE A 653 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 ( 4.0A)STI A 3 (-4.4A)None | 0.98A | 4v04B-1t46A:28.7 | 4v04B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 10 | LEU A 595VAL A 603TYR A 672ARG A 791LEU A 799ILE A 808 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 ( 4.0A)NoneSTI A 3 (-4.4A)None | 0.83A | 4v04B-1t46A:28.7 | 4v04B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | ALA A 621GLU A 640HIS A 790ASP A 810PHE A 811 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-3.9A)STI A 3 (-3.6A) | 0.80A | 4v04B-1t46A:28.7 | 4v04B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640LEU A 783CYH A 788HIS A 790ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)NoneSTI A 3 (-2.8A)STI A 3 (-4.5A)STI A 3 (-3.9A) | 0.71A | 4v04B-1t46A:28.7 | 4v04B-1t46A:48.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4WKQ_A_IREA1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.69A | 4wkqA-1t46A:30.6 | 4wkqA-1t46A:31.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XEY_A_1N1A601_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623VAL A 654THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.80A | 4xeyA-1t46A:32.9 | 4xeyA-1t46A:29.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XLI_A_1N1A601_1 (NON-SPECIFICPROTEIN-TYROSINEKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595ALA A 621GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.70A | 4xliA-1t46A:32.5 | 4xliA-1t46A:36.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XLI_B_1N1B600_1 (NON-SPECIFICPROTEIN-TYROSINEKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595ALA A 621GLU A 640VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.74A | 4xliB-1t46A:32.1 | 4xliB-1t46A:36.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XLI_B_1N1B600_1 (NON-SPECIFICPROTEIN-TYROSINEKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.65A | 4xliB-1t46A:32.1 | 4xliB-1t46A:36.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623THR A 670CYH A 673 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.25A | 4xv2A-1t46A:21.9 | 4xv2A-1t46A:30.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ZAU_A_YY3A1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 8 | LEU A 595GLY A 596VAL A 603ALA A 621GLY A 676 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 3.8A) | 0.49A | 4zauA-1t46A:30.6 | 4zauA-1t46A:31.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AJQ_A_DB8A800_1 (SERINE/THREONINE-PROTEIN KINASE 10) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595ALA A 621LYS A 623CYH A 673GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.86A | 5ajqA-1t46A:22.5 | 5ajqA-1t46A:28.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AJQ_B_DB8B800_1 (SERINE/THREONINE-PROTEIN KINASE 10) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 10 | ALA A 621CYH A 673GLY A 676LEU A 799 | STI A 3 (-3.5A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.24A | 5ajqB-1t46A:22.1 | 5ajqB-1t46A:28.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5BVW_A_1N1A1009_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 9 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.47A | 5bvwA-1t46A:28.2 | 5bvwA-1t46A:32.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623LEU A 644THR A 670 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A) | 0.69A | 5cswA-1t46A:22.1 | 5cswA-1t46A:30.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623THR A 670CYH A 673 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.26A | 5cswA-1t46A:22.1 | 5cswA-1t46A:30.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623LEU A 644THR A 670 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A) | 0.77A | 5cswB-1t46A:26.7 | 5cswB-1t46A:30.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | VAL A 603ALA A 621LYS A 623THR A 670CYH A 673 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.34A | 5cswB-1t46A:26.7 | 5cswB-1t46A:30.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_A_1N1A501_1 (PROTEIN-TYROSINEKINASE 6) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595VAL A 603ALA A 621THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.70A | 5h2uA-1t46A:25.7 | 5h2uA-1t46A:37.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595VAL A 603ALA A 621THR A 670GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.2A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.73A | 5h2uB-1t46A:25.9 | 5h2uB-1t46A:37.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HES_B_032B401_1 (MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | VAL A 603ALA A 621LYS A 623THR A 670TYR A 672CYH A 809 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 (-4.5A) | 0.66A | 5hesB-1t46A:24.7 | 5hesB-1t46A:28.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HI2_A_BAXA801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | ALA A 621LYS A 623GLU A 640LEU A 644THR A 670CYH A 673LEU A 783HIS A 790 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.4A)STI A 3 (-3.2A)STI A 3 (-4.5A)NoneSTI A 3 (-4.5A) | 0.64A | 5hi2A-1t46A:18.8 | 5hi2A-1t46A:30.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HI2_A_BAXA801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 8 | VAL A 603VAL A 643ILE A 653ILE A 808ASP A 810 | STI A 3 ( 4.6A)NoneNoneNoneSTI A 3 (-3.9A) | 0.71A | 5hi2A-1t46A:18.8 | 5hi2A-1t46A:30.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 12 | GLY A 596VAL A 603ALA A 621LYS A 623THR A 670 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A) | 0.40A | 5hieC-1t46A:23.3 | 5hieC-1t46A:30.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5I9X_A_DB8A1001_1 (EPHRIN TYPE-ARECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.94A | 5i9xA-1t46A:27.9 | 5i9xA-1t46A:33.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5I9Y_A_1N1A1001_1 (EPHRIN TYPE-ARECEPTOR 2) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.71A | 5i9yA-1t46A:33.5 | 5i9yA-1t46A:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IZJ_F_AZ1F2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR-DAR) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 7 | GLY A 596GLY A 598GLY A 601VAL A 603 | NoneNoneNoneSTI A 3 ( 4.6A) | 0.34A | 5izjB-1t46A:15.7 | 5izjB-1t46A:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L2I_A_LQQA900_1 (CYCLIN-DEPENDENTKINASE 6) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | GLY A 596VAL A 603ALA A 621VAL A 654ASP A 677LEU A 799 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)NoneSTI A 3 (-4.4A) | 0.53A | 5l2iA-1t46A:6.6 | 5l2iA-1t46A:26.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L2T_A_6ZZA900_1 (CYCLIN-DEPENDENTKINASE 6) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | GLY A 596VAL A 603ALA A 621VAL A 654ASP A 677LEU A 799 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)NoneSTI A 3 (-4.4A) | 0.89A | 5l2tA-1t46A:22.1 | 5l2tA-1t46A:26.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5LVN_A_ADNA402_1 (3-PHOSPHOINOSITIDE-DEPENDENT PROTEINKINASE 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 11 | LEU A 595GLY A 596VAL A 603ALA A 621VAL A 654TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.70A | 5lvnA-1t46A:22.9 | 5lvnA-1t46A:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MAF_A_XINA403_1 (MATERNAL EMBRYONICLEUCINE ZIPPERKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | GLY A 596VAL A 603ALA A 621LYS A 623GLU A 640TYR A 672GLY A 676 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 ( 4.0A)STI A 3 ( 3.8A) | 0.81A | 5mafA-1t46A:23.0 | 5mafA-1t46A:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MO4_A_NILA601_1 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 10 | LEU A 595VAL A 603LYS A 623GLU A 640GLY A 676PHE A 811 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 ( 3.8A)STI A 3 (-3.6A) | 1.23A | 5mo4A-1t46A:9.0 | 5mo4A-1t46A:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MO4_A_NILA601_2 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621VAL A 643VAL A 654HIS A 790LEU A 799ASP A 810 | STI A 3 (-3.5A)NoneSTI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.38A | 5mo4A-1t46A:9.0 | 5mo4A-1t46A:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5N3H_A_NCAA401_0 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 10 | LEU A 595VAL A 603ALA A 621VAL A 654TYR A 672LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.48A | 5n3hA-1t46A:21.9 | 5n3hA-1t46A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OWR_A_1N1A401_1 (SERINE/THREONINE-PROTEIN KINASE 10) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 8 | ALA A 621GLU A 640CYH A 673LEU A 799 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 (-4.4A) | 0.51A | 5owrA-1t46A:20.5 | 5owrA-1t46A:29.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5P9I_A_1E8A701_1 (TYROSINE-PROTEINKINASE BTK) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | GLY A 596VAL A 603ALA A 621THR A 670GLY A 676ASN A 680LEU A 799 | NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.2A)STI A 3 ( 3.8A)NoneSTI A 3 (-4.4A) | 1.18A | 5p9iA-1t46A:27.1 | 5p9iA-1t46A:34.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TE0_A_XINA401_2 (AP2-ASSOCIATEDPROTEIN KINASE 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 4 / 5 | LEU A 595VAL A 603CYH A 673CYH A 809 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-4.5A)STI A 3 (-4.5A) | 0.52A | 5te0A-1t46A:18.0 | 5te0A-1t46A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | ALA A 621GLU A 640TYR A 672CYH A 673GLY A 676ASP A 810 | STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 ( 4.0A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-3.9A) | 0.96A | 5vc3A-1t46A:18.2 | 5vc3A-1t46A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | GLY A 596ALA A 621TYR A 672CYH A 673GLY A 676ASP A 677 | NoneSTI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 (-4.5A)STI A 3 ( 3.8A)None | 1.07A | 5vc3A-1t46A:18.2 | 5vc3A-1t46A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | GLY A 596ALA A 621TYR A 672CYH A 673GLY A 676ASP A 810 | NoneSTI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-3.9A) | 0.93A | 5vc3A-1t46A:18.2 | 5vc3A-1t46A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VCV_A_1N1A404_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670GLY A 676 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A) | 0.97A | 5vcvA-1t46A:22.6 | 5vcvA-1t46A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VCY_A_DB8A401_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640THR A 670CYH A 673 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.66A | 5vcyA-1t46A:22.4 | 5vcyA-1t46A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5W5V_A_ANWA701_0 (SERINE/THREONINE-PROTEIN KINASE TBK1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 5 / 9 | LEU A 595ALA A 621VAL A 654CYH A 673GLY A 676 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 ( 3.8A) | 0.71A | 5w5vA-1t46A:10.4 | 5w5vA-1t46A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640CYH A 673GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.67A | 5y7zA-1t46A:23.1 | 5y7zA-1t46A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640CYH A 673GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.67A | 5y7zA-1t46A:23.1 | 5y7zA-1t46A:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y7Z_B_IREB401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | LEU A 595ALA A 621GLU A 640CYH A 673GLY A 676LEU A 799CYH A 809 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A)STI A 3 (-4.5A) | 0.58A | 5y7zB-1t46A:23.2 | 5y7zB-1t46A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y80_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640THR A 670CYH A 673GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.50A | 5y80A-1t46A:22.6 | 5y80A-1t46A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y80_A_IREA401_0 (CYCLIN-G-ASSOCIATEDKINASE) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640THR A 670CYH A 673GLY A 676 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 (-4.5A)STI A 3 ( 3.8A) | 0.59A | 5y80A-1t46A:22.6 | 5y80A-1t46A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZV2_A_LEVA801_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640TYR A 672GLY A 676 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 ( 4.0A)STI A 3 ( 3.8A) | 0.45A | 5zv2A-1t46A:28.7 | 5zv2A-1t46A:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZV2_B_LEVB801_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 6 / 12 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640GLY A 676 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 ( 3.8A) | 0.48A | 5zv2B-1t46A:28.8 | 5zv2B-1t46A:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BSD_A_1N1A901_0 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | VAL A 603ALA A 621LYS A 623GLU A 640THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.52A | 6bsdA-1t46A:27.8 | 6bsdA-1t46A:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD4_A_STIA604_0 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.54A | 6hd4A-1t46A:33.7 | 6hd4A-1t46A:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD4_B_STIB602_0 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.55A | 6hd4B-1t46A:28.2 | 6hd4B-1t46A:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD6_A_STIA603_0 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 7 / 12 | VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.55A | 6hd6A-1t46A:34.0 | 6hd6A-1t46A:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD6_B_STIB601_0 (TYROSINE-PROTEINKINASE ABL1) |
1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homosapiens) | 8 / 12 | LEU A 595VAL A 603ALA A 621GLU A 640VAL A 654THR A 670LEU A 799ASP A 810 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 (-4.4A)STI A 3 (-3.9A) | 0.63A | 6hd6B-1t46A:33.7 | 6hd6B-1t46A:14.24 |