SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'STI'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
ASN A 797
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
0.66A 1fmoE-1t46A:
21.4
1fmoE-1t46A:
24.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.72A 1iepA-1t46A:
34.7
1iepA-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
0.72A 1iepB-1t46A:
34.7
1iepB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 VAL A 643
VAL A 654
ARG A 791
LEU A 799
None
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
0.65A 1iepB-1t46A:
34.4
1iepB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.68A 1m17A-1t46A:
26.4
1m17A-1t46A:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 9 LEU A 595
GLY A 596
VAL A 603
ALA A 621
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.76A 1muoA-1t46A:
7.7
1muoA-1t46A:
27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.55A 1opjA-1t46A:
34.0
1opjA-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
0.55A 1opjB-1t46A:
34.0
1opjB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 LEU A 595
LYS A 623
VAL A 643
ARG A 791
STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
0.79A 1opjB-1t46A:
34.0
1opjB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
LEU A 644
THR A 670
CYH A 673
LEU A 783
HIS A 790
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
0.57A 1uwhA-1t46A:
19.3
1uwhA-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 VAL A 603
VAL A 643
ILE A 653
ASP A 810
STI  A   3 ( 4.6A)
None
None
STI  A   3 (-3.9A)
0.69A 1uwhA-1t46A:
19.3
1uwhA-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
CYH A 673
LEU A 783
HIS A 790
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
0.59A 1uwhB-1t46A:
18.9
1uwhB-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 VAL A 603
VAL A 643
ILE A 653
ASP A 810
STI  A   3 ( 4.6A)
None
None
STI  A   3 (-3.9A)
0.69A 1uwhB-1t46A:
18.9
1uwhB-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
LEU A 783
HIS A 790
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
0.66A 1uwjA-1t46A:
28.2
1uwjA-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 LYS A 623
LEU A 644
ILE A 653
ASP A 810
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
None
STI  A   3 (-3.9A)
0.55A 1uwjA-1t46A:
28.2
1uwjA-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
LEU A 783
HIS A 790
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
0.65A 1uwjB-1t46A:
28.4
1uwjB-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
3 / 3 ILE A 798
ASP A 810
PHE A 811
None
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.57A 1uwjB-1t46A:
28.4
1uwjB-1t46A:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
THR A 670
GLY A 676
LEU A 679
ARG A 683
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
None
None
STI  A   3 (-4.4A)
0.63A 1xkkA-1t46A:
24.4
1xkkA-1t46A:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 VAL A 603
LYS A 623
VAL A 654
ASP A 677
ASN A 797
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
None
None
STI  A   3 (-4.4A)
0.61A 2eufB-1t46A:
18.8
2eufB-1t46A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
TYR A 672
ASN A 797
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
None
0.50A 2fumC-1t46A:
17.7
2fumC-1t46A:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.70A 2gqgB-1t46A:
31.6
2gqgB-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.63A 2hyyA-1t46A:
34.4
2hyyA-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 LEU A 595
LYS A 623
VAL A 643
ARG A 791
STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
1.01A 2hyyA-1t46A:
34.4
2hyyA-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 LEU A 595
VAL A 643
VAL A 654
ARG A 791
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.3A)
None
0.61A 2hyyA-1t46A:
34.4
2hyyA-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.61A 2hyyB-1t46A:
34.9
2hyyB-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.55A 2hyyC-1t46A:
29.4
2hyyC-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.64A 2hyyD-1t46A:
34.8
2hyyD-1t46A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.74A 2itoA-1t46A:
24.9
2itoA-1t46A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.83A 2ityA-1t46A:
26.6
2ityA-1t46A:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.71A 2itzA-1t46A:
30.8
2itzA-1t46A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
GLY A 596
VAL A 603
LYS A 623
GLU A 640
LEU A 644
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.60A 2ivuA-1t46A:
33.2
2ivuA-1t46A:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.64A 2oiqA-1t46A:
26.2
2oiqA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
0.82A 2oiqA-1t46A:
26.2
2oiqA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 5 LEU A 595
VAL A 643
LEU A 647
ARG A 791
STI  A   3 ( 3.8A)
None
None
None
0.96A 2oiqA-1t46A:
26.2
2oiqA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.72A 2pl0A-1t46A:
25.2
2pl0A-1t46A:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-3.9A)
0.81A 2pl0A-1t46A:
25.2
2pl0A-1t46A:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.52A 2y6oA-1t46A:
33.0
2y6oA-1t46A:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 8 LEU A 595
ALA A 621
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.59A 2yfxA-1t46A:
25.3
2yfxA-1t46A:
36.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
VAL A 654
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.85A 2zvaA-1t46A:
24.8
2zvaA-1t46A:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 VAL A 603
ALA A 621
LEU A 656
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.66A 3bbtB-1t46A:
25.7
3bbtB-1t46A:
29.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
GLY A 596
GLU A 605
ALA A 621
LYS A 623
VAL A 654
CYH A 673
GLY A 676
LEU A 799
CYH A 809
STI  A   3 ( 3.8A)
None
None
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
0.79A 3c7qA-1t46A:
30.7
3c7qA-1t46A:
53.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
VAL A 643
THR A 670
GLY A 676
HIS A 790
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
0.50A 3cs9A-1t46A:
34.7
3cs9A-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
GLY A 676
HIS A 790
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
1.01A 3cs9B-1t46A:
32.3
3cs9B-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
VAL A 643
THR A 670
GLY A 676
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.50A 3cs9B-1t46A:
32.3
3cs9B-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
VAL A 643
THR A 670
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.47A 3cs9C-1t46A:
26.9
3cs9C-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
VAL A 643
THR A 670
GLY A 676
HIS A 790
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
0.49A 3cs9D-1t46A:
33.1
3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 LEU A 595
VAL A 603
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.78A 3cs9D-1t46A:
33.1
3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 LEU A 595
VAL A 603
LYS A 623
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.9A)
0.88A 3cs9D-1t46A:
33.1
3cs9D-1t46A:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.47A 3fupB-1t46A:
23.8
3fupB-1t46A:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.41A 3fupB-1t46A:
23.8
3fupB-1t46A:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 11 LEU A 595
VAL A 603
ALA A 621
VAL A 654
THR A 670
TYR A 672
CYH A 673
GLY A 676
LEU A 799
CYH A 809
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
0.69A 3g0eA-1t46A:
41.4
3g0eA-1t46A:
93.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
11 / 11 LEU A 595
VAL A 603
ALA A 621
THR A 670
TYR A 672
CYH A 673
GLY A 676
ASP A 677
LEU A 799
CYH A 809
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.76A 3g0fA-1t46A:
41.9
3g0fA-1t46A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 10 LEU A 595
VAL A 603
ALA A 621
THR A 670
TYR A 672
CYH A 673
GLY A 676
LEU A 799
CYH A 809
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.63A 3g0fB-1t46A:
41.6
3g0fB-1t46A:
92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.64A 3g5dA-1t46A:
30.9
3g5dA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.71A 3g5dA-1t46A:
30.9
3g5dA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.82A 3g5dB-1t46A:
31.0
3g5dB-1t46A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 ALA A 621
LEU A 644
THR A 670
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.78A 3gcsA-1t46A:
19.5
3gcsA-1t46A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LEU A 647
LEU A 644
THR A 670
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.98A 3gcsA-1t46A:
19.5
3gcsA-1t46A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
GLU A 640
LEU A 644
THR A 670
HIS A 790
ASP A 810
PHE A 811
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.73A 3gp0A-1t46A:
16.2
3gp0A-1t46A:
25.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.58A 3gvuA-1t46A:
28.7
3gvuA-1t46A:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 ALA A 621
LEU A 644
THR A 670
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.60A 3hecA-1t46A:
20.3
3hecA-1t46A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-3.6A)
0.67A 3hecA-1t46A:
20.3
3hecA-1t46A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.60A 3hegA-1t46A:
20.3
3hegA-1t46A:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.82A 3ik3A-1t46A:
28.5
3ik3A-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
VAL A 654
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.46A 3ik3A-1t46A:
28.5
3ik3A-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 LEU A 595
LYS A 623
VAL A 643
ARG A 791
STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
1.08A 3ik3A-1t46A:
28.5
3ik3A-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.84A 3ik3B-1t46A:
29.2
3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
VAL A 654
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.48A 3ik3B-1t46A:
29.2
3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 LEU A 595
LYS A 623
VAL A 643
ARG A 791
STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
1.09A 3ik3B-1t46A:
29.2
3ik3B-1t46A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.82A 3k54A-1t46A:
30.5
3k54A-1t46A:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.54A 3k5vA-1t46A:
34.0
3k5vA-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.54A 3k5vB-1t46A:
28.4
3k5vB-1t46A:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 8 ALA A 621
LYS A 623
GLU A 640
THR A 670
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
0.40A 3lfaA-1t46A:
9.0
3lfaA-1t46A:
26.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
VAL A 654
TYR A 672
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
0.61A 3lxkA-1t46A:
16.5
3lxkA-1t46A:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.62A 3lxkA-1t46A:
16.5
3lxkA-1t46A:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.49A 3lxnA-1t46A:
22.8
3lxnA-1t46A:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.64A 3ms9A-1t46A:
33.8
3ms9A-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.66A 3ms9B-1t46A:
34.4
3ms9B-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.66A 3mssA-1t46A:
34.0
3mssA-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
0.68A 3mssB-1t46A:
34.0
3mssB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.58A 3mssB-1t46A:
34.0
3mssB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.69A 3mssC-1t46A:
33.9
3mssC-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.65A 3mssD-1t46A:
34.1
3mssD-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.70A 3octA-1t46A:
30.2
3octA-1t46A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.46A 3oezA-1t46A:
31.9
3oezA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.67A 3oezA-1t46A:
31.9
3oezA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
VAL A 643
THR A 670
TYR A 672
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.56A 3oezB-1t46A:
31.9
3oezB-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
LYS A 623
VAL A 643
THR A 670
TYR A 672
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.81A 3oezB-1t46A:
31.9
3oezB-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.74A 3og7A-1t46A:
26.9
3og7A-1t46A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.35A 3og7A-1t46A:
26.9
3og7A-1t46A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 GLY A 596
VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.59A 3ohtA-1t46A:
16.2
3ohtA-1t46A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 GLY A 596
VAL A 603
ALA A 621
LYS A 623
THR A 670
LEU A 799
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
1.07A 3ohtA-1t46A:
16.2
3ohtA-1t46A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 GLY A 596
VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
GLY A 676
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
0.70A 3ohtB-1t46A:
16.2
3ohtB-1t46A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
GLY A 676
HIS A 790
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.87A 3oxzA-1t46A:
33.1
3oxzA-1t46A:
36.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.35A 3oxzA-1t46A:
33.1
3oxzA-1t46A:
36.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 9 LEU A 595
LYS A 623
VAL A 643
ARG A 791
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
STI  A   3 (-4.4A)
0.89A 3oxzA-1t46A:
33.1
3oxzA-1t46A:
36.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.47A 3pyyA-1t46A:
34.5
3pyyA-1t46A:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.57A 3pyyB-1t46A:
32.5
3pyyB-1t46A:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.87A 3qlgA-1t46A:
31.5
3qlgA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.85A 3qlgA-1t46A:
31.5
3qlgA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.83A 3qlgB-1t46A:
30.9
3qlgB-1t46A:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
LEU A 644
TYR A 672
LEU A 783
HIS A 790
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.5A)
0.85A 3rgfA-1t46A:
8.3
3rgfA-1t46A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 LEU A 799
VAL A 654
LEU A 647
ASP A 810
STI  A   3 (-4.4A)
STI  A   3 (-4.3A)
None
STI  A   3 (-3.9A)
0.64A 3rgfA-1t46A:
8.3
3rgfA-1t46A:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.56A 3sxrA-1t46A:
30.0
3sxrA-1t46A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.55A 3sxrB-1t46A:
29.7
3sxrB-1t46A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
VAL A 654
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.75A 3ue4B-1t46A:
32.8
3ue4B-1t46A:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
LEU A 644
CYH A 673
GLY A 676
CYH A 809
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
0.51A 3wzdA-1t46A:
35.2
3wzdA-1t46A:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
LEU A 644
GLY A 676
LEU A 783
HIS A 790
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.5A)
0.53A 3wzeA-1t46A:
43.5
3wzeA-1t46A:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 8 VAL A 654
CYH A 673
LEU A 799
ILE A 808
CYH A 809
ASP A 810
PHE A 811
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
None
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.41A 3wzeA-1t46A:
43.5
3wzeA-1t46A:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
LEU A 783
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.61A 3zosA-1t46A:
34.3
3zosA-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
ALA A 621
LYS A 623
THR A 670
LEU A 783
HIS A 790
ARG A 791
LEU A 799
ASP A 810
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.72A 3zosA-1t46A:
34.3
3zosA-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 ALA A 621
LYS A 623
GLU A 640
THR A 670
LEU A 783
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.61A 3zosB-1t46A:
34.9
3zosB-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 ALA A 621
LYS A 623
THR A 670
LEU A 783
HIS A 790
ARG A 791
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
None
STI  A   3 (-4.5A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.75A 3zosB-1t46A:
34.9
3zosB-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
VAL A 654
GLY A 676
LEU A 799
CYH A 809
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.50A 4ag8A-1t46A:
35.1
4ag8A-1t46A:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
LEU A 644
GLY A 676
LEU A 799
CYH A 809
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.48A 4agcA-1t46A:
42.9
4agcA-1t46A:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 11 LEU A 595
ALA A 621
LYS A 623
VAL A 654
CYH A 673
GLY A 676
LEU A 799
CYH A 809
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.65A 4agdA-1t46A:
33.3
4agdA-1t46A:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
LEU A 644
GLY A 676
LEU A 783
HIS A 790
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.70A 4asdA-1t46A:
32.9
4asdA-1t46A:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 6 VAL A 654
CYH A 673
LEU A 799
ILE A 808
CYH A 809
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
None
STI  A   3 (-4.5A)
0.32A 4asdA-1t46A:
32.9
4asdA-1t46A:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.87A 4bkjA-1t46A:
33.6
4bkjA-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.78A 4bkjB-1t46A:
33.7
4bkjB-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 5 LYS A 623
LEU A 647
TYR A 672
ARG A 791
STI  A   3 (-3.7A)
None
STI  A   3 ( 4.0A)
None
1.04A 4bkjB-1t46A:
33.7
4bkjB-1t46A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
LYS A 623
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.77A 4c8bA-1t46A:
27.3
4c8bA-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.46A 4c8bA-1t46A:
27.3
4c8bA-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 5 VAL A 603
ILE A 653
TYR A 672
ILE A 808
STI  A   3 ( 4.6A)
None
STI  A   3 ( 4.0A)
None
0.44A 4c8bA-1t46A:
27.3
4c8bA-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
LYS A 623
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.83A 4c8bB-1t46A:
26.8
4c8bB-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 ALA A 621
LYS A 623
GLU A 640
LEU A 644
ILE A 653
THR A 670
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
None
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.59A 4c8bB-1t46A:
26.8
4c8bB-1t46A:
26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 11 LEU A 595
GLY A 596
VAL A 603
ALA A 621
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.51A 4ckiA-1t46A:
33.1
4ckiA-1t46A:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 10 LEU A 595
GLY A 596
GLY A 598
VAL A 603
ALA A 621
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.53A 4ckjA-1t46A:
33.8
4ckjA-1t46A:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
LEU A 799
ASP A 810
PHE A 811
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.84A 4csvA-1t46A:
32.4
4csvA-1t46A:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.53A 4csvA-1t46A:
32.4
4csvA-1t46A:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.68A 4hjoA-1t46A:
25.4
4hjoA-1t46A:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 11 VAL A 603
ALA A 621
LYS A 623
ASP A 677
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
1.16A 4iaaA-1t46A:
3.5
4iaaA-1t46A:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 VAL A 603
ALA A 621
ASP A 677
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
None
STI  A   3 (-4.4A)
0.79A 4l9iA-1t46A:
7.9
4l9iA-1t46A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 8 VAL A 603
ALA A 621
LYS A 623
ASP A 677
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-4.4A)
0.90A 4l9iB-1t46A:
21.1
4l9iB-1t46A:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLY A 676
ASP A 677
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.4A)
0.54A 4mkcA-1t46A:
25.6
4mkcA-1t46A:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
0.88A 4mxoA-1t46A:
31.1
4mxoA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.85A 4mxoB-1t46A:
24.9
4mxoB-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.77A 4mxoB-1t46A:
24.9
4mxoB-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.80A 4mxxA-1t46A:
24.7
4mxxA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.94A 4mxxA-1t46A:
24.7
4mxxA-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.73A 4mxxB-1t46A:
25.9
4mxxB-1t46A:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 11 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
ASN A 797
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-4.4A)
0.67A 4o0sA-1t46A:
24.0
4o0sA-1t46A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 6 VAL A 603
ALA A 621
LYS A 623
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
0.63A 4o0uA-1t46A:
22.5
4o0uA-1t46A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 6 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.4A)
0.45A 4o0wA-1t46A:
24.0
4o0wA-1t46A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 8 VAL A 603
ALA A 621
ASP A 677
ASN A 797
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
None
None
STI  A   3 (-4.4A)
0.54A 4ogrA-1t46A:
22.9
4ogrA-1t46A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 7 GLY A 596
ALA A 621
CYH A 673
ASP A 677
ASN A 797
LEU A 799
None
STI  A   3 (-3.5A)
STI  A   3 (-4.5A)
None
None
STI  A   3 (-4.4A)
0.67A 4ogrE-1t46A:
17.4
4ogrE-1t46A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 9 VAL A 603
ALA A 621
CYH A 673
ASP A 677
ASN A 797
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.5A)
None
None
STI  A   3 (-4.4A)
0.52A 4ogrI-1t46A:
17.5
4ogrI-1t46A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
GLY A 596
GLY A 601
VAL A 603
ALA A 621
VAL A 654
LEU A 799
STI  A   3 ( 3.8A)
None
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-4.4A)
0.57A 4otiA-1t46A:
14.0
4otiA-1t46A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
LYS A 623
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.77A 4otwA-1t46A:
26.4
4otwA-1t46A:
29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 8 LEU A 595
VAL A 603
HIS A 790
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
0.25A 4qrcA-1t46A:
35.2
4qrcA-1t46A:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 12 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
CYH A 673
CYH A 788
LEU A 799
ASP A 810
PHE A 811
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-2.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.34A 4r7iA-1t46A:
42.4
4r7iA-1t46A:
67.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 5 LEU A 595
VAL A 654
VAL A 668
TYR A 672
ARG A 791
STI  A   3 ( 3.8A)
STI  A   3 (-4.3A)
STI  A   3 (-4.6A)
STI  A   3 ( 4.0A)
None
0.61A 4r7iA-1t46A:
42.4
4r7iA-1t46A:
67.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.31A 4rzvB-1t46A:
22.9
4rzvB-1t46A:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
GLU A 640
CYH A 788
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.79A 4tyjA-1t46A:
35.7
4tyjA-1t46A:
48.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 6 LEU A 595
VAL A 603
ILE A 653
ARG A 791
ILE A 808
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
None
None
None
0.60A 4tyjA-1t46A:
35.7
4tyjA-1t46A:
48.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
10 / 10 LEU A 595
VAL A 603
GLU A 640
LEU A 647
ILE A 653
VAL A 654
VAL A 668
TYR A 672
ARG A 791
ILE A 808
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.6A)
None
None
STI  A   3 (-4.3A)
STI  A   3 (-4.6A)
STI  A   3 ( 4.0A)
None
None
0.37A 4u0iA-1t46A:
35.8
4u0iA-1t46A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
12 / 12 ALA A 621
LYS A 623
LEU A 644
THR A 670
CYH A 673
GLY A 676
CYH A 788
HIS A 790
LEU A 799
CYH A 809
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.35A 4u0iA-1t46A:
35.8
4u0iA-1t46A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 9 LEU A 595
VAL A 603
ALA A 621
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.56A 4u5jB-1t46A:
31.3
4u5jB-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 9 LEU A 595
VAL A 603
ALA A 621
TYR A 672
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.74A 4u5jB-1t46A:
31.3
4u5jB-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
ALA A 621
GLU A 640
CYH A 788
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-2.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.73A 4uxqA-1t46A:
29.7
4uxqA-1t46A:
49.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
ALA A 621
LEU A 783
CYH A 788
HIS A 790
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.52A 4uxqA-1t46A:
29.7
4uxqA-1t46A:
49.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 ALA A 621
GLU A 640
HIS A 790
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.82A 4v01A-1t46A:
26.9
4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 ALA A 621
GLU A 640
LEU A 783
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.69A 4v01A-1t46A:
26.9
4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 9 LEU A 595
VAL A 603
LYS A 623
TYR A 672
ARG A 791
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
1.07A 4v01A-1t46A:
26.9
4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 9 LEU A 595
VAL A 603
TYR A 672
CYH A 788
ARG A 791
LEU A 799
ILE A 808
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 ( 4.0A)
STI  A   3 (-2.8A)
None
STI  A   3 (-4.4A)
None
0.86A 4v01A-1t46A:
26.9
4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
LEU A 783
CYH A 788
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.60A 4v01B-1t46A:
26.9
4v01B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 9 LEU A 595
VAL A 603
LYS A 623
TYR A 672
ARG A 791
LEU A 799
ILE A 808
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
None
0.53A 4v01B-1t46A:
26.9
4v01B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 9 LEU A 595
VAL A 603
LYS A 623
TYR A 672
LEU A 799
ILE A 653
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
None
1.05A 4v01B-1t46A:
26.9
4v01B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
LEU A 783
CYH A 788
HIS A 790
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.68A 4v04A-1t46A:
34.3
4v04A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 10 LEU A 595
VAL A 603
LYS A 623
TYR A 672
ARG A 791
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
1.09A 4v04B-1t46A:
28.7
4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 10 LEU A 595
VAL A 603
LYS A 623
TYR A 672
LEU A 799
ILE A 653
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
None
0.98A 4v04B-1t46A:
28.7
4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 10 LEU A 595
VAL A 603
TYR A 672
ARG A 791
LEU A 799
ILE A 808
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
None
0.83A 4v04B-1t46A:
28.7
4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 ALA A 621
GLU A 640
HIS A 790
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.80A 4v04B-1t46A:
28.7
4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
LEU A 783
CYH A 788
HIS A 790
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
0.71A 4v04B-1t46A:
28.7
4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.69A 4wkqA-1t46A:
30.6
4wkqA-1t46A:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
VAL A 654
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.80A 4xeyA-1t46A:
32.9
4xeyA-1t46A:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.70A 4xliA-1t46A:
32.5
4xliA-1t46A:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
ALA A 621
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.74A 4xliB-1t46A:
32.1
4xliB-1t46A:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.65A 4xliB-1t46A:
32.1
4xliB-1t46A:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.25A 4xv2A-1t46A:
21.9
4xv2A-1t46A:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 8 LEU A 595
GLY A 596
VAL A 603
ALA A 621
GLY A 676
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 3.8A)
0.49A 4zauA-1t46A:
30.6
4zauA-1t46A:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
ALA A 621
LYS A 623
CYH A 673
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.86A 5ajqA-1t46A:
22.5
5ajqA-1t46A:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 10 ALA A 621
CYH A 673
GLY A 676
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.24A 5ajqB-1t46A:
22.1
5ajqB-1t46A:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
9 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.47A 5bvwA-1t46A:
28.2
5bvwA-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.69A 5cswA-1t46A:
22.1
5cswA-1t46A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.26A 5cswA-1t46A:
22.1
5cswA-1t46A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.77A 5cswB-1t46A:
26.7
5cswB-1t46A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.34A 5cswB-1t46A:
26.7
5cswB-1t46A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
VAL A 603
ALA A 621
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.70A 5h2uA-1t46A:
25.7
5h2uA-1t46A:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
VAL A 603
ALA A 621
THR A 670
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.73A 5h2uB-1t46A:
25.9
5h2uB-1t46A:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 VAL A 603
ALA A 621
LYS A 623
THR A 670
TYR A 672
CYH A 809
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
0.66A 5hesB-1t46A:
24.7
5hesB-1t46A:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
CYH A 673
LEU A 783
HIS A 790
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
None
STI  A   3 (-4.5A)
0.64A 5hi2A-1t46A:
18.8
5hi2A-1t46A:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 8 VAL A 603
VAL A 643
ILE A 653
ILE A 808
ASP A 810
STI  A   3 ( 4.6A)
None
None
None
STI  A   3 (-3.9A)
0.71A 5hi2A-1t46A:
18.8
5hi2A-1t46A:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 12 GLY A 596
VAL A 603
ALA A 621
LYS A 623
THR A 670
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
0.40A 5hieC-1t46A:
23.3
5hieC-1t46A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.94A 5i9xA-1t46A:
27.9
5i9xA-1t46A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.71A 5i9yA-1t46A:
33.5
5i9yA-1t46A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 7 GLY A 596
GLY A 598
GLY A 601
VAL A 603
None
None
None
STI  A   3 ( 4.6A)
0.34A 5izjB-1t46A:
15.7
5izjB-1t46A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 GLY A 596
VAL A 603
ALA A 621
VAL A 654
ASP A 677
LEU A 799
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
0.53A 5l2iA-1t46A:
6.6
5l2iA-1t46A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 GLY A 596
VAL A 603
ALA A 621
VAL A 654
ASP A 677
LEU A 799
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
0.89A 5l2tA-1t46A:
22.1
5l2tA-1t46A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 11 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.70A 5lvnA-1t46A:
22.9
5lvnA-1t46A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 GLY A 596
VAL A 603
ALA A 621
LYS A 623
GLU A 640
TYR A 672
GLY A 676
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
0.81A 5mafA-1t46A:
23.0
5mafA-1t46A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 10 LEU A 595
VAL A 603
LYS A 623
GLU A 640
GLY A 676
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.6A)
1.23A 5mo4A-1t46A:
9.0
5mo4A-1t46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
VAL A 643
VAL A 654
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
None
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.38A 5mo4A-1t46A:
9.0
5mo4A-1t46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 10 LEU A 595
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.48A 5n3hA-1t46A:
21.9
5n3hA-1t46A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 8 ALA A 621
GLU A 640
CYH A 673
LEU A 799
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
0.51A 5owrA-1t46A:
20.5
5owrA-1t46A:
29.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 GLY A 596
VAL A 603
ALA A 621
THR A 670
GLY A 676
ASN A 680
LEU A 799
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.4A)
1.18A 5p9iA-1t46A:
27.1
5p9iA-1t46A:
34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
4 / 5 LEU A 595
VAL A 603
CYH A 673
CYH A 809
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.5A)
0.52A 5te0A-1t46A:
18.0
5te0A-1t46A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 ALA A 621
GLU A 640
TYR A 672
CYH A 673
GLY A 676
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
0.96A 5vc3A-1t46A:
18.2
5vc3A-1t46A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 GLY A 596
ALA A 621
TYR A 672
CYH A 673
GLY A 676
ASP A 677
None
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
None
1.07A 5vc3A-1t46A:
18.2
5vc3A-1t46A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 GLY A 596
ALA A 621
TYR A 672
CYH A 673
GLY A 676
ASP A 810
None
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
0.93A 5vc3A-1t46A:
18.2
5vc3A-1t46A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
0.97A 5vcvA-1t46A:
22.6
5vcvA-1t46A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
CYH A 673
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.66A 5vcyA-1t46A:
22.4
5vcyA-1t46A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
5 / 9 LEU A 595
ALA A 621
VAL A 654
CYH A 673
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
0.71A 5w5vA-1t46A:
10.4
5w5vA-1t46A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
CYH A 673
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.67A 5y7zA-1t46A:
23.1
5y7zA-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
CYH A 673
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.67A 5y7zA-1t46A:
23.1
5y7zA-1t46A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 LEU A 595
ALA A 621
GLU A 640
CYH A 673
GLY A 676
LEU A 799
CYH A 809
STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
0.58A 5y7zB-1t46A:
23.2
5y7zB-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.50A 5y80A-1t46A:
22.6
5y80A-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
CYH A 673
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
0.59A 5y80A-1t46A:
22.6
5y80A-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
TYR A 672
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
0.45A 5zv2A-1t46A:
28.7
5zv2A-1t46A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
6 / 12 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
0.48A 5zv2B-1t46A:
28.8
5zv2B-1t46A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.52A 6bsdA-1t46A:
27.8
6bsdA-1t46A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.54A 6hd4A-1t46A:
33.7
6hd4A-1t46A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.55A 6hd4B-1t46A:
28.2
6hd4B-1t46A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
7 / 12 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.55A 6hd6A-1t46A:
34.0
6hd6A-1t46A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo
sapiens)
8 / 12 LEU A 595
VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.63A 6hd6B-1t46A:
33.7
6hd6B-1t46A:
14.24