SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SSA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ALA A 138
TRP A 142
PHE A 215
GLU A 183
 None
None
None
SSA  A 442 ( 4.7A)
 1.08A 1dmiA-3hxwA:
undetectable
1dmiB-3hxwA:
undetectable		 1dmiA-3hxwA:
23.09
1dmiB-3hxwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		8 / 10 MET A 131
CYH A 133
ARG A 162
ASP A 182
HIS A 184
TYR A 270
GLN A 292
HIS A 319
 SSA  A1001 (-3.8A)
ZN  A1003 (-2.9A)
SSA  A1001 (-2.8A)
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
None
SSA  A1001 (-3.3A)
ZN  A1003 ( 3.5A)
 0.34A 1nyrA-4eo4A:
47.7		 1nyrA-4eo4A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		8 / 10 MET A 131
CYH A 133
ARG A 162
ASP A 182
HIS A 184
TYR A 270
GLN A 292
HIS A 319
 SSA  A1001 (-3.8A)
ZN  A1003 (-2.9A)
SSA  A1001 (-2.8A)
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
None
SSA  A1001 (-3.3A)
ZN  A1003 ( 3.5A)
 0.78A 1nyrB-4eo4A:
45.5		 1nyrB-4eo4A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 5 TYR A 323
GLU A 368
PHE A 409
ALA A 317
 None
SSA  A2002 ( 2.5A)
PT  A2004 (-0.7A)
SSA  A2002 (-4.4A)
 1.40A 1oniE-3w3sA:
0.0
1oniF-3w3sA:
0.0		 1oniE-3w3sA:
12.29
1oniF-3w3sA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  95
ARG A 162
GLN A 180
 None
SSA  A1001 (-2.8A)
SSA  A1001 (-3.4A)
 0.94A 1tw4A-4eo4A:
undetectable		 1tw4A-4eo4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 109
ARG A 162
TYR A 270
GLY A 267
ALA A 268
 None
SSA  A1001 (-2.8A)
None
None
None
 1.20A 2cojA-4eo4A:
undetectable
2cojB-4eo4A:
undetectable		 2cojA-4eo4A:
20.78
2cojB-4eo4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ILE A 243
GLY A  94
THR A 236
LEU A 114
GLY A 239
 None
None
None
None
SSA  A 442 (-3.5A)
 1.28A 2fn1A-3hxwA:
undetectable		 2fn1A-3hxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 SER A 449
GLY A 451
SER A 405
 SSA  A2002 (-3.1A)
SSA  A2002 (-3.4A)
None
 0.56A 3loqA-3w3sA:
undetectable		 3loqA-3w3sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 8 ARG A 349
ARG A 360
PHE A 364
GLY A 451
ARG A 485
 SSA  A2002 (-3.0A)
None
SSA  A2002 ( 3.5A)
SSA  A2002 (-3.4A)
SSA  A2002 ( 3.7A)
 1.14A 4k87A-3w3sA:
22.6		 4k87A-3w3sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 8 ARG A 162
PHE A 178
GLN A 287
THR A 290
ARG A 328
 SSA  A1001 (-2.8A)
SSA  A1001 (-3.8A)
SSA  A1001 (-3.6A)
SSA  A1001 ( 4.3A)
SSA  A1001 (-3.7A)
 0.50A 4k87A-4eo4A:
26.5		 4k87A-4eo4A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 ARG A 262
ASP A 336
GLU A 119
ARG A 391
 SSA  A1001 (-2.8A)
None
None
SSA  A1001 (-3.3A)
 1.41A 4kr4C-2dq3A:
undetectable		 4kr4C-2dq3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 4 ILE A 367
VAL A 450
VAL A 483
ARG A 229
 None
SSA  A2002 (-4.8A)
None
None
 0.96A 4m6tA-3w3sA:
undetectable		 4m6tA-3w3sA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.02A 4q15B-2dq3A:
22.8		 4q15B-2dq3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 12 PHE A 242
GLY A 451
ALA A 388
VAL A 402
VAL A 455
 None
SSA  A2002 (-3.4A)
None
None
None
 1.13A 4wnwB-3w3sA:
undetectable		 4wnwB-3w3sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 SER A 405
ARG A 485
SER A 449
GLU A 430
 None
SSA  A2002 ( 3.7A)
SSA  A2002 (-3.1A)
None
 1.41A 4xzkA-3w3sA:
undetectable		 4xzkA-3w3sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.00A 4ydqA-2dq3A:
22.6		 4ydqA-2dq3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.04A 4ydqB-2dq3A:
22.3		 4ydqB-2dq3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 ASN A 454
SER A 452
ARG A 366
 SSA  A2002 (-4.3A)
SSA  A2002 (-2.9A)
SSA  A2002 (-3.0A)
 0.77A 5b2qA-3w3sA:
undetectable		 5b2qA-3w3sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.04A 5f9zB-2dq3A:
22.4		 5f9zB-2dq3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ILE A 276
ASP A 336
VAL A 339
ALA A 306
GLY A 384
 None
None
None
None
SSA  A1001 (-3.7A)
 1.07A 5igjA-2dq3A:
0.1		 5igjA-2dq3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 278
LEU A 333
PHE A 211
GLY A 324
ALA A 289
 None
None
None
SSA  A1001 (-3.3A)
None
 1.15A 5mxbA-4eo4A:
1.1		 5mxbA-4eo4A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 6 LEU A 435
VAL A 433
LEU A 398
VAL A 450
 None
None
None
SSA  A2002 (-4.8A)
 0.75A 5x7zA-3w3sA:
0.9		 5x7zA-3w3sA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.12A 5xioA-2dq3A:
11.6		 5xioA-2dq3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 164
PRO A 130
ARG A 162
HIS A 184
THR A 290
 SSA  A1001 (-4.1A)
None
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
SSA  A1001 ( 4.3A)
 1.28A 5xioB-4eo4A:
26.9		 5xioB-4eo4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 LEU A 205
PRO A 230
THR A 231
GLU A 233
ARG A 262
 None
None
SSA  A1001 (-3.2A)
SSA  A1001 (-3.7A)
SSA  A1001 (-2.8A)
 1.05A 5xipD-2dq3A:
22.0		 5xipD-2dq3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 164
PRO A 130
ARG A 162
HIS A 184
THR A 290
 SSA  A1001 (-4.1A)
None
SSA  A1001 (-2.8A)
ZN  A1003 (-3.6A)
SSA  A1001 ( 4.3A)
 1.34A 5xiqB-4eo4A:
26.8		 5xiqB-4eo4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 MET A 277
ASP A 266
ARG A 162
 None
None
SSA  A1001 (-2.8A)
 0.84A 5z6jA-4eo4A:
undetectable		 5z6jA-4eo4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 MET A 277
ASP A 266
ARG A 162
 None
None
SSA  A1001 (-2.8A)
 0.78A 5z6kA-4eo4A:
undetectable		 5z6kA-4eo4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 10 ARG A 262
GLU A 264
PHE A 281
GLU A 349
ARG A 391
 SSA  A1001 (-2.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.5A)
SSA  A1001 (-3.1A)
SSA  A1001 (-3.3A)
 0.68A 6bniA-2dq3A:
4.9		 6bniA-2dq3A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 ARG A  69
HIS A  86
PHE A  90
GLU A 209
GLY A 239
ARG A 242
 SSA  A 442 (-2.7A)
None
SSA  A 442 (-3.5A)
SSA  A 442 (-3.9A)
SSA  A 442 (-3.5A)
SSA  A 442 (-3.8A)
 0.69A 6bniA-3hxwA:
13.4		 6bniA-3hxwA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 10 ARG A 349
GLU A 351
PHE A 364
GLY A 482
ARG A 485
 SSA  A2002 (-3.0A)
SSA  A2002 (-3.2A)
SSA  A2002 ( 3.5A)
SSA  A2002 (-2.8A)
SSA  A2002 ( 3.7A)
 0.84A 6bniA-3w3sA:
9.8		 6bniA-3w3sA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ARG A 162
GLU A 164
PHE A 178
GLY A 324
ARG A 328
 SSA  A1001 (-2.8A)
SSA  A1001 (-4.1A)
SSA  A1001 (-3.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.7A)
 0.69A 6bniA-4eo4A:
11.4		 6bniA-4eo4A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ARG A 302
GLU A 304
PHE A 321
GLU A 391
ARG A 435
 SSA  A 501 (-2.4A)
SSA  A 501 (-3.4A)
SSA  A 501 (-3.5A)
MG  A 503 (-3.3A)
SSA  A 501 (-4.0A)
 0.89A 6bniA-4l87A:
10.3		 6bniA-4l87A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 10 ARG A 262
GLU A 264
PHE A 281
GLU A 349
ARG A 391
 SSA  A1001 (-2.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.5A)
SSA  A1001 (-3.1A)
SSA  A1001 (-3.3A)
 0.66A 6bniB-2dq3A:
12.4		 6bniB-2dq3A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 ARG A  69
HIS A  86
PHE A  90
GLU A 209
GLY A 239
ARG A 242
 SSA  A 442 (-2.7A)
None
SSA  A 442 (-3.5A)
SSA  A 442 (-3.9A)
SSA  A 442 (-3.5A)
SSA  A 442 (-3.8A)
 0.69A 6bniB-3hxwA:
12.0		 6bniB-3hxwA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 10 ARG A 349
GLU A 351
PHE A 364
GLY A 482
ARG A 485
 SSA  A2002 (-3.0A)
SSA  A2002 (-3.2A)
SSA  A2002 ( 3.5A)
SSA  A2002 (-2.8A)
SSA  A2002 ( 3.7A)
 0.84A 6bniB-3w3sA:
10.6		 6bniB-3w3sA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ARG A 162
GLU A 164
PHE A 178
GLY A 324
ARG A 328
 SSA  A1001 (-2.8A)
SSA  A1001 (-4.1A)
SSA  A1001 (-3.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.7A)
 0.67A 6bniB-4eo4A:
12.8		 6bniB-4eo4A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ARG A 302
GLU A 304
PHE A 321
GLU A 391
ARG A 435
 SSA  A 501 (-2.4A)
SSA  A 501 (-3.4A)
SSA  A 501 (-3.5A)
MG  A 503 (-3.3A)
SSA  A 501 (-4.0A)
 0.92A 6bniB-4l87A:
12.0		 6bniB-4l87A:
10.86