SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SRT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2ot9 HYPOTHETICAL PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU A 104
ILE A 121
ASP A  88
PRO A  87
 None
None
None
SRT  A 201 ( 4.0A)
 1.11A 1ditH-2ot9A:
undetectable
1ditP-2ot9A:
undetectable		 1ditH-2ot9A:
21.32
1ditP-2ot9A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 138
ARG A  71
ARG A 136
 SRT  A 247 (-3.8A)
None
SRT  A 247 (-2.9A)
 0.88A 1l7fA-2ra5A:
undetectable		 1l7fA-2ra5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 138
ARG A  71
ARG A 136
 SRT  A 247 (-3.8A)
None
SRT  A 247 (-2.9A)
 0.89A 1l7hA-2ra5A:
undetectable		 1l7hA-2ra5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 6 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.08A 1nsiA-3igoA:
undetectable
1nsiB-3igoA:
undetectable		 1nsiA-3igoA:
21.50
1nsiB-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 6 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.05A 1nsiA-3igoA:
undetectable
1nsiB-3igoA:
undetectable		 1nsiA-3igoA:
21.50
1nsiB-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 6 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.04A 1nsiC-3igoA:
undetectable
1nsiD-3igoA:
undetectable		 1nsiC-3igoA:
21.50
1nsiD-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 6 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.05A 1nsiC-3igoA:
undetectable
1nsiD-3igoA:
undetectable		 1nsiC-3igoA:
21.50
1nsiD-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 226
LEU A 169
ARG A 136
MET A 173
LEU A 180
 None
SRT  A 247 (-4.0A)
SRT  A 247 (-2.9A)
None
None
 0.97A 1p93C-2ra5A:
undetectable		 1p93C-2ra5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 169
ALA A 137
SER A 250
MET A 171
LEU A 222
 None
None
None
SRT  A 401 ( 4.9A)
None
 1.43A 1ya3B-2jbmA:
undetectable		 1ya3B-2jbmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 HIS A 228
ALA A 146
TYR A 147
LEU A 200
GLU A 135
 SRT  A 247 ( 4.8A)
None
None
None
None
 1.45A 2azqA-2ra5A:
undetectable		 2azqA-2ra5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.06A 2nsiA-3igoA:
undetectable
2nsiB-3igoA:
undetectable		 2nsiA-3igoA:
21.50
2nsiB-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.06A 2nsiA-3igoA:
undetectable
2nsiB-3igoA:
undetectable		 2nsiA-3igoA:
21.50
2nsiB-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.05A 2nsiC-3igoA:
undetectable
2nsiD-3igoA:
undetectable		 2nsiC-3igoA:
21.50
2nsiD-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.06A 2nsiC-3igoA:
undetectable
2nsiD-3igoA:
undetectable		 2nsiC-3igoA:
21.50
2nsiD-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4be3 ALGINATE LYASE,
FAMILY PL7
(Zobellia
galactanivorans) 		4 / 6 LEU A 106
LEU A 296
ILE A  54
ARG A 103
 None
None
None
SRT  A 400 (-3.6A)
 1.03A 2rlfA-4be3A:
undetectable
2rlfB-4be3A:
undetectable		 2rlfA-4be3A:
8.17
2rlfB-4be3A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4be3 ALGINATE LYASE,
FAMILY PL7
(Zobellia
galactanivorans) 		4 / 6 LEU A 106
LEU A 296
ILE A  54
ARG A 103
 None
None
None
SRT  A 400 (-3.6A)
 0.99A 2rlfC-4be3A:
undetectable
2rlfD-4be3A:
undetectable		 2rlfC-4be3A:
8.17
2rlfD-4be3A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.07A 3e7gA-3igoA:
undetectable
3e7gB-3igoA:
undetectable		 3e7gA-3igoA:
21.88
3e7gB-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.07A 3e7gA-3igoA:
undetectable
3e7gB-3igoA:
undetectable		 3e7gA-3igoA:
21.88
3e7gB-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.07A 3e7gC-3igoA:
undetectable
3e7gD-3igoA:
undetectable		 3e7gC-3igoA:
21.88
3e7gD-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 8 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.08A 3e7gC-3igoA:
undetectable
3e7gD-3igoA:
undetectable		 3e7gC-3igoA:
21.88
3e7gD-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.06A 3ej8A-3igoA:
undetectable
3ej8B-3igoA:
undetectable		 3ej8A-3igoA:
21.88
3ej8B-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.03A 3ej8C-3igoA:
0.0
3ej8D-3igoA:
0.0		 3ej8C-3igoA:
21.88
3ej8D-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.08A 3ej8C-3igoA:
0.0
3ej8D-3igoA:
0.0		 3ej8C-3igoA:
21.88
3ej8D-3igoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a29 EXOPOLYGALACTURONATE
LYASE
(Vibrio
vulnificus) 		5 / 12 LEU A 428
ALA A 366
VAL A 332
ALA A 336
LEU A 340
 None
None
None
SRT  A1568 (-4.3A)
EDO  A1577 (-4.5A)
 1.08A 3ln1A-5a29A:
undetectable		 3ln1A-5a29A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a29 EXOPOLYGALACTURONATE
LYASE
(Vibrio
vulnificus) 		5 / 12 LEU A 428
ALA A 366
VAL A 332
ALA A 336
LEU A 340
 None
None
None
SRT  A1568 (-4.3A)
EDO  A1577 (-4.5A)
 1.09A 3ln1D-5a29A:
undetectable		 3ln1D-5a29A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4be3 ALGINATE LYASE,
FAMILY PL7
(Zobellia
galactanivorans) 		4 / 7 LEU A  55
TYR A 299
SER A  96
HIS A 149
 SRT  A 400 ( 4.0A)
None
SRT  A 400 ( 4.0A)
SRT  A 400 (-3.4A)
 1.33A 4arcA-4be3A:
undetectable		 4arcA-4be3A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 8 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.05A 4cx7A-3igoA:
undetectable
4cx7B-3igoA:
undetectable		 4cx7A-3igoA:
21.50
4cx7B-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 8 ARG A 310
ILE A 301
TRP A 298
PHE A 293
 SRT  A 543 (-3.8A)
None
None
None
 1.01A 4cx7C-3igoA:
0.0
4cx7D-3igoA:
undetectable		 4cx7C-3igoA:
21.50
4cx7D-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 7 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.06A 4cx7C-3igoA:
0.0
4cx7D-3igoA:
undetectable		 4cx7C-3igoA:
21.50
4cx7D-3igoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 VAL A  30
ALA A  32
PHE A 156
LEU A 157
VAL A 163
 None
None
None
None
SRT  A 301 ( 4.3A)
 1.20A 4eckA-3ck2A:
undetectable		 4eckA-3ck2A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rq9 PHOTORECEPTOR-HISTID
INE KINASE BPHP
(Stigmatella
aurantiaca) 		5 / 10 VAL A 165
ALA A 191
SER A 273
LEU A 276
VAL A 161
 None
SRT  A 402 (-3.7A)
BLA  A 401 (-2.5A)
None
None
 1.16A 4eilB-4rq9A:
undetectable		 4eilB-4rq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Cryptosporidium
parvum) 		4 / 6 TRP A 298
PHE A 293
ARG A 310
ILE A 301
 None
None
SRT  A 543 (-3.8A)
None
 1.12A 4nosC-3igoA:
undetectable
4nosD-3igoA:
undetectable		 4nosC-3igoA:
21.64
4nosD-3igoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4be3 ALGINATE LYASE,
FAMILY PL7
(Zobellia
galactanivorans) 		3 / 3 HIS A 149
GLU A 179
ASN A 186
 SRT  A 400 (-3.4A)
None
None
 1.01A 5wbvA-4be3A:
undetectable		 5wbvA-4be3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4be3 ALGINATE LYASE,
FAMILY PL7
(Zobellia
galactanivorans) 		3 / 3 HIS A 149
GLU A 179
ASN A 186
 SRT  A 400 (-3.4A)
None
None
 1.02A 5wbvB-4be3A:
undetectable		 5wbvB-4be3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1n97 CYP175A1
(Thermus
thermophilus) 		4 / 8 ARG A 319
ARG A 339
VAL A 226
ARG A  91
 SRT  A 601 (-4.4A)
SRT  A 601 (-2.9A)
HEM  A 602 ( 4.2A)
HEM  A 602 (-3.9A)
 1.09A 6fbvD-1n97A:
1.5		 6fbvD-1n97A:
16.77