SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SRP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APW_B_DP0B190_1 (ALPHA-1-ACID GLYCOPROTEIN 2)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 12	VAL A 402 ILE A 389 LEU A 233 GLN A 358 PHE A 228	SRP A 900 (-4.4A) None None None None	1.46A	3apwB-1wleA: undetectable	3apwB-1wleA: 17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJW_A_SRYA2001_1 (TRANSCRIPTIONAL REGULATOR TCAR)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 12	ASN A 407 LEU A 355 GLN A 358 ALA A 435 GLU A 335	None None None None SRP A 900 (-2.8A)	1.28A	4ejwA-1wleA: 0.3	4ejwA-1wleA: 15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	4 / 8	ARG A 313 ARG A 327 PHE A 331 ARG A 442	SRP A 900 (-2.6A) None SRP A 900 (-4.0A) SRP A 900 ( 4.1A)	0.89A	4k87A-1wleA: 23.6	4k87A-1wleA: 24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_ACTA605_0 (SERUM ALBUMIN)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	4 / 6	TYR A 326 GLY A 319 GLU A 315 ARG A 210	None None SRP A 900 (-3.5A) None	1.23A	4zbqA-1wleA: 2.3	4zbqA-1wleA: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EML_A_SAMA701_0 (PROTEIN ARGININE N-METHYLTRANSFERASE 5)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 12	LEU A 357 GLY A 338 LEU A 287 ARG A 236 GLU A 335	None None None None SRP A 900 (-2.8A)	1.17A	5emlA-1wleA: undetectable	5emlA-1wleA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 10	ARG A 313 GLU A 315 PHE A 331 ALA A 439 GLU A 401	SRP A 900 (-2.6A) SRP A 900 (-3.5A) SRP A 900 (-4.0A) SRP A 900 (-3.5A) SRP A 900 (-3.6A)	1.15A	6bniA-1wleA: 10.8	6bniA-1wleA: 12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_A_ADNA602_1 (LYSINE--TRNA LIGASE)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 10	ARG A 313 GLU A 315 PHE A 331 GLU A 401 ARG A 442	SRP A 900 (-2.6A) SRP A 900 (-3.5A) SRP A 900 (-4.0A) SRP A 900 (-3.6A) SRP A 900 ( 4.1A)	0.71A	6bniA-1wleA: 10.8	6bniA-1wleA: 12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_B_ADNB602_1 (LYSINE--TRNA LIGASE)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 10	ARG A 313 GLU A 315 PHE A 331 ALA A 439 GLU A 401	SRP A 900 (-2.6A) SRP A 900 (-3.5A) SRP A 900 (-4.0A) SRP A 900 (-3.5A) SRP A 900 (-3.6A)	1.20A	6bniB-1wleA: 12.1	6bniB-1wleA: 12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BNI_B_ADNB602_1 (LYSINE--TRNA LIGASE)	1wle	SERYL-TRNA SYNTHETASE (Bos taurus)	5 / 10	ARG A 313 GLU A 315 PHE A 331 GLU A 401 ARG A 442	SRP A 900 (-2.6A) SRP A 900 (-3.5A) SRP A 900 (-4.0A) SRP A 900 (-3.6A) SRP A 900 ( 4.1A)	0.72A	6bniB-1wleA: 12.1	6bniB-1wleA: 12.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3APW_B_DP0B190_1","ALPHA-1-ACID GLYCOPROTEIN 2","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"VAL A 402;ILE A 389;LEU A 233;GLN A 358;PHE A 228","SRP A 900 (-4.4A);None;None;None;None","1.46A","3apwB-1wleA:undetectable",null],["4EJW_A_SRYA2001_1","TRANSCRIPTIONAL REGULATOR TCAR","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"ASN A 407;LEU A 355;GLN A 358;ALA A 435;GLU A 335","None;None;None;None;SRP A 900 (-2.8A)","1.28A","4ejwA-1wleA:0.3","3apwB-1wleA:17.56"],["4K87_A_ADNA602_1","PROLINE--TRNA LIGASE","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",4,"ARG A 313;ARG A 327;PHE A 331;ARG A 442","SRP A 900 (-2.6A);None;SRP A 900 (-4.0A);SRP A 900 ( 4.1A)","0.89A","4k87A-1wleA:23.6","4ejwA-1wleA:15.29"],["4ZBQ_A_ACTA605_0","SERUM ALBUMIN","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",4,"TYR A 326;GLY A 319;GLU A 315;ARG A 210","None;None;SRP A 900 (-3.5A);None","1.23A","4zbqA-1wleA:2.3","4k87A-1wleA:24.01"],["5EML_A_SAMA701_0","PROTEIN ARGININE N-METHYLTRANSFERASE 5","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"LEU A 357;GLY A 338;LEU A 287;ARG A 236;GLU A 335","None;None;None;None;SRP A 900 (-2.8A)","1.17A","5emlA-1wleA:undetectable","4zbqA-1wleA:22.19"],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"ARG A 313;GLU A 315;PHE A 331;ALA A 439;GLU A 401","SRP A 900 (-2.6A);SRP A 900 (-3.5A);SRP A 900 (-4.0A);SRP A 900 (-3.5A);SRP A 900 (-3.6A)","1.15A","6bniA-1wleA:10.8","5emlA-1wleA:20.38"],["6BNI_A_ADNA602_1","LYSINE--TRNA LIGASE","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"ARG A 313;GLU A 315;PHE A 331;GLU A 401;ARG A 442","SRP A 900 (-2.6A);SRP A 900 (-3.5A);SRP A 900 (-4.0A);SRP A 900 (-3.6A);SRP A 900 ( 4.1A)","0.71A","6bniA-1wleA:10.8","6bniA-1wleA:12.16"],["6BNI_B_ADNB602_1","LYSINE--TRNA LIGASE","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"ARG A 313;GLU A 315;PHE A 331;ALA A 439;GLU A 401","SRP A 900 (-2.6A);SRP A 900 (-3.5A);SRP A 900 (-4.0A);SRP A 900 (-3.5A);SRP A 900 (-3.6A)","1.20A","6bniB-1wleA:12.1","6bniA-1wleA:12.16"],["6BNI_B_ADNB602_1","LYSINE--TRNA LIGASE","1wle","SERYL-TRNA SYNTHETASE","Bos taurus",5,"ARG A 313;GLU A 315;PHE A 331;GLU A 401;ARG A 442","SRP A 900 (-2.6A);SRP A 900 (-3.5A);SRP A 900 (-4.0A);SRP A 900 (-3.6A);SRP A 900 ( 4.1A)","0.72A","6bniB-1wleA:12.1","6bniB-1wleA:12.16"]]