SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SRO'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))
3brn LIPOCALIN
(Argas
monolakensis)
5 / 9 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
0.40A 1qftA-3brnA:
16.1
1qftA-3brnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))
3brn LIPOCALIN
(Argas
monolakensis)
5 / 9 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
0.33A 1qftB-3brnA:
8.5
1qftB-3brnA:
27.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 6 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
0.25A 2x45A-3brnA:
22.7
2x45A-3brnA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)
3brn LIPOCALIN
(Argas
monolakensis)
6 / 7 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
0.33A 2x45B-3brnA:
22.5
2x45B-3brnA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)
3brn LIPOCALIN
(Argas
monolakensis)
6 / 7 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
0.31A 2x45C-3brnA:
22.4
2x45C-3brnA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BU1_A_HSMA301_1
(LIPOCALIN)
3brn LIPOCALIN
(Argas
monolakensis)
6 / 7 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
0.48A 3bu1A-3brnA:
22.3
3bu1A-3brnA:
42.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 9 TYR A  27
VAL A  45
GLY A  26
ASN A  24
GLY A  23
SRO  A 158 (-3.5A)
None
None
None
None
1.44A 3kmoA-3brnA:
undetectable
3kmoA-3brnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 12 ASP A 106
SER A 100
SER A  18
TYR A  27
VAL A  45
SRO  A 158 (-3.2A)
None
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
None
1.46A 3mbhC-3brnA:
undetectable
3mbhC-3brnA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 12 ASP A 106
SER A 100
SER A  18
TYR A  27
VAL A  45
SRO  A 158 (-3.2A)
None
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
None
1.48A 3mbhE-3brnA:
undetectable
3mbhE-3brnA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 12 GLY A  21
PRO A  22
GLY A  23
ILE A  82
THR A  95
None
None
None
SRO  A 158 (-4.4A)
SRO  A 158 ( 4.1A)
1.13A 4n48A-3brnA:
undetectable
4n48A-3brnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 11 SER A  18
THR A  96
THR A  95
GLY A  79
ALA A  15
SRO  A 158 (-3.6A)
None
SRO  A 158 ( 4.1A)
None
None
1.39A 4qwuV-3brnA:
undetectable
4qwub-3brnA:
undetectable
4qwuV-3brnA:
23.77
4qwub-3brnA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)
3brn LIPOCALIN
(Argas
monolakensis)
5 / 9 ALA A  15
ASP A  80
GLY A  53
VAL A  84
ILE A  82
None
None
None
None
SRO  A 158 (-4.4A)
1.17A 5kr0A-3brnA:
undetectable
5kr0A-3brnA:
21.19