SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SR7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A 251
ILE A 230
PHE A 180
PHE A 293
 None
SR7  A1396 (-4.8A)
SR7  A1396 (-3.7A)
None
 0.75A 1fslB-4bn5A:
undetectable		 1fslB-4bn5A:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 6 ALA A 146
SER A 149
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.40A 1yc2A-4bn5A:
20.9		 1yc2A-4bn5A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A 146
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.34A 1yc2D-4bn5A:
20.6		 1yc2D-4bn5A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.40A 1yc2E-4bn5A:
20.8		 1yc2E-4bn5A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 ALA A 146
SER A 149
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.37A 1yc5A-4bn5A:
24.6		 1yc5A-4bn5A:
36.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 ALA A 146
ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.55A 2h4jA-4bn5A:
24.8		 2h4jA-4bn5A:
36.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 294
ILE A 154
ASP A 156
ARG A 158
PHE A 180
 SR7  A1396 (-3.5A)
CNA  A1395 (-3.8A)
SR7  A1396 ( 3.6A)
CNA  A1395 ( 3.6A)
SR7  A1396 (-3.7A)
 1.31A 3weoA-4bn5A:
undetectable		 3weoA-4bn5A:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE A 180
HIS A 248
LEU A 298
PRO A 326
 SR7  A1396 (-3.7A)
SR7  A1396 ( 3.5A)
None
None
 0.76A 4o8zA-4bn5A:
39.1		 4o8zA-4bn5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE A 180
HIS A 248
PHE A 294
LEU A 298
 SR7  A1396 (-3.7A)
SR7  A1396 ( 3.5A)
SR7  A1396 (-3.5A)
None
 0.60A 4o8zA-4bn5A:
39.1		 4o8zA-4bn5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.37A 4rmjA-4bn5A:
32.6		 4rmjA-4bn5A:
49.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 177
PHE A 294
GLU A 323
VAL A 324
 SR7  A1396 (-4.4A)
SR7  A1396 (-3.5A)
None
None
 1.35A 5h4dA-4bn5A:
17.5		 5h4dA-4bn5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 157
GLU A 177
PHE A 294
VAL A 324
 SR7  A1396 (-3.7A)
SR7  A1396 (-4.4A)
SR7  A1396 (-3.5A)
None
 1.32A 5h4dA-4bn5A:
17.5		 5h4dA-4bn5A:
100.00