SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SR1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 ASP A 137
GLY A 271
PHE A 121
VAL A 277
ASP A 122
 SR1  A 401 ( 4.9A)
None
None
None
SR1  A 401 (-3.1A)
 1.04A 1e3vA-4ry8A:
undetectable		 1e3vA-4ry8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 6 PHE A  48
TYR A  52
VAL A 300
PHE A 121
 SR1  A 401 (-3.6A)
None
None
None
 1.03A 3ltwA-4ry8A:
undetectable		 3ltwA-4ry8A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 SER A  47
ALA A  56
GLN A 135
GLY A  46
ASP A 250
 None
None
SR1  A 401 (-3.5A)
None
SR1  A 401 (-2.7A)
 1.41A 4iilA-4ry8A:
19.4		 4iilA-4ry8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 177
ILE A 235
ARG A 230
ARG A 179
LEU A 180
 None
None
None
None
SR1  A 998 ( 4.9A)
 1.15A 5h5fA-2pywA:
undetectable		 5h5fA-2pywA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 8 SER A 238
ASP A 250
PRO A 251
PHE A 253
 None
MG  A 401 ( 2.8A)
None
SR1  A 998 (-4.3A)
 1.11A 5l1fA-2punA:
undetectable
5l1fB-2punA:
undetectable		 5l1fA-2punA:
19.53
5l1fB-2punA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 SER A 243
ASP A 255
PRO A 256
PHE A 258
 MG  A 501 ( 4.5A)
MG  A 500 (-1.8A)
None
SR1  A 998 (-4.2A)
 1.10A 5l1fA-2pywA:
1.6
5l1fB-2pywA:
1.8		 5l1fA-2pywA:
19.95
5l1fB-2pywA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		5 / 12 VAL A 263
ASP A 262
ALA A 330
ARG A 340
PRO A 258
 None
None
None
SR1  A 998 (-2.9A)
None
 1.39A 5nd2B-2punA:
undetectable		 5nd2B-2punA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2pyw UNCHARACTERIZED
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 VAL A 184
VAL A 370
ILE A  72
ILE A  69
 SR1  A 998 (-4.9A)
None
None
SR1  A 998 ( 4.8A)
 0.77A 5ywmX-2pywA:
3.3		 5ywmX-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2pun METHYLTHIORIBOSE
KINASE
(Bacillus
subtilis) 		4 / 5 GLU A 337
ASP A 233
HIS A 235
THR A 177
 None
SR1  A 998 (-2.7A)
SR1  A 998 ( 4.7A)
None
 1.44A 6b58A-2punA:
undetectable		 6b58A-2punA:
21.85