SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SPV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 11 SER A 239
GLY A 234
TYR A 165
GLY A 237
HIS A 401
 None
None
None
SPV  A 704 (-3.6A)
None
 1.13A 1iolA-4ox2A:
undetectable		 1iolA-4ox2A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 7 PHE A 485
ARG A 483
ARG A  87
ASP A 478
 None
None
SPV  A 704 (-3.8A)
None
 1.15A 2e5dA-4ox2A:
undetectable
2e5dB-4ox2A:
undetectable		 2e5dA-4ox2A:
22.98
2e5dB-4ox2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 7 ASP A 478
PHE A 485
ARG A 483
ARG A  87
 None
None
None
SPV  A 704 (-3.8A)
 1.10A 2e5dA-4ox2A:
undetectable
2e5dB-4ox2A:
undetectable		 2e5dA-4ox2A:
22.98
2e5dB-4ox2A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		7 / 8 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.33A 2rk8A-4ox2A:
61.0		 2rk8A-4ox2A:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		7 / 7 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.36A 2rk8B-4ox2A:
61.9		 2rk8B-4ox2A:
99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 TYR A 235
GLY A 236
PHE A 333
ASP A 311
ARG A 483
 None
SPV  A 704 ( 3.8A)
SPV  A 704 (-4.9A)
MN  A 701 (-2.5A)
None
 1.36A 4gcpA-4ox2A:
0.0		 4gcpA-4ox2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 9 TYR A 235
GLY A 236
PHE A 333
ASP A 311
ARG A 483
 None
SPV  A 704 ( 3.8A)
SPV  A 704 (-4.9A)
MN  A 701 (-2.5A)
None
 1.36A 4gcpB-4ox2A:
0.0		 4gcpB-4ox2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_G_FOLG301_0
(FOLATE RECEPTOR
ALPHA)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 TYR A 235
ARG A 405
LYS A 243
GLY A 242
SER A 286
 None
GTP  A 703 ( 2.8A)
SPV  A 704 (-4.5A)
None
SPV  A 704 ( 2.8A)
 1.09A 4lrhG-4ox2A:
0.0		 4lrhG-4ox2A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 5 ARG A  87
ARG A 115
GLY A 114
SER A 286
 SPV  A 704 (-3.8A)
None
None
SPV  A 704 ( 2.8A)
 1.15A 4z3oA-4ox2A:
undetectable
4z3oB-4ox2A:
undetectable		 4z3oA-4ox2A:
23.65
4z3oB-4ox2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		4 / 5 SER A 286
ARG A 115
GLY A 114
ARG A  87
 SPV  A 704 ( 2.8A)
None
None
SPV  A 704 (-3.8A)
 1.15A 5cdqA-4ox2A:
2.9
5cdqB-4ox2A:
undetectable
5cdqC-4ox2A:
2.8		 5cdqA-4ox2A:
21.19
5cdqB-4ox2A:
16.29
5cdqC-4ox2A:
21.19