SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SPM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		3 / 3 GLY A 198
GLU A 220
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
SPM  A 501 ( 3.2A)
 0.64A 2b25B-3c6mA:
11.6		 2b25B-3c6mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 199
ASP A 201
THR A 178
ILE A 181
 MTA  A 401 (-3.9A)
SPM  A 501 ( 3.8A)
None
None
 0.78A 2f9wA-3c6mA:
2.2
2f9wB-3c6mA:
2.2		 2f9wA-3c6mA:
24.16
2f9wB-3c6mA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 198
GLU A 220
ILE A 221
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.8A)
SPM  A 501 ( 3.2A)
 0.82A 3a7eA-3c6mA:
13.7		 3a7eA-3c6mA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.02A 3b7pA-3c6mA:
25.6		 3b7pA-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
GLN A 315
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 ( 4.0A)
SPM  A 501 (-3.5A)
 0.73A 3b7pA-3c6mA:
25.6		 3b7pA-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.04A 3b7pB-3c6mA:
25.6		 3b7pB-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
GLN A 315
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 ( 4.0A)
SPM  A 501 (-3.5A)
 0.70A 3b7pB-3c6mA:
25.6		 3b7pB-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.05A 3b7pC-3c6mA:
25.5		 3b7pC-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A 148
TYR A 177
GLY A 198
ILE A 221
ASP A 222
VAL A 225
ASP A 255
 MTA  A 401 (-3.5A)
SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.2A)
MTA  A 401 (-3.6A)
 0.41A 3bwcA-3c6mA:
23.8		 3bwcA-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 148
TYR A 177
GLY A 199
ASP A 222
VAL A 225
 MTA  A 401 (-3.5A)
SPM  A 501 (-4.2A)
MTA  A 401 (-3.9A)
None
MTA  A 401 (-4.2A)
 0.98A 3bwcA-3c6mA:
23.8		 3bwcA-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		8 / 12 LEU A 164
TYR A 177
GLY A 198
ASP A 201
ILE A 221
ASP A 222
VAL A 225
ASP A 276
 None
SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
SPM  A 501 ( 3.8A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.2A)
SPM  A 501 ( 3.2A)
 0.46A 3bwcB-3c6mA:
23.6		 3bwcB-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 164
TYR A 177
GLY A 199
ASP A 222
VAL A 225
ASP A 276
 None
SPM  A 501 (-4.2A)
MTA  A 401 (-3.9A)
None
MTA  A 401 (-4.2A)
SPM  A 501 ( 3.2A)
 1.05A 3bwcB-3c6mA:
23.6		 3bwcB-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		6 / 12 TYR A 177
GLY A 198
ASP A 201
ILE A 282
VAL A 225
ASP A 276
 SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
SPM  A 501 ( 3.8A)
MTA  A 401 (-3.6A)
MTA  A 401 (-4.2A)
SPM  A 501 ( 3.2A)
 1.15A 3bwcB-3c6mA:
23.6		 3bwcB-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 4 GLY A 198
GLU A 220
ASP A 255
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
SPM  A 501 ( 3.2A)
 0.81A 3mb5A-3c6mA:
14.7		 3mb5A-3c6mA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 200
GLU A 220
ASP A 255
ASP A 276
 MTA  A 401 (-3.7A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
SPM  A 501 ( 3.2A)
 0.69A 3vywC-3c6mA:
14.7		 3vywC-3c6mA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 8 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.11A 4mj8A-4mi4A:
31.8
4mj8C-4mi4A:
30.9		 4mj8A-4mi4A:
100.00
4mj8C-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		8 / 8 TRP A  31
GLU A  33
ILE A  74
GLU A  75
GLU A  84
GLN A  86
ILE A  87
LEU A 121
 None
SPM  A 201 (-3.2A)
None
None
None
None
None
None
 0.12A 4mj8A-4mi4A:
31.8		 4mj8A-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 8 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.12A 4mj8B-4mi4A:
31.2
4mj8C-4mi4A:
30.9		 4mj8B-4mi4A:
100.00
4mj8C-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.41A 4mj8C-4mi4A:
30.9		 4mj8C-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 TYR A4287
ASP A4092
GLU A4412
VAL A4053
 None
SPM  A9016 ( 4.4A)
None
None
 1.49A 4nkvB-3vkgA:
undetectable		 4nkvB-3vkgA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 199
GLY A 200
ASP A 201
LEU A 170
ILE A 196
 MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 4.3A)
None
 1.13A 4pghA-3c6mA:
12.0		 4pghA-3c6mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 199
GLY A 200
ASP A 201
LEU A 170
ILE A 196
 MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 4.3A)
None
 1.08A 4pghD-3c6mA:
12.1		 4pghD-3c6mA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 5 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.71A 4r87E-4mi4A:
29.8		 4r87E-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_G_SPMG202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 9 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.49A 4r87E-4mi4A:
29.8
4r87G-4mi4A:
30.3		 4r87E-4mi4A:
100.00
4r87G-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		6 / 6 ASN A  22
MET A  28
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.72A 4r87H-4mi4A:
29.8		 4r87H-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.71A 4r87I-4mi4A:
30.1		 4r87I-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 7 MET A  28
TRP A  31
GLU A  33
GLU A  37
GLU A  41
 SPM  A 201 ( 4.5A)
None
SPM  A 201 (-3.2A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.90A 4r87J-4mi4A:
29.6
4r87L-4mi4A:
29.4		 4r87J-4mi4A:
100.00
4r87L-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 7 MET A  28
TRP A  31
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 ( 4.5A)
None
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.60A 4r87J-4mi4A:
29.6
4r87L-4mi4A:
29.4		 4r87J-4mi4A:
100.00
4r87L-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_K_SPMK202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		8 / 9 ASN A  22
MET A  28
TRP A  31
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
None
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.63A 4r87I-4mi4A:
30.1
4r87K-4mi4A:
29.8		 4r87I-4mi4A:
100.00
4r87K-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 280
ALA A 279
ASN A 317
GLN A 315
 None
SPM  A 501 ( 4.5A)
None
SPM  A 501 ( 4.0A)
 1.43A 4zgfA-3c6mA:
undetectable		 4zgfA-3c6mA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 201
ASN A 160
PHE A 158
 SPM  A 501 ( 3.8A)
None
None
 0.73A 5dsgB-3c6mA:
undetectable		 5dsgB-3c6mA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 TYR A 177
GLY A 198
GLU A 220
ASP A 255
 SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 1.30A 5emlA-3c6mA:
3.4		 5emlA-3c6mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 ILE A4083
ARG A4424
MET A4426
LEU A4430
 None
SPM  A9016 ( 3.8A)
None
None
 0.97A 5xdqA-3vkgA:
undetectable
5xdqJ-3vkgA:
undetectable		 5xdqA-3vkgA:
9.59
5xdqJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.18A 5yn6A-3c6mA:
8.6		 5yn6A-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.92A 5yn6A-3c6mA:
8.6		 5yn6A-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.16A 5yniA-3c6mA:
8.5		 5yniA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.87A 5yniA-3c6mA:
8.5		 5yniA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.15A 5ynmA-3c6mA:
8.6		 5ynmA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.88A 5ynmA-3c6mA:
8.6		 5ynmA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ASP A4092
ASP A4051
ASN A4650
 SPM  A9016 ( 4.4A)
None
None
 0.86A 6gngB-3vkgA:
undetectable		 6gngB-3vkgA:
10.79