SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SPL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.23A 2oaxB-4ezdA:
undetectable		 2oaxB-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.30A 2oaxD-4ezdA:
undetectable		 2oaxD-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.20A 2oaxE-4ezdA:
undetectable		 2oaxE-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1mqt POLYPROTEIN
(Enterovirus
B) 		5 / 12 THR A 246
SER A 192
TYR A 191
ASP A 115
PHE A 114
 None
None
SPL  A 284 ( 3.9A)
None
SPL  A 284 (-4.9A)
 1.24A 3vw1D-1mqtA:
undetectable		 3vw1D-1mqtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 6 LEU A 159
ASN A 160
LEU A 342
ILE A 359
 None
None
SPL  A 408 ( 4.5A)
None
 0.91A 4okxA-4ezdA:
undetectable		 4okxA-4ezdA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN
(Enterovirus
B) 		4 / 8 PHE A 114
ASP C  18
ASP C  17
TYR A 238
 SPL  A 284 (-4.9A)
None
None
None
 1.21A 4qb9D-1mqtA:
0.0		 4qb9D-1mqtA:
18.33