SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SPH'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0P_A_TE4A201_1 (BETA-LACTOGLOBULIN)	5osn	CAPSID PROTEIN (Enterovirus E)	5 / 12	ILE A 90 VAL A 175 VAL A 173 PHE A 114 MET A 112	SPH A 301 (-4.1A) SPH A 301 (-4.9A) None SPH A 301 ( 4.2A) SPH A 301 ( 4.2A)	1.02A	4y0pA-5osnA: undetectable	4y0pA-5osnA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0R_A_PX9A201_0 (BETA-LACTOGLOBULIN)	5osn	CAPSID PROTEIN (Enterovirus E)	5 / 12	LEU A 213 ILE A 90 VAL A 175 PHE A 114 MET A 112	SPH A 301 (-4.6A) SPH A 301 (-4.1A) SPH A 301 (-4.9A) SPH A 301 ( 4.2A) SPH A 301 ( 4.2A)	0.99A	4y0rA-5osnA: undetectable	4y0rA-5osnA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NR3_A_95EA401_0 (DNA (CYTOSINE-5)-METHYLT RANSFERASE 3B)	3epc	PROTEIN VP1 (Enterovirus C)	4 / 7	ILE 1 110 PHE 1 237 LYS 1 113 SER 1 128	SPH 1 0 (-4.5A) SPH 1 0 ( 3.1A) None None	1.37A	5nr3A-3epc1: undetectable	5nr3A-3epc1: 18.73