SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SPF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 MET A  61
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.72A 1h1dA-1susA:
21.3		 1h1dA-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.78A 1vidA-1susA:
21.3		 1vidA-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 MET A  61
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.73A 2cl5A-1susA:
21.4		 2cl5A-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.76A 2cl5B-1susA:
21.7		 2cl5B-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.77A 2zvjA-1susA:
21.7		 2zvjA-1susA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 MET A  61
GLU A  85
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.7A)
None
None
 0.90A 3a7eA-1susA:
21.5		 3a7eA-1susA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLY A  87
TYR A  89
TYR A  92
ILE A 112
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-4.0A)
None
 0.74A 3bwmA-1susA:
21.0		 3bwmA-1susA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ILE A 112
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-4.0A)
 0.80A 3bwyA-1susA:
21.0		 3bwyA-1susA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 10 MET A  61
GLU A  85
GLY A  87
TYR A  89
SER A  93
ASP A 163
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
SAH  A 301 (-2.7A)
CA  A 305 (-2.5A)
 0.61A 3s68A-1susA:
20.8		 3s68A-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 10 MET A  61
ASP A 163
LYS A 166
ASP A 189
ASN A 190
 SPF  A 401 (-4.1A)
CA  A 305 (-2.5A)
SPF  A 401 (-3.8A)
CA  A 305 (-3.2A)
CA  A 305 (-2.9A)
 0.74A 3s68A-1susA:
20.8		 3s68A-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 10 MET A  61
ASP A 163
LYS A 166
ASP A 189
ASN A 190
 SPF  A 401 (-4.1A)
CA  A 305 (-2.5A)
SPF  A 401 (-3.8A)
CA  A 305 (-3.2A)
CA  A 305 (-2.9A)
 0.71A 4pylA-1susA:
21.2		 4pylA-1susA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ILE A 112
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-4.0A)
 0.75A 4xucA-1susA:
20.9		 4xucA-1susA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ILE A 112
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-4.0A)
 0.78A 4xudA-1susA:
20.8		 4xudA-1susA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		7 / 12 MET A  61
GLY A  87
TYR A  89
TYR A  92
SER A  93
ILE A 112
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-2.7A)
SAH  A 301 (-4.0A)
None
 0.80A 4xueB-1susA:
20.9		 4xueB-1susA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 9 MET A  61
GLY A  87
TYR A  89
SER A  93
ASP A 163
 SPF  A 401 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
SAH  A 301 (-2.7A)
CA  A 305 (-2.5A)
 0.54A 5fhqA-1susA:
17.4		 5fhqA-1susA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.78A 5fhrA-1susA:
18.6		 5fhrA-1susA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.76A 5fhrB-1susA:
17.6		 5fhrB-1susA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		12 / 12 MET A  61
THR A  62
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ILE A 112
ALA A 140
ASP A 163
ALA A 164
ASP A 165
TYR A 172
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.7A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.9A)
CA  A 305 (-2.5A)
SAH  A 301 ( 3.7A)
SAH  A 301 ( 2.8A)
None
 0.46A 5kvaA-1susA:
39.3		 5kvaA-1susA:
71.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		12 / 12 MET A  61
THR A  62
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ILE A 112
ALA A 140
ASP A 163
ALA A 164
ASP A 165
TYR A 172
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.7A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.9A)
CA  A 305 (-2.5A)
SAH  A 301 ( 3.7A)
SAH  A 301 ( 2.8A)
None
 0.49A 5kvaB-1susA:
38.9		 5kvaB-1susA:
71.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		6 / 6 MET A  61
ASP A 163
LYS A 166
ASP A 189
ASN A 190
TRP A 193
 SPF  A 401 (-4.1A)
CA  A 305 (-2.5A)
SPF  A 401 (-3.8A)
CA  A 305 (-3.2A)
CA  A 305 (-2.9A)
None
 0.60A 5logA-1susA:
30.7		 5logA-1susA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		5 / 12 MET A  61
GLU A  85
GLY A  87
TYR A  89
ILE A 112
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
SAH  A 301 (-4.0A)
 0.75A 5lsaA-1susA:
20.9		 5lsaA-1susA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1sus CAFFEOYL-COA
O-METHYLTRANSFERASE
(Medicago
sativa) 		3 / 3 ASP A  27
ASP A 238
ASN A 220
 None
SPF  A 401 ( 4.1A)
None
 0.53A 6gngB-1susA:
2.4		 6gngB-1susA:
17.19