SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SPD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 10 GLY A  57
PHE A  58
SER A 126
MET A 127
HIS A 257
 SPD  A 301 (-3.5A)
None
SPD  A 301 ( 2.3A)
None
SPD  A 301 (-3.2A)
 0.84A 1a8uA-4fblA:
21.7		 1a8uA-4fblA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 10 GLY A  57
PHE A  58
SER A 126
MET A 127
HIS A 257
 SPD  A 301 (-3.5A)
None
SPD  A 301 ( 2.3A)
None
SPD  A 301 (-3.2A)
 0.84A 1a8uB-4fblA:
21.6		 1a8uB-4fblA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 1jffB-1typA:
undetectable		 1jffB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 HIS A 257
VAL A 258
THR A  59
LEU A 188
 SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.3A)
None
 1.03A 1oq5A-4fblA:
undetectable		 1oq5A-4fblA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 8 GLY A  20
GLY A  16
GLY A  15
LEU A  17
 None
None
FAD  A 493 (-3.7A)
SPD  A 496 (-4.6A)
 0.66A 1qzzA-1typA:
2.3		 1qzzA-1typA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 TYR 1 293
GLY 1 132
THR 1 134
GLU 1 171
ILE 1 130
 SPD  1 400 ( 4.6A)
None
None
SPD  1 400 (-3.5A)
None
 1.34A 2azxA-1poy1:
undetectable		 2azxA-1poy1:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 TYR 1 293
GLY 1 132
THR 1 134
GLU 1 171
ILE 1 130
 SPD  1 400 ( 4.6A)
None
None
SPD  1 400 (-3.5A)
None
 1.34A 2azxB-1poy1:
undetectable		 2azxB-1poy1:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 GLU 1  36
LEU 1 304
GLY 1 292
SER 1 232
ILE 1 291
 SPD  1 400 (-3.5A)
None
None
None
None
 1.25A 2e7fA-1poy1:
undetectable		 2e7fA-1poy1:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2hxfB-1typA:
undetectable		 2hxfB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2hxhB-1typA:
undetectable		 2hxhB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 12 ALA A  92
GLN A 145
TYR A  57
ASP A  45
ASP A 110
 None
SPD  A 200 (-3.8A)
None
None
SPD  A 200 (-3.3A)
 1.30A 2nv4B-1bo4A:
0.0		 2nv4B-1bo4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2p4nB-1typA:
undetectable		 2p4nB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2wbeB-1typA:
undetectable		 2wbeB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 GLY A 172
ALA A 173
HIS A 143
HIS A  76
HIS A  81
 SPD  A 304 ( 4.2A)
SPD  A 304 (-3.9A)
None
ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
 1.27A 3boyA-2p18A:
0.0
3boyC-2p18A:
undetectable		 3boyA-2p18A:
18.06
3boyC-2p18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 HIS A  76
HIS A  81
GLY A 172
ALA A 173
HIS A 143
 ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
SPD  A 304 ( 4.2A)
SPD  A 304 (-3.9A)
None
 1.27A 3boyA-2p18A:
0.0
3boyB-2p18A:
undetectable		 3boyA-2p18A:
18.06
3boyB-2p18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 10 HIS A  76
HIS A  81
GLY A 172
ALA A 173
HIS A 143
 ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
SPD  A 304 ( 4.2A)
SPD  A 304 (-3.9A)
None
 1.27A 3boyB-2p18A:
undetectable
3boyC-2p18A:
undetectable		 3boyB-2p18A:
18.06
3boyC-2p18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 3dcoB-1typA:
undetectable		 3dcoB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.20A 3edlB-1typA:
undetectable		 3edlB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.18A 3iz0B-1typA:
undetectable		 3iz0B-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 HIS A  87
GLY A  60
GLY A 128
ALA A  99
ASP A 101
 None
SPD  A 301 ( 3.8A)
None
None
None
 1.13A 3keeD-4fblA:
undetectable		 3keeD-4fblA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 12 HIS A 210
GLY A 209
ASP A  80
GLY A 172
PHE A 175
 ZN  A 301 ( 3.3A)
None
ZN  A 301 ( 2.7A)
SPD  A 304 ( 4.2A)
ACY  A1022 (-4.9A)
 1.13A 3sudB-2p18A:
undetectable		 3sudB-2p18A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 VAL A 230
HIS A 257
ASP A 227
GLY A  57
SER A 126
 None
SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 0.89A 3sufB-4fblA:
undetectable		 3sufB-4fblA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 VAL A 230
HIS A 257
ASP A 227
GLY A  57
SER A 126
 None
SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 1.01A 3sufD-4fblA:
undetectable		 3sufD-4fblA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE
(Sphingomonas
paucimobilis) 		4 / 5 PHE A 113
ALA A 131
THR A 133
LEU A  64
 GOL  A 502 (-4.9A)
GOL  A 502 (-3.0A)
SPD  A 300 (-4.0A)
SPD  A 300 ( 4.9A)
 1.05A 3t3zC-3a76A:
undetectable		 3t3zC-3a76A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 5 LEU A  17
GLY A  13
PHE A 122
ASN A  54
 SPD  A 496 (-4.6A)
FAD  A 493 (-3.2A)
None
None
 1.08A 3uq6B-1typA:
5.2		 3uq6B-1typA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 9 HIS A  78
ASP A  80
HIS A  76
GLY A 172
HIS A 210
 ZN  A 302 ( 3.2A)
ZN  A 301 ( 2.7A)
ZN  A 302 (-3.4A)
SPD  A 304 ( 4.2A)
ZN  A 301 ( 3.3A)
 1.04A 4c1hA-2p18A:
16.4		 4c1hA-2p18A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 11 TYR A 109
TYR A  94
SER A  73
TYR A  66
GLY A  68
 SPD  A 200 (-3.8A)
None
None
None
None
 1.26A 4ey7A-1bo4A:
undetectable		 4ey7A-1bo4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 11 TYR A 109
TYR A  94
SER A  73
TYR A  66
GLY A  68
 SPD  A 200 (-3.8A)
None
None
None
None
 1.29A 4ey7B-1bo4A:
undetectable		 4ey7B-1bo4A:
14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 6 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.89A 4mi4A-3wr7A:
28.6		 4mi4A-3wr7A:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 7 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.84A 4mi4B-3wr7A:
28.9
4mi4C-3wr7A:
28.6		 4mi4B-3wr7A:
53.65
4mi4C-3wr7A:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 7 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.82A 4mi4A-3wr7A:
28.6
4mi4C-3wr7A:
28.6		 4mi4A-3wr7A:
53.65
4mi4C-3wr7A:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 8 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.79A 4mj8A-3wr7A:
28.7
4mj8C-3wr7A:
28.7		 4mj8A-3wr7A:
57.06
4mj8C-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		7 / 8 TRP A  31
GLU A  33
GLU A  74
GLU A  83
GLN A  85
ILE A  86
LEU A 120
 COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
None
None
COA  A 202 ( 4.7A)
COA  A 202 (-4.1A)
COA  A 202 ( 4.6A)
 0.87A 4mj8A-3wr7A:
28.7		 4mj8A-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 8 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.78A 4mj8B-3wr7A:
28.8
4mj8C-3wr7A:
28.7		 4mj8B-3wr7A:
57.06
4mj8C-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 7 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.64A 4mj8C-3wr7A:
28.7		 4mj8C-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 5 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.63A 4r87E-3wr7A:
28.3		 4r87E-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_G_SPMG202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 9 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.73A 4r87E-3wr7A:
28.3
4r87G-3wr7A:
28.6		 4r87E-3wr7A:
57.06
4r87G-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 6 MET A  28
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.73A 4r87H-3wr7A:
28.1		 4r87H-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 7 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.55A 4r87I-3wr7A:
28.3		 4r87I-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 7 MET A  28
TRP A  31
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 None
COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.76A 4r87J-3wr7A:
28.0
4r87L-3wr7A:
27.9		 4r87J-3wr7A:
57.06
4r87L-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_K_SPMK202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		7 / 9 MET A  28
TRP A  31
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.80A 4r87I-3wr7A:
28.3
4r87K-3wr7A:
28.4		 4r87I-3wr7A:
57.06
4r87K-3wr7A:
57.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE
(Sphingomonas
paucimobilis) 		4 / 5 LEU A  59
ALA A 131
THR A 133
ILE A 109
 None
GOL  A 502 (-3.0A)
SPD  A 300 (-4.0A)
None
 0.97A 4xe3A-3a76A:
undetectable		 4xe3A-3a76A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 ASP 1 168
SER 1  83
TYR 1  85
 SPD  1 400 (-3.6A)
SPD  1 400 ( 3.7A)
None
 0.77A 5glmA-1poy1:
0.0		 5glmA-1poy1:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2p18 GLYOXALASE II
(Leishmania
infantum) 		5 / 11 LEU A 160
ALA A 136
GLY A 172
ILE A 171
PRO A 208
 None
None
SPD  A 304 ( 4.2A)
None
None
 1.21A 5kr2B-2p18A:
undetectable		 5kr2B-2p18A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 8 SER A 255
SER A 224
MET A  65
SER A 126
 None
None
None
SPD  A 301 ( 2.3A)
 1.02A 5l5fY-4fblA:
undetectable
5l5fZ-4fblA:
undetectable		 5l5fY-4fblA:
21.20
5l5fZ-4fblA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 9 THR A  59
GLY A  60
ALA A 189
GLY A  57
SER A 126
 SPD  A 301 (-3.3A)
SPD  A 301 ( 3.8A)
SPD  A 301 (-3.2A)
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 0.72A 5vw4A-4fblA:
undetectable		 5vw4A-4fblA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE
(Sphingomonas
paucimobilis) 		3 / 3 LEU A  21
THR A 133
ASN A 134
 None
SPD  A 300 (-4.0A)
None
 0.74A 6baaE-3a76A:
undetectable		 6baaE-3a76A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE
(Sphingomonas
paucimobilis) 		3 / 3 LEU A  21
THR A 133
ASN A 134
 None
SPD  A 300 (-4.0A)
None
 0.74A 6baaF-3a76A:
undetectable		 6baaF-3a76A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE
(Sphingomonas
paucimobilis) 		3 / 3 LEU A  21
THR A 133
ASN A 134
 None
SPD  A 300 (-4.0A)
None
 0.74A 6baaG-3a76A:
undetectable		 6baaG-3a76A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE
(Sphingomonas
paucimobilis) 		3 / 3 LEU A  21
THR A 133
ASN A 134
 None
SPD  A 300 (-4.0A)
None
 0.74A 6baaH-3a76A:
undetectable		 6baaH-3a76A:
7.71