SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SO3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3ttb EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
paradoxus) 		4 / 8 VAL A 129
ALA A 179
PHE A 109
GLU A 112
 HEC  A1004 (-3.9A)
HEC  A1004 ( 4.9A)
SO3  A 526 (-4.6A)
None
 1.13A 1dmiA-3ttbA:
undetectable
1dmiB-3ttbA:
undetectable		 1dmiA-3ttbA:
21.88
1dmiB-3ttbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT GAMA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		4 / 7 ASP C  14
GLY A  69
GLY A  68
TYR A  84
 SO3  A6573 ( 4.7A)
SO3  A6573 (-3.6A)
SO3  A6573 ( 4.3A)
None
 0.95A 1ekjE-3or2C:
undetectable
1ekjF-3or2C:
undetectable		 1ekjE-3or2C:
18.47
1ekjF-3or2C:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4wqe THIOSULFATE
DEHYDROGENASE
(Allochromatium
vinosum) 		5 / 12 SER A 100
ALA A 193
PRO A 182
GLY A  46
GLY A  44
 SO3  A1006 ( 2.6A)
SO3  A1006 (-4.2A)
HEC  A1002 (-4.6A)
None
None
 1.14A 2igtA-4wqeA:
undetectable		 2igtA-4wqeA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC
(Rattus
norvegicus) 		5 / 12 ILE E  16
ILE E  18
PHE E 157
VAL E 305
VAL E 307
 None
FAD  E 505 (-4.9A)
None
SO3  E 501 (-4.7A)
None
 1.03A 2ygoA-4kprE:
undetectable		 2ygoA-4kprE:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		3 / 3 PRO A 222
PHE A 264
LYS A 224
 None
None
SO3  A 606 ( 2.2A)
 1.01A 3bjwG-3vlyA:
undetectable		 3bjwG-3vlyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		3 / 3 LYS A 197
ARG A  74
ASP A 179
 None
SO3  A1374 (-2.0A)
None
 1.24A 3o7wA-1okgA:
undetectable		 3o7wA-1okgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		5 / 6 GLY A 254
VAL A 257
HIS A  75
SER A 255
THR A 258
 SO3  A1374 (-3.3A)
None
None
SO3  A1374 (-3.5A)
SO3  A1374 ( 4.5A)
 1.31A 3tj7A-1okgA:
0.0
3tj7B-1okgA:
0.0		 3tj7A-1okgA:
17.20
3tj7B-1okgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		5 / 6 GLY A 254
VAL A 257
HIS A  75
SER A 255
THR A 258
 SO3  A1374 (-3.3A)
None
None
SO3  A1374 (-3.5A)
SO3  A1374 ( 4.5A)
 1.31A 3tj7C-1okgA:
0.0
3tj7D-1okgA:
0.5		 3tj7C-1okgA:
17.20
3tj7D-1okgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		5 / 6 VAL A 257
HIS A  75
SER A 255
THR A 258
GLY A 254
 None
None
SO3  A1374 (-3.5A)
SO3  A1374 ( 4.5A)
SO3  A1374 (-3.3A)
 1.31A 3tj7C-1okgA:
0.0
3tj7D-1okgA:
0.5		 3tj7C-1okgA:
17.20
3tj7D-1okgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2e1d TRANSALDOLASE
(Mus
musculus) 		3 / 3 ASP A 318
ARG A 192
LYS A 314
 None
SO3  A3016 (-4.0A)
None
 1.17A 3wipG-2e1dA:
undetectable		 3wipG-2e1dA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Desulfovibrio
vulgaris) 		3 / 3 ASP A 233
ARG A 172
LYS A 215
 None
SO3  B 504 (-2.7A)
SRM  B 503 ( 2.4A)
 1.17A 3wipG-2v4jA:
undetectable		 3wipG-2v4jA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
(Desulfomicrobium
norvegicum) 		3 / 3 ASP A 233
ARG A 172
LYS A 215
 None
SO3  B 504 (-3.0A)
SRM  B 503 ( 2.6A)
 1.13A 3wipG-2xsjA:
undetectable		 3wipG-2xsjA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 231
ARG A 170
LYS A 213
 None
SO3  A 590 (-3.0A)
SO3  A 590 ( 2.6A)
 1.15A 3wipG-3mm5A:
undetectable		 3wipG-3mm5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 199
ASN A 192
GLY A 308
GLN A 312
 None
None
None
SO3  A 540 ( 3.8A)
 0.98A 4af0A-1yt8A:
undetectable		 4af0A-1yt8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 511
TYR A 507
ALA A 194
TYR A 494
 SO3  A 540 ( 4.7A)
None
SO3  A 540 (-3.4A)
None
 0.89A 4zz8A-1yt8A:
undetectable		 4zz8A-1yt8A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		4 / 5 GLY A 279
SER A 282
ARG A  74
GLY A 254
 None
None
SO3  A1374 (-2.0A)
SO3  A1374 (-3.3A)
 0.98A 5kprA-1okgA:
undetectable		 5kprA-1okgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 ASP A 267
LEU A 222
PRO A 209
ARG A 237
LEU A 208
 None
None
NAD  A 401 (-3.7A)
SO3  A 402 ( 2.6A)
NAD  A 401 (-4.5A)
 1.33A 5syfB-4e5kA:
undetectable		 5syfB-4e5kA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		4 / 5 LEU A  64
VAL A  60
MET A 108
CYH A 111
 None
None
SO3  A1374 ( 4.7A)
None
 1.44A 5te0A-1okgA:
undetectable		 5te0A-1okgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Leishmania
major) 		4 / 8 ALA A 259
SER A 182
THR A 211
GLY A 254
 None
None
None
SO3  A1374 (-3.3A)
 0.91A 5v0vA-1okgA:
undetectable		 5v0vA-1okgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 511
GLY A 195
ASP A 111
ASN A 499
GLY A 496
 SO3  A 540 ( 4.7A)
SO3  A 540 (-3.1A)
None
None
None
 1.14A 6gneB-1yt8A:
undetectable		 6gneB-1yt8A:
22.13