SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SME'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3mmh METHIONINE-R-SULFOXI
DE REDUCTASE
(Neisseria
meningitidis) 		4 / 6 LEU A  64
VAL A 130
VAL A  84
GLN A  87
 None
None
SME  A 168 (-3.8A)
None
 1.14A 1e7aB-3mmhA:
undetectable		 1e7aB-3mmhA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 249
TYR A 321
GLY A 353
PRO A 354
MET A 329
 SME  A 244 ( 3.8A)
None
None
None
None
 1.30A 1fdsA-5yxgA:
undetectable		 1fdsA-5yxgA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		5 / 12 GLY A 336
GLU A 355
GLY A 353
VAL A 335
ASN A 287
 SME  A 244 ( 4.9A)
None
None
SME  A 244 ( 4.5A)
None
 1.22A 1n2xA-5yxgA:
undetectable		 1n2xA-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5jf0 PEPTIDE DEFORMYLASE
(Streptococcus
agalactiae) 		5 / 12 GLY A  70
ASP A  15
ILE A  14
TYR A 167
VAL A 171
 None
SME  A  16 ( 3.7A)
None
None
None
 1.01A 2hmyB-5jf0A:
undetectable		 2hmyB-5jf0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5yxg PILUS ASSEMBLY
PROTEIN
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 274
ALA A 253
THR A 322
LEU A 265
 SME  A 275 ( 3.7A)
None
None
None
 0.96A 4ejgA-5yxgA:
undetectable		 4ejgA-5yxgA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3ksg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 PHE A  96
VAL A  90
GLU A 109
 None
None
SME  A6888 (-2.8A)
 0.78A 4fvqA-3ksgA:
undetectable		 4fvqA-3ksgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Mus
musculus) 		5 / 11 LEU A 531
HIS A 539
LEU A 538
LEU A 624
LEU A 615
 SME  A 519 ( 3.7A)
None
None
None
None
 1.10A 4p65E-5mhfA:
undetectable
4p65F-5mhfA:
undetectable
4p65J-5mhfA:
undetectable
4p65L-5mhfA:
undetectable		 4p65E-5mhfA:
undetectable
4p65F-5mhfA:
undetectable
4p65J-5mhfA:
undetectable
4p65L-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3ksg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A  81
GLY A 122
GLY A  74
ILE A 120
ILE A  71
 None
None
None
None
SME  A6888 ( 4.2A)
 0.95A 4q5mA-3ksgA:
undetectable		 4q5mA-3ksgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Mus
musculus) 		5 / 12 GLY A 434
VAL A 455
LEU A 454
GLY A 450
PRO A 515
 None
None
None
None
SME  A 519 ( 4.7A)
 1.01A 5wyqA-5mhfA:
undetectable		 5wyqA-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3h6s CLITOCYPIN ANALOG
(Clitocybe
nebularis) 		4 / 8 LEU E 130
VAL E  88
VAL E  37
ILE E  64
 None
SME  E  89 ( 3.1A)
None
None
 0.60A 5y9mA-3h6sE:
undetectable		 5y9mA-3h6sE:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3h6s CLITOCYPIN ANALOG
(Clitocybe
nebularis) 		4 / 8 LEU E 130
VAL E  88
VAL E  37
ILE E  64
 None
SME  E  89 ( 3.1A)
None
None
 0.59A 5y9mX-3h6sE:
undetectable		 5y9mX-3h6sE:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE
(Mus
musculus) 		4 / 5 GLN A 457
VAL A 455
PRO A 515
THR A 823
 SME  A 519 ( 4.7A)
None
SME  A 519 ( 4.7A)
None
 1.30A 6cduI-5mhfA:
undetectable
6cduJ-5mhfA:
undetectable		 6cduI-5mhfA:
undetectable
6cduJ-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5fft PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN A
(Rattus
norvegicus) 		4 / 8 TYR A 188
TRP A 213
THR A 212
LEU A 167
 None
SME  A 169 ( 4.1A)
None
SME  A 169 ( 3.7A)
 1.13A 6cnjD-5fftA:
undetectable
6cnjE-5fftA:
undetectable		 6cnjD-5fftA:
16.67
6cnjE-5fftA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3rfb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 TYR A  51
ASP A 128
VAL A  46
GLU A 110
 SME  A6888 (-4.9A)
SME  A6888 (-2.7A)
None
SME  A6888 (-2.1A)
 0.90A 6djzB-3rfbA:
undetectable		 6djzB-3rfbA:
20.43