SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SMD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 TYR A 606
LEU A 403
GLU A 663
TYR A 468
GLU A 467
 None
None
SMD  A1003 (-2.9A)
None
CA  A1001 ( 4.2A)
 1.20A 1mmkA-1x9dA:
undetectable		 1mmkA-1x9dA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 6 GLU A 330
ASN A 327
TRP A 284
SER A 658
 SMD  A1003 ( 4.3A)
None
None
None
 1.46A 3i9jB-1x9dA:
undetectable		 3i9jB-1x9dA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 6 LEU A 595
GLU A 570
ARG A 597
HIS A 524
 None
None
SMD  A1003 (-3.8A)
None
 1.37A 3ltwA-1x9dA:
undetectable		 3ltwA-1x9dA:
19.17