SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SMC'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_1 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 7	TYR A1498 GLY A1473 TYR A1495 ASP C3238	None SMC  A1472 ( 2.4A) None None	1.08A	2g72B-1e6yA: undetectable	2g72B-1e6yA: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HKK_A_ALEA300_1 (CARBONIC ANHYDRASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ASN A 479 HIS B 384 ASN A 458 ILE A 462	SMC  A 454 ( 3.6A) SMC  A 454 ( 4.3A) SMC  A 454 ( 3.9A) None	1.11A	2hkkA-5a8rA: undetectable	2hkkA-5a8rA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_A_SAMA1248_0 (NON-STRUCTURAL PROTEIN 5)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	GLY A 455 GLY A 412 GLY A 428 SER A 459 THR A 415	SMC  A 454 ( 2.4A) None None None None	1.19A	2wa2A-5a8rA: undetectable	2wa2A-5a8rA: 18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PS9_A_SAMA670_0 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	5 / 12	GLY B2344 ASN B2301 LYS B2338 ILE C3236 GLY B2348	None None None None SMC  A1472 ( 4.9A)	1.22A	3ps9A-1e6yB: 2.0	3ps9A-1e6yB: 20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	5hr6	RLMN METHYLASE (Escherichia coli)	10 / 12	PHE A 131 CYH A 132 MET A 176 GLU A 180 PRO A 181 HIS A 235 VAL A 280 ILE A 309 TRP A 311 ASN A 312	5AD  A 503 (-4.6A) SF4  A 502 ( 2.2A) A  C  37 ( 3.7A) MET  A 501 (-4.0A) MET  A 501 ( 4.9A) 5AD  A 503 (-3.7A) 5AD  A 503 (-4.8A) 5AD  A 503 (-4.1A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.64A	3rfaA-5hr6A: 50.5	3rfaA-5hr6A: 99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	5hr6	RLMN METHYLASE (Escherichia coli)	10 / 12	PHE A 131 CYH A 132 MET A 176 GLU A 180 PRO A 181 SER A 213 HIS A 235 VAL A 280 TRP A 311 ASN A 312	5AD  A 503 (-4.6A) SF4  A 502 ( 2.2A) A  C  37 ( 3.7A) MET  A 501 (-4.0A) MET  A 501 ( 4.9A) MET  A 501 ( 3.3A) 5AD  A 503 (-3.7A) 5AD  A 503 (-4.8A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.76A	3rfaA-5hr6A: 50.5	3rfaA-5hr6A: 99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	5hr6	RLMN METHYLASE (Escherichia coli)	9 / 12	PHE A 131 CYH A 132 MET A 176 HIS A 235 GLU A 278 VAL A 280 ILE A 309 TRP A 311 ASN A 312	5AD  A 503 (-4.6A) SF4  A 502 ( 2.2A) A  C  37 ( 3.7A) 5AD  A 503 (-3.7A) 5AD  A 503 (-3.1A) 5AD  A 503 (-4.8A) 5AD  A 503 (-4.1A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.92A	3rfaA-5hr6A: 50.5	3rfaA-5hr6A: 99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_B_SAMB406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	5hr6	RLMN METHYLASE (Escherichia coli)	11 / 12	PHE A 131 CYH A 132 MET A 176 GLU A 180 PRO A 181 SER A 211 SER A 233 HIS A 235 VAL A 280 TRP A 311 ASN A 312	5AD  A 503 (-4.6A) SF4  A 502 ( 2.2A) A  C  37 ( 3.7A) MET  A 501 (-4.0A) MET  A 501 ( 4.9A) MET  A 501 (-2.5A) MET  A 501 ( 2.6A) 5AD  A 503 (-3.7A) 5AD  A 503 (-4.8A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.31A	3rfaB-5hr6A: 52.8	3rfaB-5hr6A: 99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	SER A 401 TYR A 477 ARG A 473 GLY A 455	MGN  A 402 ( 4.4A) None None SMC  A 454 ( 2.4A)	1.06A	4fgzA-5a8rA: undetectable 4fgzB-5a8rA: undetectable	4fgzA-5a8rA: 17.81 4fgzB-5a8rA: 17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	5hr6	RLMN METHYLASE (Escherichia coli)	10 / 11	PHE A 131 MET A 176 GLU A 180 PRO A 181 SER A 211 SER A 233 HIS A 235 ILE A 309 TRP A 311 ASN A 312	5AD  A 503 (-4.6A) A  C  37 ( 3.7A) MET  A 501 (-4.0A) MET  A 501 ( 4.9A) MET  A 501 (-2.5A) MET  A 501 ( 2.6A) 5AD  A 503 (-3.7A) 5AD  A 503 (-4.1A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.46A	4pl1A-5hr6A: 49.5	4pl1A-5hr6A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	5hr6	RLMN METHYLASE (Escherichia coli)	7 / 11	PHE A 131 MET A 176 HIS A 235 GLU A 278 ILE A 309 TRP A 311 ASN A 312	5AD  A 503 (-4.6A) A  C  37 ( 3.7A) 5AD  A 503 (-3.7A) 5AD  A 503 (-3.1A) 5AD  A 503 (-4.1A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.88A	4pl1A-5hr6A: 49.5	4pl1A-5hr6A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_B_SAMB401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	5hr6	RLMN METHYLASE (Escherichia coli)	9 / 10	CYH A 132 MET A 176 GLU A 180 PRO A 181 SER A 211 SER A 233 HIS A 235 TRP A 311 ASN A 312	SF4  A 502 ( 2.2A) A  C  37 ( 3.7A) MET  A 501 (-4.0A) MET  A 501 ( 4.9A) MET  A 501 (-2.5A) MET  A 501 ( 2.6A) 5AD  A 503 (-3.7A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.41A	4pl1B-5hr6A: 51.9	4pl1B-5hr6A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_B_SAMB401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	5hr6	RLMN METHYLASE (Escherichia coli)	7 / 10	CYH A 132 MET A 176 SER A 233 HIS A 235 GLU A 278 TRP A 311 ASN A 312	SF4  A 502 ( 2.2A) A  C  37 ( 3.7A) MET  A 501 ( 2.6A) 5AD  A 503 (-3.7A) 5AD  A 503 (-3.1A) 5AD  A 503 (-4.0A) SMC  A 355 (-3.7A)	0.85A	4pl1B-5hr6A: 51.9	4pl1B-5hr6A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YMG_A_SAMA1001_0 (PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	5 / 12	GLY B 354 TYR A 448 SER B 329 ALA B 389 ASN B 335	SMC  A 454 ( 3.8A) DYA  A 452 ( 4.5A) None None None	1.28A	4ymgA-5a8rB: undetectable	4ymgA-5a8rB: 20.54