SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SM5'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_D_CCSD47_0 (GLUTATHIONES-TRANSFERASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | TRP A 423THR A 353LEU A 351GLY A 366 | SM5 A 1 (-4.3A)NoneNoneNone | 0.99A | 1gtiD-3omvA:undetectable | 1gtiD-3omvA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_E_CCSE47_0 (GLUTATHIONES-TRANSFERASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | TRP A 423THR A 353LEU A 351GLY A 366 | SM5 A 1 (-4.3A)NoneNoneNone | 0.88A | 1gtiE-3omvA:undetectable | 1gtiE-3omvA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXG_A_ACRA443_1 (ALPHA AMYLASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 8 | SER A 471ASN A 473ASP A 468GLU A 393 | NoneNoneNoneSM5 A 1 (-4.3A) | 1.09A | 1mxgA-3omvA:undetectable | 1mxgA-3omvA:17.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ALA A 373GLU A 393LEU A 397LEU A 406THR A 421TRP A 423CYH A 424LEU A 459HIS A 466GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNoneNone | 0.94A | 1uwhA-3omvA:36.3 | 1uwhA-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | ALA A 373LEU A 397LEU A 406THR A 421TRP A 423LEU A 459HIS A 466GLY A 485PHE A 475 | SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)NoneNoneNoneSM5 A 1 (-3.0A) | 1.21A | 1uwhA-3omvA:36.3 | 1uwhA-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 6 | ILE A 355VAL A 363VAL A 396ILE A 405ILE A 464 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)NoneNoneNone | 0.53A | 1uwhA-3omvA:36.4 | 1uwhA-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ALA A 373LYS A 375GLU A 393LEU A 397LEU A 406THR A 421TRP A 423CYH A 424LEU A 459GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNone | 0.95A | 1uwhB-3omvA:36.3 | 1uwhB-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWH_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ALA A 373LYS A 375LEU A 397LEU A 406THR A 421TRP A 423CYH A 424LEU A 459HIS A 466GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNoneNone | 0.81A | 1uwhB-3omvA:36.3 | 1uwhB-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | VAL A 363ALA A 373GLU A 393LEU A 406THR A 421TRP A 423CYH A 424LEU A 459GLY A 485 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNone | 0.96A | 1uwjA-3omvA:13.2 | 1uwjA-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | VAL A 363ALA A 373THR A 400LEU A 406THR A 421TRP A 423CYH A 424LEU A 459HIS A 466GLY A 485 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNoneNone | 0.71A | 1uwjA-3omvA:13.2 | 1uwjA-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 7 | ILE A 355LYS A 375LEU A 397ILE A 405ILE A 464 | SM5 A 1 (-4.3A)SM5 A 1 (-3.5A)NoneNoneNone | 0.71A | 1uwjA-3omvA:13.2 | 1uwjA-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ILE A 355VAL A 363ALA A 373GLU A 393LEU A 406THR A 421TRP A 423CYH A 424LEU A 459GLY A 485 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNone | 0.93A | 1uwjB-3omvA:13.4 | 1uwjB-3omvA:72.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ILE A 355VAL A 363ALA A 373LEU A 406THR A 421TRP A 423CYH A 424LEU A 459HIS A 466GLY A 485 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNoneNone | 0.72A | 1uwjB-3omvA:13.4 | 1uwjB-3omvA:72.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1VPT_A_SAMA400_0 (VP39) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 12 | LEU A 397GLY A 488VAL A 374ALA A 373LEU A 351 | NoneNoneNoneSM5 A 1 (-3.6A)None | 0.93A | 1vptA-3omvA:undetectable | 1vptA-3omvA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GCS_A_BAXA401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 12 | ALA A 373GLU A 393LEU A 397THR A 421HIS A 466 | SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A)None | 0.89A | 3gcsA-3omvA:19.9 | 3gcsA-3omvA:27.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GCS_A_BAXA401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 12 | VAL A 363ALA A 373GLU A 393LEU A 397THR A 421 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A) | 0.59A | 3gcsA-3omvA:19.9 | 3gcsA-3omvA:27.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HEC_A_STIA1_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 12 | ALA A 373LYS A 375GLU A 393LEU A 397THR A 421 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A) | 0.65A | 3hecA-3omvA:20.6 | 3hecA-3omvA:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HEG_A_BAXA1_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 6 / 12 | VAL A 363ALA A 373LYS A 375GLU A 393LEU A 397THR A 421 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-4.4A) | 0.59A | 3hegA-3omvA:20.2 | 3hegA-3omvA:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MSS_D_STID1_2 (TYROSINE-PROTEINKINASE ABL1) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 6 | VAL A 363LYS A 375VAL A 396ILE A 419 | SM5 A 1 (-4.0A)SM5 A 1 (-3.5A)NoneSM5 A 1 ( 4.3A) | 0.73A | 3mssD-3omvA:26.6 | 3mssD-3omvA:29.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ILE A 355VAL A 363ALA A 373LEU A 397LEU A 406THR A 421TRP A 423CYH A 424PHE A 475PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)None | 0.79A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ILE A 355VAL A 363ALA A 373LYS A 375LEU A 397LEU A 406THR A 421TRP A 423PHE A 475PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 0.81A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | ILE A 355VAL A 363ALA A 373LYS A 375TRP A 423PHE A 475GLY A 488 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 1.05A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | ILE A 355VAL A 363ALA A 373TRP A 423CYH A 424PHE A 475GLY A 488 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)None | 0.97A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OHT_A_1N1A1000_1 (P38A) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 6 / 12 | GLY A 356VAL A 363ALA A 373LYS A 375LEU A 397THR A 421 | SM5 A 1 ( 4.9A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A) | 0.72A | 3ohtA-3omvA:16.9 | 3ohtA-3omvA:29.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | ALA A 373LEU A 406ILE A 419THR A 421SER A 427SER A 428PHE A 475 | SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)NoneNoneSM5 A 1 (-3.0A) | 0.77A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | ALA A 373LEU A 406ILE A 419THR A 421TRP A 423SER A 427PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-3.0A)NoneNone | 0.85A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 12 | ALA A 373LEU A 406THR A 421TRP A 423SER A 427 | SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)None | 0.98A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | ALA A 373LYS A 375ILE A 419THR A 421SER A 427SER A 428PHE A 475 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)NoneNoneSM5 A 1 (-3.0A) | 0.80A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | ALA A 373LYS A 375ILE A 419THR A 421TRP A 423SER A 427PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-3.0A)NoneNone | 0.87A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 8 / 12 | ALA A 373LYS A 375ILE A 419TRP A 423SER A 427PHE A 475GLY A 485GLY A 488 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 ( 4.3A)SM5 A 1 (-4.3A)NoneSM5 A 1 (-3.0A)NoneNone | 1.21A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 5 | ILE A 355VAL A 363PHE A 408CYH A 424 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)NoneSM5 A 1 ( 4.4A) | 0.46A | 4rzvA-3omvA:12.9 | 4rzvA-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | VAL A 363ALA A 373LEU A 406THR A 421TRP A 423CYH A 424SER A 427 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)None | 1.05A | 4rzvB-3omvA:33.1 | 4rzvB-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | VAL A 363ALA A 373LYS A 375LEU A 406THR A 421TRP A 423CYH A 424PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneNone | 0.95A | 4rzvB-3omvA:33.1 | 4rzvB-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | VAL A 363ALA A 373LYS A 375LEU A 406THR A 421TRP A 423CYH A 424SER A 428PHE A 475 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneSM5 A 1 (-3.0A) | 1.00A | 4rzvB-3omvA:33.1 | 4rzvB-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 8 / 12 | VAL A 363ALA A 373LYS A 375TRP A 423CYH A 424PHE A 475GLY A 485GLY A 488 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneNone | 1.30A | 4rzvB-3omvA:33.1 | 4rzvB-3omvA:70.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 6 / 12 | ALA A 373LYS A 375THR A 421PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.4A)SM5 A 1 (-3.0A)NoneNone | 0.83A | 4xv2A-3omvA:35.1 | 4xv2A-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | VAL A 363ALA A 373LEU A 406THR A 421TRP A 423CYH A 424PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneNone | 0.78A | 4xv2A-3omvA:35.1 | 4xv2A-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | VAL A 363ALA A 373LEU A 406TRP A 423CYH A 424PHE A 475GLY A 485ASP A 486PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneSM5 A 1 (-3.5A)None | 1.09A | 4xv2A-3omvA:35.1 | 4xv2A-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 4 | GLY A 358LEU A 397PHE A 408ILE A 419 | NoneNoneNoneSM5 A 1 ( 4.3A) | 0.71A | 4xv2A-3omvA:35.1 | 4xv2A-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | ALA A 373LEU A 397LEU A 406THR A 421TRP A 423CYH A 424PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneNone | 0.77A | 4xv2B-3omvA:35.4 | 4xv2B-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 8 / 12 | ALA A 373LEU A 406TRP A 423CYH A 424PHE A 475GLY A 485ASP A 486PHE A 487 | SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneSM5 A 1 (-3.5A)None | 0.99A | 4xv2B-3omvA:35.4 | 4xv2B-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | ALA A 373LYS A 375LEU A 397THR A 421PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-3.0A)NoneNone | 0.89A | 4xv2B-3omvA:35.4 | 4xv2B-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_B_P06B801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 4 | GLY A 358VAL A 363PHE A 408ILE A 419 | NoneSM5 A 1 (-4.0A)NoneSM5 A 1 ( 4.3A) | 0.44A | 4xv2B-3omvA:35.4 | 4xv2B-3omvA:72.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | VAL A 363ALA A 373LEU A 397LEU A 406THR A 421TRP A 423CYH A 424PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneNone | 0.84A | 5cswA-3omvA:35.4 | 5cswA-3omvA:75.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | VAL A 363ALA A 373LYS A 375LEU A 397THR A 421TRP A 423PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)NoneNone | 0.95A | 5cswA-3omvA:35.4 | 5cswA-3omvA:75.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 8 / 12 | ALA A 373LYS A 375LEU A 397THR A 421TRP A 423PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)NoneNone | 0.95A | 5cswB-3omvA:34.5 | 5cswB-3omvA:75.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | VAL A 363ALA A 373LEU A 397LEU A 406THR A 421TRP A 423CYH A 424PHE A 475GLY A 485PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)NoneNone | 0.85A | 5cswB-3omvA:34.5 | 5cswB-3omvA:75.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_B_1N1B501_1 (PROTEIN-TYROSINEKINASE 6) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | VAL A 363ALA A 373LEU A 406ILE A 419THR A 421GLY A 485ASP A 486 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)NoneSM5 A 1 (-3.5A) | 0.80A | 5h2uB-3omvA:19.6 | 5h2uB-3omvA:32.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_C_1N1C501_1 (PROTEIN-TYROSINEKINASE 6) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 12 | ALA A 373LEU A 406ILE A 419THR A 421GLY A 485 | SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)None | 0.64A | 5h2uC-3omvA:27.1 | 5h2uC-3omvA:32.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5H2U_D_1N1D504_1 (PROTEIN-TYROSINEKINASE 6) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 6 / 12 | VAL A 363ALA A 373LEU A 406ILE A 419THR A 421GLY A 485 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)None | 0.66A | 5h2uD-3omvA:27.2 | 5h2uD-3omvA:32.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HES_B_032B401_1 (MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 6 / 12 | VAL A 363ALA A 373LYS A 375ILE A 419THR A 421PHE A 487 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)None | 0.78A | 5hesB-3omvA:26.1 | 5hesB-3omvA:30.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HI2_A_BAXA801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ALA A 373LYS A 375GLU A 393LEU A 397LEU A 406THR A 421TRP A 423CYH A 424LEU A 459GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNone | 0.95A | 5hi2A-3omvA:33.4 | 5hi2A-3omvA:71.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HI2_A_BAXA801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 10 / 12 | ALA A 373LYS A 375LEU A 397LEU A 406THR A 421TRP A 423CYH A 424LEU A 459HIS A 466GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)NoneNoneNone | 0.82A | 5hi2A-3omvA:33.4 | 5hi2A-3omvA:71.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 8 / 12 | GLY A 358ALA A 373LYS A 375LEU A 406ILE A 419THR A 421PHE A 475GLY A 485 | NoneSM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-3.0A)None | 0.92A | 5hieA-3omvA:34.7 | 5hieA-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | GLY A 358VAL A 363ALA A 373LEU A 397ILE A 419THR A 421TRP A 423 | NoneSM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-4.3A) | 1.02A | 5hieA-3omvA:34.7 | 5hieA-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | GLY A 358VAL A 363ALA A 373LEU A 406ILE A 419THR A 421TRP A 423PHE A 475GLY A 485 | NoneSM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 0.79A | 5hieA-3omvA:34.7 | 5hieA-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355CYH A 424ASP A 486PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.5A)None | 0.91A | 5hieA-3omvA:34.7 | 5hieA-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355GLY A 356PHE A 408CYH A 424 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)NoneSM5 A 1 ( 4.4A) | 0.51A | 5hieA-3omvA:34.7 | 5hieA-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | GLY A 358ALA A 373LYS A 375LEU A 406THR A 421PHE A 475GLY A 485 | NoneSM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-3.0A)None | 0.91A | 5hieB-3omvA:34.8 | 5hieB-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | GLY A 358VAL A 363ALA A 373LEU A 406ILE A 419THR A 421TRP A 423PHE A 475GLY A 485 | NoneSM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 0.81A | 5hieB-3omvA:34.8 | 5hieB-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 7 | ILE A 355GLY A 356CYH A 424ASP A 486PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.5A)None | 1.10A | 5hieB-3omvA:34.8 | 5hieB-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355GLY A 356LEU A 397PHE A 408 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)NoneNone | 0.87A | 5hieB-3omvA:34.8 | 5hieB-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355GLY A 356PHE A 408CYH A 424 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)NoneSM5 A 1 ( 4.4A) | 0.50A | 5hieB-3omvA:34.8 | 5hieB-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | GLY A 356GLY A 358VAL A 363ALA A 373LEU A 406THR A 421TRP A 423PHE A 475GLY A 485 | SM5 A 1 ( 4.9A)NoneSM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 0.78A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | GLY A 358ALA A 373LYS A 375LEU A 406THR A 421PHE A 475GLY A 485 | NoneSM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 (-4.4A)SM5 A 1 (-3.0A)None | 0.89A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | VAL A 363ALA A 373LEU A 406TRP A 423PHE A 475GLY A 485ASP A 486 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 (-4.3A)SM5 A 1 (-3.0A)NoneSM5 A 1 (-3.5A) | 1.17A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355ILE A 419CYH A 424PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.3A)SM5 A 1 ( 4.4A)None | 0.69A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355PHE A 408ILE A 419ASN A 472 | SM5 A 1 (-4.3A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-3.9A) | 0.70A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | ILE A 355PHE A 408ILE A 419CYH A 424 | SM5 A 1 (-4.3A)NoneSM5 A 1 ( 4.3A)SM5 A 1 ( 4.4A) | 0.46A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 7 | VAL A 396PHE A 408ILE A 419ASN A 472 | NoneNoneSM5 A 1 ( 4.3A)SM5 A 1 (-3.9A) | 0.98A | 5hieC-3omvA:34.8 | 5hieC-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 8 / 12 | GLY A 358ALA A 373LYS A 375LEU A 406ILE A 419THR A 421PHE A 475GLY A 485 | NoneSM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-3.0A)None | 0.93A | 5hieD-3omvA:34.6 | 5hieD-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 9 / 12 | GLY A 358VAL A 363ALA A 373LEU A 406ILE A 419THR A 421TRP A 423PHE A 475GLY A 485 | NoneSM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneSM5 A 1 ( 4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 0.79A | 5hieD-3omvA:34.6 | 5hieD-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 5 / 8 | ILE A 355GLY A 356CYH A 424ASP A 486PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.5A)None | 1.08A | 5hieD-3omvA:34.6 | 5hieD-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 8 | ILE A 355GLY A 356PHE A 408ASN A 472 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)NoneSM5 A 1 (-3.9A) | 0.88A | 5hieD-3omvA:34.6 | 5hieD-3omvA:77.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 4 / 8 | ILE A 355GLY A 356PHE A 408CYH A 424 | SM5 A 1 (-4.3A)SM5 A 1 ( 4.9A)NoneSM5 A 1 ( 4.4A) | 0.50A | 5hieD-3omvA:34.6 | 5hieD-3omvA:77.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VCV_A_1N1A404_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 6 / 12 | ALA A 373LYS A 375GLU A 393THR A 421PHE A 475GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-3.0A)None | 0.83A | 5vcvA-3omvA:23.1 | 5vcvA-3omvA:27.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VCY_A_DB8A401_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homosapiens) | 7 / 12 | VAL A 363ALA A 373LYS A 375GLU A 393THR A 421CYH A 424PHE A 475 | SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)SM5 A 1 (-4.4A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A) | 0.98A | 5vcyA-3omvA:23.1 | 5vcyA-3omvA:27.99 |