SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SM5'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 TRP A 423
THR A 353
LEU A 351
GLY A 366
SM5  A   1 (-4.3A)
None
None
None
0.99A 1gtiD-3omvA:
undetectable
1gtiD-3omvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 TRP A 423
THR A 353
LEU A 351
GLY A 366
SM5  A   1 (-4.3A)
None
None
None
0.88A 1gtiE-3omvA:
undetectable
1gtiE-3omvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 8 SER A 471
ASN A 473
ASP A 468
GLU A 393
None
None
None
SM5  A   1 (-4.3A)
1.09A 1mxgA-3omvA:
undetectable
1mxgA-3omvA:
17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ALA A 373
GLU A 393
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
0.94A 1uwhA-3omvA:
36.3
1uwhA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
LEU A 459
HIS A 466
GLY A 485
PHE A 475
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
None
None
SM5  A   1 (-3.0A)
1.21A 1uwhA-3omvA:
36.3
1uwhA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 6 ILE A 355
VAL A 363
VAL A 396
ILE A 405
ILE A 464
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
None
None
None
0.53A 1uwhA-3omvA:
36.4
1uwhA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ALA A 373
LYS A 375
GLU A 393
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
0.95A 1uwhB-3omvA:
36.3
1uwhB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ALA A 373
LYS A 375
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
0.81A 1uwhB-3omvA:
36.3
1uwhB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 VAL A 363
ALA A 373
GLU A 393
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
0.96A 1uwjA-3omvA:
13.2
1uwjA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 VAL A 363
ALA A 373
THR A 400
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
0.71A 1uwjA-3omvA:
13.2
1uwjA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 7 ILE A 355
LYS A 375
LEU A 397
ILE A 405
ILE A 464
SM5  A   1 (-4.3A)
SM5  A   1 (-3.5A)
None
None
None
0.71A 1uwjA-3omvA:
13.2
1uwjA-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ILE A 355
VAL A 363
ALA A 373
GLU A 393
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
0.93A 1uwjB-3omvA:
13.4
1uwjB-3omvA:
72.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ILE A 355
VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
0.72A 1uwjB-3omvA:
13.4
1uwjB-3omvA:
72.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 LEU A 397
GLY A 488
VAL A 374
ALA A 373
LEU A 351
None
None
None
SM5  A   1 (-3.6A)
None
0.93A 1vptA-3omvA:
undetectable
1vptA-3omvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 ALA A 373
GLU A 393
LEU A 397
THR A 421
HIS A 466
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
None
0.89A 3gcsA-3omvA:
19.9
3gcsA-3omvA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 VAL A 363
ALA A 373
GLU A 393
LEU A 397
THR A 421
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
0.59A 3gcsA-3omvA:
19.9
3gcsA-3omvA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 ALA A 373
LYS A 375
GLU A 393
LEU A 397
THR A 421
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
0.65A 3hecA-3omvA:
20.6
3hecA-3omvA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A 363
ALA A 373
LYS A 375
GLU A 393
LEU A 397
THR A 421
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-4.4A)
0.59A 3hegA-3omvA:
20.2
3hegA-3omvA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 6 VAL A 363
LYS A 375
VAL A 396
ILE A 419
SM5  A   1 (-4.0A)
SM5  A   1 (-3.5A)
None
SM5  A   1 ( 4.3A)
0.73A 3mssD-3omvA:
26.6
3mssD-3omvA:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ILE A 355
VAL A 363
ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
0.79A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ILE A 355
VAL A 363
ALA A 373
LYS A 375
LEU A 397
LEU A 406
THR A 421
TRP A 423
PHE A 475
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
0.81A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 ILE A 355
VAL A 363
ALA A 373
LYS A 375
TRP A 423
PHE A 475
GLY A 488
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
1.05A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 ILE A 355
VAL A 363
ALA A 373
TRP A 423
CYH A 424
PHE A 475
GLY A 488
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
0.97A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 GLY A 356
VAL A 363
ALA A 373
LYS A 375
LEU A 397
THR A 421
SM5  A   1 ( 4.9A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
0.72A 3ohtA-3omvA:
16.9
3ohtA-3omvA:
29.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 ALA A 373
LEU A 406
ILE A 419
THR A 421
SER A 427
SER A 428
PHE A 475
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
None
SM5  A   1 (-3.0A)
0.77A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 ALA A 373
LEU A 406
ILE A 419
THR A 421
TRP A 423
SER A 427
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-3.0A)
None
None
0.85A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 ALA A 373
LEU A 406
THR A 421
TRP A 423
SER A 427
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
0.98A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 ALA A 373
LYS A 375
ILE A 419
THR A 421
SER A 427
SER A 428
PHE A 475
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
None
SM5  A   1 (-3.0A)
0.80A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 ALA A 373
LYS A 375
ILE A 419
THR A 421
TRP A 423
SER A 427
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-3.0A)
None
None
0.87A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 ALA A 373
LYS A 375
ILE A 419
TRP A 423
SER A 427
PHE A 475
GLY A 485
GLY A 488
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-3.0A)
None
None
1.21A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 5 ILE A 355
VAL A 363
PHE A 408
CYH A 424
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
None
SM5  A   1 ( 4.4A)
0.46A 4rzvA-3omvA:
12.9
4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
SER A 427
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
1.05A 4rzvB-3omvA:
33.1
4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 VAL A 363
ALA A 373
LYS A 375
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
0.95A 4rzvB-3omvA:
33.1
4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 VAL A 363
ALA A 373
LYS A 375
LEU A 406
THR A 421
TRP A 423
CYH A 424
SER A 428
PHE A 475
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
SM5  A   1 (-3.0A)
1.00A 4rzvB-3omvA:
33.1
4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 VAL A 363
ALA A 373
LYS A 375
TRP A 423
CYH A 424
PHE A 475
GLY A 485
GLY A 488
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
1.30A 4rzvB-3omvA:
33.1
4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A 373
LYS A 375
THR A 421
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
None
0.83A 4xv2A-3omvA:
35.1
4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
0.78A 4xv2A-3omvA:
35.1
4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 VAL A 363
ALA A 373
LEU A 406
TRP A 423
CYH A 424
PHE A 475
GLY A 485
ASP A 486
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
SM5  A   1 (-3.5A)
None
1.09A 4xv2A-3omvA:
35.1
4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 4 GLY A 358
LEU A 397
PHE A 408
ILE A 419
None
None
None
SM5  A   1 ( 4.3A)
0.71A 4xv2A-3omvA:
35.1
4xv2A-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
0.77A 4xv2B-3omvA:
35.4
4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 ALA A 373
LEU A 406
TRP A 423
CYH A 424
PHE A 475
GLY A 485
ASP A 486
PHE A 487
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
SM5  A   1 (-3.5A)
None
0.99A 4xv2B-3omvA:
35.4
4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 ALA A 373
LYS A 375
LEU A 397
THR A 421
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
None
0.89A 4xv2B-3omvA:
35.4
4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 4 GLY A 358
VAL A 363
PHE A 408
ILE A 419
None
SM5  A   1 (-4.0A)
None
SM5  A   1 ( 4.3A)
0.44A 4xv2B-3omvA:
35.4
4xv2B-3omvA:
72.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 VAL A 363
ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
0.84A 5cswA-3omvA:
35.4
5cswA-3omvA:
75.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 VAL A 363
ALA A 373
LYS A 375
LEU A 397
THR A 421
TRP A 423
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
None
0.95A 5cswA-3omvA:
35.4
5cswA-3omvA:
75.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 ALA A 373
LYS A 375
LEU A 397
THR A 421
TRP A 423
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
None
0.95A 5cswB-3omvA:
34.5
5cswB-3omvA:
75.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 VAL A 363
ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
0.85A 5cswB-3omvA:
34.5
5cswB-3omvA:
75.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
GLY A 485
ASP A 486
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
SM5  A   1 (-3.5A)
0.80A 5h2uB-3omvA:
19.6
5h2uB-3omvA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 12 ALA A 373
LEU A 406
ILE A 419
THR A 421
GLY A 485
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
0.64A 5h2uC-3omvA:
27.1
5h2uC-3omvA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
GLY A 485
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
0.66A 5h2uD-3omvA:
27.2
5h2uD-3omvA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 VAL A 363
ALA A 373
LYS A 375
ILE A 419
THR A 421
PHE A 487
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
0.78A 5hesB-3omvA:
26.1
5hesB-3omvA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ALA A 373
LYS A 375
GLU A 393
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
GLY A 485
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
0.95A 5hi2A-3omvA:
33.4
5hi2A-3omvA:
71.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
10 / 12 ALA A 373
LYS A 375
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
LEU A 459
HIS A 466
GLY A 485
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
None
None
0.82A 5hi2A-3omvA:
33.4
5hi2A-3omvA:
71.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 GLY A 358
ALA A 373
LYS A 375
LEU A 406
ILE A 419
THR A 421
PHE A 475
GLY A 485
None
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
0.92A 5hieA-3omvA:
34.7
5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 GLY A 358
VAL A 363
ALA A 373
LEU A 397
ILE A 419
THR A 421
TRP A 423
None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
1.02A 5hieA-3omvA:
34.7
5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 GLY A 358
VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
TRP A 423
PHE A 475
GLY A 485
None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
0.79A 5hieA-3omvA:
34.7
5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
CYH A 424
ASP A 486
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
0.91A 5hieA-3omvA:
34.7
5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
GLY A 356
PHE A 408
CYH A 424
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
0.51A 5hieA-3omvA:
34.7
5hieA-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 GLY A 358
ALA A 373
LYS A 375
LEU A 406
THR A 421
PHE A 475
GLY A 485
None
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
0.91A 5hieB-3omvA:
34.8
5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 GLY A 358
VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
TRP A 423
PHE A 475
GLY A 485
None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
0.81A 5hieB-3omvA:
34.8
5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 7 ILE A 355
GLY A 356
CYH A 424
ASP A 486
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
1.10A 5hieB-3omvA:
34.8
5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
GLY A 356
LEU A 397
PHE A 408
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
None
0.87A 5hieB-3omvA:
34.8
5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
GLY A 356
PHE A 408
CYH A 424
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
0.50A 5hieB-3omvA:
34.8
5hieB-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 GLY A 356
GLY A 358
VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
PHE A 475
GLY A 485
SM5  A   1 ( 4.9A)
None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
0.78A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 GLY A 358
ALA A 373
LYS A 375
LEU A 406
THR A 421
PHE A 475
GLY A 485
None
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
0.89A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A 363
ALA A 373
LEU A 406
TRP A 423
PHE A 475
GLY A 485
ASP A 486
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
SM5  A   1 (-3.5A)
1.17A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
ILE A 419
CYH A 424
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.3A)
SM5  A   1 ( 4.4A)
None
0.69A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
PHE A 408
ILE A 419
ASN A 472
SM5  A   1 (-4.3A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-3.9A)
0.70A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 ILE A 355
PHE A 408
ILE A 419
CYH A 424
SM5  A   1 (-4.3A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 ( 4.4A)
0.46A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 7 VAL A 396
PHE A 408
ILE A 419
ASN A 472
None
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-3.9A)
0.98A 5hieC-3omvA:
34.8
5hieC-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
8 / 12 GLY A 358
ALA A 373
LYS A 375
LEU A 406
ILE A 419
THR A 421
PHE A 475
GLY A 485
None
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
0.93A 5hieD-3omvA:
34.6
5hieD-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
9 / 12 GLY A 358
VAL A 363
ALA A 373
LEU A 406
ILE A 419
THR A 421
TRP A 423
PHE A 475
GLY A 485
None
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
0.79A 5hieD-3omvA:
34.6
5hieD-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
5 / 8 ILE A 355
GLY A 356
CYH A 424
ASP A 486
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.5A)
None
1.08A 5hieD-3omvA:
34.6
5hieD-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 8 ILE A 355
GLY A 356
PHE A 408
ASN A 472
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 (-3.9A)
0.88A 5hieD-3omvA:
34.6
5hieD-3omvA:
77.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
4 / 8 ILE A 355
GLY A 356
PHE A 408
CYH A 424
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.9A)
None
SM5  A   1 ( 4.4A)
0.50A 5hieD-3omvA:
34.6
5hieD-3omvA:
77.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
6 / 12 ALA A 373
LYS A 375
GLU A 393
THR A 421
PHE A 475
GLY A 485
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
0.83A 5vcvA-3omvA:
23.1
5vcvA-3omvA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo
sapiens)
7 / 12 VAL A 363
ALA A 373
LYS A 375
GLU A 393
THR A 421
CYH A 424
PHE A 475
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
0.98A 5vcyA-3omvA:
23.1
5vcyA-3omvA:
27.99