SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SLA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 11 LEU A 517
ALA A 545
ALA A 583
VAL A 499
LEU A 600
 None
None
SLA  A 801 ( 4.2A)
None
None
 1.16A 1rlbF-4fwgA:
undetectable		 1rlbF-4fwgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 8 PRO A 509
SER A 471
VAL A 504
GLY A 512
 None
None
SLA  A 801 (-4.2A)
None
 1.10A 2qd5A-4fwgA:
undetectable		 2qd5A-4fwgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A 584
LEU A 502
SER A 582
ALA A 609
ASN A 650
 None
None
SLA  A 801 (-1.3A)
None
None
 1.00A 2vmyA-4fwgA:
undetectable		 2vmyA-4fwgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 10 ILE A 487
VAL A 503
LYS A 625
GLY A 512
LEU A 479
 None
SLA  A 801 (-3.8A)
SLA  A 801 (-2.9A)
None
None
 1.29A 3em0A-4fwgA:
undetectable		 3em0A-4fwgA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 5 SER A 582
ARG A 513
GLY A 512
GLU A 475
 SLA  A 801 (-1.3A)
None
None
None
 1.22A 3k9fA-4fwgA:
undetectable
3k9fB-4fwgA:
undetectable
3k9fC-4fwgA:
undetectable		 3k9fA-4fwgA:
22.80
3k9fB-4fwgA:
22.80
3k9fC-4fwgA:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		8 / 9 VAL A 503
VAL A 504
VAL A 576
ILE A 578
GLY A 580
SER A 582
ALA A 583
LYS A 625
 SLA  A 801 (-3.8A)
SLA  A 801 (-4.2A)
None
SLA  A 801 ( 4.7A)
SLA  A 801 (-3.1A)
SLA  A 801 (-1.3A)
SLA  A 801 ( 4.2A)
SLA  A 801 (-2.9A)
 0.45A 4fwdA-4fwgA:
55.0		 4fwdA-4fwgA:
99.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 5 SER A 582
ARG A 513
GLY A 628
GLU A 475
 SLA  A 801 (-1.3A)
None
None
None
 1.19A 5btiA-4fwgA:
undetectable
5btiB-4fwgA:
undetectable		 5btiA-4fwgA:
23.09
5btiB-4fwgA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4fwg TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 5 SER A 582
ARG A 513
GLY A 628
GLU A 475
 SLA  A 801 (-1.3A)
None
None
None
 1.07A 5btiC-4fwgA:
undetectable
5btiD-4fwgA:
undetectable		 5btiC-4fwgA:
23.09
5btiD-4fwgA:
17.28