SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SL0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_C_CTXC3_1 (CES1 PROTEIN)	3ubd	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus)	6 / 12	GLY A 152 GLY A 153 VAL A 131 LEU A 200 LEU A 74 LEU A 147	None None SL0 A 400 (-3.9A) SL0 A 400 (-4.7A) None SL0 A 400 (-3.7A)	1.49A	1ya4C-3ubdA: undetectable	1ya4C-3ubdA: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABL_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	3ubd	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus)	4 / 5	GLN A 138 PHE A 137 LEU A 133 PHE A 212	None None None SL0 A 400 ( 4.5A)	1.29A	3ablC-3ubdA: undetectable 3ablJ-3ubdA: undetectable	3ablC-3ubdA: 22.60 3ablJ-3ubdA: 12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HEC_A_STIA1_2 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	3ubd	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus)	4 / 4	LEU A 200 MET A 261 ILE A 189 ASP A 193	SL0 A 400 (-4.7A) None None None	1.16A	3hecA-3ubdA: 4.2	3hecA-3ubdA: 28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXV_D_MTXD2000_2 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	3ubd	RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus)	3 / 3	LEU A 145 ARG A 110 ASN A 198	SL0 A 400 ( 4.8A) None None	0.75A	3qxvD-3ubdA: undetectable	3qxvD-3ubdA: 17.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YA4_C_CTXC3_1","CES1 PROTEIN","3ubd","RIBOSOMAL PROTEIN S6 KINASE ALPHA-3","Mus musculus",6,"GLY A 152;GLY A 153;VAL A 131;LEU A 200;LEU A  74;LEU A 147","None;None;SL0 A 400 (-3.9A);SL0 A 400 (-4.7A);None;SL0 A 400 (-3.7A)","1.49A","1ya4C-3ubdA:undetectable",null],["3ABL_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","3ubd","RIBOSOMAL PROTEIN S6 KINASE ALPHA-3","Mus musculus",4,"GLN A 138;PHE A 137;LEU A 133;PHE A 212","None;None;None;SL0 A 400 ( 4.5A)","1.29A","3ablC-3ubdA:undetectable;3ablJ-3ubdA:undetectable","1ya4C-3ubdA:20.79"],["3HEC_A_STIA1_2","MITOGEN-ACTIVATED PROTEIN KINASE 14","3ubd","RIBOSOMAL PROTEIN S6 KINASE ALPHA-3","Mus musculus",4,"LEU A 200;MET A 261;ILE A 189;ASP A 193","SL0 A 400 (-4.7A);None;None;None","1.16A","3hecA-3ubdA:4.2","3ablC-3ubdA:22.60;3ablJ-3ubdA:12.19"],["3QXV_D_MTXD2000_2","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","3ubd","RIBOSOMAL PROTEIN S6 KINASE ALPHA-3","Mus musculus",3,"LEU A 145;ARG A 110;ASN A 198","SL0 A 400 ( 4.8A);None;None","0.75A","3qxvD-3ubdA:undetectable","3hecA-3ubdA:28.49"]]