SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SKZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)
(Bacillus
cereus) 		5 / 11 TYR A 235
ASP A 167
VAL A 168
TYR A 171
ASP A 257
 None
None
None
SKZ  A 290 (-4.8A)
None
 1.43A 3c6mA-3tnyA:
2.5		 3c6mA-3tnyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)
(Bacillus
cereus) 		5 / 12 GLU A  69
ARG A  91
VAL A  22
LEU A 126
GLY A  29
 None
SKZ  A 290 (-3.0A)
None
None
None
 1.15A 5vooA-3tnyA:
2.5		 5vooA-3tnyA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)
(Bacillus
cereus) 		5 / 12 GLU A  69
ARG A  91
VAL A  22
LEU A 126
GLY A  29
 None
SKZ  A 290 (-3.0A)
None
None
None
 1.14A 5vooC-3tnyA:
undetectable		 5vooC-3tnyA:
23.44