SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SKP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.36A 1odiA-2o0xA:
undetectable		 1odiA-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.40A 1odiA-2o0xA:
undetectable		 1odiA-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.33A 1odiB-2o0xA:
undetectable		 1odiB-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.41A 1odiB-2o0xA:
undetectable		 1odiB-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.43A 1odiC-2o0xA:
undetectable		 1odiC-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.32A 1odiD-2o0xA:
undetectable		 1odiD-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.39A 1odiD-2o0xA:
undetectable		 1odiD-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.32A 1odiE-2o0xA:
undetectable		 1odiE-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.39A 1odiE-2o0xA:
undetectable		 1odiE-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLU A 311
SER A  52
ILE A 236
 SKP  A 501 (-3.8A)
None
SKP  A 501 (-4.0A)
None
None
 1.33A 1odiF-2o0xA:
undetectable		 1odiF-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.37A 1odiF-2o0xA:
undetectable		 1odiF-2o0xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 100
LEU A 129
LEU A 185
VAL A 187
 SKP  A 501 ( 4.7A)
None
None
None
 1.02A 2bdmA-2o0xA:
undetectable		 2bdmA-2o0xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  57
SER A  24
ASN A  27
THR A 241
 None
SKP  A 501 (-2.6A)
None
None
 0.93A 3lm8B-2o0xA:
undetectable
3lm8D-2o0xA:
undetectable		 3lm8B-2o0xA:
17.53
3lm8D-2o0xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  95
GLY A  96
THR A  97
GLN A 169
 None
SKP  A 501 (-3.8A)
SKP  A 501 (-3.8A)
SKP  A 501 (-3.6A)
 0.84A 3rglA-2o0xA:
undetectable		 3rglA-2o0xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 385
THR A 411
GLY A  21
GLU A 311
ILE A 236
 SKP  A 501 (-3.8A)
None
None
SKP  A 501 (-4.0A)
None
 1.35A 3uayA-2o0xA:
undetectable		 3uayA-2o0xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 212
PRO A 103
PHE A 101
PHE A 181
 None
None
SKP  A 501 (-4.9A)
None
 0.97A 6aycA-2o0xA:
undetectable		 6aycA-2o0xA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 100
PHE A 101
GLY A  96
 SKP  A 501 ( 4.7A)
SKP  A 501 (-4.9A)
SKP  A 501 (-3.8A)
 0.64A 6fgdA-2o0xA:
undetectable		 6fgdA-2o0xA:
24.29