SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SKE'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_A_CCSA417_0 (ESTROGEN RECEPTOR)	5win	- (-)	3 / 3	GLU A 627 LYS A 630 VAL A 629	None None SKE A 901 (-3.9A)	0.95A	1l2iA-5winA: undetectable	1l2iA-5winA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIY_A_B49A1_1 (TYROSINE-PROTEIN KINASE ITK/TSK)	5win	- (-)	6 / 11	LYS A 581 VAL A 610 PHE A 628 GLY A 632 LEU A 680 SER A 698	SKE A 901 ( 4.7A) SKE A 901 ( 4.7A) SKE A 901 (-3.6A) SKE A 901 (-3.1A) SKE A 901 (-4.1A) SKE A 901 (-3.3A)	0.70A	3miyA-5winA: 29.2	3miyA-5winA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIY_B_B49B2_1 (TYROSINE-PROTEIN KINASE ITK/TSK)	5win	- (-)	5 / 9	LYS A 581 PHE A 628 GLY A 632 LEU A 680 SER A 698	SKE A 901 ( 4.7A) SKE A 901 (-3.6A) SKE A 901 (-3.1A) SKE A 901 (-4.1A) SKE A 901 (-3.3A)	0.72A	3miyB-5winA: 29.0	3miyB-5winA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGD_A_B49A2000_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	5win	- (-)	6 / 11	LEU A 551 LYS A 581 VAL A 610 PHE A 628 GLY A 632 LEU A 680	SKE A 901 (-3.4A) SKE A 901 ( 4.7A) SKE A 901 ( 4.7A) SKE A 901 (-3.6A) SKE A 901 (-3.1A) SKE A 901 (-4.1A)	0.68A	4agdA-5winA: 26.3	4agdA-5winA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L2I_A_CCSA417_0","ESTROGEN RECEPTOR","5win","-","-",3,"GLU A 627;LYS A 630;VAL A 629","None;None;SKE A 901 (-3.9A)","0.95A","1l2iA-5winA:undetectable",null],["3MIY_A_B49A1_1","TYROSINE-PROTEIN KINASE ITK\/TSK","5win","-","-",6,"LYS A 581;VAL A 610;PHE A 628;GLY A 632;LEU A 680;SER A 698","SKE A 901 ( 4.7A);SKE A 901 ( 4.7A);SKE A 901 (-3.6A);SKE A 901 (-3.1A);SKE A 901 (-4.1A);SKE A 901 (-3.3A)","0.70A","3miyA-5winA:29.2","1l2iA-5winA:undetectable"],["3MIY_B_B49B2_1","TYROSINE-PROTEIN KINASE ITK\/TSK","5win","-","-",5,"LYS A 581;PHE A 628;GLY A 632;LEU A 680;SER A 698","SKE A 901 ( 4.7A);SKE A 901 (-3.6A);SKE A 901 (-3.1A);SKE A 901 (-4.1A);SKE A 901 (-3.3A)","0.72A","3miyB-5winA:29.0","3miyA-5winA:undetectable"],["4AGD_A_B49A2000_1","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","5win","-","-",6,"LEU A 551;LYS A 581;VAL A 610;PHE A 628;GLY A 632;LEU A 680","SKE A 901 (-3.4A);SKE A 901 ( 4.7A);SKE A 901 ( 4.7A);SKE A 901 (-3.6A);SKE A 901 (-3.1A);SKE A 901 (-4.1A)","0.68A","4agdA-5winA:26.3","3miyB-5winA:undetectable"]]