SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SH0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 7 ILE B 184
THR B  96
ILE B 324
GLY B 133
 None
SH0  A 503 (-2.9A)
None
None
 0.96A 2v0mB-2v4jB:
undetectable		 2v0mB-2v4jB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 12 GLY A 137
VAL B 289
SER A 135
ASN B  99
ARG B  71
 SRM  B 503 (-4.2A)
SH0  A 503 (-3.5A)
SRM  B 503 (-2.9A)
None
SRM  B 503 (-3.0A)
 1.30A 2vmyB-2v4jA:
undetectable		 2vmyB-2v4jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 5 HIS A 266
TYR B 327
ARG B 336
GLY B 138
 None
None
SH0  A 503 (-3.0A)
None
 0.98A 3b9mA-2v4jA:
undetectable		 3b9mA-2v4jA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 7 VAL B 169
ILE B 184
ARG B 183
ILE B 201
 None
None
SH0  A 503 (-3.8A)
None
 0.88A 4lv9A-2v4jB:
undetectable		 4lv9A-2v4jB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 7 VAL B 169
ILE B 184
ARG B 183
ILE B 201
 None
None
SH0  A 503 (-3.8A)
None
 0.92A 4lv9B-2v4jB:
undetectable		 4lv9B-2v4jB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 ALA B 164
LEU B 316
LEU B 186
ILE B 201
ARG B  98
 None
None
None
None
SH0  A 503 (-3.9A)
 1.16A 4q0dA-2v4jB:
undetectable		 4q0dA-2v4jB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 ALA B 164
LEU B 316
LEU B 186
ILE B 201
ARG B  98
 None
None
None
None
SH0  A 503 (-3.9A)
 1.15A 4q0dB-2v4jB:
undetectable		 4q0dB-2v4jB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 ALA B 164
LEU B 316
LEU B 186
ILE B 201
ARG B  98
 None
None
None
None
SH0  A 503 (-3.9A)
 1.15A 4q0dE-2v4jB:
undetectable		 4q0dE-2v4jB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 8 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SH0  A 503 (-2.7A)
 1.33A 5tzoA-2v4jB:
undetectable		 5tzoA-2v4jB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 8 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SH0  A 503 (-2.7A)
 1.38A 5tzoB-2v4jB:
undetectable		 5tzoB-2v4jB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		4 / 8 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SH0  A 503 (-2.7A)
 1.33A 5tzoC-2v4jB:
undetectable		 5tzoC-2v4jB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 ARG B 336
GLY B 338
GLY B 202
SER B 199
ILE B 201
 SH0  A 503 (-3.0A)
None
None
None
None
 1.17A 5vooA-2v4jB:
undetectable		 5vooA-2v4jB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 ARG B 336
GLY B 338
GLY B 202
SER B 199
ILE B 201
 SH0  A 503 (-3.0A)
None
None
None
None
 1.19A 5vooC-2v4jB:
undetectable		 5vooC-2v4jB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 ARG B 336
GLY B 338
GLY B 202
SER B 199
ILE B 201
 SH0  A 503 (-3.0A)
None
None
None
None
 1.12A 5vooE-2v4jB:
undetectable		 5vooE-2v4jB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		4 / 6 SER A 235
ARG B 183
ARG A 231
ASP A 219
 None
SH0  A 503 (-3.8A)
SRM  B 503 (-4.1A)
SF4  A 501 ( 4.8A)
 1.11A 5zw4A-2v4jA:
undetectable		 5zw4A-2v4jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Desulfovibrio
vulgaris) 		5 / 12 GLY B 138
ARG B  98
VAL B 139
GLY B 286
GLY B 287
 None
SH0  A 503 (-3.9A)
None
None
None
 0.98A 6brdB-2v4jB:
undetectable		 6brdB-2v4jB:
11.83