SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SGV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 7 VAL A 247
MET A 266
ARG A 310
LEU A 318
 None
None
None
SGV  A 601 (-4.9A)
 0.97A 1iepB-4tnbA:
17.3		 1iepB-4tnbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
MET A 266
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.71A 1m17A-4tnbA:
22.6		 1m17A-4tnbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.98A 1m17A-4tnbA:
22.6		 1m17A-4tnbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 ARG A 388
ASP A 270
ASN A 267
 None
SGV  A 601 (-4.2A)
None
 0.91A 1nbhA-4tnbA:
undetectable		 1nbhA-4tnbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 ARG A 388
ASP A 270
ASN A 267
 None
SGV  A 601 (-4.2A)
None
 0.89A 1nbhD-4tnbA:
undetectable		 1nbhD-4tnbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
VAL A 247
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
 0.92A 1t46A-4tnbA:
20.0		 1t46A-4tnbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 LEU A 192
ALA A 213
LEU A 263
ASP A 270
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.2A)
SGV  A 601 (-4.9A)
 0.77A 1yi4A-4tnbA:
23.6		 1yi4A-4tnbA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 PHE A 502
LEU A 217
LEU A 263
LEU A 238
 None
None
SGV  A 601 (-4.5A)
None
 0.91A 2bfpD-4tnbA:
undetectable		 2bfpD-4tnbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
SGV  A 601 (-3.0A)
 0.83A 2ityA-4tnbA:
17.9		 2ityA-4tnbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.63A 2xp2A-4tnbA:
7.9		 2xp2A-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 ARG A 190
LEU A 192
ALA A 213
LEU A 263
MET A 266
GLY A 268
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
None
SGV  A 601 (-4.9A)
 1.18A 3aoxA-4tnbA:
20.6		 3aoxA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 ARG A 190
LEU A 192
ALA A 213
VAL A 247
LEU A 263
MET A 266
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.86A 3aoxA-4tnbA:
20.6		 3aoxA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 LEU A 192
ALA A 213
LYS A 215
VAL A 247
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.78A 3aoxA-4tnbA:
20.6		 3aoxA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
MET A 266
 SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 1.43A 3hegA-4tnbA:
2.2		 3hegA-4tnbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 ALA A 213
LYS A 215
GLU A 234
LEU A 261
 SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
 0.28A 3lfaA-4tnbA:
20.7		 3lfaA-4tnbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.93A 3qlgB-4tnbA:
20.9		 3qlgB-4tnbA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 LEU A 263
MET A 266
ASP A 270
 SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.2A)
 0.23A 3v5wA-4tnbA:
13.4		 3v5wA-4tnbA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 VAL A 246
VAL A 247
LEU A 318
ILE A 327
 None
None
SGV  A 601 (-4.9A)
None
 0.69A 3wzeA-4tnbA:
16.8		 3wzeA-4tnbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.65A 4anqA-4tnbA:
17.1		 4anqA-4tnbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
LEU A 302
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.61A 4asdA-4tnbA:
20.1		 4asdA-4tnbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 VAL A 200
ALA A 213
LEU A 263
ASP A 270
LEU A 318
 SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.2A)
SGV  A 601 (-4.9A)
 0.63A 4iaaA-4tnbA:
23.3		 4iaaA-4tnbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 VAL A 200
ALA A 213
LYS A 215
LEU A 263
ASP A 270
 SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.2A)
 0.42A 4iaaA-4tnbA:
23.3		 4iaaA-4tnbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 GLY A 193
VAL A 200
ALA A 213
LEU A 249
LEU A 261
GLY A 269
LEU A 318
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
None
None
SGV  A 601 (-4.9A)
 0.62A 4ifgA-4tnbA:
21.3		 4ifgA-4tnbA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 11 GLY A 193
VAL A 200
ALA A 213
LYS A 215
ASN A 316
LEU A 318
ASP A 329
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.77A 4o0sA-4tnbA:
23.2		 4o0sA-4tnbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 11 LEU A 192
GLY A 193
VAL A 200
ALA A 213
ASN A 316
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.69A 4o0sA-4tnbA:
23.2		 4o0sA-4tnbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 6 LEU A 192
GLY A 193
VAL A 200
ALA A 213
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
 0.22A 4o0wA-4tnbA:
22.2		 4o0wA-4tnbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		9 / 12 LEU A 192
GLY A 193
GLY A 195
GLY A 198
VAL A 200
ALA A 213
LYS A 215
VAL A 247
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
None
None
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-3.0A)
 0.67A 4otiA-4tnbA:
23.2		 4otiA-4tnbA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 8 LEU A 192
ALA A 213
ILE A 265
LEU A 318
SER A 328
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-4.2A)
 0.41A 4wboB-4tnbA:
31.0		 4wboB-4tnbA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 6 ARG A 190
LEU A 192
ALA A 213
MET A 266
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
 0.77A 4wboC-4tnbA:
32.4		 4wboC-4tnbA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.75A 5aaaA-4tnbA:
16.3		 5aaaA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 1.04A 5aabA-4tnbA:
16.3		 5aabA-4tnbA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 10 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.56A 5aacA-4tnbA:
21.1		 5aacA-4tnbA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 ARG A 190
LEU A 192
ALA A 213
LEU A 318
ASP A 329
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.59A 5h2uC-4tnbA:
19.8		 5h2uC-4tnbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 7 GLY A 193
VAL A 200
LYS A 215
LEU A 217
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 ( 4.2A)
None
 0.48A 5izjA-4tnbA:
30.1		 5izjA-4tnbA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 11 GLY A 193
VAL A 200
ALA A 213
VAL A 247
LEU A 263
LEU A 318
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.5A)
SGV  A 601 (-4.9A)
 0.50A 5lvnA-4tnbA:
27.5		 5lvnA-4tnbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 11 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 263
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.9A)
 0.39A 5lvnA-4tnbA:
27.5		 5lvnA-4tnbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 263
GLY A 269
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.5A)
None
 0.57A 5mafA-4tnbA:
26.8		 5mafA-4tnbA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.99A 5vcvA-4tnbA:
23.0		 5vcvA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.97A 5vcyA-4tnbA:
20.2		 5vcyA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 261
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.82A 5yu9A-4tnbA:
19.5		 5yu9A-4tnbA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 GLY A 193
VAL A 200
ALA A 213
LEU A 261
LEU A 318
ASP A 329
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.74A 5yu9B-4tnbA:
19.7		 5yu9B-4tnbA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
 0.65A 5zv2B-4tnbA:
17.1		 5zv2B-4tnbA:
9.17