SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SGN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3ilr HEPARIN LYASE I
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 254
SER A 276
SER A 244
ASN A 243
 None
None
None
SGN  A 377 (-3.5A)
 1.23A 1ig3A-3ilrA:
undetectable
1ig3B-3ilrA:
undetectable		 1ig3A-3ilrA:
20.26
1ig3B-3ilrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		5 / 10 GLY A 479
ALA A 542
TYR A 528
HIS A 547
TRP A 573
 None
None
SGN  A 804 (-4.3A)
None
None
 1.20A 1jglH-4pxqA:
undetectable
1jglL-4pxqA:
undetectable		 1jglH-4pxqA:
17.54
1jglL-4pxqA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 TYR A 468
TYR A 528
GLY A 479
TYR A 546
 None
SGN  A 804 (-4.3A)
None
UAP  A 801 ( 3.6A)
 1.20A 2g72A-4pxqA:
undetectable		 2g72A-4pxqA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PRO A 218
GLY A 355
PHE A 360
SER A 240
ASP A 361
 None
None
None
None
SGN  A1522 (-2.8A)
 1.31A 3iv6A-5g2vA:
undetectable		 3iv6A-5g2vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PRO A 218
GLY A 355
PHE A 360
SER A 240
ASP A 361
 None
None
None
None
SGN  A1522 (-2.8A)
 1.36A 3iv6C-5g2vA:
undetectable		 3iv6C-5g2vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 446
ASP A 361
ARG A 200
ALA A  75
GLU A 442
 SGN  A1522 (-2.9A)
SGN  A1522 (-2.8A)
SGN  A1522 (-3.6A)
None
None
 1.49A 3k39C-5g2vA:
undetectable		 3k39C-5g2vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 446
ASP A 361
ARG A 200
ALA A  75
GLU A 442
 SGN  A1522 (-2.9A)
SGN  A1522 (-2.8A)
SGN  A1522 (-3.6A)
None
None
 1.49A 3k39J-5g2vA:
undetectable		 3k39J-5g2vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 446
ASP A 361
ARG A 200
ALA A  75
GLU A 442
 SGN  A1522 (-2.9A)
SGN  A1522 (-2.8A)
SGN  A1522 (-3.6A)
None
None
 1.49A 3k39L-5g2vA:
undetectable		 3k39L-5g2vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3ilr HEPARIN LYASE I
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 301
VAL A 297
TRP A 150
PRO A 227
 None
None
None
SGN  A 377 (-4.2A)
 1.20A 3n6dA-3ilrA:
undetectable
3n6dB-3ilrA:
undetectable		 3n6dA-3ilrA:
23.58
3n6dB-3ilrA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3ilr HEPARIN LYASE I
(Bacteroides
thetaiotaomicron) 		4 / 5 GLY A 224
GLU A 222
GLY A 225
PRO A 154
 IXD  A 379 (-3.0A)
CA  A   1 (-2.2A)
SGN  A 377 ( 2.9A)
None
 0.96A 3onnA-3ilrA:
undetectable		 3onnA-3ilrA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 531
HIS A 532
LEU A 541
ASP A 529
 SGN  A 804 (-3.1A)
None
None
None
 1.38A 4cevA-4pxqA:
undetectable
4cevB-4pxqA:
undetectable		 4cevA-4pxqA:
18.89
4cevB-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ASP A 529
ARG A 531
HIS A 532
LEU A 541
 None
SGN  A 804 (-3.1A)
None
None
 1.38A 4cevA-4pxqA:
undetectable
4cevC-4pxqA:
undetectable		 4cevA-4pxqA:
18.89
4cevC-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 531
HIS A 532
LEU A 541
ASP A 529
 SGN  A 804 (-3.1A)
None
None
None
 1.36A 4cevD-4pxqA:
undetectable
4cevE-4pxqA:
undetectable		 4cevD-4pxqA:
18.89
4cevE-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 6 ARG A 531
HIS A 532
LEU A 541
ASP A 529
 SGN  A 804 (-3.1A)
None
None
None
 1.36A 4cevE-4pxqA:
undetectable
4cevF-4pxqA:
undetectable		 4cevE-4pxqA:
18.89
4cevF-4pxqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1fq9 FIBROBLAST GROWTH
FACTOR 2
(Homo
sapiens) 		4 / 8 LEU A 118
CYH A  25
PHE A 139
GLN A 134
 None
None
None
SGN  A 304 (-4.3A)
 1.06A 4j7uD-1fq9A:
undetectable		 4j7uD-1fq9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_1
(RETINOL-BINDING
PROTEIN 2)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 196
TRP A 249
GLN A 144
 None
SGN  A1522 (-4.2A)
None
 1.27A 4qzuC-5g2vA:
undetectable		 4qzuC-5g2vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3uan HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
1
(Mus
musculus) 		4 / 4 ALA A 126
VAL A  66
GLY A  70
THR A  71
 SGN  A   3 (-3.4A)
None
A3P  A 603 (-3.2A)
A3P  A 603 (-2.9A)
 1.08A 4ubeA-3uanA:
2.6		 4ubeA-3uanA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 266
ASN A 201
ASP A  38
 SGN  A1522 (-2.9A)
None
CA  A1521 ( 2.8A)
 0.88A 5gwxA-5g2vA:
undetectable		 5gwxA-5g2vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5ue2 MATRILYSIN
(Homo
sapiens) 		4 / 6 GLU A 176
GLY A 153
PHE A  22
ARG A  21
 CA  A 302 (-3.4A)
CA  A 302 (-4.5A)
None
SGN  A 305 (-3.5A)
 1.34A 5jcnB-5ue2A:
undetectable		 5jcnB-5ue2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4pxq D-GLUCURONYL C5
EPIMERASE B
(Danio
rerio) 		4 / 7 LEU A 484
SER A 420
ILE A 181
ASN A 478
 None
None
SGN  A 802 (-4.4A)
UAP  A 801 ( 4.6A)
 1.04A 5n5dA-4pxqA:
undetectable		 5n5dA-4pxqA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3ilr HEPARIN LYASE I
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 229
ALA A 230
PHE A 231
VAL A 297
ILE A 299
 None
SGN  A 377 ( 3.9A)
None
None
None
 1.08A 5om2A-3ilrA:
undetectable
5om2B-3ilrA:
undetectable		 5om2A-3ilrA:
12.22
5om2B-3ilrA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3ilr HEPARIN LYASE I
(Bacteroides
thetaiotaomicron) 		5 / 10 VAL A 297
VAL A 319
LEU A 229
ALA A 230
PRO A 228
 None
None
None
SGN  A 377 ( 3.9A)
None
 1.26A 5tt3C-3ilrA:
undetectable		 5tt3C-3ilrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A  38
ARG A 200
HIS A 199
ASP A 250
 CA  A1521 ( 2.8A)
SGN  A1522 (-3.6A)
SGN  A1522 (-4.3A)
None
 1.19A 6mn4A-5g2vA:
undetectable		 6mn4A-5g2vA:
18.36