SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SGC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.17A 2x2iA-2bodX:
2.3		 2x2iA-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 10 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.24A 2x2iB-2bodX:
2.7		 2x2iB-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.10A 2x2iC-2bodX:
4.5		 2x2iC-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 LEU A 318
LEU A 268
ARG A 394
 None
None
SGC  A 902 ( 3.5A)
 0.69A 3hcnB-1q2eA:
undetectable		 3hcnB-1q2eA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLU X 197
ASP X 218
ASP X 117
GLY X 158
SER X 160
 None
None
SGC  X1288 (-3.8A)
None
None
 1.36A 4djeB-2bodX:
7.4		 4djeB-2bodX:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 SER A 342
ASP A 259
GLN A 175
 None
SGC  A 902 ( 4.7A)
GLC  A 904 (-3.5A)
 0.70A 4oltA-1q2eA:
undetectable
4oltB-1q2eA:
undetectable		 4oltA-1q2eA:
19.62
4oltB-1q2eA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		4 / 8 THR A 231
GLY A 254
GLY A 253
ASP A 259
 None
None
None
SGC  A 902 ( 4.7A)
 0.84A 4qvvY-1q2eA:
undetectable
4qvvZ-1q2eA:
undetectable		 4qvvY-1q2eA:
19.91
4qvvZ-1q2eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 GLN A 175
SER A 342
ASP A 259
 GLC  A 904 (-3.5A)
None
SGC  A 902 ( 4.7A)
 0.67A 4qwpA-1q2eA:
undetectable
4qwpB-1q2eA:
undetectable		 4qwpA-1q2eA:
20.84
4qwpB-1q2eA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1q2e EXOCELLOBIOHYDROLASE
I
(Trichoderma
reesei) 		3 / 3 PRO A 382
ARG A 394
GLU A 385
 None
SGC  A 902 ( 3.5A)
MGL  A 901 ( 4.9A)
 0.95A 5j6hA-1q2eA:
undetectable		 5j6hA-1q2eA:
21.10