SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SFG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		3 / 3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.72A 1av2C-3lkzA:
undetectable
1av2D-3lkzA:
undetectable		 1av2C-3lkzA:
4.30
1av2D-3lkzA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		5 / 10 LEU A  43
ASP A 132
GLY A  64
ILE A  68
VAL A  56
 None
SFG  A 501 (-3.7A)
None
None
None
 1.01A 1d4yA-3axsA:
undetectable		 1d4yA-3axsA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.55A 1eizA-2yxlA:
12.0		 1eizA-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.46A 1eizA-3a4tA:
14.2		 1eizA-3a4tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 ( 4.1A)
 1.14A 1eizA-3lkzA:
15.4		 1eizA-3lkzA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.58A 1eizA-2yxlA:
12.0		 1eizA-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.51A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.42A 1ej0A-3a4tA:
11.7		 1ej0A-3a4tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  85
GLY A  86
TRP A  87
ARG A 163
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 ( 4.1A)
 1.16A 1ej0A-3lkzA:
15.3		 1ej0A-3lkzA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.63A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 8 GLU A 248
ASP A 276
THR A 278
PRO A 295
LEU A 309
 SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
SFG  A 401 ( 4.1A)
SFG  A 401 ( 4.4A)
None
 1.03A 1hmyA-3tm5A:
9.2		 1hmyA-3tm5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		5 / 8 PHE A 488
GLU A 512
ASP A 539
PRO A 566
LEU A 588
 SFG  A 700 (-4.5A)
SFG  A 700 (-2.1A)
SFG  A 700 ( 4.4A)
None
SFG  A 700 (-4.9A)
 1.32A 1hmyA-4onqA:
6.8		 1hmyA-4onqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		5 / 11 GLY A 564
PRO A 566
GLU A 294
GLY A 332
LEU A 259
 SFG  A 700 ( 4.6A)
None
None
None
None
 1.25A 1jzsA-4onqA:
undetectable		 1jzsA-4onqA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		4 / 5 GLU A 304
ARG A  66
ASP A 132
THR A 159
 None
SFG  A 501 (-4.3A)
SFG  A 501 (-3.7A)
None
 1.39A 1k4tA-3axsA:
0.1		 1k4tA-3axsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
LEU A 105
ILE A  99
LEU A 100
PHE A  92
 SFG  A1198 (-4.3A)
None
None
None
None
 0.94A 1mx1D-2xvaA:
undetectable		 1mx1D-2xvaA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 ARG A  37
GLY A 196
VAL A 214
GLY A 202
ILE A 234
 None
None
None
SFG  A 491 (-4.1A)
None
 0.84A 1n49B-3n71A:
undetectable		 1n49B-3n71A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 ARG A  37
GLY A 196
VAL A 214
GLY A 202
ILE A 234
 None
None
None
SFG  A 491 (-4.1A)
None
 0.85A 1n49C-3n71A:
undetectable		 1n49C-3n71A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.65A 1n6cA-3n71A:
6.0		 1n6cA-3n71A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		5 / 12 ALA A  62
SER A  63
SER A  86
ALA A 114
ASP A 132
 SFG  A 501 (-3.4A)
SFG  A 501 ( 4.4A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.6A)
SFG  A 501 (-3.7A)
 0.75A 1nt2A-3axsA:
13.7		 1nt2A-3axsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		3 / 3 THR A 230
GLU A 248
ASP A 276
 SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
 0.68A 1nt2A-3tm5A:
14.1		 1nt2A-3tm5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 5 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.33A 1p6kB-4onqA:
undetectable		 1p6kB-4onqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 5 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.33A 1rs6B-4onqA:
undetectable		 1rs6B-4onqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 269
GLY A 271
GLY A 272
LYS A 273
ASP A 293
ASP A 318
ARG A 320
PRO A 339
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.72A 1sqfA-2yxlA:
40.8		 1sqfA-2yxlA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		8 / 12 CYH A  91
ALA A  93
GLY A  95
GLY A  96
LYS A  97
ILE A 116
ARG A 144
PRO A 165
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.9A)
 0.58A 1sqfA-3a4tA:
28.8		 1sqfA-3a4tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		8 / 12 CYH A  91
ALA A  93
GLY A  95
GLY A  96
LYS A  97
ILE A 116
ASP A 142
ARG A 144
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
None
 0.58A 1sqfA-3a4tA:
28.8		 1sqfA-3a4tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 PRO A 270
ASP A 291
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.6A)
 0.48A 1sqfA-2yxlA:
40.8		 1sqfA-2yxlA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 LEU A  92
SER A  93
PRO A  94
GLN A  95
GLY A 118
SER A 137
ILE A 138
VAL A 142
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.29A 1uakA-5wyrA:
29.7		 1uakA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 12 PRO A  94
GLN A  95
GLY A 118
LEU A 143
GLY A 146
PRO A 149
 SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 1.28A 1uakA-5wyrA:
29.7		 1uakA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 12 SER A  93
PRO A  94
GLN A  95
GLY A 118
LEU A 143
GLY A 145
 None
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
 1.22A 1uakA-5wyrA:
29.7		 1uakA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		3 / 3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.73A 1w5uC-3lkzA:
undetectable
1w5uD-3lkzA:
undetectable		 1w5uC-3lkzA:
4.30
1w5uD-3lkzA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 5 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.33A 1zzuB-4onqA:
undetectable		 1zzuB-4onqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		5 / 12 GLY A 332
VAL A 467
ILE A 562
GLY A 563
GLY A 564
 None
None
None
None
SFG  A 700 ( 4.6A)
 0.76A 2avvD-4onqA:
undetectable		 2avvD-4onqA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
LYS A 273
ASP A 293
ARG A 296
ASP A 318
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.7A)
 0.70A 2b9eA-2yxlA:
31.1		 2b9eA-2yxlA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 CYH A  91
PRO A  94
GLY A  95
LYS A  97
ASP A 142
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-4.0A)
 0.31A 2b9eA-3a4tA:
28.7		 2b9eA-3a4tA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		3 / 3 SER A  56
ASP A 146
CYH A 180
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.8A)
None
 0.92A 2br4E-3lkzA:
6.7		 2br4E-3lkzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 321
ASN C 368
LEU C 426
GLU C 376
ARG C 375
 None
SFG  C1002 (-4.1A)
None
None
None
 1.29A 2bxfB-5hr4C:
undetectable		 2bxfB-5hr4C:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  89
ALA A  93
ILE A 116
SER A 117
ASP A 163
 SFG  A 500 ( 4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.7A)
 0.82A 2ejtA-3a4tA:
11.4		 2ejtA-3a4tA:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		5 / 12 ASP A  58
ILE A  68
ASN A  83
ILE A  85
ALA A 114
 SFG  A 501 ( 4.6A)
None
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.6A)
 1.18A 2ejtA-3axsA:
44.3		 2ejtA-3axsA:
38.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		11 / 12 ASP A  58
LEU A  60
ALA A  62
ILE A  65
ARG A  66
ASN A  83
ILE A  85
SER A  86
ALA A 114
ASP A 132
PHE A 140
 SFG  A 501 ( 4.6A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.4A)
None
SFG  A 501 (-4.3A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.7A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.6A)
SFG  A 501 (-3.7A)
None
 0.50A 2ejtA-3axsA:
44.3		 2ejtA-3axsA:
38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 267
VAL A 292
ASP A 293
ASP A 337
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.86A 2f8lA-2yxlA:
12.7		 2f8lA-2yxlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.70A 2gluA-4ox9Y:
12.5		 2gluA-4ox9Y:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 10 GLY A  18
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.60A 2h21A-3n71A:
9.2		 2h21A-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 GLY A  20
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.16A 2h21A-3n71A:
9.2		 2h21A-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 GLY A  20
LEU A 203
HIS A 206
TYR A 252
PHE A 272
 None
None
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
 1.34A 2h21A-3n71A:
9.2		 2h21A-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.28A 2h21B-3n71A:
11.9		 2h21B-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.52A 2h21B-3n71A:
11.9		 2h21B-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  20
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.19A 2h21B-3n71A:
11.9		 2h21B-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  20
LEU A 203
HIS A 206
TYR A 252
PHE A 272
 None
None
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
 1.36A 2h21B-3n71A:
11.9		 2h21B-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.33A 2h21C-3n71A:
8.6		 2h21C-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.54A 2h21C-3n71A:
8.6		 2h21C-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  20
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.16A 2h21C-3n71A:
8.6		 2h21C-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  20
LEU A 203
HIS A 206
TYR A 252
PHE A 272
 None
None
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
 1.32A 2h21C-3n71A:
8.6		 2h21C-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 LEU A 203
ASN A 205
HIS A 206
TYR A 252
PHE A 272
 None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
 1.47A 2h21C-3n71A:
8.6		 2h21C-3n71A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		6 / 12 PHE A 488
GLY A 490
GLY A 493
ASP A 539
PRO A 566
LEU A 588
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.5A)
SFG  A 700 (-3.6A)
SFG  A 700 ( 4.4A)
None
SFG  A 700 (-4.9A)
 1.25A 2hmyB-4onqA:
6.6		 2hmyB-4onqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		6 / 12 PHE A 488
GLY A 490
GLY A 494
ASP A 539
PRO A 566
LEU A 588
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.5A)
None
SFG  A 700 ( 4.4A)
None
SFG  A 700 (-4.9A)
 1.43A 2hmyB-4onqA:
6.6		 2hmyB-4onqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ASP Y  30
LEU Y  31
GLY Y  32
GLY Y  34
LEU Y 110
 SFG  Y 301 ( 4.7A)
None
SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.0A)
 0.72A 2nxeB-4ox9Y:
3.5		 2nxeB-4ox9Y:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  81
GLY A  85
TRP A  87
VAL A 132
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.32A 2nyuA-3lkzA:
14.5		 2nyuA-3lkzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 PRO A 270
ASP A 291
ASP A 318
ASP A 265
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 4.4A)
 0.96A 2nyuA-2yxlA:
11.7		 2nyuA-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 PRO A 270
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.50A 2nyuA-2yxlA:
11.7		 2nyuA-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  81
GLY A  85
TRP A  87
VAL A 132
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.36A 2nyuB-3lkzA:
14.6		 2nyuB-3lkzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 270
ASP A 291
ASP A 318
ASP A 265
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 4.4A)
 1.02A 2nyuB-2yxlA:
11.9		 2nyuB-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 270
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.46A 2nyuB-2yxlA:
11.9		 2nyuB-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		5 / 11 LEU A  43
ASP A 132
GLY A  64
ILE A  68
VAL A  56
 None
SFG  A 501 (-3.7A)
None
None
None
 1.06A 2o4pA-3axsA:
undetectable		 2o4pA-3axsA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 321
ALA C 363
GLY C 365
ASN C 481
PRO C 483
 None
SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.32A 2okcA-5hr4C:
18.2		 2okcA-5hr4C:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ILE C 321
ALA C 363
GLY C 365
ASN C 481
PRO C 483
 None
SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.34A 2okcB-5hr4C:
18.4		 2okcB-5hr4C:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.8A)
 0.64A 2oxtA-3lkzA:
39.7		 2oxtA-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.39A 2oxtA-3lkzA:
39.7		 2oxtA-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  85
TRP A  87
THR A 104
GLU A 111
LYS A 182
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.1A)
 0.66A 2oxtB-3lkzA:
39.7		 2oxtB-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		4 / 5 SER A  56
GLY A  86
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.50A 2oxtB-3lkzA:
39.7		 2oxtB-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		4 / 5 SER A  56
GLY A  86
HIS A 110
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.8A)
 0.22A 2oxtB-3lkzA:
39.7		 2oxtB-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.8A)
SFG  A 301 ( 4.1A)
 0.76A 2oxtC-3lkzA:
39.5		 2oxtC-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
ASP A  79
GLY A  81
GLY A  83
GLY A  86
THR A 104
HIS A 110
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 ( 4.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.8A)
 0.46A 2oxtD-3lkzA:
39.7		 2oxtD-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  58
ASP A  79
GLY A  83
GLY A  86
THR A 104
GLU A 111
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 ( 4.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.8A)
 0.92A 2oxtD-3lkzA:
39.7		 2oxtD-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.44A 2oxtD-3lkzA:
39.7		 2oxtD-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.39A 2pxcA-3lkzA:
43.0		 2pxcA-3lkzA:
80.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.30A 2pxcA-3lkzA:
43.0		 2pxcA-3lkzA:
80.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 319
THR A 274
ALA A 268
ASP A 291
ARG A 296
 SFG  A5748 (-3.4A)
None
None
SFG  A5748 (-2.9A)
SFG  A5748 (-3.0A)
 1.40A 2qm9A-2yxlA:
undetectable		 2qm9A-2yxlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.79A 2qmmA-5wyrA:
7.3		 2qmmA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.85A 2qmmA-5wyrA:
7.3
2qmmB-5wyrA:
7.2		 2qmmA-5wyrA:
undetectable
2qmmB-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.02A 2r3aA-3n71A:
5.4		 2r3aA-3n71A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
CYH A 274
CYH A 276
LEU A 266
 None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
None
 1.24A 2r3aA-3n71A:
5.4		 2r3aA-3n71A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 7 GLY A  40
ASP A  59
ASP A  86
LEU A  87
 SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
 0.49A 2uyqA-2xvaA:
13.4		 2uyqA-2xvaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ALA A 267
ASP A 291
ASP A 318
ARG A 320
 SFG  A5748 (-3.4A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
 0.66A 2uyqA-2yxlA:
9.4		 2uyqA-2yxlA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 GLY C 365
GLU C 413
ILE C 414
ASN C 460
ALA C 461
THR C 316
 SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.2A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.0A)
 0.87A 2vdvE-5hr4C:
7.1		 2vdvE-5hr4C:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 11 GLY C 365
GLU C 413
ILE C 414
ASN C 460
ALA C 461
THR C 316
 SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.2A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.0A)
 0.87A 2vdvF-5hr4C:
7.1		 2vdvF-5hr4C:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
ASP A 131
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.59A 2wa2A-3lkzA:
33.2		 2wa2A-3lkzA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  58
GLY A  83
THR A 104
GLU A 111
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.96A 2wa2A-3lkzA:
33.2		 2wa2A-3lkzA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.38A 2wa2B-3lkzA:
41.0		 2wa2B-3lkzA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 SER A  56
GLY A  58
GLY A  83
THR A 104
GLU A 111
VAL A 132
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.93A 2wa2B-3lkzA:
41.0		 2wa2B-3lkzA:
43.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 LEU A  37
GLY A  38
GLY A  40
LEU A  87
LEU A  90
 None
SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.8A)
None
 0.81A 2zbpA-2xvaA:
14.2		 2zbpA-2xvaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ALA A 277
PRO A 295
GLY A 227
THR A 230
GLU A 248
 SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.56A 2zifA-3tm5A:
3.2		 2zifA-3tm5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASP A  86
LEU A  87
ASN A  88
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
SFG  A1198 (-4.0A)
 0.51A 2zw9B-2xvaA:
12.3		 2zw9B-2xvaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE Y 135
LEU Y 110
LEU Y 128
LEU Y 172
TYR Y 168
 None
SFG  Y 301 (-4.0A)
None
None
None
 1.22A 3adsA-4ox9Y:
undetectable		 3adsA-4ox9Y:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		6 / 12 PHE A 488
GLY A 490
GLY A 493
PRO A 566
LEU A 588
ASN A 460
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.5A)
SFG  A 700 (-3.6A)
None
SFG  A 700 (-4.9A)
None
 1.45A 3av6A-4onqA:
undetectable		 3av6A-4onqA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		12 / 12 ARG A  36
LEU A  60
ALA A  62
ILE A  65
ARG A  66
ASP A  84
ILE A  85
SER A  86
GLU A 113
ALA A 114
ASP A 132
PHE A 134
 SFG  A 501 (-4.2A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.4A)
None
SFG  A 501 (-4.3A)
SFG  A 501 (-2.8A)
SFG  A 501 (-3.7A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-4.0A)
SFG  A 501 (-3.6A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.3A)
 0.20A 3axtA-3axsA:
66.8		 3axtA-3axsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		5 / 12 ILE A  68
ASP A  84
ILE A  85
GLU A 113
ALA A 114
 None
SFG  A 501 (-2.8A)
SFG  A 501 (-3.7A)
SFG  A 501 (-4.0A)
SFG  A 501 (-3.6A)
 1.04A 3axtA-3axsA:
66.8		 3axtA-3axsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 TYR A  91
LEU A  92
SER A  93
PRO A  94
GLY A 118
GLY A 122
SER A 137
ILE A 138
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.35A 3axzA-5wyrA:
24.7		 3axzA-5wyrA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 ASP A  36
LEU A  37
GLY A  38
ASP A  59
LEU A 108
 SFG  A1198 ( 4.7A)
None
SFG  A1198 (-4.3A)
SFG  A1198 (-2.8A)
SFG  A1198 (-4.8A)
 0.92A 3cjtC-2xvaA:
14.7		 3cjtC-2xvaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ASP Y  30
LEU Y  31
GLY Y  32
ASP Y  55
LEU Y 110
 SFG  Y 301 ( 4.7A)
None
SFG  Y 301 (-3.9A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
 0.82A 3cjtC-4ox9Y:
10.7		 3cjtC-4ox9Y:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 GLY C 365
GLU C 413
ILE C 414
ASN C 460
ALA C 461
THR C 316
 SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.2A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.0A)
 0.92A 3ckkA-5hr4C:
7.2		 3ckkA-5hr4C:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  81
GLY A  85
GLY A  86
TRP A  87
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.1A)
 0.40A 3douA-3lkzA:
14.3		 3douA-3lkzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.49A 3douA-2yxlA:
10.4		 3douA-2yxlA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 272
ASP A 293
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.7A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.93A 3eeoA-2yxlA:
9.0		 3eeoA-2yxlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		5 / 12 PHE A 488
GLY A 493
ASP A 539
LEU A 588
ASN A 460
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.6A)
SFG  A 700 ( 4.4A)
SFG  A 700 (-4.9A)
None
 0.90A 3eeoA-4onqA:
7.1		 3eeoA-4onqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
VAL A 132
PHE A 133
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.52A 3eluA-3lkzA:
39.8		 3eluA-3lkzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
VAL A 132
PHE A 133
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.45A 3elwA-3lkzA:
40.7		 3elwA-3lkzA:
52.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.34A 3elwA-3lkzA:
40.7		 3elwA-3lkzA:
52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.59A 3embA-3lkzA:
40.6		 3embA-3lkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.39A 3embA-3lkzA:
40.6		 3embA-3lkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 227
GLU A 248
LYS A 249
ALA A 277
PRO A 295
 SFG  A 401 ( 3.7A)
SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
 0.96A 3fuuA-3tm5A:
14.5		 3fuuA-3tm5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 227
GLU A 248
LYS A 249
ASP A 276
ALA A 277
 SFG  A 401 ( 3.7A)
SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
 0.87A 3fuuA-3tm5A:
14.5		 3fuuA-3tm5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.63A 3g88A-4ox9Y:
13.2		 3g88A-4ox9Y:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.62A 3g88B-4ox9Y:
12.9		 3g88B-4ox9Y:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.70A 3g89A-4ox9Y:
13.2		 3g89A-4ox9Y:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.71A 3g89B-4ox9Y:
13.1		 3g89B-4ox9Y:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.74A 3g8bA-4ox9Y:
13.1		 3g8bA-4ox9Y:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY Y  32
GLY Y  34
ASP Y  55
ALA Y  87
GLU Y  88
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
 0.73A 3g8bB-4ox9Y:
11.6		 3g8bB-4ox9Y:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.32A 3gczA-3lkzA:
40.7		 3gczA-3lkzA:
53.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.51A 3gczA-3lkzA:
40.7		 3gczA-3lkzA:
53.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 11 GLU C 413
ILE C 414
ALA C 461
ASN C 481
PRO C 483
 SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.8A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.69A 3grvA-5hr4C:
13.1		 3grvA-5hr4C:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 LEU A 202
GLU A 248
ASP A 276
ALA A 277
ASN A 293
PRO A 295
 SFG  A 401 (-4.5A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
 1.21A 3gryA-3tm5A:
15.4		 3gryA-3tm5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 GLU C 413
ILE C 414
ALA C 461
ASN C 481
PRO C 483
 SFG  C1002 (-2.8A)
SFG  C1002 (-3.9A)
SFG  C1002 (-3.8A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.71A 3gryA-5hr4C:
13.0		 3gryA-5hr4C:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		4 / 6 VAL A  22
LEU A  87
ILE A  65
LEU A 100
 None
SFG  A1198 (-3.8A)
None
None
 0.93A 3kk6A-2xvaA:
undetectable		 3kk6A-2xvaA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 314
GLY A 272
GLY A 308
MET A 307
ILE A 242
 None
SFG  A5748 (-3.7A)
None
None
None
 0.93A 3ku1C-2yxlA:
10.9		 3ku1C-2yxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		3 / 3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.72A 3l8lA-3lkzA:
undetectable
3l8lB-3lkzA:
undetectable		 3l8lA-3lkzA:
4.30
3l8lB-3lkzA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		3 / 3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.77A 3l8lC-3lkzA:
undetectable
3l8lD-3lkzA:
undetectable		 3l8lC-3lkzA:
4.30
3l8lD-3lkzA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.90A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 1.10A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.92A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		10 / 12 ALA A 267
PRO A 270
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.78A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
VAL A 292
ASP A 293
PRO A 339
LEU A 367
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-4.0A)
None
 1.50A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 LYS A  97
ARG A 120
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-2.8A)
SFG  A 500 (-4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 3m6vA-3a4tA:
31.3		 3m6vA-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  95
GLY A  96
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.47A 3m6vA-3a4tA:
31.3		 3m6vA-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.92A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 1.09A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.92A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		10 / 12 ALA A 267
PRO A 270
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.84A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
VAL A 292
ASP A 293
PRO A 339
LEU A 367
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-4.0A)
None
 1.47A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  96
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.05A 3m6vB-3a4tA:
31.1		 3m6vB-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 LYS A  97
ARG A 120
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-2.8A)
SFG  A 500 (-4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 3m6vB-3a4tA:
31.1		 3m6vB-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  95
GLY A  96
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.47A 3m6vB-3a4tA:
31.1		 3m6vB-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-4.0A)
None
 0.92A 3m6wA-2yxlA:
37.6		 3m6wA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		9 / 12 ALA A 267
PRO A 270
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-4.0A)
None
 0.83A 3m6wA-2yxlA:
37.6		 3m6wA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ARG A 296
 SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.0A)
 0.85A 3m6wA-2yxlA:
37.6		 3m6wA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 PRO A  94
GLY A  95
GLY A  96
LYS A  97
PRO A 165
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.9A)
None
 0.46A 3m6wA-3a4tA:
31.2		 3m6wA-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		3 / 3 ASP A 130
ARG A  36
ALA A  39
 None
SFG  A 501 (-4.2A)
None
 0.67A 3mbgC-3axsA:
undetectable		 3mbgC-3axsA:
12.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.19A 3mekA-3n71A:
38.4		 3mekA-3n71A:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.45A 3mekA-3n71A:
38.4		 3mekA-3n71A:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.06A 3mekA-3n71A:
38.4		 3mekA-3n71A:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY Y  32
GLY Y  34
PRO Y  56
ALA Y  85
LEU Y 104
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
None
SFG  Y 301 (-4.6A)
 1.26A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		9 / 12 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ALA Y  86
ALA Y  87
LEU Y 104
THR Y 109
LEU Y 110
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
 0.45A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		7 / 12 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ASN Y  60
LEU Y 104
THR Y 109
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
G  A1486 ( 3.9A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-3.3A)
 0.58A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		7 / 12 GLY Y  32
PRO Y  56
ALA Y  86
ALA Y  87
THR Y 109
LEU Y 110
SER Y 195
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-4.4A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
SFG  Y 301 ( 3.7A)
 0.63A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_A_SAMA220_1
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ASN Y  38
ASP Y  55
GLU Y  88
TRP Y 197
 SFG  Y 301 ( 4.5A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-3.5A)
 0.83A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		8 / 12 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
VAL Y  57
ALA Y  85
LEU Y 104
PHE Y 105
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
None
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
 1.49A 3mteB-4ox9Y:
34.2		 3mteB-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		12 / 12 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
VAL Y  57
ALA Y  86
ALA Y  87
GLU Y  88
LEU Y 104
PHE Y 105
THR Y 109
LEU Y 110
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
 0.65A 3mteB-4ox9Y:
34.2		 3mteB-4ox9Y:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 7 PHE A 558
SER A 486
VAL A 511
VAL A 508
 None
None
SFG  A 700 ( 4.9A)
None
 1.23A 3n61A-4onqA:
undetectable
3n61B-4onqA:
undetectable		 3n61A-4onqA:
21.60
3n61B-4onqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 4 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.35A 3n62A-4onqA:
0.0		 3n62A-4onqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 4 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.37A 3n65A-4onqA:
undetectable		 3n65A-4onqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 4 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.39A 3n66A-4onqA:
undetectable		 3n66A-4onqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 ARG A  37
GLY A 196
VAL A 214
GLY A 202
ILE A 234
 None
None
None
SFG  A 491 (-4.1A)
None
 0.94A 3nduC-3n71A:
undetectable		 3nduC-3n71A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASP A  86
LEU A  87
VAL A 104
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
SFG  A1198 (-3.8A)
 0.41A 3o7wA-2xvaA:
11.2		 3o7wA-2xvaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.03A 3ooiA-3n71A:
5.8		 3ooiA-3n71A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.40A 3ooiA-3n71A:
5.8		 3ooiA-3n71A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.10A 3opeA-3n71A:
6.0		 3opeA-3n71A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.50A 3opeA-3n71A:
6.0		 3opeA-3n71A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.26A 3opeA-3n71A:
6.0		 3opeA-3n71A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.90A 3opeA-3n71A:
6.0		 3opeA-3n71A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		3 / 3 GLY A  40
ASP A  59
ASP A  86
 SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
SFG  A1198 (-3.9A)
 0.16A 3ou7C-2xvaA:
15.1		 3ou7C-2xvaA:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		7 / 12 GLY Y  32
GLY Y  34
ASN Y  38
ALA Y  87
PHE Y 105
THR Y 109
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.8A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-3.5A)
 1.48A 3p2kA-4ox9Y:
31.7		 3p2kA-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		11 / 12 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
ALA Y  86
ALA Y  87
LEU Y 104
PHE Y 105
THR Y 109
LEU Y 110
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.5A)
 0.70A 3p2kA-4ox9Y:
31.7		 3p2kA-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		11 / 12 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
VAL Y  57
ALA Y  87
GLU Y  88
LEU Y 104
THR Y 109
LEU Y 110
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.5A)
 0.73A 3p2kB-4ox9Y:
31.4		 3p2kB-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		11 / 12 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ASN Y  60
ALA Y  86
ALA Y  87
LEU Y 104
PHE Y 105
LEU Y 110
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
G  A1486 ( 3.9A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.5A)
 0.64A 3p2kC-4ox9Y:
31.6		 3p2kC-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 5 ASN Y  38
ASP Y  55
GLU Y  88
THR Y 109
SER Y 195
 SFG  Y 301 ( 4.5A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-3.3A)
SFG  Y 301 ( 3.7A)
 0.81A 3p2kC-4ox9Y:
31.6		 3p2kC-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		6 / 12 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ALA Y  85
LEU Y 104
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
None
SFG  Y 301 (-4.6A)
 1.26A 3p2kD-4ox9Y:
30.9		 3p2kD-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		10 / 12 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ALA Y  86
ALA Y  87
LEU Y 104
LEU Y 110
TYR Y 113
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.0A)
None
SFG  Y 301 (-3.5A)
 0.70A 3p2kD-4ox9Y:
30.9		 3p2kD-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		9 / 12 GLY Y  32
PRO Y  56
ALA Y  86
ALA Y  87
LEU Y 104
LEU Y 110
TYR Y 113
SER Y 195
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-4.4A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.0A)
None
SFG  Y 301 ( 3.7A)
SFG  Y 301 (-3.5A)
 1.11A 3p2kD-4ox9Y:
30.9		 3p2kD-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P2K_D_SAMD6735_1
(16S RRNA METHYLASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ASN Y  38
ASP Y  55
GLU Y  88
THR Y 109
 SFG  Y 301 ( 4.5A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-3.3A)
 0.64A 3p2kD-4ox9Y:
30.9		 3p2kD-4ox9Y:
98.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.44A 3p97A-3lkzA:
41.1		 3p97A-3lkzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 3p97A-3lkzA:
41.1		 3p97A-3lkzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  86
TRP A  87
LYS A 105
HIS A 110
ASP A 146
ILE A 147
 SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 1.30A 3p97A-3lkzA:
41.1		 3p97A-3lkzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.49A 3p97C-3lkzA:
40.9		 3p97C-3lkzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
ASP A 131
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
 0.84A 3p97C-3lkzA:
40.9		 3p97C-3lkzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 1.15A 3p97C-3lkzA:
40.9		 3p97C-3lkzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.38A 3p97C-3lkzA:
40.9		 3p97C-3lkzA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 THR C 316
ASP C 361
GLU C 413
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
 0.72A 3qowA-5hr4C:
9.3		 3qowA-5hr4C:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.15A 3qwpA-3n71A:
38.3		 3qwpA-3n71A:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.46A 3qwpA-3n71A:
38.3		 3qwpA-3n71A:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.08A 3qwpA-3n71A:
38.3		 3qwpA-3n71A:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.55A 3qxyA-3n71A:
12.6		 3qxyA-3n71A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.51A 3qxyB-3n71A:
12.7
3qxyQ-3n71A:
undetectable		 3qxyB-3n71A:
21.31
3qxyQ-3n71A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.48A 3rc0A-3n71A:
11.8		 3rc0A-3n71A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.54A 3rc0B-3n71A:
12.6		 3rc0B-3n71A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 ASN A 205
HIS A 206
TYR A 252
PHE A 272
CYH A 274
 SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
 0.98A 3rq4A-3n71A:
7.2		 3rq4A-3n71A:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7B_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.61A 3s7bA-3n71A:
39.2		 3s7bA-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7F_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2
P53 PEPTIDE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 12 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.62A 3s7fA-3n71A:
39.3
3s7fI-3n71A:
undetectable		 3s7fA-3n71A:
30.83
3s7fI-3n71A:
2.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7J_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.60A 3s7jA-3n71A:
38.9		 3s7jA-3n71A:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 ASN A 205
HIS A 206
TYR A 252
PHE A 272
CYH A 274
 SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
 1.00A 3s8pA-3n71A:
6.0		 3s8pA-3n71A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
PHE A 272
CYH A 274
CYH A 276
 None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.09A 3s8pA-3n71A:
6.0		 3s8pA-3n71A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
PHE A 272
CYH A 274
CYH A 276
 None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.09A 3s8pB-3n71A:
7.1		 3s8pB-3n71A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASN A  44
LYS A  60
ASP A  86
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.3A)
SFG  A1198 (-3.9A)
 0.78A 3sglA-2xvaA:
9.7		 3sglA-2xvaA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  81
GLY A  83
LYS A 105
ASP A 131
VAL A 132
 SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
 0.88A 3sglA-3lkzA:
2.5		 3sglA-3lkzA:
16.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TG4_A_SAMA434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 10 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.58A 3tg4A-3n71A:
39.2		 3tg4A-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		12 / 12 ALA A 200
HIS A 201
LEU A 202
MET A 225
GLY A 227
LYS A 249
TYR A 250
HIS A 253
ALA A 277
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
None
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-4.9A)
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 (-3.1A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.25A 3tm4A-3tm5A:
54.6		 3tm4A-3tm5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 5 HIS A 198
SER A 228
THR A 230
GLU A 248
ASP A 276
 SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
 0.36A 3tm4A-3tm5A:
54.6		 3tm4A-3tm5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		12 / 12 ALA A 200
HIS A 201
LEU A 202
MET A 225
GLY A 227
LYS A 249
TYR A 250
HIS A 253
ALA A 277
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
None
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-4.9A)
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 (-3.1A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.24A 3tm4B-3tm5A:
55.1		 3tm4B-3tm5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 5 HIS A 198
SER A 228
THR A 230
GLU A 248
ASP A 276
 SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
 0.39A 3tm4B-3tm5A:
55.1		 3tm4B-3tm5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		7 / 12 MET A 225
GLY A 227
SER A 228
THR A 230
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.67A 3v8vA-3tm5A:
31.1		 3v8vA-3tm5A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 291
ASP A 293
ASP A 318
PRO A 339
LEU A 367
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 1.19A 3v8vB-2yxlA:
13.4		 3v8vB-2yxlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 291
ASP A 293
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 1.10A 3v8vB-2yxlA:
13.4		 3v8vB-2yxlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 11 MET A 225
GLY A 227
ASP A 276
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.4A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.59A 3v8vB-3tm5A:
27.7		 3v8vB-3tm5A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY Y  32
GLY Y  36
ASN Y  38
ALA Y  87
LEU Y 110
 SFG  Y 301 (-3.9A)
None
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.0A)
 1.08A 3vywC-4ox9Y:
7.1		 3vywC-4ox9Y:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY Y  34
LEU Y  31
ASP Y  30
ASN Y  38
ILE Y  54
 SFG  Y 301 (-3.1A)
None
SFG  Y 301 ( 4.7A)
SFG  Y 301 ( 4.5A)
None
 1.20A 3wdmA-4ox9Y:
undetectable		 3wdmA-4ox9Y:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
GLY A 272
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.75A 4b17A-2yxlA:
10.5		 4b17A-2yxlA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 SER A  56
GLY A  81
GLY A  85
GLY A  86
TRP A  87
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.62A 4b17A-3lkzA:
13.0		 4b17A-3lkzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 ASP A  79
GLY A  83
GLY A  86
HIS A 110
ASP A 146
 SFG  A 301 ( 4.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.8A)
 1.21A 4blvB-3lkzA:
undetectable		 4blvB-3lkzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 ASN A 205
HIS A 206
TYR A 252
PHE A 272
CYH A 274
 SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
 1.04A 4bupA-3n71A:
5.9		 4bupA-3n71A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
PHE A 272
CYH A 274
CYH A 276
 None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.06A 4bupA-3n71A:
5.9		 4bupA-3n71A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
PHE A 272
CYH A 274
CYH A 276
 None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.09A 4bupB-3n71A:
7.5		 4bupB-3n71A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A 136
LEU A 124
GLY A  95
THR A  99
VAL A 133
 None
None
SFG  A 500 (-4.0A)
None
None
 1.38A 4c9kB-3a4tA:
undetectable		 4c9kB-3a4tA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.45A 4ctjA-3lkzA:
41.3		 4ctjA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
LYS A 105
GLU A 111
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.89A 4ctjA-3lkzA:
41.3		 4ctjA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 4ctjA-3lkzA:
41.3		 4ctjA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
THR A 104
LYS A 105
HIS A 110
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
 0.89A 4ctjC-3lkzA:
41.0		 4ctjC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.42A 4ctjC-3lkzA:
41.0		 4ctjC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
LYS A 105
GLU A 111
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 1.19A 4ctjC-3lkzA:
41.0		 4ctjC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  58
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.88A 4ctjC-3lkzA:
41.0		 4ctjC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 4ctjC-3lkzA:
41.0		 4ctjC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.42A 4ctkA-3lkzA:
41.2		 4ctkA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.36A 4ctkA-3lkzA:
41.2		 4ctkA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 4ctkC-3lkzA:
40.9		 4ctkC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.36A 4ctkC-3lkzA:
40.9		 4ctkC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 SER A  56
GLY A  58
GLY A  83
GLY A  86
THR A 104
GLU A 111
VAL A 132
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.94A 4ctkC-3lkzA:
40.9		 4ctkC-3lkzA:
54.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 5 GLY A 492
ILE A 491
VAL A 464
SER A 461
 SFG  A 700 ( 4.9A)
SFG  A 700 (-4.1A)
None
SFG  A 700 (-2.9A)
 1.01A 4d33A-4onqA:
undetectable		 4d33A-4onqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 5 GLY A 492
ILE A 491
VAL A 464
SER A 461
 SFG  A 700 ( 4.9A)
SFG  A 700 (-4.1A)
None
SFG  A 700 (-2.9A)
 1.02A 4d33B-4onqA:
undetectable		 4d33B-4onqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 6 GLY A 492
ILE A 491
VAL A 464
SER A 461
 SFG  A 700 ( 4.9A)
SFG  A 700 (-4.1A)
None
SFG  A 700 (-2.9A)
 1.01A 4d39B-4onqA:
undetectable		 4d39B-4onqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 291
ASP A 293
ALA A 319
ASP A 337
PRO A 339
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.65A 4dmgA-2yxlA:
14.4		 4dmgA-2yxlA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 291
ASP A 293
ALA A 319
ASP A 337
PRO A 339
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.76A 4dmgB-2yxlA:
14.5		 4dmgB-2yxlA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.62A 4e47A-3n71A:
6.4		 4e47A-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.60A 4e47B-3n71A:
5.7		 4e47B-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.61A 4e47C-3n71A:
6.4		 4e47C-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.32A 4fp9A-2yxlA:
28.2		 4fp9A-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.05A 4fp9A-3a4tA:
26.3		 4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.50A 4fp9A-3a4tA:
26.3		 4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.30A 4fp9C-2yxlA:
28.2		 4fp9C-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 4fp9C-3a4tA:
26.3		 4fp9C-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.50A 4fp9C-3a4tA:
26.3		 4fp9C-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.40A 4fp9D-2yxlA:
28.3		 4fp9D-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 CYH A  91
GLY A  95
LYS A  97
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.9A)
None
 1.06A 4fp9D-3a4tA:
26.4		 4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
 0.68A 4fp9D-3a4tA:
26.4		 4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.32A 4fp9F-2yxlA:
28.1		 4fp9F-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 4fp9F-3a4tA:
26.3		 4fp9F-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.49A 4fp9F-3a4tA:
26.3		 4fp9F-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.36A 4fzvA-2yxlA:
28.1		 4fzvA-2yxlA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
 0.69A 4fzvA-3a4tA:
26.1		 4fzvA-3a4tA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 227
ILE A 231
ASN A 293
LEU A 294
PRO A 295
 SFG  A 401 ( 3.7A)
None
SFG  A 401 (-4.4A)
None
SFG  A 401 ( 4.4A)
 0.96A 4gc9A-3tm5A:
11.2		 4gc9A-3tm5A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 LEU A 202
GLY A 227
ILE A 231
LYS A 249
ASN A 293
PRO A 295
 SFG  A 401 (-4.5A)
SFG  A 401 ( 3.7A)
None
SFG  A 401 (-4.9A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
 0.90A 4gc9A-3tm5A:
11.2		 4gc9A-3tm5A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 ARG A  19
LEU A 203
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-3.9A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.51A 4ij8A-3n71A:
6.4
4ij8B-3n71A:
6.8		 4ij8A-3n71A:
15.45
4ij8B-3n71A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 LYS A  17
ARG A  19
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.64A 4ij8A-3n71A:
6.4
4ij8B-3n71A:
6.8		 4ij8A-3n71A:
15.45
4ij8B-3n71A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 LYS A  17
LEU A  21
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 1.19A 4ij8A-3n71A:
6.4
4ij8B-3n71A:
6.8		 4ij8A-3n71A:
15.45
4ij8B-3n71A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_B_SAMB501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 9 LYS A  17
ARG A  19
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.67A 4ij8A-3n71A:
6.4
4ij8B-3n71A:
6.8		 4ij8A-3n71A:
15.45
4ij8B-3n71A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.60A 4jdsA-3n71A:
7.3		 4jdsA-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.61A 4jdsB-3n71A:
6.4		 4jdsB-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.60A 4jdsC-3n71A:
7.3		 4jdsC-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.64A 4jlgA-3n71A:
6.0		 4jlgA-3n71A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 270
GLY A 272
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.51A 4n48B-2yxlA:
10.6		 4n48B-2yxlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A  94
GLY A  96
ASP A 142
ASP A 163
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.46A 4n48B-3a4tA:
9.6		 4n48B-3a4tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 ARG A  37
GLY A 196
VAL A 214
GLY A 202
ILE A 234
 None
None
None
SFG  A 491 (-4.1A)
None
 0.95A 4njvA-3n71A:
undetectable		 4njvA-3n71A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 ARG A  37
GLY A 196
VAL A 214
GLY A 202
ILE A 234
 None
None
None
SFG  A 491 (-4.1A)
None
 0.95A 4njvB-3n71A:
undetectable		 4njvB-3n71A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 ARG A  37
GLY A 196
VAL A 214
GLY A 202
ILE A 234
 None
None
None
SFG  A 491 (-4.1A)
None
 0.96A 4njvC-3n71A:
undetectable		 4njvC-3n71A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		3 / 3 SER A  56
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.56A 4uckA-3lkzA:
8.8		 4uckA-3lkzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		4 / 6 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.56A 4uckB-3lkzA:
9.5		 4uckB-3lkzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 7 ASN C 481
PRO C 482
PHE C 535
PHE C 563
 SFG  C1002 (-3.8A)
None
None
None
 1.49A 4v32C-5hr4C:
undetectable		 4v32C-5hr4C:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE Y  68
VAL Y  81
ASP Y  55
THR Y  33
ILE Y  39
 None
None
SFG  Y 301 (-2.8A)
None
None
 1.38A 4xe0A-4ox9Y:
undetectable		 4xe0A-4ox9Y:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YND_A_SAMA505_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 10 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.64A 4yndA-3n71A:
37.6		 4yndA-3n71A:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.32A 4ynmA-3n71A:
6.1		 4ynmA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.83A 4ynmA-3n71A:
6.1		 4ynmA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.12A 4ynmB-3n71A:
6.1		 4ynmB-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.40A 4ynmB-3n71A:
6.1		 4ynmB-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 0.96A 4ynpA-3n71A:
6.0		 4ynpA-3n71A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.32A 4ynpA-3n71A:
6.0		 4ynpA-3n71A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.97A 4ynpA-3n71A:
6.0		 4ynpA-3n71A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.32A 4ynpA-3n71A:
6.0		 4ynpA-3n71A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.32A 4ynpB-3n71A:
6.2		 4ynpB-3n71A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.31A 4ypaA-3n71A:
6.0		 4ypaA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.85A 4ypaA-3n71A:
6.0		 4ypaA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.31A 4ypaB-3n71A:
6.1		 4ypaB-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.74A 4ypaB-3n71A:
6.1		 4ypaB-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.34A 4ypaC-3n71A:
6.0		 4ypaC-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.79A 4ypaC-3n71A:
6.0		 4ypaC-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.32A 4ypaD-3n71A:
6.0		 4ypaD-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.75A 4ypaD-3n71A:
6.0		 4ypaD-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.35A 4ypeA-3n71A:
6.1		 4ypeA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.81A 4ypeA-3n71A:
6.1		 4ypeA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.36A 4ypeB-3n71A:
6.3		 4ypeB-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 11 LYS A  17
GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.80A 4ypeB-3n71A:
6.3		 4ypeB-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.11A 4ypuA-3n71A:
6.1		 4ypuA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.41A 4ypuA-3n71A:
6.1		 4ypuA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.33A 4ypuA-3n71A:
6.1		 4ypuA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.97A 4ypuA-3n71A:
6.1		 4ypuA-3n71A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 LEU A  92
SER A  93
PRO A  94
GLY A 118
GLU A 121
GLY A 122
SER A 137
ILE A 138
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.1A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.32A 4yvgA-5wyrA:
30.2		 4yvgA-5wyrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
None
None
None
SFG  A 491 (-3.7A)
 1.47A 5arfA-3n71A:
39.0		 5arfA-3n71A:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 12 LYS A  17
GLY A  18
ARG A  19
HIS A 135
ASN A 180
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.66A 5arfA-3n71A:
39.0		 5arfA-3n71A:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ARG_A_SAMA1434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.71A 5argA-3n71A:
39.2		 5argA-3n71A:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.61A 5ayfA-3n71A:
6.3		 5ayfA-3n71A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		7 / 12 GLY Y  32
GLY Y  34
ASP Y  55
PRO Y  56
GLU Y  88
LEU Y 104
LEU Y 110
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-4.4A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.0A)
 0.48A 5bw4A-4ox9Y:
26.3		 5bw4A-4ox9Y:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE
(Escherichia
coli) 		6 / 12 GLY Y  32
GLY Y  34
PRO Y  56
ALA Y  86
LEU Y 104
LEU Y 110
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.0A)
 0.58A 5bw4B-4ox9Y:
27.5		 5bw4B-4ox9Y:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.17A 5cclA-3n71A:
37.9		 5cclA-3n71A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.47A 5cclA-3n71A:
37.9		 5cclA-3n71A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.10A 5cclA-3n71A:
37.9		 5cclA-3n71A:
29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.18A 5ccmA-3n71A:
38.1		 5ccmA-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.45A 5ccmA-3n71A:
38.1		 5ccmA-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.09A 5ccmA-3n71A:
38.1		 5ccmA-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.40A 5e9qA-3lkzA:
41.0		 5e9qA-3lkzA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.50A 5e9qA-3lkzA:
41.0		 5e9qA-3lkzA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5e9qA-3lkzA:
41.0		 5e9qA-3lkzA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.55A 5e9qC-3lkzA:
41.0		 5e9qC-3lkzA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5e9qC-3lkzA:
41.0		 5e9qC-3lkzA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.36A 5ec8A-3lkzA:
40.9		 5ec8A-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.57A 5ec8A-3lkzA:
40.9		 5ec8A-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.46A 5ec8C-3lkzA:
40.6		 5ec8C-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
VAL A 132
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
 0.76A 5ec8C-3lkzA:
40.6		 5ec8C-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5ec8C-3lkzA:
40.6		 5ec8C-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.53A 5ehgA-3lkzA:
41.0		 5ehgA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5ehgA-3lkzA:
41.0		 5ehgA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.36A 5ehgC-3lkzA:
40.8		 5ehgC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.38A 5ehgC-3lkzA:
40.8		 5ehgC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 1.43A 5ehgC-3lkzA:
40.8		 5ehgC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.39A 5ehiA-3lkzA:
41.1		 5ehiA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.41A 5ehiA-3lkzA:
41.1		 5ehiA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
GLU A 111
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
 0.93A 5ehiA-3lkzA:
41.1		 5ehiA-3lkzA:
54.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.47A 5ehiC-3lkzA:
41.1		 5ehiC-3lkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.64A 5ehiC-3lkzA:
41.1		 5ehiC-3lkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
LYS A 105
GLU A 111
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
 1.06A 5ehiC-3lkzA:
41.1		 5ehiC-3lkzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.47A 5eifA-3lkzA:
41.2		 5eifA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5eifA-3lkzA:
41.2		 5eifA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.48A 5eifC-3lkzA:
41.0		 5eifC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.72A 5eifC-3lkzA:
41.0		 5eifC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5eifC-3lkzA:
41.0		 5eifC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.24A 5eiwA-3lkzA:
41.1		 5eiwA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
 0.41A 5eiwA-3lkzA:
41.1		 5eiwA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.30A 5eiwA-3lkzA:
41.1		 5eiwA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
VAL A 132
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
 0.36A 5eiwA-3lkzA:
41.1		 5eiwA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
GLU A 111
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
 0.86A 5eiwA-3lkzA:
41.1		 5eiwA-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.43A 5eiwC-3lkzA:
41.0		 5eiwC-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5eiwC-3lkzA:
41.0		 5eiwC-3lkzA:
54.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.37A 5ekxA-3lkzA:
41.2		 5ekxA-3lkzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 SER A  56
GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.6A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.40A 5ekxA-3lkzA:
41.2		 5ekxA-3lkzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.43A 5ekxB-3lkzA:
41.2		 5ekxB-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  58
GLY A  83
GLY A  86
THR A 104
LYS A 105
GLU A 111
VAL A 132
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.83A 5ekxB-3lkzA:
41.2		 5ekxB-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5ekxB-3lkzA:
41.2		 5ekxB-3lkzA:
54.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  86
TRP A  87
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 1.49A 5ekxB-3lkzA:
41.2		 5ekxB-3lkzA:
54.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		3 / 3 THR C 316
ASP C 361
GLU C 413
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
 0.54A 5fa8A-5hr4C:
11.0		 5fa8A-5hr4C:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.58A 5hfjA-3tm5A:
3.5		 5hfjA-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ALA C 461
PRO C 483
GLY C 365
GLU C 413
GLU C 415
 SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
None
 0.53A 5hfjA-5hr4C:
undetectable		 5hfjA-5hr4C:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ALA A 277
PRO A 295
HIS A 198
GLY A 227
SER A 228
THR A 230
 SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 (-3.8A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
 0.65A 5hfjB-3tm5A:
3.3		 5hfjB-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
 0.66A 5hfjC-3tm5A:
3.5		 5hfjC-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		7 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
SER A 228
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.78A 5hfjD-3tm5A:
3.6		 5hfjD-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ALA C 461
PRO C 483
GLY C 365
GLU C 413
GLU C 415
 SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
SFG  C1002 (-3.4A)
SFG  C1002 (-2.8A)
None
 0.62A 5hfjD-5hr4C:
2.6		 5hfjD-5hr4C:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 322
ASP A 291
PRO A 339
PHE A 290
SER A 374
 None
SFG  A5748 (-2.9A)
SFG  A5748 (-4.0A)
None
None
 1.08A 5hfjE-2yxlA:
2.9		 5hfjE-2yxlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ASP A 276
ALA A 277
GLY A 227
SER A 228
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.57A 5hfjE-3tm5A:
5.8		 5hfjE-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 0.67A 5hfjF-3tm5A:
3.4		 5hfjF-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ASP A 276
PRO A 224
GLY A 227
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
None
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 1.27A 5hfjF-3tm5A:
3.4		 5hfjF-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 4 ASP A 276
HIS A 198
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 0.64A 5hfjG-3tm5A:
3.4		 5hfjG-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
 0.66A 5hfjH-3tm5A:
4.0		 5hfjH-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		5 / 11 PHE A 488
GLY A 490
GLU A 512
ASP A 539
VAL A 540
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.5A)
SFG  A 700 (-2.1A)
SFG  A 700 ( 4.4A)
SFG  A 700 (-4.2A)
 0.67A 5hjiA-4onqA:
6.1		 5hjiA-4onqA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.32A 5ikmA-3lkzA:
41.1		 5ikmA-3lkzA:
62.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.34A 5ikmA-3lkzA:
41.1		 5ikmA-3lkzA:
62.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  83
GLY A  86
THR A 104
LYS A 105
VAL A 132
 SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
 0.95A 5ikmA-3lkzA:
41.1		 5ikmA-3lkzA:
62.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		5 / 12 GLY A 490
GLY A 493
LYS A 513
ASP A 539
VAL A 540
 SFG  A 700 (-3.5A)
SFG  A 700 (-3.6A)
SFG  A 700 (-3.4A)
SFG  A 700 ( 4.4A)
SFG  A 700 (-4.2A)
 0.89A 5ikmA-4onqA:
3.0		 5ikmA-4onqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.51A 5jhnA-3n71A:
5.7		 5jhnA-3n71A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.53A 5jhnB-3n71A:
5.7		 5jhnB-3n71A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.51A 5jiyA-3n71A:
5.6		 5jiyA-3n71A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.53A 5jiyB-3n71A:
5.7		 5jiyB-3n71A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.56A 5jj0B-3n71A:
5.7		 5jj0B-3n71A:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJK_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.61A 5kjkA-3n71A:
39.2		 5kjkA-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJL_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.62A 5kjlA-3n71A:
39.1		 5kjlA-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJM_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.61A 5kjmA-3n71A:
39.3		 5kjmA-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KJN_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		9 / 11 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.69A 5kjnA-3n71A:
39.2		 5kjnA-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.46A 5kqrA-3lkzA:
42.1		 5kqrA-3lkzA:
65.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.46A 5kqsA-3lkzA:
41.8		 5kqsA-3lkzA:
65.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.41A 5kqsA-3lkzA:
41.8		 5kqsA-3lkzA:
65.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.36A 5kqsA-3lkzA:
41.8		 5kqsA-3lkzA:
65.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 9 ALA A 290
ILE A 231
GLY A 246
ILE A 247
PRO A 295
 None
None
None
None
SFG  A 401 ( 4.4A)
 1.04A 5kr2A-3tm5A:
undetectable		 5kr2A-3tm5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		3 / 3 ASN A 205
TYR A 252
CYH A 274
 SFG  A 491 (-3.3A)
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.28A 5lsuB-3n71A:
5.7		 5lsuB-3n71A:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
ASP A 131
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.54A 5m5bA-3lkzA:
42.1		 5m5bA-3lkzA:
67.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
GLU A 111
ASP A 131
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
 0.56A 5m5bA-3lkzA:
42.1		 5m5bA-3lkzA:
67.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
 0.52A 5m5bA-3lkzA:
42.1		 5m5bA-3lkzA:
67.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.44A 5m5bA-3lkzA:
42.1		 5m5bA-3lkzA:
67.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 8 GLU A 248
LYS A 249
ASP A 276
ASN A 293
 SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.4A)
SFG  A 401 (-4.4A)
 0.57A 5mvsB-3tm5A:
12.5		 5mvsB-3tm5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1
(Aquifex
aeolicus) 		3 / 3 HIS A 110
ASN A  83
ALA A  57
 SO4  A 506 (-3.8A)
SFG  A 501 ( 4.7A)
None
 0.78A 5n4tB-3axsA:
2.0		 5n4tB-3axsA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_A_SAMA301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.38A 5njvA-3lkzA:
41.9		 5njvA-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_A_SAMA301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.49A 5njvA-3lkzA:
41.9		 5njvA-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_A_SAMA301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.35A 5njvA-3lkzA:
41.9		 5njvA-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.43A 5njvB-3lkzA:
42.5		 5njvB-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.53A 5njvB-3lkzA:
42.5		 5njvB-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.37A 5njvB-3lkzA:
42.5		 5njvB-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  86
TRP A  87
LYS A 105
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 1.43A 5njvB-3lkzA:
42.5		 5njvB-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_C_SAMC301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.50A 5njvC-3lkzA:
41.1		 5njvC-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_C_SAMC301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		8 / 12 GLY A  58
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 1.46A 5njvC-3lkzA:
41.1		 5njvC-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_C_SAMC301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.38A 5njvC-3lkzA:
41.1		 5njvC-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_D_SAMD301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.51A 5njvD-3lkzA:
40.8		 5njvD-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_D_SAMD301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
LYS A 105
GLU A 111
VAL A 132
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
 0.96A 5njvD-3lkzA:
40.8		 5njvD-3lkzA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_D_SAMD301_0
(NS5)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		9 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
LYS A 105
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.79A 5njvD-3lkzA:
40.8		 5njvD-3lkzA:
63.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  92
PRO A  94
GLY A 118
GLY A 122
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-4.2A)
 0.75A 5o96A-5wyrA:
6.9
5o96B-5wyrA:
2.6		 5o96A-5wyrA:
undetectable
5o96B-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A  94
GLY A 118
GLY A 122
VAL A 142
LEU A 143
 SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
 0.63A 5o96G-5wyrA:
6.7
5o96H-5wyrA:
7.0		 5o96G-5wyrA:
undetectable
5o96H-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.46A 5t0kA-3n71A:
5.6		 5t0kA-3n71A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.46A 5t0kB-3n71A:
5.6		 5t0kB-3n71A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.53A 5t0mB-3n71A:
5.6		 5t0mB-3n71A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 9 ARG A  19
LEU A 203
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-3.9A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.52A 5tegA-3n71A:
6.9
5tegD-3n71A:
undetectable		 5tegA-3n71A:
15.04
5tegD-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 9 LYS A  17
ARG A  19
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.60A 5tegA-3n71A:
6.9
5tegD-3n71A:
undetectable		 5tegA-3n71A:
15.04
5tegD-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 9 LYS A  17
LEU A  21
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 1.20A 5tegA-3n71A:
6.9
5tegD-3n71A:
undetectable		 5tegA-3n71A:
15.04
5tegD-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 10 GLY A  18
ARG A  19
LEU A 203
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.9A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.51A 5tegB-3n71A:
7.8
5tegE-3n71A:
undetectable		 5tegB-3n71A:
15.04
5tegE-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 10 LYS A  17
GLY A  18
ARG A  19
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 0.55A 5tegB-3n71A:
7.8
5tegE-3n71A:
undetectable		 5tegB-3n71A:
15.04
5tegE-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 10 LYS A  17
LEU A  21
ASN A 205
HIS A 206
TYR A 252
 SFG  A 491 (-4.7A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
 1.19A 5tegB-3n71A:
7.8
5tegE-3n71A:
undetectable		 5tegB-3n71A:
15.04
5tegE-3n71A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.41A 5ttfA-3n71A:
5.6		 5ttfA-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.35A 5ttfB-3n71A:
5.7		 5ttfB-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.32A 5ttfC-3n71A:
5.7		 5ttfC-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.26A 5ttfD-3n71A:
5.7		 5ttfD-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.29A 5ttgA-3n71A:
5.7		 5ttgA-3n71A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.30A 5ttgB-3n71A:
5.5		 5ttgB-3n71A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.40A 5tuyA-3n71A:
5.9		 5tuyA-3n71A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.48A 5tuyB-3n71A:
5.9		 5tuyB-3n71A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.30A 5tuzA-3n71A:
5.8		 5tuzA-3n71A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.33A 5tuzB-3n71A:
5.6		 5tuzB-3n71A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 161
GLY A 162
SER A 184
LEU A 190
VAL A 195
 SFG  A 206 ( 4.7A)
SFG  A 206 (-3.2A)
SFG  A 206 (-3.3A)
SFG  A 206 (-4.4A)
SFG  A 206 (-4.8A)
 0.47A 5twjA-3bbhA:
6.2		 5twjA-3bbhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.71A 5twjA-5wyrA:
9.4		 5twjA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 161
GLY A 162
SER A 184
LEU A 190
VAL A 195
 SFG  A 206 ( 4.7A)
SFG  A 206 (-3.2A)
SFG  A 206 (-3.3A)
SFG  A 206 (-4.4A)
SFG  A 206 (-4.8A)
 0.48A 5twjC-3bbhA:
6.4		 5twjC-3bbhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 0.95A 5updA-3n71A:
5.8		 5updA-3n71A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.51A 5updA-3n71A:
5.8		 5updA-3n71A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 HIS A 206
TYR A 252
CYH A 274
CYH A 276
LEU A 266
 None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
None
 1.30A 5updA-3n71A:
5.8		 5updA-3n71A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 GLY A  18
TYR A 271
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.13A 5v21A-3n71A:
5.7		 5v21A-3n71A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  16
TYR A 271
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.50A 5v21A-3n71A:
5.7		 5v21A-3n71A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		6 / 12 LYS A  17
GLY A  18
TYR A 271
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.47A 5v21A-3n71A:
5.7		 5v21A-3n71A:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.18A 5v37A-3n71A:
38.2		 5v37A-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.51A 5v37A-3n71A:
38.2		 5v37A-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.15A 5v37A-3n71A:
38.2		 5v37A-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V3H_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		8 / 10 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
 0.54A 5v3hA-3n71A:
37.9		 5v3hA-3n71A:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.40A 5v9iA-3n71A:
5.5		 5v9iA-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.35A 5v9iB-3n71A:
5.6		 5v9iB-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.30A 5v9iC-3n71A:
5.5		 5v9iC-3n71A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.31A 5v9jA-3n71A:
5.7		 5v9jA-3n71A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.31A 5v9jB-3n71A:
5.6		 5v9jB-3n71A:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.57A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  81
GLY A  83
GLY A  86
LYS A 105
VAL A 132
PHE A 133
ILE A 147
 SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
None
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
 0.93A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  85
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.97A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
 SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
 1.48A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		4 / 4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.40A 5vimA-3lkzA:
42.2		 5vimA-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.48A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
LYS A 105
HIS A 110
GLU A 111
VAL A 132
PHE A 133
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
 0.75A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		7 / 12 GLY A  81
GLY A  85
HIS A 110
GLU A 111
PHE A 133
ILE A 147
LYS A 182
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.2A)
SFG  A 301 (-4.1A)
SFG  A 301 ( 4.1A)
 0.93A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		4 / 4 SER A  56
THR A 104
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.32A 5vimB-3lkzA:
42.1		 5vimB-3lkzA:
69.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.46A 5vscA-3n71A:
5.7		 5vscA-3n71A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.46A 5vscB-3n71A:
5.8		 5vscB-3n71A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.30A 5vsdA-3n71A:
5.7		 5vsdA-3n71A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.33A 5vsdB-3n71A:
5.7		 5vsdB-3n71A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.46A 5vseA-3n71A:
5.8		 5vseA-3n71A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.47A 5vseB-3n71A:
5.6		 5vseB-3n71A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.31A 5vsfA-3n71A:
5.8		 5vsfA-3n71A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.32A 5vsfB-3n71A:
5.7		 5vsfB-3n71A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		4 / 5 GLY A 493
TRP A 524
VAL A 521
SER A 489
 SFG  A 700 (-3.6A)
None
None
None
 1.34A 5vunA-4onqA:
undetectable		 5vunA-4onqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
PHE A 272
CYH A 274
CYH A 276
 None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.08A 5wbvA-3n71A:
5.9		 5wbvA-3n71A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
PHE A 272
CYH A 274
CYH A 276
 None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.08A 5wbvB-3n71A:
7.0		 5wbvB-3n71A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 269
PRO A 270
ASP A 291
ASP A 318
LEU A 367
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
None
 0.93A 5wwsA-2yxlA:
32.2		 5wwsA-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 269
PRO A 270
GLY A 272
ASP A 291
ASP A 318
ASP A 337
LEU A 367
LEU A 371
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
None
None
 0.31A 5wwsA-2yxlA:
32.2		 5wwsA-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  93
PRO A  94
ASP A 142
ASP A  89
LEU A 193
 SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 ( 4.4A)
None
 1.08A 5wwsA-3a4tA:
29.5		 5wwsA-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 CYH A  91
ALA A  93
PRO A  94
GLY A  96
ASP A 142
ASP A 163
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
None
 0.50A 5wwsA-3a4tA:
29.5		 5wwsA-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 ALA A 269
PRO A 270
GLY A 272
LYS A 273
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.36A 5wwsB-2yxlA:
35.6		 5wwsB-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 CYH A  91
ALA A  93
PRO A  94
GLY A  96
LYS A  97
ASP A 142
ASP A 163
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.41A 5wwsB-3a4tA:
29.5		 5wwsB-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  40
ASP A  59
ASN A  61
LEU A 108
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
None
SFG  A1198 (-4.8A)
 0.52A 5wy0A-2xvaA:
14.0		 5wy0A-2xvaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 LEU A  92
PRO A  94
GLN A  95
GLY A 118
GLY A 122
SER A 137
ILE A 138
VAL A 142
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.22A 5wyqA-5wyrA:
32.6		 5wyqA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 TYR A  91
LEU A  92
PRO A  94
GLN A  95
GLY A 118
SER A 137
ILE A 138
TYR A 141
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.6A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.24A 5wyqB-5wyrA:
31.4		 5wyqB-5wyrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.61A 5wz1A-3lkzA:
41.7		 5wz1A-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.45A 5wz1B-3lkzA:
41.7		 5wz1B-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-4.1A)
 0.59A 5wz1B-3lkzA:
41.7		 5wz1B-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.47A 5wz1C-3lkzA:
41.6		 5wz1C-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.59A 5wz1C-3lkzA:
41.6		 5wz1C-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.48A 5wz1D-3lkzA:
41.7		 5wz1D-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.58A 5wz1D-3lkzA:
41.7		 5wz1D-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.49A 5wz1E-3lkzA:
41.6		 5wz1E-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.60A 5wz1E-3lkzA:
41.6		 5wz1E-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.48A 5wz1F-3lkzA:
41.7		 5wz1F-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.58A 5wz1F-3lkzA:
41.7		 5wz1F-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.45A 5wz1G-3lkzA:
41.6		 5wz1G-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.59A 5wz1G-3lkzA:
41.6		 5wz1G-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.48A 5wz1H-3lkzA:
41.6		 5wz1H-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.60A 5wz1H-3lkzA:
41.6		 5wz1H-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  85
TRP A  87
GLU A 111
ASP A 146
ILE A 147
 SFG  A 301 (-3.5A)
SFG  A 301 ( 4.4A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 1.17A 5wz1H-3lkzA:
41.6		 5wz1H-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.49A 5wz2A-3lkzA:
41.8		 5wz2A-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.32A 5wz2A-3lkzA:
41.8		 5wz2A-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		12 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
ASP A 131
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-3.1A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.43A 5wz2B-3lkzA:
42.0		 5wz2B-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.33A 5wz2B-3lkzA:
42.0		 5wz2B-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		11 / 12 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LYS A 105
HIS A 110
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.9A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.57A 5wz2C-3lkzA:
41.8		 5wz2C-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		10 / 12 GLY A  58
GLY A  81
GLY A  83
TRP A  87
THR A 104
LYS A 105
GLU A 111
VAL A 132
ASP A 146
ILE A 147
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
None
SFG  A 301 (-3.7A)
SFG  A 301 (-4.1A)
SFG  A 301 (-3.8A)
SFG  A 301 (-4.1A)
 0.75A 5wz2C-3lkzA:
41.8		 5wz2C-3lkzA:
61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		6 / 12 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.34A 5wz2C-3lkzA:
41.8		 5wz2C-3lkzA:
61.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 9 ILE C 290
LEU C 298
GLY C 296
PHE C 295
ASN C 368
 None
None
None
None
SFG  C1002 (-4.1A)
 1.39A 5x66C-5hr4C:
undetectable		 5x66C-5hr4C:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.17A 5xxdA-3n71A:
38.1		 5xxdA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.49A 5xxdA-3n71A:
38.1		 5xxdA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.16A 5xxdA-3n71A:
38.1		 5xxdA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.15A 5xxgA-3n71A:
38.2		 5xxgA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.48A 5xxgA-3n71A:
38.2		 5xxgA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.13A 5xxgA-3n71A:
38.2		 5xxgA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.19A 5xxjA-3n71A:
38.3		 5xxjA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.43A 5xxjA-3n71A:
38.3		 5xxjA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.10A 5xxjA-3n71A:
38.3		 5xxjA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 ALA C 363
GLY C 365
PRO C 418
LEU C 462
ASN C 481
 SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
None
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
 0.57A 5ybbA-5hr4C:
16.9		 5ybbA-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		4 / 5 THR C 316
ASP C 361
GLU C 413
ASN C 460
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.2A)
 0.53A 5ybbA-5hr4C:
16.9		 5ybbA-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 THR C 316
ASP C 361
CYH C 366
LEU C 462
ASN C 481
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-3.2A)
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
 1.04A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 THR C 316
ASP C 361
PRO C 418
LEU C 462
ASN C 481
PRO C 483
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
None
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.62A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 7 ALA C 363
GLY C 365
GLY C 367
GLU C 413
ASN C 460
 SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
None
SFG  C1002 (-2.8A)
SFG  C1002 (-3.2A)
 0.74A 5ybbB-5hr4C:
16.9		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.20A 5yjoA-3n71A:
38.2		 5yjoA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		7 / 12 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.46A 5yjoA-3n71A:
38.2		 5yjoA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.13A 5yjoA-3n71A:
38.2		 5yjoA-3n71A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		3 / 3 MET A 210
ASP A 223
ARG A 194
 None
None
SFG  A 401 ( 4.9A)
 1.17A 5z6jA-3tm5A:
2.7		 5z6jA-3tm5A:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
PRO A 270
GLY A 272
LYS A 273
ASP A 318
ALA A 319
ARG A 320
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.32A 5zvgA-2yxlA:
38.4		 5zvgA-2yxlA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  96
LYS A  97
SER A 117
ASP A 142
ARG A 144
PRO A 165
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
None
SFG  A 500 (-3.9A)
 0.61A 5zvgA-3a4tA:
31.7		 5zvgA-3a4tA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
PRO A 270
GLY A 272
LYS A 273
ASP A 318
ALA A 319
ARG A 320
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.32A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  96
LYS A  97
SER A 117
ASP A 142
ARG A 144
PRO A 165
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
None
SFG  A 500 (-3.9A)
 0.65A 5zvgB-3a4tA:
31.7		 5zvgB-3a4tA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ARG A 296
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.89A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 GLU A 115
ARG A 120
ASP A 142
ASP A 163
 SFG  A 500 (-2.6A)
SFG  A 500 (-4.4A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.86A 5zw4A-3a4tA:
15.2		 5zw4A-3a4tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.10A 6a5kA-3n71A:
5.4		 6a5kA-3n71A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.42A 6a5kA-3n71A:
5.4		 6a5kA-3n71A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.35A 6a5mA-3n71A:
5.4		 6a5mA-3n71A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 HIS A 206
TYR A 252
CYH A 274
CYH A 276
LEU A 266
 None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
None
 1.16A 6a5mA-3n71A:
5.4		 6a5mA-3n71A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  16
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 None
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.26A 6agoA-3n71A:
6.0		 6agoA-3n71A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 0.97A 6agoA-3n71A:
6.0		 6agoA-3n71A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.92A 6agoA-3n71A:
6.0		 6agoA-3n71A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.31A 6agoA-3n71A:
6.0		 6agoA-3n71A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.35A 6bp4A-3n71A:
5.4		 6bp4A-3n71A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 0.94A 6bp4B-3n71A:
5.5		 6bp4B-3n71A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.85A 6bp4B-3n71A:
5.5		 6bp4B-3n71A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.41A 6bp4B-3n71A:
5.5		 6bp4B-3n71A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 291
ASP A 293
ASP A 318
ALA A 319
LEU A 371
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
None
 0.83A 6bq4A-2yxlA:
11.3		 6bq4A-2yxlA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 11 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.53A 6cenA-3n71A:
5.6		 6cenA-3n71A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 185
SER A  61
TRP A 193
ILE A 198
CYH A 196
 SFG  A 206 (-4.5A)
None
None
None
None
 1.24A 6gsdA-3bbhA:
undetectable		 6gsdA-3bbhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 0.92A 6ineA-3n71A:
5.8		 6ineA-3n71A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.39A 6ineA-3n71A:
5.8		 6ineA-3n71A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  16
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.36A 6ineA-3n71A:
5.8		 6ineA-3n71A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.00A 6ineA-3n71A:
5.8		 6ineA-3n71A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1
(Mus
musculus) 		5 / 12 LYS A  17
GLY A  18
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 (-4.7A)
SFG  A 491 ( 4.2A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 1.32A 6ineA-3n71A:
5.8		 6ineA-3n71A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4onq DNA
METHYLTRANSFERASE
(Nicotiana
tabacum) 		6 / 12 PHE A 488
GLY A 490
GLY A 493
ASP A 539
ASN A 460
SER A 461
 SFG  A 700 (-4.5A)
SFG  A 700 (-3.5A)
SFG  A 700 (-3.6A)
SFG  A 700 ( 4.4A)
None
SFG  A 700 (-2.9A)
 0.66A 6mhtA-4onqA:
6.7		 6mhtA-4onqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2xva TELLURITE RESISTANCE
PROTEIN TEHB
(Escherichia
coli) 		5 / 12 ASP A  36
GLY A  38
GLY A  40
LYS A  60
ASP A  86
 SFG  A1198 ( 4.7A)
SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.3A)
SFG  A1198 (-3.9A)
 0.63A 6nj9K-2xvaA:
11.8		 6nj9K-2xvaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3lkz NON-STRUCTURAL
PROTEIN 5
(West
Nile
virus) 		5 / 12 ASP A  79
GLY A  81
GLY A  83
LYS A 105
ASP A 131
 SFG  A 301 ( 4.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.1A)
 0.86A 6nj9K-3lkzA:
7.6		 6nj9K-3lkzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		6 / 12 LEU C 428
ILE C 290
LEU C 298
GLY C 296
PHE C 295
ASN C 368
 None
None
None
None
None
SFG  C1002 (-4.1A)
 1.19A 6qxsB-5hr4C:
undetectable		 6qxsB-5hr4C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 12 LEU C 428
ILE C 290
LEU C 298
GLY C 296
ASN C 368
 None
None
None
None
SFG  C1002 (-4.1A)
 1.00A 6qxsD-5hr4C:
undetectable		 6qxsD-5hr4C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5hr4 MMEI
(Methylophilus
methylotrophus) 		5 / 11 ILE C 290
LEU C 298
GLY C 296
PHE C 295
ASN C 368
 None
None
None
None
SFG  C1002 (-4.1A)
 1.33A 6r2eG-5hr4C:
undetectable		 6r2eG-5hr4C:
15.67