SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SFE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.94A 1eizA-2ykyA:
2.5		 1eizA-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.92A 1ej0A-2ykyA:
2.7		 1ej0A-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 TYR A  89
GLY A 170
TYR A 172
GLU A 220
GLY A 226
 SFE  A1546 (-4.0A)
None
SFE  A1546 ( 3.7A)
PLP  A1446 (-3.9A)
None
 1.15A 3f8wA-2ykyA:
undetectable		 3f8wA-2ykyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 TYR A  89
GLY A 170
TYR A 172
GLU A 220
GLY A 226
 SFE  A1546 (-4.0A)
None
SFE  A1546 ( 3.7A)
PLP  A1446 (-3.9A)
None
 1.17A 3f8wB-2ykyA:
undetectable		 3f8wB-2ykyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 PHE A 133
LEU A 368
LEU A 269
MET A 268
TYR A 333
 None
SFE  A1447 (-4.9A)
SFE  A1447 ( 4.5A)
SFE  A1447 ( 4.2A)
None
 1.20A 3vn2A-2ykyA:
undetectable		 3vn2A-2ykyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 171
GLY A 170
GLY A 224
ALA A 225
GLN A 266
 None
None
None
SFE  A1546 (-3.4A)
None
 1.05A 4rtmA-2ykyA:
undetectable		 4rtmA-2ykyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		3 / 3 SER A 383
LEU A 368
MET A 222
 None
SFE  A1447 (-4.9A)
None
 0.58A 5ikrB-2ykyA:
undetectable		 5ikrB-2ykyA:
23.38