SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SFD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		4 / 8 SER A 111
LEU A  42
TYR A  15
VAL A   6
 SFD  A1418 (-2.8A)
SFD  A1418 (-4.4A)
None
None
 1.07A 1fduB-2vfvA:
undetectable		 1fduB-2vfvA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 11 GLY A 164
ALA A 165
ALA A 398
LEU A 397
VAL A 415
 SFD  A1418 (-3.4A)
None
None
None
None
 1.16A 1ukbA-2vfvA:
undetectable		 1ukbA-2vfvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 1.11A 2bm9A-2vfvA:
undetectable		 2bm9A-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 1.02A 2bm9C-2vfvA:
undetectable		 2bm9C-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 1.13A 2bm9D-2vfvA:
undetectable		 2bm9D-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.85A 2br4A-2vfvA:
undetectable		 2br4A-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.92A 2br4C-2vfvA:
undetectable		 2br4C-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.91A 2br4D-2vfvA:
undetectable		 2br4D-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.87A 2br4E-2vfvA:
undetectable		 2br4E-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.91A 2br4F-2vfvA:
undetectable		 2br4F-2vfvA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VFT_A_SORA1419_0
(XYLITOL OXIDASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		12 / 12 HIS A 248
PRO A 249
VAL A 250
HIS A 274
PHE A 275
GLN A 288
THR A 318
GLU A 320
ARG A 322
HIS A 343
THR A 345
LYS A 375
 None
None
None
None
None
SFD  A1418 (-3.2A)
None
SFD  A1418 ( 4.7A)
SFD  A1418 (-2.9A)
SFD  A1418 (-3.4A)
None
SFD  A1418 (-2.7A)
 0.23A 2vftA-2vfvA:
71.6		 2vftA-2vfvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VFU_A_MTLA1419_0
(XYLITOL OXIDASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		12 / 12 SER A 106
HIS A 248
PRO A 249
VAL A 250
HIS A 274
PHE A 275
GLN A 288
THR A 318
ARG A 322
HIS A 343
THR A 345
LYS A 375
 SFD  A1418 (-2.9A)
None
None
None
None
None
SFD  A1418 (-3.2A)
None
SFD  A1418 (-2.9A)
SFD  A1418 (-3.4A)
None
SFD  A1418 (-2.7A)
 0.32A 2vfuA-2vfvA:
72.0		 2vfuA-2vfvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VFU_A_MTLA1419_0
(XYLITOL OXIDASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 SER A 106
HIS A 274
PHE A 275
THR A 345
ARG A 322
 SFD  A1418 (-2.9A)
None
None
None
SFD  A1418 (-2.9A)
 1.11A 2vfuA-2vfvA:
72.0		 2vfuA-2vfvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		4 / 6 LEU A  42
SER A  62
ALA A  64
LEU A  60
 SFD  A1418 (-4.4A)
None
None
None
 1.00A 3ravA-2vfvA:
undetectable		 3ravA-2vfvA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 PHE A 394
ALA A  52
TRP A 373
ALA A 117
THR A 118
 None
SFD  A1418 ( 4.3A)
None
SFD  A1418 (-3.2A)
SFD  A1418 (-2.8A)
 1.24A 4fiaA-2vfvA:
undetectable		 4fiaA-2vfvA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 PHE A 394
ALA A  52
TRP A 373
ALA A 117
THR A 118
 None
SFD  A1418 ( 4.3A)
None
SFD  A1418 (-3.2A)
SFD  A1418 (-2.8A)
 1.24A 4fiaA-2vfvA:
undetectable		 4fiaA-2vfvA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 10 ALA A  52
ASN A  49
ILE A  13
GLY A  55
VAL A   6
 SFD  A1418 ( 4.3A)
None
None
None
None
 1.08A 4j5jB-2vfvA:
undetectable		 4j5jB-2vfvA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 12 GLN A 288
GLU A 320
SER A 106
LEU A 107
ILE A 110
 SFD  A1418 (-3.2A)
SFD  A1418 ( 4.7A)
SFD  A1418 (-2.9A)
SFD  A1418 ( 4.3A)
SFD  A1418 (-4.1A)
 1.26A 4k38A-2vfvA:
undetectable
4k38D-2vfvA:
undetectable		 4k38A-2vfvA:
22.15
4k38D-2vfvA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		3 / 3 LEU A 107
ILE A 110
ARG A  86
 SFD  A1418 ( 4.3A)
SFD  A1418 (-4.1A)
None
 0.42A 4mk4B-2vfvA:
undetectable		 4mk4B-2vfvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		5 / 9 ASN A  12
GLY A  11
ALA A  10
GLY A  45
VAL A 376
 None
None
None
SFD  A1418 (-3.4A)
None
 1.04A 5kr0B-2vfvA:
undetectable		 5kr0B-2vfvA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2vfv XYLITOL OXIDASE
(Streptomyces
coelicolor) 		6 / 12 LEU A  60
LEU A  20
GLY A  45
GLY A  43
GLY A  84
PRO A  23
 None
None
SFD  A1418 (-3.4A)
SFD  A1418 (-3.0A)
None
None
 1.36A 6ce2B-2vfvA:
undetectable		 6ce2B-2vfvA:
11.99