SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SEY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.27A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.26A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.27A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.27A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 PRO A  70
GLY A  73
LEU A 116
ARG A  59
PHE A  66
 None
None
None
None
SEY  A 402 (-4.8A)
 1.31A 2b9eA-4ezdA:
undetectable		 2b9eA-4ezdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 6 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.39A 2vmyA-6cczA:
57.3		 2vmyA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ILE A 530
ALA A 525
LEU A 109
PHE A 117
THR A 526
 None
None
None
None
SEY  A 610 ( 3.7A)
 1.13A 2w9sD-6cczA:
undetectable		 2w9sD-6cczA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ILE A 530
ALA A 525
LEU A 109
PHE A 117
THR A 526
 None
None
None
None
SEY  A 610 ( 3.7A)
 1.14A 2w9sF-6cczA:
undetectable		 2w9sF-6cczA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 7 TYR A 119
PHE A  66
PHE A 296
ASN A 120
 SEY  A 402 (-3.7A)
SEY  A 402 (-4.8A)
None
None
 0.96A 2zseA-4ezdA:
undetectable		 2zseA-4ezdA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A303_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5v51 PR-1 PROTEIN
(Moniliophthora
perniciosa) 		4 / 4 ASN A 161
SER A 115
SER A 109
ARG A 114
 SEY  A 201 (-4.7A)
None
None
None
 1.17A 3hlwA-5v51A:
undetectable		 3hlwA-5v51A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5v51 PR-1 PROTEIN
(Moniliophthora
perniciosa) 		4 / 5 ASN A 161
SER A 115
SER A 109
ARG A 114
 SEY  A 201 (-4.7A)
None
None
None
 1.16A 3hlwB-5v51A:
undetectable		 3hlwB-5v51A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 9 ARG A 454
LEU A 410
ASN A 408
VAL A 383
GLY A 295
 ACT  A 612 (-2.9A)
None
SEY  A 605 (-4.4A)
None
None
 1.14A 3spkA-6cczA:
undetectable		 3spkA-6cczA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		3 / 3 PRO A 336
THR A 334
LEU A 287
 None
SEY  A 401 ( 4.7A)
None
 0.75A 3ttrA-4ezdA:
undetectable		 3ttrA-4ezdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5v51 PR-1 PROTEIN
(Moniliophthora
perniciosa) 		5 / 12 ASP A 113
SER A 115
THR A 160
ALA A 162
ALA A 123
 None
None
None
SEY  A 201 ( 3.7A)
SEY  A 201 ( 4.0A)
 1.47A 4u15A-5v51A:
undetectable		 4u15A-5v51A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 GLY A 333
VAL A  64
ILE A 228
GLY A 230
ILE A 130
 SEY  A 401 (-3.6A)
None
None
SEY  A 401 ( 4.0A)
None
 0.92A 6dj1B-4ezdA:
undetectable		 6dj1B-4ezdA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 GLY A 333
VAL A  64
ILE A 228
GLY A 230
ILE A 130
 SEY  A 401 (-3.6A)
None
None
SEY  A 401 ( 4.0A)
None
 0.95A 6dj2B-4ezdA:
undetectable		 6dj2B-4ezdA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5v51 PR-1 PROTEIN
(Moniliophthora
perniciosa) 		3 / 3 ASN A  90
PRO A 117
GLN A 119
 None
None
SEY  A 201 (-4.9A)
 0.87A 6jnhA-5v51A:
undetectable		 6jnhA-5v51A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5v51 PR-1 PROTEIN
(Moniliophthora
perniciosa) 		3 / 3 ASN A  90
PRO A 117
GLN A 119
 None
None
SEY  A 201 (-4.9A)
 0.88A 6jogA-5v51A:
undetectable		 6jogA-5v51A:
19.90