SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SER'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 10 GLY A 506
SER A 505
LEU A 387
THR A 614
LEU A 500
 GLY  A 506 ( 0.0A)
SER  A 505 ( 0.0A)
LEU  A 387 ( 0.5A)
THR  A 614 ( 0.8A)
LEU  A 500 ( 0.6A)
 1.38A 1a8uA-4mtpA:
undetectable		 1a8uA-4mtpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 9 VAL A 509
GLY A 426
ALA A 427
PHE A 470
ILE A 451
 None
None
None
SER  A 603 (-4.3A)
None
 0.97A 1cetA-4yj5A:
3.0		 1cetA-4yj5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 8 GLY A  86
GLY A 149
LEU A 150
SER A 108
 GLY  A  86 ( 0.0A)
GLY  A 149 ( 0.0A)
LEU  A 150 ( 0.6A)
SER  A 108 ( 0.0A)
 0.71A 1d0vA-5xluA:
undetectable		 1d0vA-5xluA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 0.99A 1dfoA-2ogsA:
undetectable		 1dfoA-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 0.99A 1dfoB-2ogsA:
undetectable		 1dfoB-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 0.99A 1dfoC-2ogsA:
undetectable		 1dfoC-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 0.99A 1dfoD-2ogsA:
undetectable		 1dfoD-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1ng0 COAT PROTEIN
(Cocksfoot
mottle
virus) 		5 / 12 ALA A  94
SER A 239
ILE A 241
PRO A 110
LEU A 243
 ALA  A  94 ( 0.0A)
SER  A 239 ( 0.0A)
ILE  A 241 ( 0.7A)
PRO  A 110 ( 1.1A)
LEU  A 243 ( 0.6A)
 0.99A 1drfA-1ng0A:
undetectable		 1drfA-1ng0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 300
GLY A  56
GLY A  57
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.01A 1dx6A-4mwtA:
8.6		 1dx6A-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 PHE A  26
LEU A 330
SER A 308
 PHE  A  26 ( 1.3A)
LEU  A 330 ( 0.6A)
SER  A 308 ( 0.0A)
 0.92A 1e7aA-2nvvA:
undetectable		 1e7aA-2nvvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 PHE A  29
LEU A  70
SER A  57
 PHE  A  29 ( 1.3A)
LEU  A  70 ( 0.6A)
SER  A  57 ( 0.0A)
 0.81A 1e7aA-3r9rA:
undetectable		 1e7aA-3r9rA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 MET A 648
LEU A 651
SER A 652
 MET  A 648 ( 0.0A)
LEU  A 651 ( 0.5A)
SER  A 652 ( 0.0A)
 0.65A 1ee2A-5c6dA:
undetectable		 1ee2A-5c6dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 1.00A 1eqbA-2ogsA:
undetectable		 1eqbA-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 1.01A 1eqbB-2ogsA:
undetectable		 1eqbB-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 1.00A 1eqbC-2ogsA:
undetectable		 1eqbC-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 1.01A 1eqbD-2ogsA:
undetectable		 1eqbD-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 HIS A  35
GLU A  99
ALA A 102
SER A 109
 HIS  A  35 ( 1.0A)
GLU  A  99 ( 0.5A)
ALA  A 102 ( 0.0A)
SER  A 109 ( 0.0A)
 1.11A 1errA-4mwtA:
undetectable
1errB-4mwtA:
undetectable		 1errA-4mwtA:
20.65
1errB-4mwtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5x5l ADER
(Acinetobacter
baumannii) 		3 / 3 GLU A 204
ALA A 202
SER A 200
 GLU  A 204 ( 0.6A)
ALA  A 202 ( 0.0A)
SER  A 200 ( 0.0A)
 0.68A 1errB-5x5lA:
undetectable		 1errB-5x5lA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		5 / 12 LEU A 150
GLY A  86
SER A 233
PHE A 236
MET A 162
 LEU  A 150 ( 0.6A)
GLY  A  86 ( 0.0A)
SER  A 233 ( 0.0A)
PHE  A 236 ( 1.3A)
MET  A 162 ( 0.0A)
 1.42A 1fdsA-5xluA:
undetectable		 1fdsA-5xluA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 VAL A 551
GLY A 552
LEU A 593
LEU A 620
SER A 619
 VAL  A 551 ( 0.6A)
GLY  A 552 ( 0.0A)
LEU  A 593 ( 0.5A)
LEU  A 620 ( 0.6A)
SER  A 619 ( 0.0A)
 1.04A 1fduA-1v0fA:
undetectable		 1fduA-1v0fA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 7 GLU A  71
SER A  89
THR A  87
VAL A 104
ALA A  79
 GLU  A  71 ( 0.6A)
SER  A  89 ( 0.0A)
THR  A  87 ( 0.8A)
VAL  A 104 ( 0.6A)
ALA  A  79 ( 0.0A)
 1.23A 1fo4B-1wsvA:
undetectable		 1fo4B-1wsvA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1ng0 COAT PROTEIN
(Cocksfoot
mottle
virus) 		4 / 6 ALA A  94
SER A  85
TRP A 236
LEU A  95
 ALA  A  94 ( 0.0A)
SER  A  85 ( 0.0A)
TRP  A 236 ( 0.5A)
LEU  A  95 ( 0.6A)
 1.18A 1gahA-1ng0A:
undetectable		 1gahA-1ng0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE
(Thymus
vulgaris) 		4 / 8 LEU A 562
LEU A 482
TYR A 478
SER A 416
 LEU  A 562 ( 0.6A)
LEU  A 482 ( 0.5A)
TYR  A 478 ( 1.3A)
SER  A 416 ( 0.0A)
 1.20A 1hk2A-5c05A:
2.2		 1hk2A-5c05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 VAL A 177
SER A 174
ASN A 171
ASP A 225
 VAL  A 177 ( 0.6A)
SER  A 174 ( 0.0A)
ASN  A 171 ( 0.6A)
ASP  A 225 ( 0.6A)
 1.29A 1hwiC-1vhoA:
undetectable		 1hwiC-1vhoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 VAL A 177
SER A 174
ASN A 171
ASP A 225
 VAL  A 177 ( 0.6A)
SER  A 174 ( 0.0A)
ASN  A 171 ( 0.6A)
ASP  A 225 ( 0.6A)
 1.29A 1hwiD-1vhoA:
undetectable		 1hwiD-1vhoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 LEU A 384
ALA A 387
LEU A 411
LEU A 417
SER A 418
 LEU  A 384 ( 0.5A)
ALA  A 387 ( 0.0A)
LEU  A 411 ( 0.5A)
LEU  A 417 ( 0.5A)
SER  A 418 ( 0.0A)
 1.24A 1ictA-5cdnA:
undetectable
1ictC-5cdnA:
undetectable		 1ictA-5cdnA:
14.55
1ictC-5cdnA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 1.04A 1ictB-4w65A:
undetectable		 1ictB-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 PHE A 381
GLY A 397
SER A 244
PHE A 395
 PHE  A 381 ( 1.3A)
GLY  A 397 ( 0.0A)
SER  A 244 ( 0.0A)
PHE  A 395 ( 1.3A)
 1.34A 1icuC-2vbfA:
undetectable
1icuD-2vbfA:
undetectable		 1icuC-2vbfA:
18.27
1icuD-2vbfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1aoa T-FIMBRIN
(Homo
sapiens) 		5 / 8 VAL A 211
VAL A 165
SER A 203
ILE A 207
LEU A 230
 VAL  A 211 ( 0.6A)
VAL  A 165 ( 0.6A)
SER  A 203 ( 0.0A)
ILE  A 207 ( 0.7A)
LEU  A 230 ( 0.6A)
 1.34A 1igxA-1aoaA:
undetectable		 1igxA-1aoaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 SER A  31
GLY A  57
LEU A 305
GLY A  25
GLU A 329
 SER  A  31 ( 0.0A)
GLY  A  57 ( 0.0A)
LEU  A 305 ( 0.6A)
GLY  A  25 ( 0.0A)
GLU  A 329 ( 0.6A)
 1.45A 1iolA-3i4kA:
3.3		 1iolA-3i4kA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 1jdvE-4g41A:
23.8
1jdvF-4g41A:
23.7		 1jdvE-4g41A:
24.70
1jdvF-4g41A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.81A 1jdvE-4g41A:
23.8
1jdvF-4g41A:
23.7		 1jdvE-4g41A:
24.70
1jdvF-4g41A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 8 GLU A 393
SER A 216
GLU A 221
LEU A 218
 GLU  A 393 (-0.6A)
SER  A 216 ( 0.0A)
GLU  A 221 (-0.6A)
LEU  A 218 ( 0.6A)
 0.86A 1jg4A-3ulkA:
3.6		 1jg4A-3ulkA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 8 GLY A  86
GLY A 149
LEU A 150
SER A 108
 GLY  A  86 ( 0.0A)
GLY  A 149 ( 0.0A)
LEU  A 150 ( 0.6A)
SER  A 108 ( 0.0A)
 0.72A 1jhaA-5xluA:
undetectable		 1jhaA-5xluA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 PHE A 718
GLU A 721
GLY A 720
SER A 700
 PHE  A 718 ( 1.3A)
GLU  A 721 ( 0.6A)
GLY  A 720 ( 0.0A)
SER  A 700 ( 0.0A)
 1.16A 1kqbC-1v0fA:
undetectable
1kqbD-1v0fA:
undetectable		 1kqbC-1v0fA:
14.61
1kqbD-1v0fA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 SER A 379
LEU A  13
TYR A   6
GLY A 361
 SER  A 379 ( 0.0A)
LEU  A  13 ( 0.6A)
TYR  A   6 ( 1.3A)
GLY  A 361 (-0.0A)
 1.48A 1liiA-5d7wA:
undetectable		 1liiA-5d7wA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1tza APAG PROTEIN
(Shewanella
oneidensis) 		4 / 8 ASP A   5
GLU A  41
GLY A  40
SER A 104
 ASP  A   5 ( 0.6A)
GLU  A  41 ( 0.6A)
GLY  A  40 ( 0.0A)
SER  A 104 ( 0.0A)
 0.89A 1m4iA-1tzaA:
undetectable		 1m4iA-1tzaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 300
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.23A 1maaA-4mwtA:
11.4		 1maaA-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  57
GLU A 149
SER A 150
HIS A 429
 GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 0.79A 1maaD-4mwtA:
11.4		 1maaD-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 6 SER A 181
ASN A 186
LEU A 190
ASP A 187
 SER  A 181 ( 0.0A)
ASN  A 186 ( 0.6A)
LEU  A 190 ( 0.6A)
ASP  A 187 ( 0.6A)
 1.16A 1mxdA-4mwtA:
undetectable		 1mxdA-4mwtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 SER A  99
LEU A 136
ASP A 120
GLU A 175
 SER  A  99 ( 0.0A)
LEU  A 136 ( 0.6A)
ASP  A 120 ( 0.5A)
GLU  A 175 ( 0.6A)
 1.21A 1mxgA-2qc5A:
undetectable		 1mxgA-2qc5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 SER A 181
ASN A 186
LEU A 190
ASP A 187
 SER  A 181 ( 0.0A)
ASN  A 186 ( 0.6A)
LEU  A 190 ( 0.6A)
ASP  A 187 ( 0.6A)
 1.12A 1mxgA-4mwtA:
undetectable		 1mxgA-4mwtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 12 GLY A 136
SER A 139
ALA A 165
ASP A  95
ILE A 135
 GLY  A 136 ( 0.0A)
SER  A 139 ( 0.0A)
ALA  A 165 ( 0.0A)
ASP  A  95 ( 0.6A)
ILE  A 135 ( 0.7A)
 1.12A 1nt2A-1rynA:
undetectable		 1nt2A-1rynA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ASP A 274
PRO A 235
LYS A 342
SER A 265
ALA A 273
 ASP  A 274 ( 0.6A)
PRO  A 235 ( 1.1A)
LYS  A 342 ( 0.0A)
SER  A 265 ( 0.0A)
ALA  A 273 ( 0.0A)
 1.27A 1nw5A-2vbfA:
undetectable		 1nw5A-2vbfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.22A 1nx9A-1rrvA:
3.4		 1nx9A-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.19A 1nx9A-2ogsA:
10.2		 1nx9A-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.24A 1nx9B-1rrvA:
3.3		 1nx9B-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.19A 1nx9B-2ogsA:
16.6		 1nx9B-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.23A 1nx9C-1rrvA:
3.4		 1nx9C-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.18A 1nx9C-2ogsA:
10.2		 1nx9C-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.23A 1nx9D-1rrvA:
3.8		 1nx9D-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 369
TYR A 348
GLU A 373
SER A 224
 ARG  A 369 ( 0.6A)
TYR  A 348 ( 1.3A)
GLU  A 373 ( 0.5A)
SER  A 224 ( 0.0A)
 1.18A 1nx9D-2ogsA:
16.5		 1nx9D-2ogsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.92A 1odiC-4g41A:
23.2		 1odiC-4g41A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1
(Rattus
norvegicus) 		4 / 6 GLY A 344
VAL A 292
ALA A 340
SER A 342
 GLY  A 344 ( 0.0A)
VAL  A 292 ( 0.6A)
ALA  A 340 ( 0.0A)
SER  A 342 ( 0.0A)
 1.02A 1p6kA-2pnnA:
undetectable		 1p6kA-2pnnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.40A 1p6kB-4mwtA:
undetectable		 1p6kB-4mwtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.64A 1pk7A-4g41A:
25.1		 1pk7A-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.90A 1pk7C-4g41A:
24.6		 1pk7C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.80A 1pk7C-4g41A:
24.6		 1pk7C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.74A 1pk9A-4g41A:
25.0		 1pk9A-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.66A 1pk9A-4g41A:
25.0		 1pk9A-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.72A 1pk9B-4g41A:
24.6		 1pk9B-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.91A 1pk9C-4g41A:
24.8		 1pk9C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.74A 1pk9C-4g41A:
24.8		 1pk9C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.68A 1pw7A-4g41A:
25.1		 1pw7A-4g41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 1pw7C-4g41A:
24.7		 1pw7C-4g41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6c0w CENTROMERE PROTEIN N
(Homo
sapiens) 		5 / 12 THR K 163
SER K 164
LEU K 112
VAL K 119
ALA K 136
 THR  K 163 ( 0.8A)
SER  K 164 ( 0.0A)
LEU  K 112 ( 0.6A)
VAL  K 119 ( 0.6A)
ALA  K 136 ( 0.0A)
 1.48A 1q23D-6c0wK:
2.7
1q23E-6c0wK:
undetectable		 1q23D-6c0wK:
15.28
1q23E-6c0wK:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 12 GLU A 329
ASN A 347
GLY A 363
SER A 311
ILE A 328
 GLU  A 329 (-0.6A)
ASN  A 347 (-0.6A)
GLY  A 363 (-0.0A)
SER  A 311 ( 0.0A)
ILE  A 328 ( 0.7A)
 1.12A 1q8jB-5d7wA:
undetectable		 1q8jB-5d7wA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		6 / 12 ASP A 300
GLY A  56
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.14A 1qtiA-4mwtA:
9.6		 1qtiA-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 8 SER A 112
ARG A 116
ASN A 135
TRP A 320
 SER  A 112 ( 0.0A)
ARG  A 116 ( 0.6A)
ASN  A 135 ( 0.6A)
TRP  A 320 ( 0.5A)
 1.27A 1rs6A-3ulkA:
undetectable		 1rs6A-3ulkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.42A 1rs6B-4mwtA:
undetectable		 1rs6B-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Saccharomonospor
a
viridis) 		3 / 3 SER A 209
GLY A 208
ARG A  72
 SER  A 209 (-0.0A)
GLY  A 208 (-0.0A)
ARG  A  72 ( 0.6A)
 0.52A 1t9wA-4jbeA:
undetectable		 1t9wA-4jbeA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		3 / 3 SER A 125
GLY A 126
ARG A 143
 SER  A 125 ( 0.0A)
GLY  A 126 ( 0.0A)
ARG  A 143 ( 0.6A)
 0.67A 1t9wA-5nqfA:
undetectable		 1t9wA-5nqfA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 SER A 327
ILE A 301
GLY A 167
VAL A 382
ALA A 242
 SER  A 327 ( 0.0A)
ILE  A 301 ( 0.4A)
GLY  A 167 ( 0.0A)
VAL  A 382 ( 0.6A)
ALA  A 242 ( 0.0A)
 1.13A 1tsnA-3wd7A:
undetectable		 1tsnA-3wd7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 LEU A 227
ALA A 229
LEU A 170
SER A 233
 LEU  A 227 ( 0.6A)
ALA  A 229 ( 0.0A)
LEU  A 170 ( 0.5A)
SER  A 233 ( 0.0A)
 1.11A 1tt6B-4kqnA:
undetectable		 1tt6B-4kqnA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		4 / 7 ALA A3956
LEU A3954
SER A3951
VAL A3798
 ALA  A3956 ( 0.0A)
LEU  A3954 ( 0.6A)
SER  A3951 ( 0.0A)
VAL  A3798 ( 0.6A)
 0.99A 1tyrB-5w6lA:
undetectable		 1tyrB-5w6lA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.98A 1tz8C-4w65A:
undetectable
1tz8D-4w65A:
undetectable		 1tz8C-4w65A:
20.22
1tz8D-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 12 ALA A 139
LEU A 250
PHE A  57
SER A 127
ASN A  66
 ALA  A 139 ( 0.0A)
LEU  A 250 ( 0.6A)
PHE  A  57 ( 1.3A)
SER  A 127 ( 0.0A)
ASN  A  66 ( 0.6A)
 1.23A 1u72A-4w65A:
undetectable		 1u72A-4w65A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 12 ALA A 139
LEU A 250
PHE A  57
SER A 127
VAL A 278
 ALA  A 139 ( 0.0A)
LEU  A 250 ( 0.6A)
PHE  A  57 ( 1.3A)
SER  A 127 ( 0.0A)
VAL  A 278 ( 0.6A)
 1.29A 1u72A-4w65A:
undetectable		 1u72A-4w65A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 300
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.03A 1w76A-4mwtA:
13.1		 1w76A-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 300
GLY A  56
GLY A  57
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.00A 1w76B-4mwtA:
13.4		 1w76B-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2loe 6-CYSTEINE PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 PHE A 109
LEU A  99
PHE A 123
SER A  17
 PHE  A 109 ( 1.4A)
LEU  A  99 ( 0.6A)
PHE  A 123 ( 1.4A)
SER  A  17 ( 0.0A)
 1.20A 1wrlC-2loeA:
undetectable		 1wrlC-2loeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)
(Homo
sapiens) 		5 / 12 GLU A  52
SER A  54
PHE A  61
TYR A  24
ASN A 108
 GLU  A  52 (-0.6A)
SER  A  54 ( 0.0A)
PHE  A  61 ( 1.3A)
TYR  A  24 ( 1.3A)
ASN  A 108 (-0.6A)
 1.05A 1x70A-1szbA:
undetectable		 1x70A-1szbA:
11.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 315
LEU A 399
THR A 333
SER A 368
GLN A 369
 HIS  A 315 ( 1.0A)
LEU  A 399 ( 0.6A)
THR  A 333 ( 0.8A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
 1.31A 1xlxA-3sl5A:
51.0		 1xlxA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
LEU A 319
ASN A 321
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 1xlxA-3sl5A:
51.0		 1xlxA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.74A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.61A 1xmuA-3sl5A:
51.4		 1xmuA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.44A 1xmuB-3sl5A:
51.1		 1xmuB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.57A 1xomA-3sl5A:
53.0		 1xomA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.59A 1xomB-3sl5A:
52.8		 1xomB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.54A 1xoqA-3sl5A:
53.5		 1xoqA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.52A 1xoqA-3sl5A:
53.5		 1xoqA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.49A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.50A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
SER A 355
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
SER  A 355 ( 0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.02A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.74A 1xotA-3sl5A:
50.9		 1xotA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.59A 1xotB-3sl5A:
50.9		 1xotB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.73A 1xotB-3sl5A:
50.9		 1xotB-3sl5A:
84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 LEU A 104
SER A  76
LEU A  67
LEU A  63
 LEU  A 104 ( 0.6A)
SER  A  76 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  63 ( 0.5A)
 1.14A 1yajA-5hxkA:
undetectable		 1yajA-5hxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3s6f HYPOTHETICAL
ACETYLTRANSFERASE
(Deinococcus
radiodurans) 		4 / 4 GLY A  88
SER A  91
VAL A  80
LEU A   6
 GLY  A  88 (-0.0A)
SER  A  91 (-0.0A)
VAL  A  80 (-0.6A)
LEU  A   6 ( 0.5A)
 1.29A 1yajB-3s6fA:
undetectable		 1yajB-3s6fA:
14.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 8 GLY A 196
GLY A 107
GLY A 108
SER A 194
ALA A 195
 GLY  A 196 ( 0.0A)
GLY  A 107 ( 0.0A)
GLY  A 108 ( 0.0A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
 1.03A 1yajC-2ogsA:
47.9		 1yajC-2ogsA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 5 LEU A 104
SER A  76
LEU A  67
LEU A  63
 LEU  A 104 ( 0.6A)
SER  A  76 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  63 ( 0.5A)
 1.16A 1yajD-5hxkA:
undetectable		 1yajD-5hxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		3 / 3 SER A  44
VAL A 124
LEU A  96
 SER  A  44 ( 0.0A)
VAL  A 124 ( 0.6A)
LEU  A  96 ( 0.6A)
 0.62A 1yajG-3c3nA:
2.3		 1yajG-3c3nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5crc SDEA
(Legionella
pneumophila) 		4 / 4 GLY A  83
SER A  86
ILE A  66
HIS A  64
 GLY  A  83 ( 0.0A)
SER  A  86 ( 0.0A)
ILE  A  66 ( 0.7A)
HIS  A  64 ( 1.0A)
 1.25A 1yajJ-5crcA:
undetectable		 1yajJ-5crcA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1it2 HEMOGLOBIN
(Eptatretus
burgeri) 		4 / 6 ALA A  48
SER A  51
PHE A  45
ILE A 112
 ALA  A  48 ( 0.0A)
SER  A  51 (-0.0A)
PHE  A  45 ( 1.3A)
ILE  A 112 ( 0.4A)
 1.01A 1yc2A-1it2A:
undetectable		 1yc2A-1it2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 5 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.19A 1yvpA-5ec3A:
undetectable		 1yvpA-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 6 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.17A 1yvpB-5ec3A:
undetectable		 1yvpB-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 1z35A-4g41A:
23.2		 1z35A-4g41A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.80A 1z37A-4g41A:
23.1		 1z37A-4g41A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.81A 1z37A-4g41A:
23.1		 1z37A-4g41A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.41A 1zzqB-4mwtA:
undetectable		 1zzqB-4mwtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.42A 1zzuB-4mwtA:
undetectable		 1zzuB-4mwtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 TYR A 716
GLY A 597
SER A 605
ARG A 596
 TYR  A 716 ( 1.3A)
GLY  A 597 ( 0.0A)
SER  A 605 ( 0.0A)
ARG  A 596 ( 0.6A)
 1.24A 2a3cA-1v0fA:
undetectable		 2a3cA-1v0fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 TYR A 716
GLY A 597
SER A 605
ARG A 596
 TYR  A 716 ( 1.3A)
GLY  A 597 ( 0.0A)
SER  A 605 ( 0.0A)
ARG  A 596 ( 0.6A)
 1.22A 2a3cB-1v0fA:
undetectable		 2a3cB-1v0fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 8 GLY A  17
ASN A  42
SER A  43
GLN A  47
 GLY  A  17 ( 0.0A)
ASN  A  42 ( 0.6A)
SER  A  43 ( 0.0A)
GLN  A  47 (-0.6A)
 0.93A 2a8tB-4dlkA:
undetectable		 2a8tB-4dlkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 LEU A  50
SER A  54
ASP A  91
ALA A  29
ALA A  32
 LEU  A  50 ( 0.6A)
SER  A  54 ( 0.0A)
ASP  A  91 ( 0.6A)
ALA  A  29 ( 0.0A)
ALA  A  32 ( 0.0A)
 1.09A 2bm9A-5ec3A:
undetectable		 2bm9A-5ec3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 305
ALA A 117
LEU A 148
ASP A 108
 SER  A 305 ( 0.0A)
ALA  A 117 ( 0.0A)
LEU  A 148 ( 0.6A)
ASP  A 108 ( 0.6A)
 1.08A 2bxkA-2b92A:
undetectable		 2bxkA-2b92A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4c9g ADP, ATP CARRIER
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  89
SER A  85
ARG A 152
GLU A  81
 GLY  A  89 (-0.0A)
SER  A  85 ( 0.0A)
ARG  A 152 ( 0.6A)
GLU  A  81 ( 0.6A)
 0.93A 2c8aB-4c9gA:
undetectable		 2c8aB-4c9gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4c9g ADP, ATP CARRIER
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  89
SER A  85
ARG A 152
GLU A  81
 GLY  A  89 (-0.0A)
SER  A  85 ( 0.0A)
ARG  A 152 ( 0.6A)
GLU  A  81 ( 0.6A)
 0.99A 2c8aD-4c9gA:
undetectable		 2c8aD-4c9gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		4 / 8 SER A  62
ARG A  64
LEU A  66
GLU A  70
 SER  A  62 ( 0.0A)
ARG  A  64 ( 0.6A)
LEU  A  66 ( 0.5A)
GLU  A  70 ( 0.6A)
 0.99A 2cdqA-6gefA:
1.3		 2cdqA-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 7 ASP A 102
SER A  62
LEU A 105
GLU A 284
 ASP  A 102 ( 0.6A)
SER  A  62 ( 0.0A)
LEU  A 105 ( 0.6A)
GLU  A 284 ( 0.5A)
 1.10A 2cdqB-2nvvA:
undetectable		 2cdqB-2nvvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		4 / 7 SER A  62
ARG A  64
LEU A  66
GLU A  70
 SER  A  62 ( 0.0A)
ARG  A  64 ( 0.6A)
LEU  A  66 ( 0.5A)
GLU  A  70 ( 0.6A)
 1.10A 2cdqB-6gefA:
undetectable		 2cdqB-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Saccharomonospor
a
viridis) 		5 / 10 ALA A  34
LEU A 162
SER A 173
LEU A 170
ARG A  41
 ALA  A  34 ( 0.0A)
LEU  A 162 ( 0.6A)
SER  A 173 ( 0.0A)
LEU  A 170 ( 0.6A)
ARG  A  41 ( 0.6A)
 1.35A 2ceoB-4jbeA:
undetectable		 2ceoB-4jbeA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		8 / 11 VAL A  31
GLY A  32
GLY A  34
VAL A  39
ALA A  52
SER A 112
LEU A 160
ASP A 171
 VAL  A  31 (-0.6A)
GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
SER  A 112 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.72A 2evaA-5d7aA:
26.3		 2evaA-5d7aA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 ALA A 236
GLY A 205
ILE A 242
VAL A 230
ILE A 232
 None
SER  A 314 ( 4.7A)
None
None
None
 0.84A 2fxeA-3q1xA:
undetectable		 2fxeA-3q1xA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 SER  A1205 (-3.9A)
None
None
None
None
 0.95A 2h42C-5vawA:
undetectable		 2h42C-5vawA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5oie -
(-) 		4 / 8 TYR A 225
ASP A 182
TYR A 222
TYR A 375
 None
SER  A 507 (-3.3A)
None
None
 1.16A 2ha2A-5oieA:
undetectable		 2ha2A-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1nf3 PAR-6B
(Mus
musculus) 		5 / 12 LEU C 216
VAL C 246
SER C 178
VAL C 231
LEU C 242
 LEU  C 216 ( 0.6A)
VAL  C 246 ( 0.6A)
SER  C 178 ( 0.0A)
VAL  C 231 ( 0.6A)
LEU  C 242 ( 0.6A)
 1.17A 2hc4A-1nf3C:
undetectable		 2hc4A-1nf3C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 THR A  87
SER A 369
PRO A  52
SER A 368
 THR  A  87 ( 0.8A)
SER  A 369 ( 0.0A)
PRO  A  52 ( 1.1A)
SER  A 368 ( 0.0A)
 1.45A 2hdnA-4kqnA:
undetectable
2hdnB-4kqnA:
3.2
2hdnD-4kqnA:
3.6		 2hdnA-4kqnA:
7.37
2hdnB-4kqnA:
22.64
2hdnD-4kqnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 SER A 368
THR A  87
SER A 369
PRO A  52
 SER  A 368 ( 0.0A)
THR  A  87 ( 0.8A)
SER  A 369 ( 0.0A)
PRO  A  52 ( 1.1A)
 1.45A 2hdnB-4kqnA:
3.2
2hdnC-4kqnA:
undetectable
2hdnD-4kqnA:
3.3		 2hdnB-4kqnA:
22.64
2hdnC-4kqnA:
7.37
2hdnD-4kqnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		4 / 6 SER A 237
VAL A 200
THR A  91
ASP A  89
 SER  A 237 ( 0.0A)
VAL  A 200 ( 0.6A)
THR  A  91 ( 0.8A)
ASP  A  89 ( 0.6A)
 1.28A 2hdnJ-5ep8A:
2.4
2hdnK-5ep8A:
undetectable
2hdnL-5ep8A:
2.6		 2hdnJ-5ep8A:
21.43
2hdnK-5ep8A:
9.45
2hdnL-5ep8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 VAL  A 314 ( 0.6A)
ILE  A 303 ( 0.7A)
LEU  A 266 ( 0.6A)
ALA  A 318 ( 0.0A)
SER  A 301 ( 0.0A)
 1.28A 2iyfB-1fxjA:
2.4		 2iyfB-1fxjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 ASP A 429
SER A 451
LEU A 454
GLY A 448
 ASP  A 429 ( 0.5A)
SER  A 451 ( 0.0A)
LEU  A 454 ( 0.5A)
GLY  A 448 ( 0.0A)
 1.11A 2j2pA-5l5nA:
undetectable
2j2pB-5l5nA:
undetectable		 2j2pA-5l5nA:
11.41
2j2pB-5l5nA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  93
SER A 106
ASP A 498
ASP A 103
 LEU  A  93 ( 0.6A)
SER  A 106 ( 0.0A)
ASP  A 498 ( 0.6A)
ASP  A 103 ( 0.6A)
 1.15A 2j2pE-4g9kA:
undetectable
2j2pF-4g9kA:
undetectable		 2j2pE-4g9kA:
17.78
2j2pF-4g9kA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 SER A  42
LYS A  44
SER A  85
SER A  58
 SER  A  42 ( 0.0A)
LYS  A  44 ( 0.0A)
SER  A  85 ( 0.0A)
SER  A  58 ( 0.0A)
 1.11A 2j9cA-3qviA:
undetectable
2j9cB-3qviA:
undetectable
2j9cC-3qviA:
undetectable		 2j9cA-3qviA:
14.74
2j9cB-3qviA:
14.74
2j9cC-3qviA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 SER A  85
SER A  58
SER A  42
LYS A  44
 SER  A  85 ( 0.0A)
SER  A  58 ( 0.0A)
SER  A  42 ( 0.0A)
LYS  A  44 ( 0.0A)
 1.15A 2j9cA-3qviA:
undetectable
2j9cB-3qviA:
undetectable
2j9cC-3qviA:
undetectable		 2j9cA-3qviA:
14.74
2j9cB-3qviA:
14.74
2j9cC-3qviA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 11 GLY A  11
SER A  66
ILE A  75
ALA A  79
VAL A  62
 GLY  A  11 ( 0.0A)
SER  A  66 ( 0.0A)
ILE  A  75 ( 0.7A)
ALA  A  79 ( 0.0A)
VAL  A  62 ( 0.5A)
 1.09A 2nnhA-1rynA:
undetectable		 2nnhA-1rynA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 4 SER A 108
GLY A 145
HIS A 154
ASP A 164
 SER  A 108 ( 0.0A)
GLY  A 145 ( 0.0A)
HIS  A 154 ( 1.0A)
ASP  A 164 ( 0.5A)
 1.19A 2oxtC-5xluA:
undetectable		 2oxtC-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 6 ILE A  62
ARG A  64
SER A 319
MET A 290
 ILE  A  62 ( 0.6A)
ARG  A  64 (-0.6A)
SER  A 319 ( 0.0A)
MET  A 290 ( 0.0A)
 1.12A 2qd3B-4yzrA:
undetectable		 2qd3B-4yzrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3ig0 DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		3 / 3 SER A 453
TYR A 524
HIS A 525
 SER  A 453 ( 0.0A)
TYR  A 524 ( 1.3A)
HIS  A 525 ( 1.0A)
 0.74A 2r2vD-3ig0A:
undetectable		 2r2vD-3ig0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens) 		4 / 7 PHE A 163
PHE A 140
SER A 147
PHE A  42
 PHE  A 163 ( 1.3A)
PHE  A 140 ( 1.3A)
SER  A 147 ( 0.0A)
PHE  A  42 ( 1.3A)
 0.93A 2v0mC-5jjaA:
undetectable		 2v0mC-5jjaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE
(Thymus
vulgaris) 		4 / 8 VAL A 448
THR A 454
PRO A 453
SER A 457
 VAL  A 448 ( 0.5A)
THR  A 454 ( 0.8A)
PRO  A 453 ( 1.1A)
SER  A 457 ( 0.0A)
 0.95A 2v32C-5c05A:
undetectable
2v32D-5c05A:
undetectable		 2v32C-5c05A:
17.32
2v32D-5c05A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 1.03A 2vmyB-2ogsA:
undetectable		 2vmyB-2ogsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 VAL A 428
ILE A 350
LEU A 239
PHE A 238
SER A 386
 VAL  A 428 ( 0.6A)
ILE  A 350 ( 0.6A)
LEU  A 239 ( 0.6A)
PHE  A 238 ( 1.3A)
SER  A 386 ( 0.0A)
 1.11A 2w3vA-2nvvA:
undetectable		 2w3vA-2nvvA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		4 / 7 VAL A 302
GLY A 125
ALA A 124
SER A 300
 VAL  A 302 ( 0.6A)
GLY  A 125 ( 0.0A)
ALA  A 124 ( 0.0A)
SER  A 300 ( 0.0A)
 0.93A 2wekB-1wlyA:
32.3		 2wekB-1wlyA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 10 PHE A 345
SER A 344
SER A 286
GLY A 362
ALA A 358
 PHE  A 345 (-1.3A)
SER  A 344 (-0.0A)
SER  A 286 ( 0.0A)
GLY  A 362 ( 0.0A)
ALA  A 358 (-0.0A)
 1.31A 2x2iB-4yzrA:
undetectable		 2x2iB-4yzrA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5ve2 ENOYL-COA HYDRATASE
(Pseudoalteromona
s
atlantica) 		5 / 10 VAL A 184
SER A  15
SER A   8
ASN A  11
ALA A 191
 VAL  A 184 ( 0.6A)
SER  A  15 ( 0.0A)
SER  A   8 ( 0.0A)
ASN  A  11 ( 0.6A)
ALA  A 191 ( 0.0A)
 1.47A 2x2iB-5ve2A:
undetectable		 2x2iB-5ve2A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3pw9 UPF0603 PROTEIN
AT1G54780,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 PHE A 132
TYR A 216
VAL A 100
ALA A 224
LEU A 122
 None
GOL  A 302 ( 4.3A)
SER  A 305 (-4.5A)
None
None
 1.28A 2x2nC-3pw9A:
undetectable		 2x2nC-3pw9A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		4 / 4 VAL A 521
TYR A 520
VAL A 417
SER A 382
 VAL  A 521 ( 0.6A)
TYR  A 520 ( 1.3A)
VAL  A 417 ( 0.6A)
SER  A 382 ( 0.0A)
 1.17A 2x45B-5gprA:
undetectable		 2x45B-5gprA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5gru DIABODY PROTEIN
(Mus
musculus) 		3 / 3 SER L 215
THR L 218
PHE L 192
 SER  L 215 ( 0.0A)
THR  L 218 ( 0.8A)
PHE  L 192 ( 1.3A)
 0.64A 2x91A-5gruL:
undetectable		 2x91A-5gruL:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5ve2 ENOYL-COA HYDRATASE
(Pseudoalteromona
s
atlantica) 		3 / 3 ARG A 161
GLY A 160
SER A 140
 ARG  A 161 ( 0.6A)
GLY  A 160 ( 0.0A)
SER  A 140 ( 0.0A)
 0.60A 2xctB-5ve2A:
undetectable		 2xctB-5ve2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 197
GLU A 200
SER A  44
 ARG  A 197 ( 0.6A)
GLU  A 200 ( 0.6A)
SER  A  44 ( 0.0A)
 0.73A 2xctD-3r64A:
undetectable		 2xctD-3r64A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 4 ARG A 223
GLY A 222
GLU A 219
SER A 233
 ARG  A 223 ( 0.6A)
GLY  A 222 ( 0.0A)
GLU  A 219 ( 0.6A)
SER  A 233 ( 0.0A)
 1.41A 2xctS-4kqnA:
undetectable
2xctU-4kqnA:
undetectable		 2xctS-4kqnA:
20.86
2xctU-4kqnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 SER A 384
ALA A 382
GLY A 381
SER A 323
PHE A 359
 SER  A 384 ( 0.0A)
ALA  A 382 ( 0.0A)
GLY  A 381 ( 0.0A)
SER  A 323 ( 0.0A)
PHE  A 359 ( 1.3A)
 1.37A 2xf3A-5hiuA:
undetectable		 2xf3A-5hiuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 SER A 384
ALA A 382
GLY A 381
SER A 323
PHE A 359
 SER  A 384 ( 0.0A)
ALA  A 382 ( 0.0A)
GLY  A 381 ( 0.0A)
SER  A 323 ( 0.0A)
PHE  A 359 ( 1.3A)
 1.36A 2xf3B-5hiuA:
undetectable		 2xf3B-5hiuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5wm9 RV0078
(Mycobacterium
tuberculosis) 		3 / 3 SER A  12
ARG A  11
GLN A   8
 SER  A  12 ( 0.0A)
ARG  A  11 (-0.6A)
GLN  A   8 ( 0.6A)
 0.98A 2xnrA-5wm9A:
undetectable		 2xnrA-5wm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		4 / 5 SER A 213
ARG A 216
GLY A 221
TRP A 225
 SER  A 213 ( 0.0A)
ARG  A 216 ( 0.6A)
GLY  A 221 ( 0.0A)
TRP  A 225 ( 0.5A)
 1.47A 2y7kB-2hk0A:
undetectable		 2y7kB-2hk0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		4 / 6 SER A 213
ARG A 216
GLY A 221
TRP A 225
 SER  A 213 ( 0.0A)
ARG  A 216 ( 0.6A)
GLY  A 221 ( 0.0A)
TRP  A 225 ( 0.5A)
 1.47A 2y7pA-2hk0A:
undetectable		 2y7pA-2hk0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1nf3 PAR-6B
(Mus
musculus) 		5 / 12 LEU C 216
VAL C 246
SER C 178
VAL C 231
LEU C 242
 LEU  C 216 ( 0.6A)
VAL  C 246 ( 0.6A)
SER  C 178 ( 0.0A)
VAL  C 231 ( 0.6A)
LEU  C 242 ( 0.6A)
 1.32A 2zlcA-1nf3C:
undetectable		 2zlcA-1nf3C:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 SER A 186
GLU A 249
ASP A 219
 SER  A 186 ( 0.0A)
GLU  A 249 (-0.6A)
ASP  A 219 (-0.5A)
 0.65A 2zulA-1omoA:
5.0		 2zulA-1omoA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 SER A 174
GLU A 274
ASP A 236
 SER  A 174 ( 0.0A)
GLU  A 274 ( 0.6A)
ASP  A 236 ( 0.6A)
 0.80A 2zulA-1vhoA:
undetectable		 2zulA-1vhoA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 SER  A 493 ( 0.0A)
GLU  A 330 ( 0.5A)
ASP  A 259 ( 0.6A)
 0.71A 2zulA-4flxA:
undetectable		 2zulA-4flxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1
(Rattus
norvegicus) 		4 / 7 SER A 343
ALA A 295
VAL A 305
ILE A 352
 SER  A 343 ( 0.0A)
ALA  A 295 ( 0.0A)
VAL  A 305 ( 0.6A)
ILE  A 352 ( 0.6A)
 0.77A 3a2qA-2pnnA:
undetectable		 3a2qA-2pnnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
SER  A1205 (-3.9A)
None
None
None
 0.97A 3a51C-5vawA:
undetectable		 3a51C-5vawA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE
(Thymus
vulgaris) 		5 / 9 ILE A 450
GLY A 486
SER A 419
LEU A 420
SER A 416
 ILE  A 450 ( 0.4A)
GLY  A 486 ( 0.0A)
SER  A 419 ( 0.0A)
LEU  A 420 ( 0.6A)
SER  A 416 ( 0.0A)
 1.00A 3ai9X-5c05A:
undetectable		 3ai9X-5c05A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 SER A 132
LEU A 166
GLY A  60
GLU A  63
 SER  A 132 ( 0.0A)
LEU  A 166 ( 0.5A)
GLY  A  60 ( 0.0A)
GLU  A  63 ( 0.6A)
 0.96A 3aiaA-2v9uA:
undetectable
3aiaB-2v9uA:
undetectable		 3aiaA-2v9uA:
16.51
3aiaB-2v9uA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 VAL A  70
SER A  21
HIS A  20
LEU A 157
 VAL  A  70 ( 0.6A)
SER  A  21 ( 0.0A)
HIS  A  20 ( 1.0A)
LEU  A 157 ( 0.6A)
 1.07A 3arrA-5ec3A:
undetectable		 3arrA-5ec3A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARR_A_PNXA607_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 7 TRP A 160
SER A 203
HIS A 222
THR A 269
LEU A 270
TRP A 532
 TRP  A 160 ( 0.5A)
SER  A 203 ( 0.0A)
HIS  A 222 ( 1.0A)
THR  A 269 ( 0.8A)
LEU  A 270 ( 0.6A)
TRP  A 532 ( 0.5A)
 0.59A 3arrA-5gprA:
56.3		 3arrA-5gprA:
50.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARU_A_PNXA608_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		5 / 6 TRP A 160
SER A 203
ALA A 206
HIS A 222
ASP A 223
 TRP  A 160 ( 0.5A)
SER  A 203 ( 0.0A)
ALA  A 206 ( 0.0A)
HIS  A 222 ( 1.0A)
ASP  A 223 ( 0.5A)
 0.57A 3aruA-5gprA:
56.0		 3aruA-5gprA:
50.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 9 GLU A  71
SER A  89
THR A  87
VAL A 104
ALA A  79
 GLU  A  71 ( 0.6A)
SER  A  89 ( 0.0A)
THR  A  87 ( 0.8A)
VAL  A 104 ( 0.6A)
ALA  A  79 ( 0.0A)
 1.23A 3ax7B-1wsvA:
0.0		 3ax7B-1wsvA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 8 LEU A 270
SER A 271
ALA A 233
ALA A 232
 LEU  A 270 ( 0.5A)
SER  A 271 ( 0.0A)
ALA  A 233 ( 0.0A)
ALA  A 232 (-0.0A)
 0.82A 3ax9B-5d7wA:
undetectable		 3ax9B-5d7wA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 LEU A 305
SER A 304
GLY A 307
GLY A 310
GLY A 332
 LEU  A 305 ( 0.6A)
SER  A 304 ( 0.0A)
GLY  A 307 ( 0.0A)
GLY  A 310 ( 0.0A)
GLY  A 332 ( 0.0A)
 0.95A 3axzA-3i4kA:
undetectable		 3axzA-3i4kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 4 SER A 250
GLY A 249
GLY A 189
GLY A 219
 SER  A 250 ( 0.0A)
GLY  A 249 ( 0.0A)
GLY  A 189 (-0.0A)
GLY  A 219 ( 0.0A)
 0.82A 3bogB-3iccA:
undetectable
3bogD-3iccA:
undetectable		 3bogB-3iccA:
undetectable
3bogD-3iccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5oie -
(-) 		4 / 7 TYR A  88
TYR A 375
TRP A 381
TRP A  40
 SER  A 507 (-4.3A)
None
None
GOL  A 501 ( 4.0A)
 1.04A 3cotA-5oieA:
undetectable		 3cotA-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ILE A 427
SER A 431
LEU A 432
THR A 435
 ILE  A 427 ( 0.7A)
SER  A 431 (-0.0A)
LEU  A 432 ( 0.5A)
THR  A 435 ( 0.8A)
 0.86A 3deuB-2vbfA:
undetectable		 3deuB-2vbfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 SER A 186
GLU A 249
ASP A 219
 SER  A 186 ( 0.0A)
GLU  A 249 (-0.6A)
ASP  A 219 (-0.5A)
 0.63A 3dmhA-1omoA:
5.2		 3dmhA-1omoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 SER A 174
GLU A 274
ASP A 236
 SER  A 174 ( 0.0A)
GLU  A 274 ( 0.6A)
ASP  A 236 ( 0.6A)
 0.79A 3dmhA-1vhoA:
undetectable		 3dmhA-1vhoA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 SER  A 493 ( 0.0A)
GLU  A 330 ( 0.5A)
ASP  A 259 ( 0.6A)
 0.72A 3dmhA-4flxA:
undetectable		 3dmhA-4flxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 278
LEU A 262
SER A 249
ILE A 286
ILE A 280
 ILE  A 278 ( 0.7A)
LEU  A 262 ( 0.6A)
SER  A 249 ( 0.0A)
ILE  A 286 ( 0.7A)
ILE  A 280 ( 0.7A)
 0.97A 3drcA-3whlA:
undetectable		 3drcA-3whlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A  67
GLU A 251
SER A  52
THR A  75
 LEU  A  67 (-0.6A)
GLU  A 251 ( 0.6A)
SER  A  52 ( 0.0A)
THR  A  75 ( 0.8A)
 1.32A 3dzgB-2b92A:
undetectable		 3dzgB-2b92A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 9 ARG A  43
ALA A 442
LEU A 465
PRO A 471
ILE A 450
 SER  A 603 (-3.9A)
None
None
SER  A 603 (-4.5A)
None
 1.09A 3em4B-4yj5A:
undetectable		 3em4B-4yj5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLY A  32
GLY A  34
GLY A  37
VAL A  39
LYS A  54
SER A 112
ASN A 158
LEU A 160
ASP A 171
 GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
GLY  A  37 ( 0.0A)
VAL  A  39 (-0.6A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.94A 3eygA-5d7aA:
24.2		 3eygA-5d7aA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLY A  32
GLY A  37
VAL A  39
ALA A  52
LYS A  54
SER A 112
ASN A 158
LEU A 160
ASP A 171
 GLY  A  32 ( 0.0A)
GLY  A  37 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.71A 3eygA-5d7aA:
24.2		 3eygA-5d7aA:
27.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.52A 3g4lA-3sl5A:
53.4		 3g4lA-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.44A 3g4lA-3sl5A:
53.4		 3g4lA-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		3 / 3 SER A 368
GLN A 369
PHE A 372
 SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.45A 3g4lC-3sl5A:
53.0		 3g4lC-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
 0.33A 3g4lD-3sl5A:
52.9		 3g4lD-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		5 / 12 VAL A 290
SER A 354
ILE A 187
VAL A 366
TYR A 368
 VAL  A 290 ( 0.6A)
SER  A 354 ( 0.0A)
ILE  A 187 ( 0.7A)
VAL  A 366 ( 0.6A)
TYR  A 368 ( 1.3A)
 0.99A 3g8iA-5gprA:
undetectable		 3g8iA-5gprA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 GLY A 307
SER A 302
LEU A 268
VAL A 312
ILE A 367
 GLY  A 307 ( 0.0A)
SER  A 302 ( 0.0A)
LEU  A 268 ( 0.6A)
VAL  A 312 ( 0.6A)
ILE  A 367 ( 0.4A)
 1.28A 3g9eA-4kqnA:
undetectable		 3g9eA-4kqnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 LEU A 367
PRO A 239
SER A 226
GLY A 358
 LEU  A 367 ( 0.6A)
PRO  A 239 ( 1.1A)
SER  A 226 ( 0.0A)
GLY  A 358 ( 0.0A)
 1.07A 3hcnA-5ec3A:
undetectable		 3hcnA-5ec3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		5 / 9 LEU A 150
PRO A 168
SER A 169
VAL A  59
GLY A  56
 LEU  A 150 ( 0.6A)
PRO  A 168 ( 1.1A)
SER  A 169 ( 0.0A)
VAL  A  59 ( 0.6A)
GLY  A  56 ( 0.0A)
 1.38A 3hcnB-5xluA:
undetectable		 3hcnB-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4gow CALMODULIN
(Homo
sapiens) 		4 / 7 VAL D 142
TYR D 138
LYS D  81
GLU D  83
 VAL  D 142 ( 0.6A)
TYR  D 138 ( 1.3A)
SER  D  81 ( 0.0A)
GLU  D  83 ( 0.5A)
 1.20A 3hs4A-4gowD:
undetectable		 3hs4A-4gowD:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 SER A  98
GLY A 139
ALA A 140
LEU A 144
LEU A 147
 SER  A  98 ( 0.0A)
GLY  A 139 ( 0.0A)
ALA  A 140 ( 0.0A)
LEU  A 144 ( 0.5A)
LEU  A 147 ( 0.6A)
 1.05A 3hs6A-3wd7A:
undetectable		 3hs6A-3wd7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 7 PHE A 149
VAL A 153
LEU A 115
SER A 116
 PHE  A 149 ( 1.3A)
VAL  A 153 ( 0.6A)
LEU  A 115 ( 0.6A)
SER  A 116 ( 0.0A)
 0.92A 3hs6B-1c8xA:
0.0		 3hs6B-1c8xA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  67
GLU A 251
SER A  52
PHE A  65
 LEU  A  67 (-0.6A)
GLU  A 251 ( 0.6A)
SER  A  52 ( 0.0A)
PHE  A  65 ( 1.3A)
 1.28A 3i9jB-2b92A:
3.2		 3i9jB-2b92A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 6 GLU A 157
ASN A 187
SER A 259
PHE A 151
 GLU  A 157 ( 0.5A)
ASN  A 187 ( 0.6A)
SER  A 259 ( 0.0A)
PHE  A 151 ( 1.3A)
 1.49A 3i9jB-4hneA:
undetectable		 3i9jB-4hneA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 8 ASP A  93
GLY A 100
SER A 102
ILE A 103
 ASP  A  93 ( 0.5A)
GLY  A 100 ( 0.0A)
SER  A 102 ( 0.0A)
ILE  A 103 ( 0.6A)
 0.69A 3ihzB-3r6yA:
undetectable		 3ihzB-3r6yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4c9g ADP, ATP CARRIER
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 142
SER A 141
ILE A 200
SER A 133
GLY A 134
 LEU  A 142 ( 0.6A)
SER  A 141 ( 0.0A)
ILE  A 200 ( 0.7A)
SER  A 133 ( 0.0A)
GLY  A 134 ( 0.0A)
 1.33A 3iluB-4c9gA:
undetectable
3iluE-4c9gA:
undetectable		 3iluB-4c9gA:
22.02
3iluE-4c9gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4c9g ADP, ATP CARRIER
PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 200
SER A 133
GLY A 134
LEU A 142
SER A 141
 ILE  A 200 ( 0.7A)
SER  A 133 ( 0.0A)
GLY  A 134 ( 0.0A)
LEU  A 142 ( 0.6A)
SER  A 141 ( 0.0A)
 1.36A 3iluB-4c9gA:
undetectable
3iluE-4c9gA:
undetectable		 3iluB-4c9gA:
22.02
3iluE-4c9gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 ASN A 138
SER A 141
GLU A 175
PRO A 137
GLU A 217
 ASN  A 138 ( 0.6A)
SER  A 141 ( 0.0A)
GLU  A 175 ( 0.6A)
PRO  A 137 ( 1.1A)
GLU  A 217 ( 0.6A)
 1.46A 3jb2A-2qc5A:
undetectable		 3jb2A-2qc5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 GLU A 498
SER A 497
ARG A 430
VAL A 480
 GLU  A 498 ( 0.5A)
SER  A 497 ( 0.0A)
ARG  A 430 ( 0.6A)
VAL  A 480 ( 0.6A)
 1.33A 3jx1A-5l5nA:
undetectable
3jx1B-5l5nA:
undetectable		 3jx1A-5l5nA:
16.53
3jx1B-5l5nA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3bpo INTERLEUKIN 13
(Homo
sapiens) 		5 / 12 LEU A 103
SER A  50
ILE A  37
GLY A  42
ALA A  41
 LEU  A 103 ( 0.6A)
SER  A  50 ( 0.0A)
ILE  A  37 ( 0.4A)
GLY  A  42 ( 0.0A)
ALA  A  41 ( 0.0A)
 1.07A 3kk6A-3bpoA:
undetectable		 3kk6A-3bpoA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 0.98A 3ko0B-4g9kA:
undetectable		 3ko0B-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 1.01A 3ko0S-4g9kA:
undetectable		 3ko0S-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 9 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 THR  A 121 ( 0.8A)
ALA  A 122 ( 0.0A)
LEU  A 124 ( 0.6A)
ALA  A 126 ( 0.0A)
SER  A 127 ( 0.0A)
 1.50A 3kp6B-1gc7A:
0.0		 3kp6B-1gc7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 THR A 237
VAL A 210
ILE A 276
SER A 272
PRO A 208
 THR  A 237 ( 0.8A)
VAL  A 210 ( 0.6A)
ILE  A 276 ( 0.6A)
SER  A 272 ( 0.0A)
PRO  A 208 ( 1.1A)
 1.24A 3kpbA-2vbfA:
undetectable		 3kpbA-2vbfA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		5 / 11 ILE A 175
SER A 174
PHE A 341
ALA A 182
GLU A 180
 ILE  A 175 ( 0.3A)
SER  A 174 ( 0.0A)
PHE  A 341 ( 1.3A)
ALA  A 182 ( 0.0A)
GLU  A 180 ( 0.5A)
 0.95A 3kw4A-1txuA:
undetectable		 3kw4A-1txuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		4 / 7 LEU A3825
LEU A3837
SER A3832
ASP A3838
 LEU  A3825 ( 0.6A)
LEU  A3837 ( 0.5A)
SER  A3832 ( 0.0A)
ASP  A3838 ( 0.6A)
 1.02A 3lm8A-5w6lA:
undetectable
3lm8C-5w6lA:
undetectable		 3lm8A-5w6lA:
21.31
3lm8C-5w6lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A 102
LEU A 104
SER A 176
ASN A 175
 ASP  A 102 ( 0.5A)
LEU  A 104 ( 0.6A)
SER  A 176 ( 0.0A)
ASN  A 175 ( 0.6A)
 0.98A 3lm8A-5e37A:
undetectable
3lm8C-5e37A:
undetectable		 3lm8A-5e37A:
21.21
3lm8C-5e37A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		4 / 8 ASP A3838
LEU A3825
LEU A3837
SER A3832
 ASP  A3838 ( 0.6A)
LEU  A3825 ( 0.6A)
LEU  A3837 ( 0.5A)
SER  A3832 ( 0.0A)
 0.93A 3lm8B-5w6lA:
undetectable
3lm8D-5w6lA:
undetectable		 3lm8B-5w6lA:
21.31
3lm8D-5w6lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 239
SER A 290
ARG A 108
 ASP  A 239 ( 0.5A)
SER  A 290 (-0.0A)
ARG  A 108 (-0.6A)
 0.97A 3loqA-1omoA:
4.0		 3loqA-1omoA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 245
SER A 101
ARG A 248
 ASP  A 245 (-0.6A)
SER  A 101 (-0.0A)
ARG  A 248 (-0.6A)
 0.88A 3loqA-1wqaA:
2.5		 3loqA-1wqaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		3 / 3 SER A 285
GLY A 281
SER A 314
 SER  A 285 ( 0.0A)
GLY  A 281 ( 0.0A)
SER  A 314 ( 0.0A)
 0.55A 3loqA-3i4kA:
3.7		 3loqA-3i4kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		4 / 8 PHE A 170
SER A 173
LEU A 231
ASP A 257
 PHE  A 170 ( 1.3A)
SER  A 173 ( 0.0A)
LEU  A 231 ( 0.5A)
ASP  A 257 ( 0.6A)
 1.06A 3m0wE-2an1A:
undetectable
3m0wF-2an1A:
undetectable
3m0wG-2an1A:
undetectable
3m0wH-2an1A:
undetectable		 3m0wE-2an1A:
13.79
3m0wF-2an1A:
13.79
3m0wG-2an1A:
13.79
3m0wH-2an1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 211
GLY A  75
SER A  76
ILE A 190
ILE A  71
 ILE  A 211 ( 0.7A)
GLY  A  75 ( 0.0A)
SER  A  76 ( 0.0A)
ILE  A 190 ( 0.7A)
ILE  A  71 ( 0.7A)
 1.05A 3mb5A-4g41A:
undetectable		 3mb5A-4g41A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3cb7 LYS-RICH LYSOZYME 2
(Musca
domestica) 		5 / 11 LEU A  12
PHE A   7
SER A  11
ILE A  57
ALA A  93
 LEU  A  12 ( 0.6A)
PHE  A   7 ( 1.3A)
SER  A  11 ( 0.0A)
ILE  A  57 ( 0.6A)
ALA  A  93 ( 0.0A)
 0.99A 3mdtB-3cb7A:
undetectable		 3mdtB-3cb7A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 11 VAL A 121
GLY A 103
ALA A 102
SER A 100
LEU A  34
 VAL  A 121 ( 0.6A)
GLY  A 103 ( 0.0A)
ALA  A 102 ( 0.0A)
SER  A 100 ( 0.0A)
LEU  A  34 ( 0.6A)
 1.19A 3n8yA-4mwtA:
undetectable		 3n8yA-4mwtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.21A 3o94A-5d7aA:
undetectable		 3o94A-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.22A 3o94B-5d7aA:
undetectable		 3o94B-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.21A 3o94C-5d7aA:
undetectable		 3o94C-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.21A 3o94D-5d7aA:
undetectable		 3o94D-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 195
SER A 201
LEU A  94
PRO A  95
 LEU  A 195 (-0.6A)
SER  A 201 ( 0.0A)
LEU  A  94 ( 0.6A)
PRO  A  95 ( 1.1A)
 1.23A 3onnA-4g9kA:
undetectable		 3onnA-4g9kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 LEU  A 196 ( 0.6A)
ALA  A 153 ( 0.0A)
GLY  A 149 ( 0.0A)
SER  A 150 ( 0.0A)
LEU  A 154 ( 0.5A)
 1.02A 3ou7A-2qc5A:
undetectable		 3ou7A-2qc5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 372
GLU A  69
SER A 189
 ASP  A 372 ( 0.6A)
GLU  A  69 ( 0.5A)
SER  A 189 ( 0.0A)
 0.70A 3p2kA-4mwtA:
undetectable		 3p2kA-4mwtA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5ve2 ENOYL-COA HYDRATASE
(Pseudoalteromona
s
atlantica) 		4 / 5 ASN A  43
GLU A 137
THR A 109
SER A  42
 ASN  A  43 ( 0.6A)
GLU  A 137 ( 0.6A)
THR  A 109 ( 0.8A)
SER  A  42 (-0.0A)
 1.14A 3p2kC-5ve2A:
undetectable		 3p2kC-5ve2A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350
(Thermus
thermophilus) 		4 / 8 ALA A  16
LEU A 115
ASP A   8
SER A  10
 ALA  A  16 ( 0.0A)
LEU  A 115 ( 0.6A)
ASP  A   8 ( 0.6A)
SER  A  10 ( 0.0A)
 1.01A 3qj7A-3ab7A:
undetectable
3qj7D-3ab7A:
undetectable		 3qj7A-3ab7A:
27.16
3qj7D-3ab7A:
27.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gru DIABODY PROTEIN
(Mus
musculus) 		5 / 12 ALA L 153
SER L 214
SER L 215
MET L 125
ALA L 146
 ALA  L 153 ( 0.0A)
SER  L 214 ( 0.0A)
SER  L 215 ( 0.0A)
MET  L 125 ( 0.0A)
ALA  L 146 ( 0.0A)
 1.25A 3qxvE-5gruL:
16.2		 3qxvE-5gruL:
44.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		3 / 4 SER A 145
GLY A 101
GLU A 105
 SER  A 145 (-0.0A)
GLY  A 101 ( 0.0A)
GLU  A 105 ( 0.6A)
 0.49A 3raeA-3iccA:
undetectable
3raeC-3iccA:
3.0		 3raeA-3iccA:
20.69
3raeC-3iccA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  67
GLU A 251
SER A  52
THR A  75
 LEU  A  67 (-0.6A)
GLU  A 251 ( 0.6A)
SER  A  52 ( 0.0A)
THR  A  75 ( 0.8A)
 1.40A 3ropA-2b92A:
4.0		 3ropA-2b92A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 9 ASP A 541
SER A 604
ASN A 613
GLY A 667
ASP A 668
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
 1.04A 3sfuA-4mtpA:
19.2		 3sfuA-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 11 ASP A 541
SER A 604
ASN A 613
GLY A 667
ASP A 668
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
 1.04A 3sfuC-4mtpA:
19.6		 3sfuC-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 11 ASP A 541
SER A 604
THR A 609
ASN A 613
GLY A 667
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
THR  A 609 ( 0.8A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
 1.11A 3sfuC-4mtpA:
19.6		 3sfuC-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)
(Homo
sapiens) 		3 / 3 LYS A 110
SER A  79
GLN A  77
 LYS  A 110 ( 0.0A)
SER  A  79 ( 0.0A)
GLN  A  77 ( 0.6A)
 1.12A 3si7A-1szbA:
undetectable		 3si7A-1szbA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 PHE A 262
SER A 283
GLN A 285
 PHE  A 262 ( 1.3A)
SER  A 283 ( 0.0A)
GLN  A 285 ( 0.6A)
 0.62A 3smtA-1wojA:
undetectable		 3smtA-1wojA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 PHE A 359
SER A 324
GLN A 320
 PHE  A 359 ( 1.3A)
SER  A 324 ( 0.0A)
GLN  A 320 ( 0.6A)
 0.85A 3smtA-5hiuA:
undetectable		 3smtA-5hiuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2qvs CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT
(Mus
musculus) 		5 / 12 GLY B 349
GLY B 300
ARG B 283
SER B 303
GLU B 289
 GLY  B 349 ( 0.0A)
GLY  B 300 ( 0.0A)
ARG  B 283 ( 0.6A)
SER  B 303 ( 0.0A)
GLU  B 289 ( 0.6A)
 1.38A 3tkaA-2qvsB:
undetectable		 3tkaA-2qvsB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3kqg C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER K
(Homo
sapiens) 		4 / 5 SER A 218
THR A 215
GLU A 220
ASP A 269
 SER  A 218 ( 0.0A)
THR  A 215 ( 0.8A)
GLU  A 220 ( 0.6A)
ASP  A 269 ( 0.5A)
 1.34A 3tm4A-3kqgA:
undetectable		 3tm4A-3kqgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 385
SER A 386
THR A 360
ASP A 227
 HIS  A 385 ( 1.0A)
SER  A 386 ( 0.0A)
THR  A 360 ( 0.8A)
ASP  A 227 ( 0.6A)
 1.14A 3tm4A-3wd7A:
undetectable		 3tm4A-3wd7A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3kqg C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER K
(Homo
sapiens) 		4 / 5 SER A 218
THR A 215
GLU A 220
ASP A 269
 SER  A 218 ( 0.0A)
THR  A 215 ( 0.8A)
GLU  A 220 ( 0.6A)
ASP  A 269 ( 0.5A)
 1.35A 3tm4B-3kqgA:
undetectable		 3tm4B-3kqgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 385
SER A 386
THR A 360
ASP A 227
 HIS  A 385 ( 1.0A)
SER  A 386 ( 0.0A)
THR  A 360 ( 0.8A)
ASP  A 227 ( 0.6A)
 1.13A 3tm4B-3wd7A:
undetectable		 3tm4B-3wd7A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1ng0 COAT PROTEIN
(Cocksfoot
mottle
virus) 		3 / 3 SER A 246
PHE A  64
LYS A 244
 SER  A 246 ( 0.0A)
PHE  A  64 ( 1.3A)
LYS  A 244 ( 0.0A)
 1.02A 3u88A-1ng0A:
undetectable		 3u88A-1ng0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 8 ILE A 299
ILE A 301
SER A 326
THR A   5
VAL A 181
 ILE  A 299 ( 0.7A)
ILE  A 301 ( 0.7A)
SER  A 326 ( 0.0A)
THR  A   5 ( 0.8A)
VAL  A 181 ( 0.6A)
 1.46A 3ua5A-1vhoA:
undetectable		 3ua5A-1vhoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.90A 3uawA-4g41A:
23.9		 3uawA-4g41A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.80A 3uawA-4g41A:
23.9		 3uawA-4g41A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 5 SER A 145
ILE A  16
TYR A 158
GLY A 189
 SER  A 145 (-0.0A)
ILE  A  16 (-0.7A)
TYR  A 158 (-1.3A)
GLY  A 189 (-0.0A)
 1.04A 3uboB-3iccA:
6.9		 3uboB-3iccA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 SER A 356
ASP A 270
ASP A 293
 SER  A 356 ( 0.0A)
ASP  A 270 ( 0.6A)
ASP  A 293 ( 0.6A)
 0.84A 3uj7A-1wqaA:
undetectable		 3uj7A-1wqaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 5 TYR A 105
VAL A  54
SER A 304
GLY A  58
 TYR  A 105 ( 1.3A)
VAL  A  54 ( 0.6A)
SER  A 304 ( 0.0A)
GLY  A  58 ( 0.0A)
 1.49A 3v4tA-3i4kA:
undetectable
3v4tD-3i4kA:
undetectable		 3v4tA-3i4kA:
23.42
3v4tD-3i4kA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 SER  A1205 (-3.1A)
SER  A1205 (-3.2A)
SER  A1205 ( 4.5A)
SER  A1205 (-3.9A)
 0.59A 3vfjA-5vawA:
51.6		 3vfjA-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 6ezy -
(-) 		4 / 6 ARG A  15
PRO A  54
GLU A  65
SER A  66
 ARG  A  15 ( 0.6A)
PRO  A  54 ( 1.1A)
GLU  A  65 ( 0.6A)
SER  A  66 ( 0.0A)
 0.95A 3vlnA-6ezyA:
20.5		 3vlnA-6ezyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 5 ASP A  52
SER A  80
GLY A  81
ASP A  11
 ASP  A  52 ( 0.6A)
SER  A  80 ( 0.0A)
GLY  A  81 ( 0.0A)
ASP  A  11 ( 0.5A)
 1.26A 3w9tB-3eqzA:
undetectable		 3w9tB-3eqzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 5 ASP A  52
SER A  80
GLY A  81
ASP A  11
 ASP  A  52 ( 0.6A)
SER  A  80 ( 0.0A)
GLY  A  81 ( 0.0A)
ASP  A  11 ( 0.5A)
 1.26A 3w9tC-3eqzA:
undetectable		 3w9tC-3eqzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE
(Thymus
vulgaris) 		4 / 5 SER A 377
GLU A 374
THR A 378
ASP A 372
 SER  A 377 ( 0.0A)
GLU  A 374 ( 0.6A)
THR  A 378 ( 0.8A)
ASP  A 372 ( 0.6A)
 1.49A 3zs3A-5c05A:
undetectable		 3zs3A-5c05A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		5 / 9 GLY A  89
GLY A  88
PHE A 236
SER A 108
GLY A  90
 GLY  A  89 ( 0.0A)
GLY  A  88 ( 0.0A)
PHE  A 236 ( 1.3A)
SER  A 108 ( 0.0A)
GLY  A  90 ( 0.0A)
 1.26A 3ztvA-5xluA:
undetectable		 3ztvA-5xluA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 SER A 148
GLY A 377
ALA A 373
HIS A  58
PHE A  92
 SER  A 148 ( 0.0A)
GLY  A 377 ( 0.0A)
ALA  A 373 ( 0.0A)
HIS  A  58 (-1.0A)
PHE  A  92 ( 1.3A)
 1.34A 4bupB-4kqnA:
undetectable		 4bupB-4kqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		5 / 12 VAL A 437
PHE A 434
GLY A 436
SER A 363
GLU A 367
 VAL  A 437 ( 0.6A)
PHE  A 434 ( 1.3A)
GLY  A 436 ( 0.0A)
SER  A 363 ( 0.0A)
GLU  A 367 ( 0.6A)
 1.36A 4bvaA-5nksA:
1.4		 4bvaA-5nksA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 VAL A 252
PHE A 286
GLY A 249
VAL A 276
SER A 300
 VAL  A 252 ( 0.6A)
PHE  A 286 ( 1.3A)
GLY  A 249 ( 0.0A)
VAL  A 276 ( 0.6A)
SER  A 300 ( 0.0A)
 1.49A 4bvaB-1vhoA:
undetectable		 4bvaB-1vhoA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 174
GLY A 177
ASP A 380
GLY A 179
SER A 181
 LEU  A 174 ( 0.5A)
GLY  A 177 ( 0.0A)
ASP  A 380 ( 0.5A)
GLY  A 179 ( 0.0A)
SER  A 181 ( 0.0A)
 1.13A 4bwlC-4mwtA:
undetectable		 4bwlC-4mwtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		5 / 12 SER A 385
GLN A 196
THR A 253
ILE A 391
HIS A  73
 SER  A 385 ( 0.0A)
GLN  A 196 ( 0.6A)
THR  A 253 ( 0.8A)
ILE  A 391 ( 0.6A)
HIS  A  73 ( 1.0A)
 1.33A 4c49B-5nksA:
undetectable		 4c49B-5nksA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 129
ARG A  52
GLY A  22
SER A  26
 ASN  A 129 (-0.6A)
ARG  A  52 ( 0.6A)
GLY  A  22 (-0.0A)
SER  A  26 ( 0.0A)
 0.77A 4cp3A-3c3nA:
undetectable
4cp3B-3c3nA:
undetectable		 4cp3A-3c3nA:
20.77
4cp3B-3c3nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.97A 4d7bB-4w65A:
undetectable		 4d7bB-4w65A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 120
ALA A 122
SER A 113
THR A 115
 THR  A 120 ( 0.8A)
ALA  A 122 ( 0.0A)
SER  A 113 ( 0.0A)
THR  A 115 (-0.8A)
 0.82A 4d7bA-3gwmA:
undetectable		 4d7bA-3gwmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.72A 4d9hA-4g41A:
23.9		 4d9hA-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.77A 4da7A-4g41A:
23.8		 4da7A-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.78A 4danA-4g41A:
23.4		 4danA-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.83A 4danA-4g41A:
23.4
4danB-4g41A:
23.4		 4danA-4g41A:
25.86
4danB-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 TYR A 282
ARG A 331
SER A 336
 TYR  A 282 ( 1.3A)
ARG  A 331 ( 0.6A)
SER  A 336 ( 0.0A)
 1.07A 4dr2I-2nvvA:
undetectable
4dr2J-2nvvA:
undetectable		 4dr2I-2nvvA:
14.83
4dr2J-2nvvA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.86A 4dx5B-4g9kA:
undetectable		 4dx5B-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 ARG A 238
ILE A 224
GLY A 332
SER A 240
GLY A 229
 ARG  A 238 ( 0.6A)
ILE  A 224 ( 0.7A)
GLY  A 332 ( 0.0A)
SER  A 240 ( 0.0A)
GLY  A 229 ( 0.0A)
 1.07A 4e1gB-5cdnA:
undetectable		 4e1gB-5cdnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 GLY A 253
SER A 252
TRP A 246
 GLY  A 253 ( 0.0A)
SER  A 252 ( 0.0A)
TRP  A 246 ( 0.5A)
 0.97A 4e7cD-3r9rA:
undetectable		 4e7cD-3r9rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.19A 4eckB-2vbfA:
undetectable		 4eckB-2vbfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.24A 4eilA-2vbfA:
2.1		 4eilA-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.20A 4eilC-2vbfA:
undetectable		 4eilC-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4eilE-2vbfA:
undetectable		 4eilE-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A  62
LEU A  99
LEU A  48
ILE A  33
SER A  44
 LEU  A  62 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  48 ( 0.6A)
ILE  A  33 ( 0.7A)
SER  A  44 ( 0.0A)
 1.17A 4f4dB-2hk0A:
undetectable		 4f4dB-2hk0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 SER A 327
ILE A 301
GLY A 167
VAL A 382
ALA A 242
 SER  A 327 ( 0.0A)
ILE  A 301 ( 0.4A)
GLY  A 167 ( 0.0A)
VAL  A 382 ( 0.6A)
ALA  A 242 ( 0.0A)
 1.20A 4foxD-3wd7A:
undetectable		 4foxD-3wd7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 HIS A 423
TYR A 406
GLY A  58
SER A 414
 HIS  A 423 ( 1.0A)
TYR  A 406 ( 1.3A)
GLY  A  58 ( 0.0A)
SER  A 414 ( 0.0A)
 1.30A 4fu8A-2vbfA:
undetectable		 4fu8A-2vbfA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2an1 PUTATIVE KINASE
(Salmonella
enterica) 		5 / 12 ILE A 223
ALA A 205
LEU A 129
SER A 191
ILE A 180
 ILE  A 223 ( 0.7A)
ALA  A 205 ( 0.0A)
LEU  A 129 ( 0.6A)
SER  A 191 ( 0.0A)
ILE  A 180 ( 0.7A)
 1.30A 4gh8B-2an1A:
undetectable		 4gh8B-2an1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 1.00A 4i89A-4w65A:
undetectable		 4i89A-4w65A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		4 / 5 SER A 150
LYS A 147
ARG A 165
LEU A  96
 SER  A 150 ( 0.0A)
LYS  A 147 ( 0.0A)
ARG  A 165 ( 0.6A)
LEU  A  96 ( 0.6A)
 1.31A 4ifxA-4ursA:
1.2		 4ifxA-4ursA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		4 / 5 SER A 150
LYS A 147
ARG A 165
LEU A  96
 SER  A 150 ( 0.0A)
LYS  A 147 ( 0.0A)
ARG  A 165 ( 0.6A)
LEU  A  96 ( 0.6A)
 1.29A 4ig1A-4ursA:
undetectable		 4ig1A-4ursA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		5 / 8 LEU A  62
ALA A 164
LEU A 166
THR A 176
SER A   7
 LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
SER  A   7 ( 0.0A)
 1.43A 4ikkA-2v9uA:
3.3
4ikkB-2v9uA:
3.2		 4ikkA-2v9uA:
23.88
4ikkB-2v9uA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		3 / 4 SER A 145
GLY A 101
GLU A 105
 SER  A 145 (-0.0A)
GLY  A 101 ( 0.0A)
GLU  A 105 ( 0.6A)
 0.52A 4juoA-3iccA:
undetectable
4juoC-3iccA:
2.8		 4juoA-3iccA:
20.69
4juoC-3iccA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 GLU A 185
ARG A 212
PRO A 289
SER A 241
 GLU  A 185 ( 0.5A)
ARG  A 212 ( 0.6A)
PRO  A 289 ( 1.1A)
SER  A 241 ( 0.0A)
 1.38A 4k17B-4kqnA:
undetectable		 4k17B-4kqnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 7 ASP A  36
PRO A  96
HIS A 101
SER A  99
 ASP  A  36 ( 0.6A)
PRO  A  96 ( 1.1A)
HIS  A 101 ( 1.0A)
SER  A  99 ( 0.0A)
 1.16A 4k7gB-5wpiA:
undetectable		 4k7gB-5wpiA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 382
ARG A 354
SER A 353
 TYR  A 382 ( 1.3A)
ARG  A 354 ( 0.6A)
SER  A 353 ( 0.0A)
 1.11A 4khpI-1v0fA:
undetectable
4khpJ-1v0fA:
undetectable		 4khpI-1v0fA:
11.48
4khpJ-1v0fA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 8 LEU A 367
PRO A 239
SER A 226
GLY A 358
 LEU  A 367 ( 0.6A)
PRO  A 239 ( 1.1A)
SER  A 226 ( 0.0A)
GLY  A 358 ( 0.0A)
 0.94A 4klrB-5ec3A:
undetectable		 4klrB-5ec3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		4 / 5 MET A 127
LEU A 289
ARG A  87
SER A 326
 MET  A 127 ( 0.0A)
LEU  A 289 ( 0.6A)
ARG  A  87 ( 0.6A)
SER  A 326 ( 0.0A)
 1.49A 4kmmB-1wlyA:
3.9		 4kmmB-1wlyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 5 LEU A 200
ARG A 217
PRO A 188
SER A 145
 LEU  A 200 ( 0.6A)
ARG  A 217 ( 0.6A)
PRO  A 188 (-1.1A)
SER  A 145 (-0.0A)
 1.31A 4kmmB-3iccA:
3.4		 4kmmB-3iccA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.29A 4kyaA-2vbfA:
2.2		 4kyaA-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.33A 4kyaB-2vbfA:
2.2		 4kyaB-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 10 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4kyaC-2vbfA:
undetectable		 4kyaC-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4kyaD-2vbfA:
undetectable		 4kyaD-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.27A 4kyaE-2vbfA:
undetectable		 4kyaE-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4kyaG-2vbfA:
2.0		 4kyaG-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.30A 4kyaH-2vbfA:
undetectable		 4kyaH-2vbfA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		8 / 11 THR A  84
TYR A 165
ARG A 168
VAL A 174
ILE A 180
SER A 183
MET A 208
LEU A 217
 THR  A  84 ( 0.8A)
TYR  A 165 ( 1.3A)
ARG  A 168 ( 0.6A)
VAL  A 174 ( 0.5A)
ILE  A 180 ( 0.7A)
SER  A 183 ( 0.0A)
MET  A 208 ( 0.0A)
LEU  A 217 ( 0.6A)
 0.63A 4lhmA-5ep8A:
52.9		 4lhmA-5ep8A:
45.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		3 / 3 ASP A 134
TRP A 444
SER A  90
 ASP  A 134 ( 0.6A)
TRP  A 444 (-0.5A)
SER  A  90 ( 0.0A)
 0.94A 4lrhB-3gnrA:
undetectable		 4lrhB-3gnrA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		3 / 3 ASP A 361
TRP A 268
SER A 357
 ASP  A 361 ( 0.5A)
TRP  A 268 ( 0.5A)
SER  A 357 ( 0.0A)
 0.78A 4lrhB-5gprA:
undetectable		 4lrhB-5gprA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 HIS A 223
TRP A 295
SER A 304
 HIS  A 223 ( 1.0A)
TRP  A 295 ( 0.5A)
SER  A 304 ( 0.0A)
 1.18A 4lrhD-5nksA:
undetectable		 4lrhD-5nksA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		3 / 3 ASP A 134
TRP A 444
SER A  90
 ASP  A 134 ( 0.6A)
TRP  A 444 (-0.5A)
SER  A  90 ( 0.0A)
 1.03A 4lrhF-3gnrA:
undetectable		 4lrhF-3gnrA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		3 / 3 ASP A 361
TRP A 268
SER A 357
 ASP  A 361 ( 0.5A)
TRP  A 268 ( 0.5A)
SER  A 357 ( 0.0A)
 0.77A 4lrhF-5gprA:
undetectable		 4lrhF-5gprA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 114
LEU A 115
ALA A 155
SER A 153
LEU A 149
 ILE  A 114 ( 0.7A)
LEU  A 115 ( 0.5A)
ALA  A 155 ( 0.0A)
SER  A 153 ( 0.0A)
LEU  A 149 ( 0.6A)
 1.29A 4m11C-5svdA:
undetectable		 4m11C-5svdA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 11 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 VAL  A 314 ( 0.6A)
ILE  A 303 ( 0.7A)
LEU  A 266 ( 0.6A)
ALA  A 318 ( 0.0A)
SER  A 301 ( 0.0A)
 1.28A 4m83A-1fxjA:
undetectable		 4m83A-1fxjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 SER A 233
ALA A 258
PHE A 234
GLU A 260
 SER  A 233 ( 0.0A)
ALA  A 258 ( 0.0A)
PHE  A 234 ( 1.3A)
GLU  A 260 ( 0.6A)
 1.04A 4m93B-3r64A:
undetectable
4m93C-3r64A:
undetectable		 4m93B-3r64A:
16.27
4m93C-3r64A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 8 PRO A 154
SER A 131
VAL A 152
GLY A 158
 PRO  A 154 (-1.1A)
SER  A 131 (-0.0A)
VAL  A 152 ( 0.6A)
GLY  A 158 ( 0.0A)
 0.96A 4mk4A-3ulkA:
2.9		 4mk4A-3ulkA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A  52
MET A  55
ASP A 184
 SER  A  52 ( 0.0A)
MET  A  55 ( 0.0A)
ASP  A 184 (-0.6A)
 0.96A 4mm4B-2b92A:
0.0		 4mm4B-2b92A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2p5d UPF0310 PROTEIN
MJECL36
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 125
MET A 129
ASP A 140
 SER  A 125 ( 0.0A)
MET  A 129 ( 0.0A)
ASP  A 140 ( 0.6A)
 0.71A 4mm4B-2p5dA:
undetectable		 4mm4B-2p5dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 VAL A  72
GLY A  27
SER A  67
GLY A  69
ASP A  74
 VAL  A  72 ( 0.6A)
GLY  A  27 ( 0.0A)
SER  A  67 ( 0.0A)
GLY  A  69 ( 0.0A)
ASP  A  74 ( 0.6A)
 1.04A 4mm9A-1wqaA:
undetectable		 4mm9A-1wqaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 1ng0 COAT PROTEIN
(Cocksfoot
mottle
virus) 		5 / 10 VAL A 180
ALA A 179
GLY A 233
SER A 166
GLY A 163
 VAL  A 180 ( 0.6A)
ALA  A 179 ( 0.0A)
GLY  A 233 ( 0.0A)
SER  A 166 ( 0.0A)
GLY  A 163 ( 0.0A)
 1.33A 4mmdA-1ng0A:
undetectable		 4mmdA-1ng0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.10A 4n09A-4zkeA:
undetectable		 4n09A-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.09A 4n09B-4zkeA:
4.1		 4n09B-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.10A 4n09D-4zkeA:
3.7		 4n09D-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		5 / 12 ILE A 666
LEU A 670
GLY A 677
SER A 711
ASN A 735
 ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
SER  A 711 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.20A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		3 / 3 SER A 142
ALA A 140
VAL A 139
 SER  A 142 (-0.0A)
ALA  A 140 ( 0.0A)
VAL  A 139 ( 0.6A)
 0.50A 4o2bA-4nonA:
undetectable		 4o2bA-4nonA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.64A 4o2bC-2v9uA:
undetectable		 4o2bC-2v9uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 SER B 293
ASP B 290
GLN B 300
 SER  B 293 ( 0.0A)
ASP  B 290 ( 0.6A)
GLN  B 300 ( 0.6A)
 0.88A 4oltA-4oudB:
undetectable
4oltB-4oudB:
undetectable		 4oltA-4oudB:
20.60
4oltB-4oudB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 491
SER A 463
LEU A 466
LEU A 494
LEU A 465
 LEU  A 491 ( 0.6A)
SER  A 463 ( 0.0A)
LEU  A 466 ( 0.6A)
LEU  A 494 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.46A 4or0A-5svdA:
undetectable		 4or0A-5svdA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		5 / 12 GLY C 200
GLU C 225
ASN C 365
SER C 378
ILE C 367
 GLY  C 200 ( 0.0A)
GLU  C 225 ( 0.5A)
ASN  C 365 ( 0.6A)
SER  C 378 ( 0.0A)
ILE  C 367 ( 0.5A)
 1.26A 4pb1A-3ghgC:
undetectable		 4pb1A-3ghgC:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		5 / 12 GLY A 225
ASN A 226
ASP A  52
ILE A 184
SER A 183
 GLY  A 225 ( 0.0A)
ASN  A 226 ( 0.6A)
ASP  A  52 ( 0.6A)
ILE  A 184 ( 0.4A)
SER  A 183 ( 0.0A)
 1.28A 4pooA-5ep8A:
undetectable		 4pooA-5ep8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		5 / 12 GLY A 225
ASN A 226
ASP A  52
ILE A 184
SER A 183
 GLY  A 225 ( 0.0A)
ASN  A 226 ( 0.6A)
ASP  A  52 ( 0.6A)
ILE  A 184 ( 0.4A)
SER  A 183 ( 0.0A)
 1.32A 4pooB-5ep8A:
undetectable		 4pooB-5ep8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1wha KIAA0147 PROTEIN
(Homo
sapiens) 		4 / 6 THR A  89
ALA A  91
LEU A  93
SER A  65
 THR  A  89 ( 0.8A)
ALA  A  91 ( 0.0A)
LEU  A  93 ( 0.6A)
SER  A  65 ( 0.0A)
 0.76A 4pwjA-1whaA:
undetectable		 4pwjA-1whaA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 120
ALA A 122
SER A 113
THR A 115
 THR  A 120 ( 0.8A)
ALA  A 122 ( 0.0A)
SER  A 113 ( 0.0A)
THR  A 115 (-0.8A)
 0.79A 4pwjB-3gwmA:
undetectable		 4pwjB-3gwmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 7 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.99A 4pwjB-4w65A:
undetectable		 4pwjB-4w65A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 PRO A 196
THR A 197
ARG A  94
SER A 208
GLY A 200
 PRO  A 196 ( 1.1A)
THR  A 197 ( 0.8A)
ARG  A  94 ( 0.6A)
SER  A 208 ( 0.0A)
GLY  A 200 ( 0.0A)
 1.32A 4q15A-3wd7A:
undetectable		 4q15A-3wd7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 PRO A 196
THR A 197
ARG A  94
SER A 208
GLY A 200
 PRO  A 196 ( 1.1A)
THR  A 197 ( 0.8A)
ARG  A  94 ( 0.6A)
SER  A 208 ( 0.0A)
GLY  A 200 ( 0.0A)
 1.32A 4q15B-3wd7A:
undetectable		 4q15B-3wd7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4c9g ADP, ATP CARRIER
PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 155
THR A 153
ARG A 253
SER A  42
 LEU  A 155 ( 0.6A)
THR  A 153 ( 0.8A)
ARG  A 253 ( 0.6A)
SER  A  42 ( 0.0A)
 1.17A 4qknA-4c9gA:
undetectable		 4qknA-4c9gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 TYR A 165
GLN A 162
SER A 132
ASP A 207
 TYR  A 165 ( 1.3A)
GLN  A 162 ( 0.6A)
SER  A 132 ( 0.0A)
ASP  A 207 ( 0.6A)
 1.06A 4qtuB-3wd7A:
undetectable		 4qtuB-3wd7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 5 LEU A 202
SER A 205
ASP A 292
ASP A 274
 LEU  A 202 ( 0.6A)
SER  A 205 (-0.0A)
ASP  A 292 (-0.6A)
ASP  A 274 ( 0.5A)
 1.34A 4qtuD-3o96A:
undetectable		 4qtuD-3o96A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLN B 300
SER B 293
ASP B 290
 GLN  B 300 ( 0.6A)
SER  B 293 ( 0.0A)
ASP  B 290 ( 0.6A)
 0.96A 4qwpA-4oudB:
undetectable
4qwpB-4oudB:
undetectable		 4qwpA-4oudB:
20.15
4qwpB-4oudB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 8 PHE A 102
SER A 104
ALA A 155
LEU A 152
 PHE  A 102 ( 1.3A)
SER  A 104 ( 0.0A)
ALA  A 155 ( 0.0A)
LEU  A 152 ( 0.6A)
 1.02A 4rkuA-1c8xA:
undetectable
4rkuJ-1c8xA:
0.0		 4rkuA-1c8xA:
16.15
4rkuJ-1c8xA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 227
LEU A 218
GLY A 201
SER A 205
LEU A 206
 LEU  A 227 ( 0.6A)
LEU  A 218 ( 0.6A)
GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
LEU  A 206 ( 0.6A)
 1.08A 4rrxA-2ogsA:
undetectable		 4rrxA-2ogsA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 227
LEU A 218
GLY A 201
SER A 205
LEU A 206
 LEU  A 227 ( 0.6A)
LEU  A 218 ( 0.6A)
GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
LEU  A 206 ( 0.6A)
 1.07A 4rrxB-2ogsA:
undetectable		 4rrxB-2ogsA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		6 / 12 LEU A 423
SER A 314
SER A 313
PHE A 312
GLY A 420
GLY A 227
 LEU  A 423 ( 0.6A)
SER  A 314 ( 0.0A)
SER  A 313 ( 0.0A)
PHE  A 312 ( 1.3A)
GLY  A 420 ( 0.0A)
GLY  A 227 ( 0.0A)
 1.41A 4rzvA-3ulkA:
undetectable		 4rzvA-3ulkA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 VAL A  39
ALA A  52
LYS A  54
SER A 112
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
PHE  A 172 ( 1.3A)
 0.65A 4rzvB-5d7aA:
25.4		 4rzvB-5d7aA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 LEU A 250
SER A 252
ILE A 236
VAL A 210
 LEU  A 250 ( 0.6A)
SER  A 252 ( 0.0A)
ILE  A 236 ( 0.6A)
VAL  A 210 ( 0.6A)
 1.15A 4tvtA-2vbfA:
undetectable		 4tvtA-2vbfA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.87A 4u8vB-4g9kA:
undetectable		 4u8vB-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.90A 4u8yB-4g9kA:
undetectable		 4u8yB-4g9kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.84A 4u95B-4g9kA:
undetectable		 4u95B-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		4 / 7 SER A 414
GLU A 221
TRP A 320
ASP A 319
 SER  A 414 ( 0.0A)
GLU  A 221 (-0.6A)
TRP  A 320 ( 0.5A)
ASP  A 319 ( 0.6A)
 1.18A 4uacA-3ulkA:
undetectable		 4uacA-3ulkA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 LEU A 315
LEU A 274
SER A 320
THR A 321
ILE A 324
 LEU  A 315 ( 0.6A)
LEU  A 274 ( 0.6A)
SER  A 320 ( 0.0A)
THR  A 321 ( 0.8A)
ILE  A 324 ( 0.7A)
 1.30A 4ubsA-3i4kA:
undetectable		 4ubsA-3i4kA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 SER A  97
ASP A 163
ASP A  94
 SER  A  97 ( 0.0A)
ASP  A 163 ( 0.6A)
ASP  A  94 ( 0.6A)
 0.78A 4uckA-1rynA:
undetectable		 4uckA-1rynA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		8 / 12 HIS H  35
SER H  59
PHE H 111
GLN L  89
GLN L  90
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
SER  H  59 ( 0.0A)
PHE  H 111 ( 1.3A)
GLN  L  89 ( 0.6A)
GLN  L  90 ( 0.6A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 1.00A 4uilH-1fgvH:
20.2
4uilL-1fgvH:
5.2		 4uilH-1fgvH:
53.23
4uilL-1fgvH:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		6 / 12 TRP H  47
SER H  59
PHE H 111
GLY L  91
LEU L  94
PRO L  96
 TRP  H  47 ( 0.4A)
SER  H  59 ( 0.0A)
PHE  H 111 ( 1.3A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.91A 4uinH-1fgvH:
21.2
4uinL-1fgvH:
13.6		 4uinH-1fgvH:
52.42
4uinL-1fgvH:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  83
GLU A 128
PRO A 345
ILE A 347
SER A 174
 SER  A  83 (-0.0A)
GLU  A 128 (-0.5A)
PRO  A 345 ( 1.1A)
ILE  A 347 ( 0.7A)
SER  A 174 ( 0.0A)
 1.31A 4uroB-4g9kA:
undetectable		 4uroB-4g9kA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1ted PKS18
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 315
LEU A 352
ALA A 311
SER A 337
ALA A 334
 GLY  A 315 ( 0.0A)
LEU  A 352 ( 0.6A)
ALA  A 311 ( 0.0A)
SER  A 337 ( 0.0A)
ALA  A 334 ( 0.0A)
 1.26A 4wnuD-1tedA:
undetectable		 4wnuD-1tedA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 SER A 293
LEU A 294
ASP A 295
LEU A 345
 SER  A 293 ( 0.0A)
LEU  A 294 ( 0.6A)
ASP  A 295 ( 0.6A)
LEU  A 345 ( 0.6A)
 0.86A 4wozA-3sagA:
undetectable
4wozB-3sagA:
undetectable		 4wozA-3sagA:
21.20
4wozB-3sagA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 7 GLY A 354
GLN A 355
SER A 351
ASN A 359
 GLY  A 354 ( 0.0A)
GLN  A 355 ( 0.6A)
SER  A 351 ( 0.0A)
ASN  A 359 ( 0.6A)
 0.95A 4ws0A-3r6yA:
undetectable		 4ws0A-3r6yA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		4 / 8 GLY A 354
GLN A 355
SER A 351
ASN A 359
 GLY  A 354 ( 0.0A)
GLN  A 355 ( 0.6A)
SER  A 351 ( 0.0A)
ASN  A 359 ( 0.6A)
 0.94A 4ws1A-3r6yA:
undetectable		 4ws1A-3r6yA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.56A 4x1iA-2v9uA:
undetectable		 4x1iA-2v9uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		3 / 3 SER A 182
ALA A 241
VAL A 240
 SER  A 182 ( 0.0A)
ALA  A 241 ( 0.0A)
VAL  A 240 ( 0.6A)
 0.51A 4x20C-1wqaA:
undetectable		 4x20C-1wqaA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 10 LEU A 431
LEU A 432
SER A 425
ALA A 297
ILE A 295
 LEU  A 431 ( 0.6A)
LEU  A 432 ( 0.5A)
SER  A 425 ( 0.0A)
ALA  A 297 ( 0.0A)
ILE  A 295 ( 0.6A)
 1.04A 4xj7C-3ulkA:
2.8
4xj7D-3ulkA:
2.6		 4xj7C-3ulkA:
20.28
4xj7D-3ulkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 7 PHE A 102
SER A 104
ALA A 155
LEU A 152
 PHE  A 102 ( 1.3A)
SER  A 104 ( 0.0A)
ALA  A 155 ( 0.0A)
LEU  A 152 ( 0.6A)
 1.09A 4xk8A-1c8xA:
undetectable		 4xk8A-1c8xA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		5 / 10 VAL A 132
ASP A 133
PHE A 249
SER A 204
SER A 135
 VAL  A 132 ( 0.6A)
ASP  A 133 ( 0.6A)
PHE  A 249 ( 1.3A)
SER  A 204 ( 0.0A)
SER  A 135 ( 0.0A)
 1.39A 4xp1A-5w0aA:
undetectable		 4xp1A-5w0aA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 SER A 488
HIS A 523
LEU A 472
LEU A 467
LEU A 465
 SER  A 488 ( 0.0A)
HIS  A 523 ( 1.0A)
LEU  A 472 ( 0.5A)
LEU  A 467 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.31A 4xumA-5svdA:
undetectable		 4xumA-5svdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 SER A  36
VAL A  52
LEU A  55
ILE A  63
GLY A  19
 SER  A  36 ( 0.0A)
VAL  A  52 ( 0.6A)
LEU  A  55 ( 0.6A)
ILE  A  63 ( 0.7A)
GLY  A  19 ( 0.0A)
 0.98A 4y8wA-4egsA:
undetectable		 4y8wA-4egsA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 SER A  36
VAL A  52
LEU A  55
ILE A  63
GLY A  19
 SER  A  36 ( 0.0A)
VAL  A  52 ( 0.6A)
LEU  A  55 ( 0.6A)
ILE  A  63 ( 0.7A)
GLY  A  19 ( 0.0A)
 1.02A 4y8wB-4egsA:
undetectable		 4y8wB-4egsA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 PRO A 196
THR A 197
ARG A  94
SER A 208
GLY A 200
 PRO  A 196 ( 1.1A)
THR  A 197 ( 0.8A)
ARG  A  94 ( 0.6A)
SER  A 208 ( 0.0A)
GLY  A 200 ( 0.0A)
 1.29A 4ydqB-3wd7A:
undetectable		 4ydqB-3wd7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 5ohe GLOBIN-COUPLED
HISTIDINE KINASE
(Anaeromyxobacter
sp.
Fw109-5) 		5 / 10 LEU A 146
LEU A 120
SER A  28
LEU A  29
LEU A  76
 LEU  A 146 ( 0.6A)
LEU  A 120 ( 0.6A)
SER  A  28 ( 0.0A)
LEU  A  29 ( 0.5A)
LEU  A  76 ( 0.6A)
 1.19A 4yiaA-5oheA:
undetectable		 4yiaA-5oheA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 SER A 605
GLU A 651
GLU A 721
 SER  A 605 ( 0.0A)
GLU  A 651 ( 0.6A)
GLU  A 721 ( 0.6A)
 0.87A 4ymgB-1v0fA:
undetectable		 4ymgB-1v0fA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 9 SER A 233
ALA A 178
PHE A 458
VAL A 182
LEU A 170
 SER  A 233 ( 0.0A)
ALA  A 178 ( 0.0A)
PHE  A 458 ( 1.3A)
VAL  A 182 ( 0.6A)
LEU  A 170 ( 0.5A)
 1.27A 4z69A-4kqnA:
undetectable		 4z69A-4kqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		5 / 12 SER A 347
GLU A 348
GLU A 211
THR A 202
GLY A 203
 SER  A 347 ( 0.0A)
GLU  A 348 ( 0.6A)
GLU  A 211 ( 0.6A)
THR  A 202 ( 0.8A)
GLY  A 203 ( 0.0A)
 1.45A 4zjlA-5ep8A:
undetectable		 4zjlA-5ep8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1
(Saccharomyces
cerevisiae) 		4 / 8 SER C  90
TYR C 163
ALA C 164
PHE C  85
 SER  C  90 ( 0.0A)
TYR  C 163 ( 1.3A)
ALA  C 164 ( 0.0A)
PHE  C  85 ( 1.3A)
 0.85A 5albL-5lmxC:
undetectable		 5albL-5lmxC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 6 LEU A 359
TRP A 360
SER A 380
PHE A 381
 LEU  A 359 ( 0.5A)
TRP  A 360 ( 0.5A)
SER  A 380 ( 0.0A)
PHE  A 381 ( 1.3A)
 1.29A 5b8iA-2vbfA:
undetectable		 5b8iA-2vbfA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 TYR A 295
GLY A 362
SER A 366
LEU A 367
 TYR  A 295 ( 1.3A)
GLY  A 362 ( 0.0A)
SER  A 366 ( 0.0A)
LEU  A 367 ( 0.6A)
 1.10A 5bphB-5ec3A:
undetectable		 5bphB-5ec3A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 7 SER A 233
ASP A 163
ARG A 223
GLU A 219
 SER  A 233 ( 0.0A)
ASP  A 163 ( 0.6A)
ARG  A 223 ( 0.6A)
GLU  A 219 ( 0.6A)
 1.11A 5btfA-4kqnA:
undetectable
5btfC-4kqnA:
undetectable
5btfD-4kqnA:
undetectable		 5btfA-4kqnA:
22.00
5btfC-4kqnA:
22.00
5btfD-4kqnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 278
GLU A 241
SER A 318
 ASP  A 278 ( 0.6A)
GLU  A 241 ( 0.6A)
SER  A 318 ( 0.0A)
 0.64A 5bw4B-5jjaA:
undetectable		 5bw4B-5jjaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		4 / 6 SER A   8
GLU A  11
GLY A 106
GLY A  67
 SER  A   8 ( 0.0A)
GLU  A  11 ( 0.6A)
GLY  A 106 ( 0.0A)
GLY  A  67 ( 0.0A)
 0.82A 5cdnA-2hk0A:
undetectable
5cdnB-2hk0A:
undetectable		 5cdnA-2hk0A:
23.31
5cdnB-2hk0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 6 SER A  83
GLU A 126
GLY A 382
ASP A 383
GLY A  64
 SER  A  83 (-0.0A)
GLU  A 126 ( 0.5A)
GLY  A 382 (-0.0A)
ASP  A 383 (-0.5A)
GLY  A  64 (-0.0A)
 1.05A 5cdnA-4g9kA:
undetectable
5cdnB-4g9kA:
2.2		 5cdnA-4g9kA:
22.75
5cdnB-4g9kA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		4 / 6 SER A   8
GLU A  11
GLY A 106
GLY A  67
 SER  A   8 ( 0.0A)
GLU  A  11 ( 0.6A)
GLY  A 106 ( 0.0A)
GLY  A  67 ( 0.0A)
 0.81A 5cdnR-2hk0A:
undetectable
5cdnS-2hk0A:
undetectable		 5cdnR-2hk0A:
23.31
5cdnS-2hk0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 12 GLY A  36
ALA A  35
SER A 215
TYR A 190
GLU A  42
 GLY  A  36 ( 0.0A)
ALA  A  35 ( 0.0A)
SER  A 215 ( 0.0A)
TYR  A 190 ( 1.3A)
GLU  A  42 ( 0.6A)
 1.31A 5cprB-5d7wA:
undetectable		 5cprB-5d7wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 SER A 412
ALA A 409
ALA A 406
GLY A 415
ALA A 418
 SER  A 412 ( 0.0A)
ALA  A 409 ( 0.0A)
ALA  A 406 ( 0.0A)
GLY  A 415 ( 0.0A)
ALA  A 418 ( 0.0A)
 0.97A 5d0xK-3r64A:
undetectable
5d0xL-3r64A:
undetectable		 5d0xK-3r64A:
17.26
5d0xL-3r64A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 SER A 412
ALA A 409
ALA A 406
GLY A 415
ALA A 418
 SER  A 412 ( 0.0A)
ALA  A 409 ( 0.0A)
ALA  A 406 ( 0.0A)
GLY  A 415 ( 0.0A)
ALA  A 418 ( 0.0A)
 0.96A 5d0xY-3r64A:
undetectable
5d0xZ-3r64A:
undetectable		 5d0xY-3r64A:
17.26
5d0xZ-3r64A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.20A 5dzkb-1gc7A:
0.0
5dzkp-1gc7A:
undetectable		 5dzkb-1gc7A:
19.68
5dzkp-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 6 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.23A 5dzkB-1gc7A:
0.0
5dzkP-1gc7A:
undetectable		 5dzkB-1gc7A:
19.68
5dzkP-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.22A 5dzkc-1gc7A:
0.0
5dzkq-1gc7A:
undetectable		 5dzkc-1gc7A:
19.68
5dzkq-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 7 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.08A 5dzkD-1gc7A:
undetectable
5dzkR-1gc7A:
undetectable		 5dzkD-1gc7A:
19.68
5dzkR-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.06A 5dzkf-1gc7A:
0.0
5dzkt-1gc7A:
undetectable		 5dzkf-1gc7A:
19.68
5dzkt-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5oie -
(-) 		4 / 6 TYR A 225
ASP A 182
TYR A 222
TYR A 375
 None
SER  A 507 (-3.3A)
None
None
 1.14A 5e2iA-5oieA:
undetectable		 5e2iA-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3s2w TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Methanosarcina
mazei) 		5 / 12 GLY A  46
SER A  47
PHE A  50
VAL A 105
LEU A  67
 GLY  A  46 (-0.0A)
SER  A  47 (-0.0A)
PHE  A  50 ( 1.3A)
VAL  A 105 ( 0.6A)
LEU  A  67 ( 0.6A)
 1.04A 5ergB-3s2wA:
undetectable		 5ergB-3s2wA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 201
SER A 205
VAL A 202
HIS A 287
 GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
VAL  A 202 ( 0.6A)
HIS  A 287 ( 1.0A)
 1.09A 5ewuA-2ogsA:
undetectable		 5ewuA-2ogsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 201
SER A 205
VAL A 202
HIS A 287
 GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
VAL  A 202 ( 0.6A)
HIS  A 287 ( 1.0A)
 1.06A 5ewuB-2ogsA:
undetectable		 5ewuB-2ogsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.56A 5eypA-2v9uA:
undetectable		 5eypA-2v9uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  73
SER A  99
GLU A 127
SER A  67
GLY A 224
 LEU  A  73 (-0.6A)
SER  A  99 ( 0.0A)
GLU  A 127 ( 0.5A)
SER  A  67 ( 0.0A)
GLY  A 224 (-0.0A)
 1.34A 5f9zB-3c3nA:
undetectable		 5f9zB-3c3nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 213
PHE A 258
SER A 257
PHE A 126
GLY A 131
 LEU  A 213 ( 0.6A)
PHE  A 258 ( 1.3A)
SER  A 257 ( 0.0A)
PHE  A 126 ( 1.3A)
GLY  A 131 ( 0.0A)
 1.08A 5f9zB-5svdA:
undetectable		 5f9zB-5svdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		3 / 3 PRO A  68
LEU A 147
SER A 110
 PRO  A  68 ( 1.1A)
LEU  A 147 ( 0.6A)
SER  A 110 ( 0.0A)
 0.65A 5fsaB-2hk0A:
undetectable		 5fsaB-2hk0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 VAL A 169
LEU A 149
MET A 122
SER A 197
GLY A 237
 VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
MET  A 122 ( 0.0A)
SER  A 197 ( 0.0A)
GLY  A 237 ( 0.0A)
 1.49A 5g6sA-3sl5A:
0.7
5g6sG-3sl5A:
0.0		 5g6sA-3sl5A:
22.85
5g6sG-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 MET A 122
SER A 197
GLY A 237
VAL A 169
LEU A 149
 MET  A 122 ( 0.0A)
SER  A 197 ( 0.0A)
GLY  A 237 ( 0.0A)
VAL  A 169 ( 0.6A)
LEU  A 149 ( 0.6A)
 1.49A 5g6sB-3sl5A:
undetectable
5g6sC-3sl5A:
undetectable		 5g6sB-3sl5A:
22.85
5g6sC-3sl5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		3 / 3 ASP A  68
SER A  58
TYR A  64
 ASP  A  68 ( 0.5A)
SER  A  58 ( 0.0A)
TYR  A  64 ( 1.3A)
 0.66A 5glmA-3qviA:
undetectable		 5glmA-3qviA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GQB_A_GCSA605_1
(CHITINASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		3 / 3 TRP A 160
ILE A 200
SER A 203
 TRP  A 160 ( 0.5A)
ILE  A 200 ( 0.7A)
SER  A 203 ( 0.0A)
 0.27A 5gqbA-5gprA:
67.9		 5gqbA-5gprA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 TRP A 129
ILE A 136
SER A 148
 TRP  A 129 ( 0.5A)
ILE  A 136 ( 0.6A)
SER  A 148 ( 0.0A)
 0.91A 5gqbA-5hiuA:
undetectable		 5gqbA-5hiuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 ASN A 725
SER A 756
SER A 757
 ASN  A 725 ( 0.6A)
SER  A 756 ( 0.0A)
SER  A 757 ( 0.0A)
 0.63A 5gsnA-5l5nA:
undetectable		 5gsnA-5l5nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 365
GLY A 374
SER A 375
GLY A 363
SER A 360
 ALA  A 365 ( 0.0A)
GLY  A 374 ( 0.0A)
SER  A 375 ( 0.0A)
GLY  A 363 ( 0.0A)
SER  A 360 ( 0.0A)
 1.11A 5gwxA-4g9kA:
3.1		 5gwxA-4g9kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		5 / 9 SER A 326
GLY A  39
ALA A 314
VAL A  40
ILE A  38
 SER  A 326 ( 0.0A)
GLY  A  39 ( 0.0A)
ALA  A 314 ( 0.0A)
VAL  A  40 ( 0.6A)
ILE  A  38 ( 0.6A)
 1.35A 5i3cA-1wlyA:
undetectable		 5i3cA-1wlyA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 5i3cC-4g41A:
24.8		 5i3cC-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 121
GLY A 103
ALA A 102
SER A 100
LEU A  34
 VAL  A 121 ( 0.6A)
GLY  A 103 ( 0.0A)
ALA  A 102 ( 0.0A)
SER  A 100 ( 0.0A)
LEU  A  34 ( 0.6A)
 1.17A 5ikrA-4mwtA:
undetectable		 5ikrA-4mwtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 6 SER A 309
GLY A 342
ASN A 343
ILE A 303
 SER  A 309 ( 0.0A)
GLY  A 342 ( 0.0A)
ASN  A 343 (-0.6A)
ILE  A 303 ( 0.7A)
 0.86A 5j4nA-5d7wA:
undetectable		 5j4nA-5d7wA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.85A 5jsdA-4ki5E:
2.5		 5jsdA-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.85A 5jsdB-4ki5E:
undetectable		 5jsdB-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.84A 5jsdC-4ki5E:
undetectable		 5jsdC-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.86A 5jseA-4ki5E:
2.5		 5jseA-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.87A 5jseB-4ki5E:
3.0		 5jseB-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4ki5 MURINE MONOCLONAL
G99 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 THR  E  28 ( 0.8A)
SER  E  31 ( 0.0A)
TYR  E  32 ( 1.3A)
 0.86A 5jseC-4ki5E:
undetectable		 5jseC-4ki5E:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 6 THR A 282
SER A 281
GLY A 279
ASN A 315
 THR  A 282 (-0.8A)
SER  A 281 ( 0.0A)
GLY  A 279 (-0.0A)
ASN  A 315 (-0.6A)
 0.86A 5k4pA-4zkeA:
undetectable		 5k4pA-4zkeA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 THR A 227
SER A 300
ASP A 285
 THR  A 227 ( 0.8A)
SER  A 300 ( 0.0A)
ASP  A 285 ( 0.5A)
 0.80A 5kvaA-1vhoA:
undetectable		 5kvaA-1vhoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		5 / 10 SER A  81
ASP A  83
PRO A  33
LEU A  85
SER A 114
 SER  A  81 ( 0.0A)
ASP  A  83 ( 0.6A)
PRO  A  33 ( 1.1A)
LEU  A  85 ( 0.6A)
SER  A 114 ( 0.0A)
 1.49A 5l1fD-2ogsA:
2.7		 5l1fD-2ogsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5gru DIABODY PROTEIN
(Mus
musculus) 		4 / 8 THR L 195
SER L 184
THR L 193
SER L 186
 THR  L 195 ( 0.8A)
SER  L 184 ( 0.0A)
THR  L 193 ( 0.8A)
SER  L 186 ( 0.0A)
 0.97A 5l4eA-5gruL:
undetectable
5l4eB-5gruL:
2.6
5l4eC-5gruL:
undetectable
5l4eD-5gruL:
undetectable
5l4eE-5gruL:
undetectable		 5l4eA-5gruL:
20.37
5l4eB-5gruL:
20.37
5l4eC-5gruL:
20.37
5l4eD-5gruL:
20.37
5l4eE-5gruL:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.97A 5l4iA-4w65A:
undetectable		 5l4iA-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		4 / 6 LEU A 109
ALA A 101
LEU A 103
SER A  63
 LEU  A 109 ( 0.6A)
ALA  A 101 ( 0.0A)
LEU  A 103 ( 0.6A)
SER  A  63 ( 0.0A)
 0.95A 5l4iB-4w65A:
undetectable		 5l4iB-4w65A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 6c0w CENTROMERE PROTEIN N
(Homo
sapiens) 		3 / 3 SER K 156
TYR K 155
TYR K 154
 SER  K 156 ( 0.0A)
TYR  K 155 ( 1.3A)
TYR  K 154 ( 1.3A)
 0.76A 5lakA-6c0wK:
undetectable
5lakI-6c0wK:
undetectable		 5lakA-6c0wK:
undetectable
5lakI-6c0wK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 6c0w CENTROMERE PROTEIN N
(Homo
sapiens) 		3 / 3 SER K 156
TYR K 155
TYR K 154
 SER  K 156 ( 0.0A)
TYR  K 155 ( 1.3A)
TYR  K 154 ( 1.3A)
 0.73A 5lakC-6c0wK:
undetectable
5lakJ-6c0wK:
undetectable		 5lakC-6c0wK:
undetectable
5lakJ-6c0wK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4yba REGULATORY PROTEIN C
(Klebsiella
pneumoniae) 		4 / 5 ILE A  57
PHE A  68
SER A  17
ALA A  60
 ILE  A  57 ( 0.7A)
PHE  A  68 ( 1.3A)
SER  A  17 ( 0.0A)
ALA  A  60 ( 0.0A)
 1.25A 5msdA-4ybaA:
undetectable		 5msdA-4ybaA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		3 / 3 SER A 295
SER A 301
PHE A 325
 SER  A 295 ( 0.0A)
SER  A 301 ( 0.0A)
PHE  A 325 ( 1.3A)
 0.90A 5mugA-5svdA:
undetectable		 5mugA-5svdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 4 SER A 235
ALA A 232
GLN A 155
THR A  44
 SER  A 235 ( 0.0A)
ALA  A 232 ( 0.0A)
GLN  A 155 ( 0.6A)
THR  A  44 ( 0.8A)
 1.46A 5n0rA-1wsvA:
undetectable		 5n0rA-1wsvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 4 SER A 235
ALA A 232
GLN A 155
THR A  44
 SER  A 235 ( 0.0A)
ALA  A 232 ( 0.0A)
GLN  A 155 ( 0.6A)
THR  A  44 ( 0.8A)
 1.44A 5n0sA-1wsvA:
undetectable		 5n0sA-1wsvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 4 SER A 235
ALA A 232
GLN A 155
THR A  44
 SER  A 235 ( 0.0A)
ALA  A 232 ( 0.0A)
GLN  A 155 ( 0.6A)
THR  A  44 ( 0.8A)
 1.46A 5n0wA-1wsvA:
undetectable		 5n0wA-1wsvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 4 SER A 235
ALA A 232
GLN A 155
THR A  44
 SER  A 235 ( 0.0A)
ALA  A 232 ( 0.0A)
GLN  A 155 ( 0.6A)
THR  A  44 ( 0.8A)
 1.47A 5n0xA-1wsvA:
undetectable		 5n0xA-1wsvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 7 LEU A  41
SER A  72
ILE A  77
ASP A  47
 LEU  A  41 ( 0.6A)
SER  A  72 ( 0.0A)
ILE  A  77 ( 0.7A)
ASP  A  47 ( 0.6A)
 0.94A 5n5dA-3eqzA:
3.2		 5n5dA-3eqzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.98A 5n8jB-1v0fA:
undetectable		 5n8jB-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.80A 5n8jB-3r9rA:
undetectable		 5n8jB-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.93A 5n8jA-1v0fA:
undetectable		 5n8jA-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.81A 5n8jA-3r9rA:
undetectable		 5n8jA-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		3 / 3 TYR A 592
SER A 610
TRP A 678
 TYR  A 592 ( 1.3A)
SER  A 610 ( 0.0A)
TRP  A 678 ( 0.5A)
 0.90A 5n8jD-1v0fA:
undetectable		 5n8jD-1v0fA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A 105
SER A 133
TRP A 224
 TYR  A 105 ( 1.3A)
SER  A 133 ( 0.0A)
TRP  A 224 ( 0.5A)
 0.85A 5n8jD-3r9rA:
undetectable		 5n8jD-3r9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1
(Rattus
norvegicus) 		4 / 4 ASN A 125
SER A 116
ALA A 120
VAL A 121
 ASN  A 125 ( 0.6A)
SER  A 116 ( 0.0A)
ALA  A 120 ( 0.0A)
VAL  A 121 ( 0.6A)
 1.39A 5nm5A-2pnnA:
undetectable		 5nm5A-2pnnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 SER A 327
ASN A  34
GLU A  99
GLU A  94
LEU A  96
 SER  A 327 ( 0.0A)
ASN  A  34 ( 0.6A)
GLU  A  99 ( 0.6A)
GLU  A  94 ( 0.6A)
LEU  A  96 ( 0.6A)
 1.11A 5nvpA-3r64A:
0.0		 5nvpA-3r64A:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 12 ALA A 231
GLY A 232
SER A 233
GLU A 243
LEU A 444
 ALA  A 231 ( 0.0A)
GLY  A 232 ( 0.0A)
SER  A 233 ( 0.0A)
GLU  A 243 ( 0.6A)
LEU  A 444 ( 0.6A)
 0.94A 5nwuA-3ulkA:
undetectable		 5nwuA-3ulkA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5me6 EUKARYOTIC
TRANSCRIPTION
INITIATION FACTOR 4E
(Cucumis
melo) 		3 / 3 LYS A 138
TRP A 139
SER A 185
 LYS  A 138 ( 0.0A)
TRP  A 139 ( 0.5A)
SER  A 185 ( 0.0A)
 1.13A 5nwwA-5me6A:
undetectable		 5nwwA-5me6A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 GLY A 334
PRO A 335
THR A 103
SER A 327
 GLY  A 334 ( 0.0A)
PRO  A 335 ( 1.1A)
THR  A 103 ( 0.8A)
SER  A 327 ( 0.0A)
 1.13A 5ny7A-3r64A:
undetectable		 5ny7A-3r64A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 329
GLY A 331
SER A 316
LEU A 302
THR A 324
 GLU  A 329 ( 0.6A)
GLY  A 331 (-0.0A)
SER  A 316 ( 0.0A)
LEU  A 302 ( 0.6A)
THR  A 324 ( 0.8A)
 1.02A 5o96A-4zkeA:
2.4
5o96B-4zkeA:
undetectable		 5o96A-4zkeA:
20.56
5o96B-4zkeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 HIS A 175
HIS A  77
HIS A 186
 None
SER  A 500 (-4.0A)
None
 0.90A 5oexA-1tkeA:
undetectable		 5oexA-1tkeA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 251
SER A 252
PHE A 255
HIS A 299
 LEU  A 251 ( 0.5A)
SER  A 252 ( 0.0A)
PHE  A 255 ( 1.3A)
HIS  A 299 ( 1.0A)
 1.09A 5om3A-5hiuA:
undetectable
5om3B-5hiuA:
undetectable		 5om3A-5hiuA:
11.93
5om3B-5hiuA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 8 SER A  36
ALA A  17
ALA A  51
LEU A  55
 SER  A  36 ( 0.0A)
ALA  A  17 ( 0.0A)
ALA  A  51 ( 0.0A)
LEU  A  55 ( 0.6A)
 0.69A 5te8B-4egsA:
undetectable		 5te8B-4egsA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 12 GLY A 507
VAL A 672
SER A 501
HIS A 386
LEU A 387
 GLY  A 507 ( 0.0A)
VAL  A 672 ( 0.6A)
SER  A 501 ( 0.0A)
HIS  A 386 ( 1.0A)
LEU  A 387 ( 0.5A)
 1.04A 5ubbA-4mtpA:
undetectable		 5ubbA-4mtpA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 293
GLN A 296
SER A 290
ASN A 214
ILE A 216
 LEU  A 293 ( 0.6A)
GLN  A 296 ( 0.6A)
SER  A 290 (-0.0A)
ASN  A 214 ( 0.6A)
ILE  A 216 (-0.7A)
 1.21A 5uhbC-1omoA:
2.1		 5uhbC-1omoA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 4 LEU A 392
GLY A 382
SER A 381
SER A 378
 LEU  A 392 ( 0.6A)
GLY  A 382 ( 0.0A)
SER  A 381 ( 0.0A)
SER  A 378 ( 0.0A)
 1.28A 5uunA-3o96A:
undetectable		 5uunA-3o96A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3p9w HUMAN VEGF
(Homo
sapiens) 		4 / 4 LEU B   4
GLY B 104
SER B 103
SER B 102
 LEU  B   4 ( 0.6A)
GLY  B 104 ( 0.0A)
SER  B 103 ( 0.0A)
SER  B 102 ( 0.0A)
 1.18A 5uunA-3p9wB:
undetectable		 5uunA-3p9wB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 4 LEU A 134
GLY A 268
SER A 267
SER A 266
 LEU  A 134 ( 0.6A)
GLY  A 268 ( 0.0A)
SER  A 267 ( 0.0A)
SER  A 266 ( 0.0A)
 1.39A 5uunA-3pu5A:
undetectable		 5uunA-3pu5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 7 PHE A  38
VAL A  63
ILE A  77
SER A  72
 PHE  A  38 ( 1.3A)
VAL  A  63 ( 0.6A)
ILE  A  77 ( 0.7A)
SER  A  72 ( 0.0A)
 1.02A 5vkqA-3eqzA:
undetectable
5vkqD-3eqzA:
undetectable		 5vkqA-3eqzA:
5.66
5vkqD-3eqzA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		4 / 7 SER A 181
THR A 178
PRO A 140
ILE A 139
 SER  A 181 ( 0.0A)
THR  A 178 ( 0.8A)
PRO  A 140 ( 1.1A)
ILE  A 139 ( 0.7A)
 1.23A 5vkqA-6gefA:
undetectable
5vkqB-6gefA:
undetectable		 5vkqA-6gefA:
undetectable
5vkqB-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 8 SER A 120
PHE A  26
VAL A 113
ILE A  50
 SER  A 120 ( 0.0A)
PHE  A  26 ( 1.3A)
VAL  A 113 ( 0.6A)
ILE  A  50 ( 0.7A)
 1.11A 5vkqB-3eqzA:
undetectable
5vkqC-3eqzA:
undetectable		 5vkqB-3eqzA:
5.66
5vkqC-3eqzA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		4 / 7 SER A 181
THR A 178
PRO A 140
ILE A 139
 SER  A 181 ( 0.0A)
THR  A 178 ( 0.8A)
PRO  A 140 ( 1.1A)
ILE  A 139 ( 0.7A)
 1.22A 5vkqC-6gefA:
undetectable
5vkqD-6gefA:
undetectable		 5vkqC-6gefA:
undetectable
5vkqD-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 182
SER A 186
GLU A 208
LEU A 191
ILE A 213
 ALA  A 182 ( 0.0A)
SER  A 186 ( 0.0A)
GLU  A 208 ( 0.6A)
LEU  A 191 ( 0.6A)
ILE  A 213 ( 0.7A)
 1.50A 5vlmA-1omoA:
0.0		 5vlmA-1omoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.44A 5vunA-4mwtA:
undetectable		 5vunA-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.55A 5xiwC-2v9uA:
undetectable		 5xiwC-2v9uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		3 / 3 SER A 110
HIS A 158
TYR A 116
 SER  A 110 ( 0.0A)
HIS  A 158 ( 1.0A)
TYR  A 116 ( 1.3A)
 1.04A 5y2tA-2hk0A:
undetectable		 5y2tA-2hk0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 ALA A 411
SER A 414
GLY A  58
TYR A 406
 ALA  A 411 ( 0.0A)
SER  A 414 ( 0.0A)
GLY  A  58 ( 0.0A)
TYR  A 406 ( 1.3A)
 1.27A 5yodB-2vbfA:
undetectable		 5yodB-2vbfA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 5 HIS C 343
SER C 332
TYR C 211
GLY C 333
 HIS  C 343 ( 1.0A)
SER  C 332 ( 0.0A)
TYR  C 211 ( 1.3A)
GLY  C 333 ( 0.0A)
 1.37A 5yodH-3ghgC:
undetectable		 5yodH-3ghgC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 194
SER A 191
THR A  29
VAL A  26
 GLY  A 194 ( 0.0A)
SER  A 191 ( 0.0A)
THR  A  29 ( 0.8A)
VAL  A  26 ( 0.6A)
 1.21A 5ysiA-4rhyA:
undetectable		 5ysiA-4rhyA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 LYS A  33
ASN A  31
SER A  24
 LYS  A  33 ( 0.0A)
ASN  A  31 ( 0.6A)
SER  A  24 ( 0.0A)
 1.17A 5yw0A-2nvvA:
undetectable		 5yw0A-2nvvA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		3 / 3 LYS A   1
ASN A 160
SER A 168
 GLN  A   1 ( 0.0A)
ASN  A 160 ( 0.6A)
SER  A 168 ( 0.0A)
 1.13A 5yw0A-5w0aA:
undetectable		 5yw0A-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  -1
SER A   4
ALA A  87
ARG A  86
PRO A 295
 GLY  A  -1 ( 0.0A)
SER  A   4 ( 0.0A)
ALA  A  87 ( 0.0A)
ARG  A  86 ( 0.6A)
PRO  A 295 ( 1.1A)
 1.07A 5zvgA-3r9rA:
undetectable		 5zvgA-3r9rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  -1
SER A   4
ALA A  87
ARG A  86
PRO A 295
 GLY  A  -1 ( 0.0A)
SER  A   4 ( 0.0A)
ALA  A  87 ( 0.0A)
ARG  A  86 ( 0.6A)
PRO  A 295 ( 1.1A)
 1.05A 5zvgB-3r9rA:
undetectable		 5zvgB-3r9rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		4 / 6 ASN A  26
PHE A  31
LEU A 409
SER A 405
 ASN  A  26 ( 0.6A)
PHE  A  31 ( 1.3A)
LEU  A 409 ( 0.5A)
SER  A 405 ( 0.0A)
 1.25A 6a7pB-5nksA:
undetectable		 6a7pB-5nksA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1tke THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 TYR A 104
HIS A  77
MET A 181
 SER  A 500 (-4.2A)
SER  A 500 (-4.0A)
None
 1.24A 6af6A-1tkeA:
undetectable		 6af6A-1tkeA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1aoy ARGININE REPRESSOR
(Escherichia
coli) 		3 / 3 SER A  44
LYS A  45
SER A  47
 SER  A  44 ( 0.0A)
LYS  A  45 ( 0.0A)
SER  A  47 ( 0.0A)
 0.78A 6az3P-1aoyA:
undetectable		 6az3P-1aoyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254
(Thermotoga
maritima) 		3 / 3 SER A 168
LYS A 167
SER A 166
 SER  A 168 (-0.0A)
LYS  A 167 (-0.0A)
SER  A 166 (-0.0A)
 0.85A 6az3P-3kbbA:
undetectable		 6az3P-3kbbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 121
ASP A 118
LEU A 129
SER A 100
GLY A 153
 VAL  A 121 ( 0.6A)
ASP  A 118 ( 0.6A)
LEU  A 129 ( 0.6A)
SER  A 100 ( 0.0A)
GLY  A 153 ( 0.0A)
 1.14A 6b0lB-4mwtA:
undetectable		 6b0lB-4mwtA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ALA A  61
SER A  62
VAL A 285
VAL A 259
GLY A 378
 ALA  A  61 ( 0.0A)
SER  A  62 ( 0.0A)
VAL  A 285 ( 0.6A)
VAL  A 259 ( 0.6A)
GLY  A 378 ( 0.0A)
 1.02A 6bklA-2nvvA:
undetectable
6bklB-2nvvA:
undetectable
6bklC-2nvvA:
undetectable
6bklD-2nvvA:
undetectable		 6bklA-2nvvA:
11.88
6bklB-2nvvA:
11.88
6bklC-2nvvA:
11.88
6bklD-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 SER A  62
ALA A  29
VAL A 285
SER A 306
GLY A 141
 SER  A  62 ( 0.0A)
ALA  A  29 ( 0.0A)
VAL  A 285 ( 0.6A)
SER  A 306 ( 0.0A)
GLY  A 141 ( 0.0A)
 1.24A 6bklA-2nvvA:
undetectable
6bklB-2nvvA:
undetectable
6bklC-2nvvA:
undetectable
6bklD-2nvvA:
undetectable		 6bklA-2nvvA:
11.88
6bklB-2nvvA:
11.88
6bklC-2nvvA:
11.88
6bklD-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 SER A  62
ALA A  29
VAL A 285
SER A 306
GLY A 143
 SER  A  62 ( 0.0A)
ALA  A  29 ( 0.0A)
VAL  A 285 ( 0.6A)
SER  A 306 ( 0.0A)
GLY  A 143 ( 0.0A)
 1.22A 6bklA-2nvvA:
undetectable
6bklB-2nvvA:
undetectable
6bklC-2nvvA:
undetectable
6bklD-2nvvA:
undetectable		 6bklA-2nvvA:
11.88
6bklB-2nvvA:
11.88
6bklC-2nvvA:
11.88
6bklD-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ALA A  29
GLY A 141
ALA A  61
GLY A 143
SER A  62
 ALA  A  29 ( 0.0A)
GLY  A 141 ( 0.0A)
ALA  A  61 ( 0.0A)
GLY  A 143 ( 0.0A)
SER  A  62 ( 0.0A)
 1.09A 6bklE-2nvvA:
undetectable
6bklF-2nvvA:
undetectable
6bklG-2nvvA:
undetectable
6bklH-2nvvA:
undetectable		 6bklE-2nvvA:
11.88
6bklF-2nvvA:
11.88
6bklG-2nvvA:
11.88
6bklH-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ALA A  29
SER A 306
GLY A 141
GLY A 143
SER A  62
 ALA  A  29 ( 0.0A)
SER  A 306 ( 0.0A)
GLY  A 141 ( 0.0A)
GLY  A 143 ( 0.0A)
SER  A  62 ( 0.0A)
 1.18A 6bklE-2nvvA:
undetectable
6bklF-2nvvA:
undetectable
6bklG-2nvvA:
undetectable
6bklH-2nvvA:
undetectable		 6bklE-2nvvA:
11.88
6bklF-2nvvA:
11.88
6bklG-2nvvA:
11.88
6bklH-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		5 / 12 SER A 110
GLY A 192
ALA A 191
PHE A 139
ASN A 315
 SER  A 110 (-0.0A)
GLY  A 192 ( 0.0A)
ALA  A 191 ( 0.0A)
PHE  A 139 ( 1.3A)
ASN  A 315 ( 0.6A)
 1.19A 6bqgA-5ep8A:
undetectable		 6bqgA-5ep8A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 THR A  42
VAL A 194
SER A 199
VAL A  66
GLU A  22
 THR  A  42 ( 0.8A)
VAL  A 194 ( 0.6A)
SER  A 199 (-0.0A)
VAL  A  66 ( 0.5A)
GLU  A  22 ( 0.6A)
 1.35A 6bzoC-1vhoA:
0.0		 6bzoC-1vhoA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 1fgv H52 FV (HEAVY CHAIN)
(Homo
sapiens) 		5 / 9 ARG H  38
ALA H  88
VAL H 122
SER H 123
ASP H  90
 ARG  H  38 ( 0.7A)
ALA  H  88 ( 0.0A)
VAL  H 122 ( 0.6A)
SER  H 123 ( 0.0A)
ASP  H  90 ( 0.6A)
 1.43A 6c2mA-1fgvH:
undetectable		 6c2mA-1fgvH:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 3p9w HUMAN VEGF
(Homo
sapiens) 		5 / 9 ARG B  38
ALA B  84
VAL B 111
SER B 112
ASP B  86
 ARG  B  38 ( 0.6A)
ALA  B  84 ( 0.0A)
VAL  B 111 ( 0.6A)
SER  B 112 ( 0.0A)
ASP  B  86 ( 0.5A)
 1.47A 6c2mA-3p9wB:
undetectable		 6c2mA-3p9wB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		5 / 10 PRO A 294
LEU A 302
SER A 213
ILE A 290
GLY A 225
 PRO  A 294 ( 1.1A)
LEU  A 302 ( 0.6A)
SER  A 213 ( 0.0A)
ILE  A 290 ( 0.7A)
GLY  A 225 ( 0.0A)
 1.10A 6dlzA-5w0aA:
undetectable
6dlzD-5w0aA:
undetectable		 6dlzA-5w0aA:
20.93
6dlzD-5w0aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		5 / 10 ILE A 290
GLY A 225
PRO A 294
LEU A 302
SER A 213
 ILE  A 290 ( 0.7A)
GLY  A 225 ( 0.0A)
PRO  A 294 ( 1.1A)
LEU  A 302 ( 0.6A)
SER  A 213 ( 0.0A)
 1.10A 6dlzB-5w0aA:
undetectable
6dlzC-5w0aA:
undetectable		 6dlzB-5w0aA:
20.93
6dlzC-5w0aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		5 / 10 PRO A 294
LEU A 302
SER A 213
ILE A 290
GLY A 225
 PRO  A 294 ( 1.1A)
LEU  A 302 ( 0.6A)
SER  A 213 ( 0.0A)
ILE  A 290 ( 0.7A)
GLY  A 225 ( 0.0A)
 1.10A 6dm1A-5w0aA:
undetectable
6dm1D-5w0aA:
undetectable		 6dm1A-5w0aA:
20.93
6dm1D-5w0aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		5 / 10 ILE A 290
GLY A 225
PRO A 294
LEU A 302
SER A 213
 ILE  A 290 ( 0.7A)
GLY  A 225 ( 0.0A)
PRO  A 294 ( 1.1A)
LEU  A 302 ( 0.6A)
SER  A 213 ( 0.0A)
 1.10A 6dm1B-5w0aA:
undetectable
6dm1C-5w0aA:
undetectable		 6dm1B-5w0aA:
20.93
6dm1C-5w0aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 LEU A 361
VAL A 365
SER A 369
THR A 370
VAL A 394
 LEU  A 361 ( 0.5A)
VAL  A 365 ( 0.5A)
SER  A 369 ( 0.0A)
THR  A 370 ( 0.8A)
VAL  A 394 ( 0.6A)
 1.40A 6drxA-4kqnA:
undetectable		 6drxA-4kqnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 9 ASP A 390
SER A  88
GLY A  54
ILE A  55
ILE A 453
 ASP  A 390 ( 0.6A)
SER  A  88 ( 0.0A)
GLY  A  54 ( 0.0A)
ILE  A  55 ( 0.6A)
ILE  A 453 ( 0.8A)
 1.25A 6ebpA-4kqnA:
undetectable		 6ebpA-4kqnA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 10 ASP A 390
SER A  88
GLY A  54
ILE A  55
ILE A 453
 ASP  A 390 ( 0.6A)
SER  A  88 ( 0.0A)
GLY  A  54 ( 0.0A)
ILE  A  55 ( 0.6A)
ILE  A 453 ( 0.8A)
 1.26A 6ebpB-4kqnA:
undetectable		 6ebpB-4kqnA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 LYS A 220
SER A 215
SER A 217
 LYS  A 220 ( 0.0A)
SER  A 215 ( 0.0A)
SER  A 217 ( 0.0A)
 1.00A 6gbfA-2j5bA:
3.2		 6gbfA-2j5bA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		5 / 9 ASP A3935
SER A3934
GLY A3847
SER A3851
ILE A3848
 ASP  A3935 ( 0.6A)
SER  A3934 ( 0.0A)
GLY  A3847 ( 0.0A)
SER  A3851 ( 0.0A)
ILE  A3848 ( 0.7A)
 1.38A 6giqA-5w6lA:
1.0
6giqE-5w6lA:
undetectable
6giqI-5w6lA:
undetectable		 6giqA-5w6lA:
undetectable
6giqE-5w6lA:
undetectable
6giqI-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 SER A 286
MET A 280
GLY A 340
ALA A 178
ASN A 279
 SER  A 286 ( 0.0A)
MET  A 280 ( 0.0A)
GLY  A 340 ( 0.0A)
ALA  A 178 ( 0.0A)
ASN  A 279 ( 0.6A)
 1.35A 6hu9L-4g9kA:
undetectable
6hu9P-4g9kA:
undetectable
6hu9T-4g9kA:
undetectable		 6hu9L-4g9kA:
23.60
6hu9P-4g9kA:
16.74
6hu9T-4g9kA:
11.03