SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SDP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4flm S-FORMYLGLUTATHIONE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 160
THR A 158
GLY A 164
GLY A  57
ASN A 295
 SDP  A 161 ( 3.9A)
None
SDP  A 161 ( 3.4A)
SDP  A 161 ( 3.5A)
None
 1.25A 1n2xA-4flmA:
undetectable		 1n2xA-4flmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4flm S-FORMYLGLUTATHIONE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  57
SER A  56
GLY A 159
ASP A 103
ILE A 197
 SDP  A 161 ( 3.5A)
None
None
None
None
 0.92A 2b25B-4flmA:
undetectable		 2b25B-4flmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4flm S-FORMYLGLUTATHIONE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 111
TYR A 165
ILE A 189
GLY A 109
 None
None
SDP  A 161 ( 4.7A)
None
 1.01A 2du8G-4flmA:
undetectable		 2du8G-4flmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4flm S-FORMYLGLUTATHIONE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 111
TYR A 165
ILE A 189
GLY A 109
 None
None
SDP  A 161 ( 4.7A)
None
 1.01A 2du8J-4flmA:
undetectable		 2du8J-4flmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4flm S-FORMYLGLUTATHIONE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 280
TYR A 278
GLY A 164
ILE A 189
 None
None
SDP  A 161 ( 3.4A)
SDP  A 161 ( 4.7A)
 0.96A 4qoiA-4flmA:
undetectable
4qoiB-4flmA:
2.1		 4qoiA-4flmA:
21.68
4qoiB-4flmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4flm S-FORMYLGLUTATHIONE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 278
PHE A 110
GLY A 198
HIS A 160
MET A 162
 None
None
None
SDP  A 161 ( 3.9A)
None
 1.36A 5esgA-4flmA:
undetectable		 5esgA-4flmA:
19.53