SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SD4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_D_ADND500_1 (ADENOSYLHOMOCYSTEINA SE)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	5 / 12	GLU A 301 THR A 416 ASP A 264 GLY A 123 HIS A 440	SD4 A 504 (-2.7A) None ZN A 502 (-2.4A) None ZN A 501 (-3.3A)	1.39A	3ce6D-4dyoA: undetectable	3ce6D-4dyoA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PQA_A_X8ZA401_1 (SUCCINYL-DIAMINOPIME LATE DESUCCINYLASE)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	6 / 11	HIS A 94 ASP A 264 GLU A 301 GLU A 302 GLY A 414 HIS A 440	ZN A 502 ( 3.4A) ZN A 502 (-2.4A) SD4 A 504 (-2.7A) ZN A 501 (-2.0A) SD4 A 504 (-3.4A) ZN A 501 (-3.3A)	0.41A	4pqaA-4dyoA: 21.6	4pqaA-4dyoA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_D_SAMD301_1 (UNCHARACTERIZED PROTEIN)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	3 / 3	ARG A 380 GLU A 301 TYR A 381	None SD4 A 504 (-2.7A) SD4 A 504 (-4.7A)	1.00A	4r29D-4dyoA: undetectable	4r29D-4dyoA: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5Q_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	4 / 6	ASP A 431 THR A 416 THR A 415 TYR A 381	None None None SD4 A 504 (-4.7A)	1.30A	4w5qA-4dyoA: undetectable	4w5qA-4dyoA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5R_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	4 / 6	ASP A 431 THR A 416 THR A 415 TYR A 381	None None None SD4 A 504 (-4.7A)	1.28A	4w5rA-4dyoA: undetectable	4w5rA-4dyoA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5T_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	4 / 6	ASP A 431 THR A 416 THR A 415 TYR A 381	None None None SD4 A 504 (-4.7A)	1.31A	4w5tA-4dyoA: undetectable	4w5tA-4dyoA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6J_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	3 / 3	MET A 439 ASP A 346 ARG A 380	SD4 A 504 ( 3.7A) ZN A 502 ( 2.0A) None	1.18A	5z6jA-4dyoA: undetectable	5z6jA-4dyoA: 13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	4dyo	ASPARTYL AMINOPEPTIDASE (Homo sapiens)	3 / 3	MET A 439 ASP A 346 ARG A 380	SD4 A 504 ( 3.7A) ZN A 502 ( 2.0A) None	1.13A	5z6kA-4dyoA: undetectable	5z6kA-4dyoA: 13.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3CE6_D_ADND500_1","ADENOSYLHOMOCYSTEINASE","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",5,"GLU A 301;THR A 416;ASP A 264;GLY A 123;HIS A 440","SD4 A 504 (-2.7A);None; ZN A 502 (-2.4A);None; ZN A 501 (-3.3A)","1.39A","3ce6D-4dyoA:undetectable",null],["4PQA_A_X8ZA401_1","SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",6,"HIS A  94;ASP A 264;GLU A 301;GLU A 302;GLY A 414;HIS A 440"," ZN A 502 ( 3.4A); ZN A 502 (-2.4A);SD4 A 504 (-2.7A); ZN A 501 (-2.0A);SD4 A 504 (-3.4A); ZN A 501 (-3.3A)","0.41A","4pqaA-4dyoA:21.6","3ce6D-4dyoA:21.80"],["4R29_D_SAMD301_1","UNCHARACTERIZED PROTEIN","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",3,"ARG A 380;GLU A 301;TYR A 381","None;SD4 A 504 (-2.7A);SD4 A 504 (-4.7A)","1.00A","4r29D-4dyoA:undetectable","4pqaA-4dyoA:22.18"],["4W5Q_A_IPHA905_0","PROTEIN ARGONAUTE-2","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",4,"ASP A 431;THR A 416;THR A 415;TYR A 381","None;None;None;SD4 A 504 (-4.7A)","1.30A","4w5qA-4dyoA:undetectable","4r29D-4dyoA:18.89"],["4W5R_A_IPHA905_0","PROTEIN ARGONAUTE-2","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",4,"ASP A 431;THR A 416;THR A 415;TYR A 381","None;None;None;SD4 A 504 (-4.7A)","1.28A","4w5rA-4dyoA:undetectable","4w5qA-4dyoA:21.31"],["4W5T_A_IPHA905_0","PROTEIN ARGONAUTE-2","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",4,"ASP A 431;THR A 416;THR A 415;TYR A 381","None;None;None;SD4 A 504 (-4.7A)","1.31A","4w5tA-4dyoA:undetectable","4w5rA-4dyoA:21.31"],["5Z6J_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",3,"MET A 439;ASP A 346;ARG A 380","SD4 A 504 ( 3.7A); ZN A 502 ( 2.0A);None","1.18A","5z6jA-4dyoA:undetectable","4w5tA-4dyoA:21.31"],["5Z6K_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","4dyo","ASPARTYL AMINOPEPTIDASE","Homo sapiens",3,"MET A 439;ASP A 346;ARG A 380","SD4 A 504 ( 3.7A); ZN A 502 ( 2.0A);None","1.13A","5z6kA-4dyoA:undetectable","5z6jA-4dyoA:13.81"]]