SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SCA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2vzz RV0802C
(Mycobacterium
tuberculosis) 		4 / 5 SER A 109
ARG A 127
ARG A 159
GLY A 162
 SCA  A 601 (-2.5A)
SCA  A 601 (-3.5A)
None
None
 1.19A 3k9fA-2vzzA:
undetectable
3k9fB-2vzzA:
undetectable
3k9fC-2vzzA:
undetectable		 3k9fA-2vzzA:
18.07
3k9fB-2vzzA:
18.07
3k9fC-2vzzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2vzz RV0802C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 110
ARG A 127
ALA A 153
HIS A  39
PHE A  46
 SCA  A 601 (-3.3A)
SCA  A 601 (-3.5A)
SCA  A 601 (-3.6A)
None
SCA  A 601 (-4.4A)
 1.42A 5arfA-2vzzA:
undetectable		 5arfA-2vzzA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2vzz RV0802C
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  84
VAL A  91
GLN A 118
 None
None
SCA  A 601 (-3.4A)
 0.70A 5qglA-2vzzA:
undetectable		 5qglA-2vzzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2vzz RV0802C
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  84
VAL A  91
GLN A 118
 None
None
SCA  A 601 (-3.4A)
 0.65A 5qgnA-2vzzA:
undetectable		 5qgnA-2vzzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2vzz RV0802C
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  84
VAL A  91
GLN A 118
 None
None
SCA  A 601 (-3.4A)
 0.72A 5qhgA-2vzzA:
undetectable		 5qhgA-2vzzA:
19.41